Review
Biochemistry & Molecular Biology
Denis Swolana, Robert D. Wojtyczka
Summary: The article introduces the effects of Staphylococcus epidermidis and Staphylococcus aureus on human health, as well as silver nanoparticles as a potential new substance for neutralizing bacterial cells. By reviewing the data on the activity of silver nanoparticles in inhibiting bacterial growth and biofilm formation, it provides insights for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Muhammad Yasir, Debarun Dutta, Mark D. P. Willcox
Summary: The potential use of melimine and Mel4 in combination with conventional antibiotics shows promising effectiveness in disrupting Staphylococcus aureus biofilms.
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Matilde Concilio, Ramon Garcia Maset, Laia Pasquina Lemonche, Vito Kontrimas, Ji-Inn Song, Santhosh Kalash Rajendrakumar, Freya Harrison, C. Remzi Becer, Sebastien Perrier
Summary: Antimicrobial-resistant pathogens have become a significant global health concern, demanding the development of new treatments. Synthetic nanoengineered antimicrobial polymers (SNAPs) show promise as an alternative to antimicrobial peptides, with high activity against Staphylococcus aureus and good biocompatibility. The lead compounds disrupt the cell membrane of S. aureus, while leaving the cell wall unaffected. In addition, there is a potential interaction of the compounds with bacterial DNA, suggesting implications on bacterial division. Finally, one of the compounds exhibits high efficacy in vivo in an insect infection model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Chahrazed Gheffar, Hung Le, Thierry Jouenne, Annick Schaumann, Auriane Corbiere, David Vaudry, Didier Le Cerf, Carole Karakasyan
Summary: Research has shown that drug-loaded nanoparticles have better efficacy in treating Staphylococcus aureus biofilms than traditional free antibiotics, further confirming the potential of nanotechnology in drug delivery.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2021)
Article
Biochemistry & Molecular Biology
Hosein Khabaz, Mehdi Rahimi-Nasrabadi, Amir Homayoun Keihan
Summary: In this study, a hierarchical machine learning model was developed to classify peptides with antimicrobial activity against Staphylococcus aureus. The final model showed high accuracy on the test set, utilizing a comprehensive set of features and feature selection steps.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Eduardo Gomez-Sanchez, Lorenzo Franco-de La Torre, Adriana Hernandez-Gomez, Angel Josabad Alonso-Castro, Nicolas Serafin-Higuera, Flavio Teran-Rosales, Ronell Eduardo Bologna-Molina, Mario Alberto Isiordia-Espinoza
Summary: The aim of this in vitro study was to evaluate the interaction between ciprofloxacin and amoxicillin against beta-lactamase-producing Staphylococcus aureus. Different ratios of the ciprofloxacin-amoxicillin combination were assessed, and the results showed synergistic, additive, or antagonistic antimicrobial effects. The data mainly support antimicrobial additive results of the ciprofloxacin-amoxicillin combination against beta-lactamase-producing S. aureus.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Iva Sovadinova, Kenichi Kuroda, Edmund F. Palermo
Summary: Cationic and amphiphilic polymers exhibit broad-spectrum antibacterial activity by disrupting cell membranes. While nonspecific binding to hydrophobic components in serum was thought to hinder their effectiveness, it was unexpectedly found that the addition of fetal bovine serum actually enhances their antimicrobial activity against S. aureus but not E. coli.
Article
Polymer Science
Aftab Alam, Ahmed I. Foudah, Mohammad Ayman Salkini, Mohammad Raish, Jyotiram Sawale
Summary: Antimicrobial resistance is a significant global threat, and fennel essential oils encapsulated in nanoparticles can be used as antibacterial agents against Staphylococcus aureus, with promising drug release and antimicrobial efficacy.
Review
Biochemistry & Molecular Biology
Isabella Hernandez-Aristizabal, Ivan Dario Ocampo-Ibanez
Summary: The emergence of bacteria resistant to conventional antibiotics, especially VRSA and VISA strains, poses a serious threat to global health. Developing new antimicrobial alternatives, such as antimicrobial peptides (AMPs), is urgently needed as a promising therapeutic strategy to combat resistant strains. Evaluating natural, artificial, and synthetic AMPs against VRSA and VISA strains shows great potential for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Edward J. A. Douglas, Abdulaziz H. H. Alkhzem, Toska Wonfor, Shuxian Li, Timothy J. J. Woodman, Ian S. S. Blagbrough, Maisem Laabei
Summary: This study demonstrates that polyamine derivatives based on spermine and norspermine possess potent anti-Staphylococcus aureus activity and low toxicity towards human cells. The study also identifies a gain of function mutation in the mprF gene as a mechanism of AHA-1394 resistance. Additionally, AHA-1394 shows the ability to potentiate the activity of certain antibiotics.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Diana Gutierrez, Lorena Rodriguez-Rubio, Patricia Ruas-Madiedo, Lucia Fernandez, Ana Belen Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar Garcia, Ana Rodriguez
Summary: A series of engineered proteins based on endolysins were designed and screened, with LysRODI Delta Ami identified as having high lytic activity, stability, and antimicrobial properties to effectively prevent and treat Staphylococcus aureus skin infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Blanca de Juan Mora, Luis Filipe, Andreia Forte, Miguel M. Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luis C. Branco, Sandra Gago
Summary: In this study, two nanomaterials based on mesoporous silica nanoparticles immobilized with ciprofloxacin were prepared and characterized for their structures and antimicrobial activities. The nanomaterials showed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae, with higher activity than the precursor and neutral ciprofloxacin.
Article
Microbiology
Jonggwan Park, Hyeongsun Kim, Hee-Kyoung Kang, Moon-Chang Choi, Yoonkyung Park
Summary: Lycosin-II, an antimicrobial peptide, exhibits antifungal activity against Candida albicans by damaging the fungal membrane and inducing oxidative stress. It also inhibits dual-species biofilm formation of Candida albicans and Staphylococcus aureus.
Article
Biochemistry & Molecular Biology
Mengyan Shi, Yubin Bai, Yanhua Qiu, Xinxin Zhang, Zikang Zeng, Lingling Chen, Fusheng Cheng, Jiyu Zhang
Summary: Piceatannol (PIC) has an inhibitory effect on Staphylococcus aureus (S. aureus) and exhibits a synergistic effect when combined with ciprofloxacin (CIP). Further experiments showed that PIC enhances the sensitivity of S. aureus to CIP by dissipating the bacterial proton motive force (PMF), rather than increasing membrane permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Arefeh Baygan, Mohammad Reza Afshar Mogaddam, Farzaneh Lotfipour, Mahboob Nemati
Summary: This study assessed the contamination of heavy metals in salt samples from Lake Urmia. Analysis showed that two samples had heavy metal concentrations exceeding the recommended levels. Continuous monitoring of heavy metal levels in Lake Urmia salt samples is highly recommended.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Ali Ehsani, Asma Jodaei, Mohammad Barzegar-Jalali, Ezzatollah Fathi, Raheleh Farahzadi, Khosro Adibkia
Summary: Nanoparticles play important roles in the proliferation and differentiation of stem cells, offering potential applications in tissue engineering. The physicochemical properties of nanoparticles determine their biological function, and various mechanisms such as modulation of signaling pathways and generation of reactive oxygen species are involved in nanoparticles-induced cellular proliferation and differentiation.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Hossein Maleki-Ghaleh, M. Hossein Siadati, Yadollah Omidi, Majid Kavanlouei, Jaleh Barar, Ali Akbari-Fakhrabadi, Khosro Adibkia, Younes Beygi-Khosrowshahi
Summary: Hydroxyapatite (HA) nanoparticles were prepared from natural bone and doped with zinc (Zn-HA) using solid state reaction method. The Zn-HA nanoparticles significantly improved stem cell osteogenic differentiation, making them a promising option for bone tissue engineering.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Solmaz Zakhireh, Jaleh Barar, Khosro Adibkia, Younes Beygi-Khosrowshahi, Marziyeh Fathi, Hossein Omidain, Yadollah Omidi
Summary: This review provides a detailed overview of the synthesis and utilization of chitosan-based bioactive scaffolds integrated with metals and metalloids, and their potential value in tissue engineering and regenerative medicine. It also discusses the recent progress in the formulation, surface modification, characterization, biocompatibility, and cytotoxicity of various types of chitosan-based organometallic scaffolds.
TOPICS IN CURRENT CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Khosro Adibkia, Khudaverdi Ganbarov, Mehdi Yousefi, Majid Ahmadi, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, citric acid-based quantum dots were used as a crosslinked agent to synthesize carboxymethyl cellulose/polyvinyl alcohol nanofibers. The resulting nanofibers demonstrated good cytocompatibility and antibacterial efficacy, making them potential wound healing scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Solmaz Zakhireh, Yadollah Omidi, Younes Beygi-Khosrowshahi, Abolfazl Barzegari, Jaleh Barar, Khosro Adibkia
Summary: The incorporation of Fe(3)O(4) nanoparticles into Pistacia vera L. pollen shell (PSh) could effectively increase the anticancer effects on MG-63 bone cancer cells.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Fatemeh Mehdizadeh, Mohammad Barzegar-Jalali, Ebrahim Izadi, Karim Osouli-Bostanabad, Seraj Mohaghegh, Mohammad Sadegh Shakeri, Hossein Nazemiyeh, Yadollah Omidi, Khosro Adibkia
Summary: This study compares the effect of using Lycium ruthenicum for green synthesis and wet chemical extraction using citrate reduction to synthesize stable gold nanoparticles. The pH value was found to be influential in the synthesis process. The results indicate that Lycium ruthenicum extract can be considered a simple, facile, and green technique for synthesizing stimuli-sensitive gold nanoparticles.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Parsa Soleymanijadidi, Meysam Moradi, Fahimeh Hamedirad, Zahra Ghanavati, Solmaz Maleki Dizaj, Sara Salatin
Summary: The study assessed the release pattern, antimicrobial action, and flexural strength of self-cured acrylic resins with added curcumin nanoparticles. The results showed a two-step release pattern for the nanocurcumin and an increase in antimicrobial activity against Streptococcus mutans. However, the flexural strength decreased with increasing weight percentage of curcumin nanoparticles. Despite this decrease, all strength values were higher than the standard. The study suggests that using self-cured resins containing curcumin nanoparticles can be beneficial for antimicrobial purposes in orthodontic removable applications.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Armin Mahmoudi, Mohammad Ali Ghavimi, Solmaz Maleki Dizaj, Simin Sharifi, Seyyede Shabnam Sajjadi, Amir Reza Jamei Khosroshahi
Summary: This study aimed to evaluate a novel gelatin-based biodegradable sponge's abilities in controlling bleeding, pain, and dry socket after mandibular posterior teeth extraction compared to a commercial sponge. In a randomized, double-blind, split-mouth clinical trial, 26 patients underwent tooth extraction with the test group using the prepared gelatin sponge and the control group using the commercial sponge. Results showed that the test group had better bleeding control, reduced bleeding within 1 hour, 1-4 hours, and after 4 hours post-operatively, decreased pain over time, and a lower occurrence of dry socket compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Mehdizadeh, Ramin Mohammadzadeh, Hossein Nazemiyeh, Mehran Mesgari-Abbasi, Mohammad Barzegar-Jalali, Morteza Eskandani, Khosro Adibkia
Summary: The aim of this study was to prepare electrosprayed nanoparticles (EP-Eudragit RS100 NPs) containing Echinacea purpurea extract to enhance its immunomodulatory effects. The results showed that EP-Eudragit RS100 NPs significantly increased the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-13 (IL1-13), as well as the white blood cell count (WBCs).
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Article
Medicine, General & Internal
Solmaz Maleki Dizaj, Ali Torab, Shadi Kouhkani, Simin Sharifi, Ramin Negahdari, Sepideh Bohlouli, Shirin Fattahi, Sara Salatin
Summary: This study aimed to evaluate the stability of gelatin-curcumin nanocomposite coating on healing abutments. The nanocomposite showed a relatively rapid release pattern of curcumin in the first 10 days, followed by a slow release until the 30th day. The weight changes of the coated healing abutments were statistically significant during this time. The results indicated successful coating with gelatin-curcumin nanocomposite and the consistency of the coating lasted for at least one month. Further evaluations in different aspects are necessary.
CLINICS AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Sara Salatin, Mehdi Farhoudi, Afsaneh Farjami, Solmaz Maleki Dizaj, Simin Sharifi, Shahriar Shahi
Summary: Stroke is a leading cause of morbidity and mortality worldwide, but effective treatment options are lacking. Reactive oxygen species (ROS) have been identified as a major factor in brain injury after ischemic stroke. Antioxidant therapy appears to be effective in managing oxidative stress related to inflammatory disorders like stroke, but traditional antioxidants are limited in their distribution and localization in the body. However, recent breakthroughs in the use of antioxidant nanoparticles (NPs) have shown promise in stroke treatment by efficiently delivering antioxidants to the damaged areas of the brain.
Article
Biochemistry & Molecular Biology
Mina Yekani, Robab Azargun, Simin Sharifi, Javid Sadri Nahand, Alka Hasani, Hadi Ghanbari, Zahra Sadat Seyyedi, Mohammad Yousef Memar, Solmaz Maleki Dizaj
Summary: Mesoporous silica nanoparticles (MSNPs) loaded with vancomycin and meropenem (Van/Mrp-MSNPs) demonstrated effective antimicrobial properties, favorable biocompatibility, and low cytotoxicity, making them a potential system for the treatment of infections.
Review
Biochemistry & Molecular Biology
Tooba Gholikhani, Shalen Kumar, Hadi Valizadeh, Somayeh Mahdinloo, Khosro Adibkia, Parvin Zakeri-Milani, Mohammad Barzegar-Jalali, Balam Jimenez
Summary: This article introduces the application of aptamers in the treatment of breast tumors, including their use as delivery agents and treatment strategies, as well as the chemical synthesis and modification characteristics of aptamers. The article summarizes different aptamer adoption approaches and discusses future developments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Solmaz Zakhireh, Jaleh Barar, Younes Beygi-Khosrowshahi, Abolfaz Barzegar, Yadollah Omidi, Khosro Adibkia
Summary: The study suggests that Pistacia vera L. pollen grains can be used as scaffolding building blocks with encapsulation capability of bioactive compounds. The modified method produces non-allergic hollow pollen grains, which are biocompatible and promote cell metabolic activities. The incorporation of BMP4 in these pollen grains enhances osteoblast maturation, making them suitable for bone remodeling.
