Article
Chemistry, Medicinal
Meng-ying Chen, Qin Wang, Zhao-jun Meng, Wei-jie Men, Ju-yang Huang, Bin Yu, Kun Zhou
Summary: In this study, it was found that psoralen treatment induced liver injury in mice, especially in male mice. Further analysis showed that psoralen disrupted the balance of bile acid metabolism by inhibiting the expression of efflux transporter, leading to liver damage.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Gabriel O. de Souza, Frederick Wasinski, Jose Donato
Summary: This study aimed to compare the responses of male and female C57BL/6 mice to various metabolic challenges. The results showed that male mice had stronger responses to food restriction and refeeding, while female mice had higher protection against diet-induced obesity. Additionally, male mice had different feeding responses to ghrelin and leptin compared to females. However, these sex differences were not explained by differences in central responsiveness or neuron fiber density.
Article
Pharmacology & Pharmacy
Fabiana Troisi, Simona Pace, Paul M. Jordan, Katharina P. L. Meyer, Rossella Bilancia, Armando Ialenti, Francesca Borrelli, Antonietta Rossi, Lidia Sautebin, Charles N. Serhan, Oliver Werz
Summary: Sex differences and the role of sex hormones in lipid mediator biosynthetic networks were observed in acute self-resolving inflammation in mice, indicating advantages in males controlled by androgens.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sarah M. Zala, Brian Church, Wayne K. Potts, Felix Knauer, Dustin J. Penn
Summary: Exposing juvenile male mice to female urine accelerates their growth and body mass gain, but has no effect on muscle mass or sexual organ development. The accelerated growth does not trade-off with immune resistance to bacterial infection. This study provides the first evidence that juvenile male mice accelerate their growth when exposed to adult females' urine, without negative trade-offs on immune resistance.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Yuxin Cao, Xinming Zhang, Meilin Hu, Song Yang, Xiaoyan Li, Ruohui Han, Jun Zhou, Dengwen Li, Dayong Liu
Summary: Periodontitis is a chronic immune inflammatory disease that leads to the destruction and loss of tooth-supporting apparatus. Depletion of CYLD in mice results in osteoporotic bone phenotype and significantly contributes to periodontal bone loss. This study provides insights into the underlying mechanisms of CYLD deficiency in periodontal tissue homeostasis and suggests its potential therapeutic effect on periodontal inflammatory responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biology
Lianna W. Wat, Zahid S. Chowdhury, Jason W. Millington, Puja Biswas, Elizabeth J. Rideout
Summary: Sex differences in whole-body fat storage exist in many species, with females storing more fat than males in fruit flies. The sex determination gene transformer (tra) plays a key role in regulating this difference, with its function in neurons, specifically Akh-producing cells (APCs), influencing fat storage in a sex-specific manner. This study identifies the Akh pathway as a mechanism underlying the male-female difference in whole-body triglyceride levels and provides insight into conserved mechanisms of sexual dimorphism in fat storage.
Article
Nutrition & Dietetics
Jorge Briseno-Bugarin, Isabel Hernandez-Ochoa, Xelha Araujo-Padilla, Maria Angelica Mojica-Villegas, Ricardo Ivan Montano-Gonzalez, Gabriela Gutierrez-Salmean, German Chamorro-Cevallos
Summary: Our study demonstrated that PBP crude extract at 200 mg/kg mitigated oxidative damage in the testes and ameliorated alterations in sperm parameters in mice treated with CP, indicating the potential of PBP extract as a protective agent against CP toxicity.
Article
Immunology
Eva M. Medina -Rodriguez, Kenner C. Rice, Richard S. Jope, Eleonore Beurel
Summary: This study found that chronic restraint stress induces depressive-like behaviors in mice, with both males and females showing similar behavioral changes. However, there are differences in the inflammatory response, changes in microglia, and Toll-like receptor 4 expression between male and female mice. Treatment with a Toll-like receptor 4 antagonist shows more effective anti-depressant-like effects in male mice than in females, and this effect is not mediated by the microbiome. These findings suggest the need to consider different mechanisms in potential sex-specific treatments for depression.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Kim Browne, Emily Zhang, James K. Sullivan, Kirsten S. Evonuk, Tara M. DeSilva, Trine N. Jorgensen
Summary: The study found that the B6.Nba2 mouse model exhibits NPSLE-like phenotypes, including elevated levels of autoantibodies, anxiety and depression behaviors, and memory deficits. Male B6.Nba2 mice developed this phenotype slightly later than females, and female B6.Nba2 mice showed reduced numbers of neurons in the hippocampal region.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Betul R. Erdogan, Martina B. Michel, Jan Matthes, Tamara R. Castaneda, Urs Christen, Ebru Arioglu-Inan, Martin C. Michel, Andrea Pautz
Summary: Diabetes often leads to lower urinary tract dysfunction. This study compared bladder weight and bladder/body weight ratio in different mouse models of obesity and diabetes, and found that sex differences in diabetes/obesity-associated bladder enlargement may be model dependent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Tadatoshi Sato, Christian D. Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J. Greenlee, Patricia C. Weber, Usha Viswanathan, John Kulp, Daniel J. Brooks, Marie B. Demay, Mary L. Bouxsein, Bruce Mitlak, Beate Lanske, Marc N. Wein
Summary: This study identifies SIK2/SIK3 as potential drug targets for treating osteoporosis and successfully develops an orally available SIK2/SIK3 inhibitor. The inhibitor stimulates bone formation and increases bone density without apparent toxicity. These findings provide a new approach for the pharmacological treatment of osteoporosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Eleanor R. Schrems, Wesley S. Haynie, Richard A. Perry, Francielly Morena, Ana Regina Cabrera, Megan E. Rosa-Caldwell, Nicholas P. Greene, Tyrone A. Washington
Summary: Leucine supplementation exacerbates moribundity in male cancer patients and does not mitigate muscle or fat loss during cancer cachexia in either sex.
Article
Pharmacology & Pharmacy
Casey-Tyler Berezin, Nikolas Bergum, Glenda M. Torres Lopez, Jozsef Vigh
Summary: Opioids are effective analgesics, but their dangerous side effects need to be considered. Research on opioid pharmacokinetics provides crucial information on drug effects. This study found that morphine accumulates in the mouse retina at higher concentrations than in the brain and that reduced P-gp expression may be the cause. P-gp was identified as the main opioid transporter at the blood-retina barrier, and its expression correlated with morphine concentration in the retina.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Federico Ravanelli, Laura Musazzi, Silvia Stella Barbieri, Gianenrico Rovati, Maurizio Popoli, Alessandro Barbon, Alessandro Ieraci
Summary: Alzheimer's disease is a neurodegenerative disease that causes memory loss and cognitive impairment in elderly people. The causes of this disease are not well understood and involve genetic, environmental, and epigenetic factors. In the study, SAMP8 mice were used as a model to investigate epigenetic changes in the dorsal hippocampus. The results showed differential regulation of epigenetic markers between male and female SAMP8 mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wietse In het Panhuis, Milena Schoenke, Ricky Siebeler, Dorien Banen, Amanda C. M. Pronk, Trea C. M. Streefland, Salwa Afkir, Hetty C. M. Sips, Jan Kroon, Patrick C. N. Rensen, Sander Kooijman
Summary: Circadian disruption affects glucose and lipid metabolism with sex-specific effects. This study demonstrates that circadian disruption has sex-dependent effects on glucose metabolism, aggravated by male sex hormones and partially rescued by female sex hormones.