4.5 Article

Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification

Journal

BIOMATERIALS SCIENCE
Volume 4, Issue 9, Pages 1314-1317

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6bm00296j

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Funding

  1. KIST
  2. Global Innovative Research Center program of the National Research Foundation of Korea [2012K1A1A2A01055811]
  3. National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2014-R1A2A2A04002526]
  4. Pioneer Research Center Program through NRF - Ministry of Science, ICT & Future Planning [2014M3C1A3054141]

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Although rolling circle amplification (RCA) is an efficient method to produce DNA materials for biomedical applications, it does not yield nano-sized products suitable for intracellular delivery. We here provide the ways to control the size of RCA products and show a potential application of the size-controlled DNA nanoparticles.

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