Review
Clinical Neurology
Georgiana Soares Leandro, Mario Emilio Teixeira Dourado Junior, Glauciane Costa Santana, Luan Samy Xavier Dantas
Summary: The main coping strategy used by ALS patients is seeking social support, while Confrontive coping and Distancing are less commonly mentioned. The coping strategies of ALS patients do not seem to focus on emotions or stress-triggering problems, and age and gender do not modify the chosen strategy.
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott
Summary: The gut microbiome may play a significant role in the pathogenesis of ALS, with research indicating that microbial changes can affect disease outcomes. Variability in gut microbiota between individuals may explain the different disease outcomes seen in ALS patients.
Review
Biochemistry & Molecular Biology
Travis W. Stevens, Fatimah K. Khalaf, Sophia Soehnlen, Prajwal Hegde, Kyle Storm, Chandramohan Meenakshisundaram, Lance D. Dworkin, Deepak Malhotra, Steven T. Haller, David J. Kennedy, Prabhatchandra Dube
Summary: This article introduces the importance and impact of cardiovascular disease worldwide, and explains in detail the role and mechanisms of macrophages in the development of cardiovascular disease. It emphasizes the potential value of macrophages in the prevention, diagnosis, and treatment of cardiovascular disease.
Article
Biochemistry & Molecular Biology
Yang-Sheng Wu, David Taniar, Kiki Adhinugraha, Li-Kai Tsai, Tun-Wen Pai
Summary: This study uses a principal tree-based model to analyze clinical data from ALS patients in a population-based database in Taiwan, revealing different disease association patterns at different stages of ALS progression. It proposes a new concept of ALS progression as a migration process instead of a sequence of isolated events.
Review
Biochemistry & Molecular Biology
Katarina Maksimovic, Mohieldin Youssef, Justin You, Hoon-Ki Sung, Jeehye Park
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons, leading to muscle weakness, paralysis, and eventual death. Recent research has shown that ALS is not only limited to motor neurons, but also involves systemic metabolic dysfunction. This review examines the metabolic dysfunction in ALS at various levels, including muscle tissue, adipose tissue, liver, pancreas, and the central nervous system. It also discusses the future prospects of metabolic research in ALS and potential treatment options.
Article
Clinical Neurology
F. C. Garton, B. B. Trabjerg, N. R. Wray, E. Agerbo
Summary: The study revealed a linear relationship between ALS incidence and age, with individuals with prior cardiovascular disease diagnosis having a higher risk of developing ALS. Gender differences were also found to play a role in ALS risk, with men showing a slightly lower risk compared to women.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agueda Ferrer-Donato, Ana Contreras, Laura M. Frago, Julie A. Chowen, Carmen M. Fernandez-Martos
Summary: The study revealed alterations in leptin signaling in the spinal cord and hypothalamus of TDP-43-induced mice, offering new evidence about the pathways linking leptin signaling to ALS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alexandra Maximova, Eryn L. Werry, Michael Kassiou
Summary: ALS is a progressive motor neurodegenerative disease with no cure, characterized by dysfunction in glial cells and motor neurons leading to neuroinflammation and degeneration. Targeting senescent glial cells may offer a new therapeutic approach to slow down motor neuron degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Christina N. Fournier
Summary: Thoughtful clinical trial design and the use of statistical enrichment techniques are crucial for efficient therapeutic development in ALS research. Further advancements in biomarker development are needed to confirm target engagement in treatment trials. Involving patients with ALS as advisors and advocates can strengthen clinical trial design and retention. Respect for patient autonomy and improving access to experimental treatments are important challenges in ALS therapeutic development.
Article
Clinical Neurology
Sebastian Michels, Deborah Kurz, Angela Rosenbohm, Raphael S. Peter, Steffen Just, Hansjörg Baezner, Axel Boertlein, Christian Dettmers, Hans-Jürgen Gold, Andreas Kohler, Markus Naumann, Peter Ratzka, Albert C. Ludolph, Dietrich Rothenbacher, Gabriele Nagel, Johannes Dorst
Summary: This large-scale population-based case-control study examined the associations between blood lipid levels and the onset and prognosis of ALS. The results showed a positive correlation between high total cholesterol levels and the risk of ALS. Furthermore, higher levels of HDL and LDL cholesterol were associated with higher mortality in ALS patients, whereas higher triglyceride levels were associated with lower mortality.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Radhika Khosla, Manjari Rain, Suresh Sharma, Akshay Anand
Summary: ALS is a degenerative disorder of motor neurons, and early diagnosis is crucial for predicting the disease and its progression. The study presents a predictive statistical model for ALS using plasma and CSF biomarkers, showing good validity, sensitivity, and specificity.
Article
Medicine, General & Internal
Christine Zizzi, Jamison Seabury, Spencer Rosero, Danae Alexandrou, Ellen Wagner, Jennifer S. Weinstein, Anika Varma, Nuran Dilek, John Heatwole, Joanne Wuu, James Caress, Richard Bedlack, Volkan Granit, Jeffrey M. Statland, Paul Mehta, Michael Benatar, Chad Heatwole
Summary: This study used data from two multi-center randomized controlled trials and found that depression symptoms in patients can be categorized into four clusters, which have differential responses to repetitive transcranial magnetic stimulation (rTMS) treatment. Further research aims to personalize rTMS protocols based on individual clinical presentations.
Review
Biochemistry & Molecular Biology
Soju Seki, Yoshihiro Kitaoka, Sou Kawata, Akira Nishiura, Toshihiro Uchihashi, Shin-ichiro Hiraoka, Yusuke Yokota, Emiko Tanaka Isomura, Mikihiko Kogo, Susumu Tanaka
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of motor neurons, with emerging evidence suggesting involvement of sensory neurons. Clinical research has shown sensory symptoms and abnormal nerve conduction in ALS patients, while preclinical research has identified genetic abnormalities in both sensory and motor neurons. This review highlights the potential of targeting sensory neuron abnormalities in ALS for new therapies.
Article
Environmental Sciences
Angeline Andrew, Jie Zhou, Jiang Gui, Antoinette Harrison, Xun Shi, Meifang Li, Bart Guetti, Ramaa Nathan, Maeve Tischbein, Erik Pioro, Elijah Stommel, Walter Bradley
Summary: This study used geospatial estimation to assess the exposure of ALS patients to airborne contaminants and found that airborne lead and polychlorinated biphenyls (PCBs) may be associated with an increased risk of ALS. The main sources of these contaminants include small aircraft, power plants burning biomass, and industrial boilers. The association with a residential history of lead exposure was confirmed in two additional cohorts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Fan Wu, Angela M. Malek, Jeanine M. Buchanich, Vincent C. Arena, Judith R. Rager, Ravi K. Sharma, John E. Vena, Todd Bear, Evelyn O. Talbott
Summary: This study aimed to investigate the risk factors for ALS and found that high exposure to vinyl chloride, 2,4-dinitrotoluene, cyanide, cadmium, and carbon disulfide was associated with an increased risk of ALS. Additionally, residential air selenium showed an inverse association with ALS, while exposure to organic/chlorinated solvents was associated with ALS. These findings highlight the importance of ongoing surveillance of potential exposures for at-risk populations.
ENVIRONMENTAL RESEARCH
(2024)
Article
Rheumatology
Julia F. Simard, Marios Rossides, Elizabeth V. Arkema, Elisabet Svenungsson, Anna-Karin Wikstrom, Murray A. Mittleman, Jane E. Salmon
Summary: This study investigated the association between hypertensive disorders of pregnancy (HDPs) and cardiovascular disease risk in pregnant women, especially those with systemic lupus erythematosus (SLE). The results showed that women with SLE had a higher prevalence of HDPs, and HDPs were significantly associated with cardiovascular outcomes and incident hypertension.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Critical Care Medicine
Andrew J. Synn, Wenyuan Li, Gary M. Hunninghake, George R. Washko, Raul San Jose Estepar, George T. O'Connor, Cyrus A. Kholdani, Robert W. Hallowell, Alexander A. Bankier, Murray A. Mittleman, Mary B. Rice
Summary: In a community-based sample, lower pulmonary vascular volumes on CT were associated with increased odds of ILA, ILA progression, and restrictive pattern on spirometry. This suggests that more severe vascular pruning on CT may be an indicator of early pulmonary vasculopathy associated with interstitial lung disease.
Article
Clinical Neurology
Wenyuan Li, Suzanne M. Bertisch, Elizabeth Mostofsky, Angeliki Vgontzas, Murray A. Mittleman
Letter
Critical Care Medicine
Andrew J. Synn, Wenyuan Li, Raul San Jose Estepar, George R. Washko, George T. O'Connor, Connie W. Tsao, Murray A. Mittleman, Mary B. Rice
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Surgery
Brandon McGuinness, Akash Goel, Fadi Elias, Theodore Rapanos, Murray A. Mittleman, Karim S. Ladha
Summary: This study focused on the perioperative risks of cannabis use disorder (CUD) in vascular surgery patients, revealing that CUD patients had a higher incidence of perioperative myocardial infarction and stroke, but a lower incidence of sepsis. Further investigation in prospective cohorts is warranted to confirm these findings.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Yongmei Huang, Marianthi-Anna Kioumourtzoglou, Murray A. Mittleman, Zev Ross, Michelle A. Williams, Alexander M. Friedman, Joel Schwartz, Ronald J. Wapner, Cande Ananth
Summary: The study found that exposure to high concentrations of PM2.5 in the third trimester and to nitrogen dioxide in the first trimester is associated with an increased risk of placental abruption. Simultaneous exposure to high levels of PM2.5 and nitrogen dioxide also increases the likelihood of abruption.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Kobina K. Hagan, Wenyuan Li, Elizabeth Mostofsky, Suzanne M. Bertisch, Angeliki Vgontzas, Catherine Buettner, Murray A. Mittleman
Summary: Regular moderate to vigorous exercise at least three times per week is associated with fewer headache days per month in adults with episodic migraines, especially among those using prophylactic medications. However, exercise does not appear to affect headache intensity or duration.
Article
Clinical Neurology
Angeliki Vgontzas, Wenyuan Li, Elizabeth Mostofsky, Murray A. Mittleman, Suzanne M. Bertisch
Summary: In patients with episodic migraine, poor sleep quality was associated with a higher rate of headache recurrence over the next 6 weeks, especially among those with coexisting moderate to high stress levels.
Article
Environmental Sciences
Jessica A. Montresor-Lopez, Stephanie R. Reading, Jeffrey D. Yanosky, Murray A. Mittleman, Ronny A. Bell, Tessa L. Crume, Dana Dabelea, Lawrence Dolan, Ralph B. D'Agostino, Santica M. Marcovina, Catherine Pihoker, Kristi Reynolds, Elaine Urbina, Angela D. Liese, Lesliam Quiros-Alcala, J. Carson Smith, P. Jacob Bueno de Mesquita, Robin C. Puett
Summary: In a study investigating the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score among youth with type 1 diabetes, no consistent relationships were observed. However, associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.
ENVIRONMENTAL RESEARCH
(2021)
Letter
Hematology
Matthew Moll, Rebecca L. Zon, Katelyn W. Sylvester, Jessica Rimsans, Evan C. Chen, Auyon J. Ghosh, Eric Abston, Andy Kim, Henry Rutherford, Xhoi Mitre, Aaron Hakim, Nathan T. Connell, Elisabeth Battinelli, Laura E. Fredenburgh, Rebecca M. Baron, Brian D. Hobbs, Michael H. Cho, Murray A. Mittleman, Ann E. Woolley, Jean M. Connors
THROMBOSIS RESEARCH
(2021)
Article
Environmental Sciences
Joel D. Schwartz, Ma'ayan Yitshak-Sade, Antonella Zanobetti, Qian Di, Weeberb J. Requia, Francesca Dominici, Murray A. Mittleman
Summary: This study demonstrates that the long-term exposure to PM2.5 is associated with an increased mortality rate, while the effects of O3 and NO2 are more complicated. The impact of PM2.5 is more significant among Black individuals.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Clinical Neurology
Angeliki Vgontzas, Elizabeth Mostofsky, Kobina Hagan, Michael Rueschman, Murray A. Mittleman, Suzanne M. Bertisch
Summary: The study found that napping may be an uncommonly used behavioral strategy for prolonged migraine attacks and does not contribute to nightly sleep disturbance. Future studies are needed to examine the acute analgesic effects of daytime napping in patients with migraine.
Article
Cardiac & Cardiovascular Systems
Andrew J. Synn, Constance De Margerie-Mellon, Sun Young Jeong, Farbod N. Rahaghi, Iny Jhun, George R. Washko, Raul San Jose Estepar, Alexander A. Bankier, Murray A. Mittleman, Paul A. VanderLaan, Mary B. Rice
Summary: This study found that more severe CT-based vascular pruning was associated with greater histologic arterial remodeling, suggesting that CT imaging may be a non-invasive indicator of pulmonary vascular pathology.
PULMONARY CIRCULATION
(2021)
Review
Surgery
Ali Hage, Fadi Hage, Hussein Al-Amodi, Suruchi Gupta, Stefania I. Papatheodorou, Robert Hawkins, Gorav Ailawadi, Murray A. Mittleman, Michael W. A. Chu
Summary: In elderly patients, minimally invasive mitral valve surgery was associated with lower postoperative complications, reduced blood transfusion, shorter ICU and hospital stay, but longer cross-clamp and bypass times compared to conventional sternotomy.
INNOVATIONS-TECHNOLOGY AND TECHNIQUES IN CARDIOTHORACIC AND VASCULAR SURGERY
(2021)
Article
Environmental Sciences
Andrew J. Synn, Katerina L. Byanova, Wenyuan Li, Diane R. Gold, Qian Di, Itai Kloog, Joel Schwartz, Raul San Jose Estepar, George R. Washko, George T. O'Connor, Murray A. Mittleman, Mary B. Rice
Summary: The study found that higher exposure to O-3 was associated with lower small pulmonary vessel volumes in community-dwelling adults in the northeastern United States, while 1-year EC exposure and proximity to roads were weakly correlated with small vessel volumes. PM2.5 was not significantly associated with small vascular volumes.
ENVIRONMENTAL EPIDEMIOLOGY
(2021)