Review
Nutrition & Dietetics
Emanuele D'Amico, Giuseppe Grosso, Jeri W. Nieves, Aurora Zanghi, Pam Factor-Litvak, Hiroshi Mitsumoto
Summary: ALS is a devastating neurodegenerative disease that affects motor neurons and leads to muscle paralysis and respiratory failure. Metabolic abnormalities and nutritional factors may play a role in disease progression. Nutritional assessment and maintenance of weight are important for ALS patients, potentially influencing disease progression.
Article
Geriatrics & Gerontology
Tatiane Lopes De Pontes, F. Pinheiro Amador Dos Santos Pessanha, R. C. Freire Junior, K. Pfrimer, N. M. Da Cruz Alves, P. G. Fassini, O. L. S. Almeida, J. C. Moriguti, N. K. Da Costa Lima, J. L. Ferreira Santos, E. Ferriolli
Summary: This study found that higher total energy expenditure in older adults was associated with better performance in gait speed tests, 6-minute walk tests, and handgrip strength. Multivariate analysis adjusted for sex and fat-free mass showed an association between total energy expenditure and the 6-minute walk test, as well as the number of sedentary events. Therefore, in clinical practice, older individuals with lower gait speed, worse performance in the 6-minute walk test, and lower handgrip strength may benefit from increasing their total energy expenditure to prevent potential issues related to low energy expenditure.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Clinical Neurology
Philippe Fayemendy, Benoit Marin, Anais Labrunie, Yves Boirie, Stephane Walrand, Najate Achamrah, Moise Coeffier, Pierre-Marie Preux, Geraldine Lautrette, Jean-Claude Desport, Philippe Couratier, Pierre Jesus
Summary: The study confirmed the presence of hypermetabolism (HM) in ALS patients, with more than half of the patients affected by HM. HM was strongly and positively associated with ALS, indicating a frequent metabolic deterioration during the disease. Identifying HM can facilitate better adaptation of patients' nutritional intake.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Oana A. Tatucu-Babet, Kay Nguo, Kate J. Lambell, Lorena Romero, Carrie P. Earthman, Emma J. Ridley
Summary: This scoping review aims to summarize the available literature on measuring total energy expenditure (TEE) using doubly labelled water (DLW) in the Intensive Care Unit (ICU) and acute care settings. The review found that DLW technique can be used in medically stable ICU and acute care patients, but careful considerations need to be given to protocol design and various factors.
CLINICAL NUTRITION
(2022)
Article
Clinical Neurology
Philippe Corcia, Pascal Lejeune, Patrick Vourc'h, Stephane Beltran, Anne-Sophie Piegay, Helene Blasco, Vincent Meininger
Summary: This study characterized the prototypical phenotype of patients with amyotrophic lateral sclerosis (ALS) associated with PFN1 mutations and identified clinical indications for testing mutations in this gene. The main clinical findings for familial ALS linked to PFN1 were identified as pedigrees with over five cases, an onset age around 50 years, onset in the lower limbs, and the absence of cognitive impairment. The similarities with other ALS mutations prompt a review of ALS classifications based on both phenotype and genotype.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Nutrition & Dietetics
Mohammad Sharifzadeh, Minoo Bagheri, John R. Speakman, Kurosh Djafarian
Summary: The study evaluated various physical activity questionnaires for estimating physical activity and energy expenditure, and found that only Active-Q and 3-day PA diaries were identified as valid tools for estimating total energy expenditure.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Jihyun Eom, Bugyeong Son, Seung Hyun Kim, Yongsoon Park
Summary: Intake of antioxidants, especially those derived from vegetables and legumes, has a beneficial effect on delaying disease progression and prolonging survival in patients with ALS.
Review
Clinical Neurology
Thomas H. Julian, Sarah Boddy, Mahjabin Islam, Julian Kurz, Katherine J. Whittaker, Tobias Moll, Calum Harvey, Sai Zhang, Michael P. Snyder, Christopher McDermott, Johnathan Cooper-Knock, Pamela J. Shaw
Summary: Mendelian randomization studies on amyotrophic lateral sclerosis show a causal link between blood lipids and the disease risk, while factors like smoking and immune function require further investigation for confirmation. The use of high methodological standards and replication across different datasets are essential for reliable results in Mendelian randomization studies.
Review
Medicine, General & Internal
Can Cui, Jiangwei Sun, Kyla A. McKay, Caroline Ingre, Fang Fang
Summary: This systematic review investigated the association between medication use and ALS risk, and found no strong evidence linking any medication use with the risk of ALS.
Article
Neurosciences
Shuangwu Liu, Yuying Zhao, Qingguo Ren, Dong Zhang, Kai Shao, Pengfei Lin, Ying Yuan, Tingjun Dai, Yongqing Zhang, Ling Li, Wei Li, Peiyan Shan, Xiangshui Meng, Qian Wang, Chuanzhu Yan
Summary: This study investigated amygdala abnormalities in ALS patients, revealing distinct patterns at different clinical disease stages and highlighting their impact on anxiety and cognitive dysfunction.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Philippe Corcia, Christian Lunetta, Philippe Couratier, Patrick Vourc'h, Marta Gromicho, Claude Desnuelle, Marie-Helene Soriani, Susana Pinto, Mamede de Carvalho
Summary: The study found that PLS and ALS cases occurred in nine families, generally among first-degree relatives. Patients with both diseases exhibited typical disease characteristics, and genetic studies revealed mutations in specific genes in some patients. These results strongly support a phenotypic continuum between PLS and ALS.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Stephanie L. Silveira, Brenda Jeng, Barbara A. Gower, Robert W. Motl
Summary: The study demonstrated the feasibility and acceptability of the Automated Self-Administered 24-H (ASA24) Dietary Assessment Tool in persons with MS, but further validation is needed to assess its accuracy.
Article
Physiology
Sanjoy K. Deb, Eimear Dolan, Catherine Hambly, John R. Speakman, Olav Eftedal, Mohammed Gulrez Zariwala, Ingrid Eftedal
Summary: Commercial saturation divers exhibit high daily energy expenditure during diving operations, leading to a negative energy balance, potentially influenced by time spent underwater.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Barbara Teruel-Pena, Jose Luis Gomez-Urquiza, Nora Suleiman-Martos, Isabel Prieto, Francisco Jose Garcia-Cozar, Manuel Ramirez-Sanchez, Carmen Fernandez-Martos, German Dominguez-Vias
Summary: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons and biomarkers for ALS are important for disease detection and therapeutic targets. This study conducted a systematic review and meta-analyses of genetic loci associated with ALS using genome-wide association studies (GWASs). Aminopeptidases were identified as possible biomarkers, but the meta-analyses did not show a risk association between the genetic variation rs1060404 in the DPP6 gene and ALS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francesca Pregnolato, Lidia Cova, Alberto Doretti, Donatella Bardelli, Vincenzo Silani, Patrizia Bossolasco
Summary: This pilot study did not find a strong pathological role of exosome-derived miRNA in ALS, but identified six biological processes shared across miRNAs in samples with the highest miRNA content. Further investigation is needed to elucidate the role of exosome-derived miRNA in ALS.
Article
Clinical Neurology
Utako Nagaoka, Toshio Shimizu, Toshiki Uchihara
NEUROLOGICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Ryo Morishima, Utako Nagaoka, Masahiro Nagao, Eiji Isozaki
Article
Clinical Neurology
Toshio Shimizu, Masayuki Honda, Takuya Ohashi, Motoyoshi Tsujino, Utako Nagaoka, Akihiro Kawata, Kazuhiko Watabe, Shiro Matsubara, Hideaki Hayashi
AMYOTROPHIC LATERAL SCLEROSIS
(2011)
Article
Clinical Neurology
Toshio Shimizu, Utako Nagaoka, Yuki Nakayama, Akihiro Kawata, Chiharu Kugimoto, Yoshiyuki Kuroiwa, Mitsuru Kawai, Takayoshi Shimohata, Masatoyo Nishizawa, Ban Mihara, Hajime Arahata, Naoki Fujii, Reiko Namba, Hiroaki Ito, Takashi Imai, Keigo Nobukuni, Kiyohiko Kondo, Mieko Ogino, Takashi Nakajima, Tetsuo Komori
AMYOTROPHIC LATERAL SCLEROSIS
(2012)
Letter
Clinical Neurology
T. Homma, U. Nagaoka, A. Kawata, Y. Mochizuki, H. Kawakami, H. Maruyama, S. Matsubara, T. Komori
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2014)
Letter
Clinical Neurology
T. Homma, U. Nagaoka, A. Kawata, Y. Mochizuki, H. Kawakami, H. Maruyama, S. Matsubara, T. Komori
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2014)
Article
Neurosciences
Utako Nagaoka, Toshio Shimizu, Toshiki Uchihara, Takashi Komori, Hiroshi Hosoda, Kazushi Takahashi
Summary: Ghrelin levels are an independent predictor of survival in ALS, especially among male patients. Low plasma ghrelin may be associated with poor prognosis in ALS.
NEUROSCIENCE RESEARCH
(2022)
Letter
Clinical Neurology
Rui Shimazaki, Akinori Uruha, Hideki Kimura, Utako Nagaoka, Tomoya Kawazoe, Satoshi Yamashita, Takashi Komori, Kazuhito Miyamoto, Shiro Matsubara, Keizo Sugaya, Masahiro Nagao, Eiji Isozaki
JOURNAL OF CLINICAL NEUROLOGY
(2020)
Article
Oncology
Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-Ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Kunimasa Arima, Kenji Ishii, Shigeo Murayama, Hiroshi Matsuda, Hisateru Tachimori, Yumiko M. Araki, Hidehiro Mizusawa
BIOMARKER RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
S Kotliarova, NR Jana, N Sakamoto, M Kurosawa, H Miyazaki, M Nekooki, H Doi, Y Machida, HK Wong, T Suzuki, C Uchikawa, Y Kotliarov, K Uchida, Y Nagao, U Nagaoka, A Tamaoka, K Oyanagi, F Oyama, N Nukina
JOURNAL OF NEUROCHEMISTRY
(2005)
Article
Biochemistry & Molecular Biology
U Nagaoka, K Kim, NR Jana, H Doi, M Maruyama, K Mitsui, F Oyama, N Nukina
JOURNAL OF NEUROCHEMISTRY
(2004)
Article
Clinical Neurology
U Nagaoka, T Uchihara, K Iwabuchi, H Konno, M Tobita, N Funata, S Yagishita, T Kato
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2003)
Article
Cell Biology
T Uchihara, A Nakamura, U Nagaoka, M Yamazaki, O Mori
HISTOCHEMISTRY AND CELL BIOLOGY
(2000)
Article
Genetics & Heredity
M Takashima, K Ishikawa, U Nagaoka, S Shoji, H Mizusawa
JOURNAL OF HUMAN GENETICS
(2001)