Article
Engineering, Environmental
A. Ringaci, A. V. Yaremenko, K. G. Shevchenko, S. D. Zvereva, M. P. Nikitin
Summary: This study presents a novel nanoscale modified MOFs that allow co-delivery of a transgene and a drug-like molecule, opening up new opportunities for gene delivery while retaining the advantages of small molecule transport. Experimental results demonstrate the performance of these multimodal nanoparticles in vitro for different cell lines and in vivo upon intravenous injection in mice, showing potential applications in lung disease treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Erica Quagliarini, Junbiao Wang, Serena Renzi, Lishan Cui, Luca Digiacomo, Gianmarco Ferri, Luca Pesce, Valentina De Lorenzi, Giulia Matteoli, Heinz Amenitsch, Laura Masuelli, Roberto Bei, Daniela Pozzi, Augusto Amici, Francesco Cardarelli, Cristina Marchini, Giulio Caracciolo
Summary: Lipid nanoparticles (LNPs) have shown promise as effective gene delivery vehicles, with a specific formulation (LNP15) demonstrating successful transfection and potential application in cancer vaccines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Chavee Laomeephol, Sudartip Areecheewakul, Supannikar Tawinwung, Koramit Suppipat, Preedakorn Chunhacha, Nuno M. Neves, Jittima Amie Luckanagul
Summary: Chimeric antigen receptor (CAR) T cell therapy has shown remarkable efficacy in cancer treatment, but its complex manufacturing process limits its application. In vivo generation of CAR T cells provides an alternative immunotherapy. Hyaluronic acid (HA) is a natural biopolymer that can be used for gene delivery due to its inherent properties. This review discusses the potential of HA in delivering CAR constructs and provides insights into rational design of HA-based systems for efficient CAR delivery to circulating T cells.
Review
Medicine, Research & Experimental
Saurabh Shah, Paras Famta, Deepkumar Bagasariya, Kondasingh Charankumar, Anupama Sikder, Rama Kashikar, Arun K. Kotha, Mahavir Bhupal Chougule, Dharmendra Kumar Khatri, Amit Asthana, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSN) as delivery vehicles in cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters affecting MSN synthesis, drug loading characteristics, and targeting cancer cells specifically are explained. The applications and potential of MSN in nanotheranostics and imaging are illustrated. The review also discusses the hurdles encountered during the translation process and potential solutions.
MOLECULAR PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Physiology
Victoria L. Messerschmidt, Uday Chintapula, Fabrizio Bonetesta, Samantha Laboy-Segarra, Amir Naderi, Kytai T. Nguyen, Hung Cao, Edward Mager, Juhyun Lee
Summary: In the era of advanced nanomaterials, the use of nanoparticles for biomedical research is important. This study investigated the delivery of a NICD-encoded plasmid using PLGA nanoparticles and the potential toxic effects. The results showed successful delivery of the plasmid and increased expression of Notch signaling related genes. The nanoparticles caused fewer malformations compared to the positive control, ZnO nanoparticles.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ly Porosk, Heleri Heike Haerk, Piret Arukuusk, Uku Haljasorg, Part Peterson, Kaido Kurrikoff
Summary: mRNA-based therapeutics have great potential as preventive vaccines, but the challenge lies in delivering mRNA to non-hepatic tissues, such as the spleen and lymph nodes, in order to transition from preventive to therapeutic vaccines. This study discovered new cell-penetrating peptides NF424 and NF436 that can selectively deliver mRNA to the spleen without the need for active targeting mechanisms. The majority of mRNA expression occurs in dendritic cells within the spleen, making NF424 and NF436 promising candidates for cancer immunotherapeutic applications with tumor antigens.
Article
Materials Science, Biomaterials
Xu-Ying Liu, Jing-Bo Yang, Cheng-Yan Wu, Quan Tang, Zhong-Lin Lu, Lan Lin
Summary: Six amphiphiles were designed and synthesized for synergistic anticancer gene therapy and photodynamic therapy. They exhibited strong AIE fluorescence emissions and efficient gene transfection, as well as the ability to deliver siRNA and generate reactive oxygen species for enhanced cancer therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Review
Pharmacology & Pharmacy
Xiaowei Xie, Tianxiang Yue, Wenting Gu, Weiyi Cheng, Li He, Weiye Ren, Fanzhu Li, Ji-Gang Piao
Summary: This paper discusses the use of surface-functionalized mesoporous silica nanoparticles (MSN) as delivery vehicles for siRNA in cancer therapy. The advantages of using MSNs for siRNA loading and strategies to improve cellular uptake and endosomal escape are highlighted. Attention is also paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.
Article
Chemistry, Analytical
Jennifer Lien, Tawni Bull, Richard W. Michelmore, Ting Guo
Summary: Fluorescence titration using magnetic nanoparticles (FTMN) is a rapid, inexpensive, and simple method for quantifying the amount of fluorophore-intercalated plasmid DNA on DNA attractive nanoparticles. By confirming the binding of propidium iodide (PI)-intercalated DNA to polyethylenimine (PEI)-coated monodisperse iron oxide magnetic nanoparticles (PEI-MNs), the FTMN method provides a way to determine the amount of DNA on MNs, the dissociation constant, and binding energy. This method is validated by utilizing quantitative polymerase chain reaction to measure the amount of free PI/DNA in solution.
ANALYTICAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Engineering, Biomedical
Seongchan Kim, You Kyeong Jeong, Chang Sik Cho, SeokHoon Lee, Chang Ho Sohn, Jeong Hun Kim, Youngdo Jeong, Dong Hyun Jo, Sangsu Bae, Hyojin Lee
Summary: A robust RNP delivery platform based on a biocompatible silica nanoconstruct has been designed, which can safely and effectively deliver therapeutic RNPs into cells. Compared with commercialized materials, this platform achieves higher gene deletion and base substitution efficiency without significant impact on cellular function.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Mengxi Xiang, Yongkui Li, Jia Liu, Jie Shi, Yizhi Ge, Chen Peng, Yawen Bin, Zheng Wang, Lin Wang
Summary: Delivering genes into tumor cells is a major challenge in tumor gene therapy. Researchers have developed a vector-free gene transfer strategy by utilizing nucleolin to effectively and selectively deliver genes. This strategy offers benefits such as low cytotoxicity, high efficiency, ease of synthesis, high serum stability, direct access into nuclei, and specific targeting of nucleolin-positive tumor cells.
Review
Pharmacology & Pharmacy
Ruma Rani, Parth Malik, Sunena Dhania, Tapan Kumar Mukherjee
Summary: Breast cancer ranks second in cancer-related global female deaths. Late diagnosis and drug resistance limit the effectiveness of chemotherapeutic drugs, leading to relapse and metastasis. Core-shell mesoporous silica nanoparticles (MSNPs) have emerged as potential drug carriers for breast cancer treatment due to their high surface area, drug loading capacity, and stealth drug delivery capabilities. This article discusses the preparation methods, drug delivery mechanisms, and emerging utility of MSNPs in breast cancer treatment.
Article
Chemistry, Multidisciplinary
Selvaraj Shyamsivappan, Raju Vivek, Thangaraj Suresh, Palanivel Naveen, Adhigaman Kaviyarasu, Sundarasamy Amsaveni, Shunmuganarayanan Athimoolam, Palathurai Subramaniam Mohan
Summary: A series of new N-(3'-acetyl-8-nitro-2,3-dihydro-1H,3'H-spiro[quinoline-4,2'-[1,3,4]thiadiazol]-5'-yl) acetamide derivatives were synthesized and evaluated for their anticancer properties against MCF-7 and HeLa cells, with compound 4a showing significant inhibitory activity by inducing cell death through G2/M phase cell cycle arrest. Molecular docking studies confirmed the binding affinity of the compounds with ER alpha and their pharmacokinetic properties.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Optics
Subash Chandra Bose Ragunathan, Chandrababu Rejeeth, Ganesan Muthusamy, Parveen Abdulhaniff, Thayumanavan Palvannan
Summary: A green approach for synthesizing silver nanoparticles using corncob as a reducing and stabilizing agent was developed in this study. The synthesized nanoparticles showed good dispersibility and high sensitivity for the rapid detection of L-Cysteine. Selective detection of Cys was achieved among 12 amino acids.
Article
Biophysics
K. V. Kavya, Stella Vargheese, Shruti Shukla, Imran Khan, Debasish Kumar Dey, Vivek K. Bajpai, Kavitha Thangavelu, Raju Vivek, R. T. Rajendra Kumar, Young-Kyu Han, Yun Suk Huh, Yuvaraj Haldorai
Summary: This study explores the ability of a drug-loaded polymer to inhibit cervical cancer cells. The results show that the polymer treatment activates cell death mechanisms and disrupts the cell membrane. Further experiments demonstrate that the polymer treatment effectively suppresses a protein and simulates a cellular pathway. This combination therapy approach has the potential to enhance treatment efficacy and overcome chemosensitivity issues.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Chemical
Santhosh Chinnaraj, Vino Palani, Viji Maluventhen, Rejeeth Chandrababu, Kannan Soundarapandian, Durairaj Kaliannan, Baskaran Rathinasamy, Wen-Chao Liu, Balamuralikrishnan Balasubramanian, Maruthupandian Arumugam
Summary: This study aims to prepare silver nanoparticles derived from the leaf extract of Goniothalamus wightii and evaluate their potential applications in biomedicine and pharmaceutical industry. The results demonstrate that Gw-AgNPs exhibit strong antibacterial, antioxidant, and larvicidal activities, as well as high photocatalytic degradation activity towards dyes.
PARTICULATE SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Chinnaraj Santhosh, Balamuralikrishnan Balasubramanian, Palani Vino, Maluventhen Viji, Chandrababu Rejeeth, Soundarapandian Kannan, Hammad Ullah, Kannan R. R. Rengasamy, Maria Daglia, Arumugam Maruthupandian
Summary: This study successfully biosynthesized selenium nanoparticles (Gw-SeNPs) from Goniothalamus wightii and characterized their properties. The Gw-SeNPs exhibited a polygonal shape and highly crystalline structure. They showed good antibacterial potential against both gram-positive and gram-negative pathogens, as well as demonstrated antioxidant, cytotoxic, and dye degradation abilities.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Chadrababu Rejeeth, Alok Sharma, Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam, Nipun Babu Varukattu, Samson Afewerki
Summary: A new strategy using bimetallic metal-organic framework nanoparticles has been developed to study the molecular changes in cardiovascular diseases (CVDs) and coronary artery disease (CAD). The bimetallic nanoparticles were designed based on Zeolitic Imidazolate Frameworks (ZIFs) and were able to analyze serum metabolic fingerprints using assisted laser desorption/ionization mass spectrometry (LDI MS). By utilizing this technology, CVD patients can be distinguished from controls and CAD patients with high sensitivity and specificity. This study presents a cutting-edge molecular approach for the metabolomic characterization of CVD and CAD, with the potential for personalized therapy in cardiovascular disorders.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Laxmanan Karthikeyan, Vellingiri Yasothamani, Yuvaraj Haldorai, Johnson Retnaraj Samuel Selvan Christyraj, Raju Vivek
Summary: Functionalized theranostic agents have the potential to effectively target tumor cells for cancer imaging and therapy. Near-infrared (NIR) light is advantageous for deep tissue penetration with minimal damage, but toxicity and long-term retention pose challenges for clinical translation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemical Research Methods
Chandrababu Rejeeth, Nipun Babu Varukattu, Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam
Summary: This study outlines a unique technique for detecting and extracting human serum CD44 biomarkers through ligand-protein interactions using macropores silica particles modified with hyaluronic acid. The nanoreactors designed as micropipette tips demonstrated favorable sensitivity, selectivity, durability, reuse, and minimal memory impact in MS-based proteome analysis. Additionally, specific surface chemistries of nanoparticles were examined to profile the HA-binding serum proteome, setting a preliminary benchmark for future databases. This study not only establishes a new platform for the extraction/detection of CD44 and identification of the HA-binding proteome, but also provides design recommendations for ligand affinity-based techniques for antibody-free study of serum biomarkers for diagnostic applications.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Laxmanan Karthikeyan, Pathath Abdul Rasheed, Yuvaraj Haldorai, Raju Vivek
Summary: Emerging and promising tools against cancer are theranostic nanoplatforms that combine imaging and therapy. A major challenge is unsatisfactory antitumor efficiency, which is accompanied by a great risk of tumor relapse. Therefore, a multimodal therapeutic functional strategy is highly desirable that can eradicate tumors, preventing tumor relapses and impeding the metastases.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Bartholomew Richard, C. Shahana, Raju Vivek, M. Amarendar Reddy, P. Abdul Rasheed
Summary: Acoustics has a wide range of applications in various aspects of human life, such as health, energy, and environment. The nanomaterial MXene plays a significant role in acoustic technologies, showing great potential in applications such as photoacoustic imaging, acoustic sensors, and sonodynamic therapy.
Article
Materials Science, Biomaterials
Laxmanan Karthikeyan, Babu Rithisa, Raju Vivek
Summary: PTT and immunotherapy can be combined to improve the therapeutic effect in cancer treatment. This study designed a nanosystem that combines PTT with immunotherapy to provide a nanovaccine strategy for targeted antitumor therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Nanoscience & Nanotechnology
Chandrababu Rejeeth, Alok Sharma
Summary: This review summarizes current research on the successful enrichment of various intriguing glycoproteins and glycol peptides using surface affinity materials with distinctive qualities such as low cost, excellent structural stability, diversity, and multifunction, providing a quick overview for scholars from different backgrounds in this interdisciplinary field.
FRONTIERS IN NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Alagarsamy Vasanthakumar, Chandrababu Rejeeth, Raju Vivek, Thondhi Ponraj, Karunyadevi Jayaraman, Suresh Kumar Anandasadagopan, Puthamohan Vinayaga Moorthi
Summary: The advent of bio-nanotechnology has revolutionized nanodrug delivery by improving drug efficacy and safety. Graphene material-based and polymer-based nanocarriers have shown clinical advantages in delivering drugs. We developed a CDDP@CS-GO NCs nanodrug delivery system that increased drug accumulation in tumor cells and induced apoptosis, leading to excellent cancer therapeutic effects.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Alagarsamy Vasanthakumar, Chandrababu Rejeeth, Raju Vivek, Thondhi Ponraj, Karunyadevi Jayaraman, Suresh Kumar Anandasadagopan, Puthamohan Vinayaga Moorthi
Summary: The advent of bio-nanotechnology has revolutionized nanodrug delivery by improving drug efficacy and safety. CDDP@CS-GO NCs have shown to significantly increase intracellular drug accumulation and induce cancer cell apoptosis, making them promising for cancer therapy.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Vellingiri Yasothamani, Raju Vivek
Summary: This study presents a strategy of combining immune checkpoint blockade with nanoparticles for targeted breast cancer treatment. The nanoparticles can activate an immune response and develop immune resistance based on PD-L1 checkpoint, resulting in tumor eradication and inhibition of tumor recurrence.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
