Article
Cell Biology
Thomas Mueller, Eugen Schlegel, Stephanie Zingler, Hans Michael Thiede
Summary: The catechol-O-methyltransferase inhibitors entacapone and opicapone prolong the efficacy of conventional oral levodopa/dopa decarboxylase inhibitor formulations through an increase in levodopa plasma bioavailability. The study compared the impact of single-day entacapone or opicapone intake on the pharmacokinetic plasma behavior of levodopa, 3-O-methyldopa, and total homocysteine in Parkinson's disease patients. It was found that opicapone had higher levodopa bioavailability and better baseline scores compared to entacapone.
Article
Clinical Neurology
Federic Sampedro, Saul Martinez-Horta, Andrea Horta-Barba, Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesus, Astrid Adarmes-Gomez, Fatima Carrillo, Arnau Puig-Davi, Florinda Roldan Lora, Miquel Aguilar Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots Foraster, Javier Ruiz Martinez, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Isabel Gonzalez Aramburu, Jon Infante Ceberio, Jorge Hernandez Vara, Oriol de Fabregues-Boixar, Teresa de Deus Fonticoba, Asuncion Avila, Juan Carlos Martinez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, Pablo Martinez-Martin, Diego Santos-Garcia, Pablo Mir, Jaime Kulisevsky
Summary: This study found that blood homocysteine levels were increased in Parkinson's disease patients and were associated with cognitive performance and structural damage in the cerebral cortex.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Maria Teresa Perinan, Daniel Macias-Garcia, Silvia Jesus, Juan Francisco Martin-Rodriguez, Laura Munoz-Delgado, Maria Valle Jimenez-Jaraba, Dolores Buiza-Rueda, Marta Bonilla-Toribio, Astrid Daniela Adarmes-Gomez, Pilar Gomez-Garre, Pablo Mir
Summary: Elevated homocysteine levels are associated with cognitive impairment in Parkinson's disease, but not with polymorphisms in genes involved in homocysteine metabolism.
JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Alessandro F. Fois, Rod Conrad, Toni Hampe
Summary: Chronic diarrhea in patients with Parkinson's disease may be caused by drug-induced microscopic colitis and should be considered as a potential cause.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Werner Poewe
Summary: Adjunct therapy with entacapone is an effective approach to treat motor fluctuations in Parkinson's disease patients. It can increase ON time and improve motor function and quality of life. However, it may also increase adverse events, such as dyskinesias, which can be controlled by reducing the levodopa dose. Entacapone may cause severe diarrhea and require discontinuation of treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaoyu Ding, Ying Wang, Jia Liu, Guang Wang
Summary: The study found that individuals with decreased sensitivity to thyroid hormones are more likely to have elevated Hcy levels, even after adjusting for multiple risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Immunology
Kasra Honarmand Tamizkar, Pooneh Gorji, Mahdi Gholipour, Bashdar Mahmud Hussen, Mehrdokht Mazdeh, Solat Eslami, Mohammad Taheri, Soudeh Ghafouri-Fard
Summary: The study revealed differential expression of HULC, PVT1, DSCAM-AS1, SPRY4-IT1, LINC-ROR, and MEG3 lncRNAs in the circulation of PD patients, with MEG3 and LINC-ROR showing higher diagnostic power.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Heinz Reichmann
Summary: The aim of long-term levodopa therapy is to prolong symptomatic efficacy without increasing peak plasma concentrations above the threshold for dyskinesias. Levodopa, carbidopa, and entacapone (LCE) is a combination medication that enhances levodopa delivery to the brain, leading to improved clinical efficacy. The safety and efficacy of LCE have been established through trials and experience.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Shih-Chen Fu, Chung-Han Lee, Yi-Chen Hsieh, Pei-Hua Wu, Sheng-Hsuan Lin, Hsiuying Wang
Summary: This study suggests that discomfort induced by entacapone may be related to shifts in microbial composition, leading to gastrointestinal problems and other side effects. Manipulation of gut microbiota could potentially reduce these unpleasant effects in the long term.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Geriatrics & Gerontology
Yuxin Quan, Jisen Xu, Qing Xu, Zhiqing Guo, Ruwei Ou, Huifang Shang, Qianqian Wei
Summary: This meta-analysis summarizes the relationship between homocysteine, vitamin B12, folate, and Parkinson's disease (PD). The results show that PD patients have lower folate and vitamin B12 levels, but higher homocysteine levels compared to healthy individuals. PD is also significantly associated with hyperhomocysteinemia. Various factors are linked to homocysteine levels in PD patients. Further research is needed to fully understand their roles in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Johannes J. Gaare, Christia Dolle, Brage Brakedal, Kim Brugger, Kristoffe Haugaravall, Gonzalo S. Nido, Charalampos Tzoulis
Summary: Studies have shown that supplementing nicotinamide adenine dinucleotide (NAD) through nicotinamide riboside (NR) can provide neuroprotective effects in aging and neurodegenerative disease models, including Parkinson's disease (PD). This study investigated the impact of NR supplementation on DNA methylation in 29 human subjects with PD. The results indicate that short-term therapy with high-dose NR for up to 30 days does not negatively affect methylation homeostasis.
Article
Nutrition & Dietetics
Karel Kalecky, Paula Ashcraft, Teodoro Bottiglieri
Summary: This study explores the alterations in one-carbon metabolism in Alzheimer's disease (AD) and Parkinson's disease (PD), and finds a potential link between levodopa-carbidopa therapy and dementia in PD patients, as well as the correlation between betaine and cognitive score in PD patients.
Article
Clinical Neurology
Chumpol Anamnart, Ram Kitjarak
Summary: In this study, levodopa-treated Parkinson's disease patients had higher plasma homocysteine (Hcy) levels compared to levodopa-naive patients. Supplementation with vitamin B12 and folate significantly reduced Hcy levels, while entacapone showed only mild effects and was not statistically significant. Monitoring of Hcy levels and supplementation with inexpensive vitamin B12 and folate is recommended for levodopa-treated patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Lei Chen, Chunhua Wu, Zhaoying Dong, Shanshan Cao, Ning Ren, Xiaoyan Yan
Summary: This study investigated the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with small vessel disease (SVD) risk. The findings revealed that SVD patients had elevated plasma total homocysteine (tHcy) levels and decreased folate levels. Significant differences were observed in the rs1801133 (C677T) gene polymorphism, with higher tHcy levels in individuals carrying the TT allele. The rs1801131 (A1298C) polymorphism was not associated with tHcy levels or SVD risk. Therefore, elevated plasma tHcy levels are closely associated with the development of SVD, while MTHFR gene polymorphisms are not a risk factor for SVD.
BRAIN AND BEHAVIOR
(2023)
Article
Rehabilitation
Fatih Soke, Sefa Eldemir, Taskin Ozkan, Cagla Ozkul, Elvan Ozcan Gulsen, Cagri Gulsen, Kader Eldemir, Ceyla Irkec, Bilge Gonenli Kocer, Hale Zeynep Batur Caglayan, Arzu Guclu-Gunduz
Summary: The functional reach test (FRT) showed good to excellent intrarater, interrater, and test-retest reliability in people with multiple sclerosis. It was also correlated with other outcome measures and had a cutoff distance of 35.5 centimeters that best discriminates healthy people from people with MS.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Rehabilitation
Fatih Soke, Nigar Esra Erkoc Ataoglu, Elvan Ozcan Gulsen, Oznur Yilmaz, Cagri Gulsen, Bilge Kocer, Fatos Kirteke, Sultan Basturk, Selim Selcuk Comoglu, Ayse Bora Tokcaer
Summary: This study aimed to investigate the reliability, validity, and discriminative ability of the figure-of-eight walk test (F8WT) in people with Parkinson's disease (PwPD). The F8WT showed good interrater and test-retest reliability, and was correlated with other outcome measures. The F8WT times could differentiate PwPD from healthy people and fallers from non-fallers with PD.
DISABILITY AND REHABILITATION
(2023)
Letter
Psychology, Clinical
Halil Onder, Bilge Kocer, Selcuk Comoglu
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Rehabilitation
Fatih Soke, Elvan Ozcan Gulsen, Nigar Esra Erkoc Ataoglu, Bilge Kocer, Cagri Gulsen, Duygu Turker, Selim Selcuk Comoglu, Ayse Bora Tokcaer
Summary: This study aimed to investigate the reliability and validity of the coin rotation test (CRT) in people with Parkinson's Disease (PwPD). The results showed that the CRT had excellent reliability and correlated with other outcome measures. It was also able to discriminate PwPD from healthy people and functionally dependent PwPD from functionally independent PwPD.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Cagri Gulsen, Bilge Kocer, Selim Selcuk Comoglu, Arzu Guclu Gunduz
Summary: This study investigated the effects of subthalamic nucleus deep brain stimulation (STN-DBS) and dopaminergic treatment (DT) on dual-task manual dexterity and cognitive functions in people with Parkinson's disease. The results showed that DT, STN-DBS, and the combination of both treatments had different effects on motor symptoms, single and dual-task manual dexterity, dual-task interference, and cognitive functions. DT and STN-DBS may impact motor and cognitive functions through different mechanisms, and the degree of cognitive involvement in manual dexterity tasks may influence the effects of these treatments.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Bilge Kocer, Cagri Gulsen, Fatih Soke, Elvan Ozcan Gulsen, Nursena Ersoy, Oznur Tunca Yilmaz, Selim Selcuk Comoglu
Summary: This study compared the dual task cost during different types of walking in people with Parkinson's disease (PwPD) and healthy controls. The results showed that the dual task cost was lowest during straight walking and there was no difference between the two groups. However, the dual task cost was higher in PwPD during other types of walking.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Medicine, General & Internal
Bilge Kocer, Fatih Soke, Nigar Esra Erkoc Ataoglu, Nursena Ersoy, Cagri Gulsen, Elvan Ozcan Gulsen, Mustafa Ertugrul Yasa, Ismail Uysal, Selim Selcuk Comoglu, Hatice Ayse Tokcaer Bora
Summary: This study aimed to examine the reliability and validity of the 3-m backward walk test (3MBWT) in people with Parkinson's disease (PwPD). The results showed that the 3MBWT had excellent test-retest reliability, moderate to high correlations with other outcome measures, and the ability to discriminate fallers from non-fallers with PD.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Halil Onder, Bilge Gonenli Kocer, Aynur Turan, Selcuk Comoglu
Summary: This study found that the magnetic resonance parkinsonism index-2 (MRPI-2), pontine-to-midbrain area (P/M) ratio, and 3rdV/bifrontal width ratio have good discriminative power in distinguishing between progressive supranuclear palsy (PSP) and Parkinson's disease (PD) patients. Additionally, a combination of a high P/M ratio and 3rdV/bifrontal width can provide strong evidence for the diagnosis of PSP.
NEUROLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Halil Onder, Bilge Kocer, Aynur Turan, Selcuk Comoglu
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Otorhinolaryngology
Ebru Umay, Sibel Eyigor, Kubilay Demirag, Gulcin Kaymak Karatas, Ibrahim Gundogdu, Esra Giray, Mehlika Panpalli Ates, Bilge Gonenli Kocer, Eda Gurcay, Zeliha Unlu, Serkan Bengisu, Fatih Karaahmet, Fatih Bagcier, Meltem Vural, Banu Aydeniz, Humeyra Kullukcu, Fevzi Oztekin, Sibel Alicura, Cuma Uz, Elife Barmak, Aslihan Uzunkulaoglu, Emre Adiguzel
Summary: There is a lack of multidisciplinary studies on oropharyngoesophageal dysphagia, from diagnosis to follow-up. To address this gap, a recommendation study was conducted to provide detailed recommendations for dysphagia management in the ICU, based on the opinions of experienced experts. The study utilized the seven-step process and a three-modified Delphi round to generate comprehensive recommendations.
Article
Medicine, General & Internal
Fatih Soke, Nigar Esra Erkoc Ataoglu, Mehmet Fevzi Oztekin, Bilge Kocer, Selda Karakoc, Cagri Gulsen, Selim Selcuk Comoglu, Ayse Bora Tokcaer
Summary: The aim of this study was to compare trunk control between patients with cervical dystonia (CD) and healthy people, and to investigate the relationship between trunk control and balance, functional mobility, and disease severity in patients with CD. The results showed that patients with CD had impaired trunk control, especially in dynamic sitting balance and trunk coordination. Impaired trunk control was also associated with balance and functional mobility but not disease severity. These findings suggest that trunk control deficits should be addressed in the assessment and treatment of patients with CD.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Letter
Clinical Neurology
Selcuk Comoglu, Bilge Kocer, Hayri Kertmen, Halil Onder
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Halil Onder, Bilge Kocer, Selcuk Comoglu
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Halil Onder, Bilge Kocer, Selcuk Comoglu
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
Article
Clinical Neurology
Halil Onder, Bilge Kocer, Aynur Turan, Hayri Kertmen, Selcuk Comoglu
Summary: This study compared the neuroimaging indices of iNPH and PSP and found a high overlap in the features of these two diseases. These results may provide indirect evidence for the coexistence of PSP and iNPH pathophysiology.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)