Review
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Mamone, Settimo Caruso, Mariapina Milazzo, Giorgia Porrello, Ambra Di Piazza, Giovanni Gentile, Vincenzo Carollo, Francesca Crino, Gianluca Marrone, Gianvincenzo Sparacia, Luigi Maruzzelli, Roberto Miraglia, Salvatore Gruttadauria
Summary: Liver transplantation provides the best survival benefit for hepatocellular carcinoma (HCC) patients who cannot undergo resection. The Milan criteria have been developed to select suitable candidates for transplantation, aiming to improve survival and reduce the risk of HCC recurrence. However, up to 20% of cases experience HCC recurrence after transplantation, posing a significant challenge due to poor prognosis. Various extended criteria have been proposed to accommodate the increasing demand for organs and the associated higher risk of recurrence. Radiologists need to be aware of the possibility of HCC recurrence involving multiple organs after transplantation. Understanding the location and radiologic appearance of recurrent HCC is crucial for choosing the most appropriate therapy.
INSIGHTS INTO IMAGING
(2023)
Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Darren Jun Hao Tan, Wen. Hui, Jie Ning Yong, Cheng Han Ng, Mark D. Muthiah, Eunice X. Tan, Jieling Xiao, Snow Yunni Lim, Ansel Shao Pin Tang, Xin Hui Pan, Tousif Kabir, Glenn K. Bonney, Raghav Sundar, Nicholas Syn, Beom Kyung Kim, Yock Young Dan, Mazen Noureddin, Rohit Loomba, Daniel Q. Huang
Summary: This study assessed the success rates of down-staging treatment in HCC patients and evaluated outcomes based on different criteria for baseline tumor burden. The results showed that among patients who adhered to the UNOS-DS criteria, down-staging was successful in 83.21% of cases, over half of the patients received liver transplantation, and post-transplantation outcomes were excellent. These findings provide clinical validation for the utilization of UNOS-DS criteria.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Filippo Pelizzaro, Martina Gambato, Enrico Gringeri, Alessandro Vitale, Umberto Cillo, Fabio Farinati, Patrizia Burra, Francesco Paolo Russo
Summary: Recurrence of hepatocellular carcinoma after liver transplantation is a major concern, with poor prognosis and uncertainty in management. There is currently lack of specific surveillance strategy and sufficient data to support immunosuppressive drugs and adjuvant therapy.
Review
Gastroenterology & Hepatology
Sang Jin Kim, Jong Man Kim
Summary: Liver transplantation is an effective treatment for hepatocellular carcinoma, but some patients still experience recurrence after transplantation. Prediction models for HCC recurrence after transplantation have been published, but a standard has not been established. This review summarizes the latest prediction models for HCC recurrence after liver transplantation, focusing on radiologic, serologic, and pathologic factors, and includes studies on living donor and deceased donor transplantation.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Surgery
Seong Wook Shin, Keun Soo Ahn, Sang Woo Kim, Tae-Seok Kim, Yong Hoon Kim, Koo Jeong Kang
Summary: This study found that liver resection (LR) is more effective than local ablation therapies (such as RFA, MWA, and RFA plus TACE) in treating HCC within the Milan criteria. Specifically, LR has better 5-year recurrence-free survival and lower local recurrence rates compared to local ablation therapies.
Article
Biochemistry & Molecular Biology
Chloe Paul, Camille Besch, Thierry Artzner, Baptiste Michard, Caterina Cusumano, Pietro Addeo, Philippe Bachellier, Francois Faitot
Summary: This study aimed to evaluate the predictive value of IL-6 on histopathological features and recurrence risk of HCC on explant, as well as its additional value to other scores and inflammatory markers at the time of transplantation. The results showed that high IL-6 levels at transplantation were associated with adverse histological features and increased risk of recurrence in HCC patients. Therefore, IL-6 level can serve as an independent predictor for prognosis in HCC.
Review
Biochemistry & Molecular Biology
Alessandro Parente, Hwui-Dong Cho, Ki-Hun Kim, Andrea Schlegel
Summary: The aim of this study was to assess the association between graft-to-recipient weight ratio (GRWR) and hepatocellular carcinoma (HCC) recurrence in adult-to-adult living donor liver transplantation (LDLT). Three studies were identified, involving a total of 782 patients. The results showed that GRWR < 0.8% was associated with lower survival rates and higher tumor recurrence rates in HCC recipients, particularly for patients with HCC outside the established criteria. Considering individual GRWR as a contributor to HCC recurrence in LDLT patients may be beneficial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Surgery
Virginia J. Aijtink, Vera C. Rutten, Beatrice E. M. Meijer, Renate de Jong, John L. Isaac, Wojciech G. Polak, M. Thamara P. R. Perera, Dimitri Sneiders, Hermien Hartog
Summary: This study assessed the safety of intraoperative blood salvage (IBS) in hepatocellular carcinoma (HCC) patients undergoing liver transplantation. The results showed that the use of IBS during liver transplantation did not impair disease-free survival, increase HCC recurrence, or impair overall survival. Therefore, the use of IBS in liver transplantation for HCC patients is a safe procedure.
Article
Oncology
Cheng-Maw Ho, Chih-Hsin Lee, Ming-Chia Lee, Jun-Fu Zhang, Chin-Hua Chen, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee
Summary: This study analyzed the survival of patients with post-transplant HCC recurrence, finding that early recurrence within two years after surgery had a poorer prognosis compared to late recurrence. Factors such as transplant era before 2008 and radiofrequency ablation were associated with better outcomes, while receiving sorafenib and radiotherapy were linked to poorer prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Incheon Kang, Jae Geun Lee, Sung Hoon Choi, Hyun Jeong Kim, Dai Hoon Han, Gi Hong Choi, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Dong Jin Joo
Summary: EVR in combination with CNIs may prolong long-term survival in patients undergoing LT for HCC, with the EVR group showing more aggressive tumor biology characteristics such as a higher number of tumors.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Claudia Maccali, Aline L. Chagas, Ilka Boin, Emilio Quinonez, Sebastian Marciano, Mario Vilatoba, Adriana Varon, Margarita Anders, Sergio Hoyos Duque, Agnaldo S. Lima, Josemaria Menendez, Martin Padilla-Machaca, Jaime Poniachik, Rodrigo Zapata, Martin Maraschio, Ricardo Chong Menendez, Linda Munoz, Diego Arufe, Rodrigo Figueroa, Alejandro Soza, Martin Fauda, Simone R. Perales, Rodrigo Vergara Sandoval, Carla Bermudez, Oscar Beltran, Isabel Arenas Hoyos, Lucas McCormack, Francisco Juan Mattera, Adrian Gadano, Jose H. Parente Garcia, Claudia Megumi Tani, Luiz Augusto Carneiro D'Albuquerque, Flair J. Carrilho, Marcelo Silva, Federico Pinero
Summary: This study evaluated the post-recurrence survival (PRS) of HCC patients after liver transplantation, finding that early recurrence, sorafenib therapy, and surgery/TACE treatment were associated with improved survival rates. Any treatment, sorafenib therapy, and surgery/TACE treatment all significantly improved PRS.
LIVER INTERNATIONAL
(2021)
Review
Oncology
Yao Yang, Hongli Yu, Xu Tan, Yajing You, Fangyuan Liu, Tong Zhao, Jianni Qi, Jie Li, Yuemin Feng, Qiang Zhu
Summary: Through comparing the efficacy and safety of LR and RFA for recurrent HCC, LR showed significantly better overall survival compared to RFA, especially in 2-, 3-, and 4-year survival rates. While there was no significant difference in disease-free survival between LR and RFA during the whole follow-up period, LR had higher 2- to 5-year DFS rates. Additionally, LR was associated with more major complications and longer hospital stay.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Review
Gastroenterology & Hepatology
Beshoy Effat Elkomos, Mostafa Abdo, Remon Mamdouh, Amr Abdelaal
Summary: This study aimed to explore the long-term outcomes of living donor liver transplantation (LDLT) versus deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) and predictors of recurrence after transplantation. The findings showed that there was no significant difference in overall survival (OS) between LDLT and DDLT, but LDLT provided better survival benefits in regions with low deceased organ availability. Milan criteria, level of alpha-fetoprotein (AFP), presence of vascular invasion, and tumor differentiation were significant predictors of recurrence.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Oncology
Helena Degroote, Anja Geerts, Xavier Verhelst, Hans Van Vlierberghe
Summary: Liver transplantation is the preferred treatment for early-stage hepatocellular carcinoma. However, there is a risk of recurrence in the transplanted liver, and predicting this risk and related prognosis for individual patients is challenging. Various scoring systems have been proposed, but there is no consensus on the optimal model or its implications in clinical practice.
Article
Surgery
Fatima Qays Ismail, Stina Oberg, Anita Bilde Wozniak, Birthe Thing Oggesen, Jacob Rosenberg
Summary: The aim of this study was to determine the length of bowel specimens and assess the impact of certain characteristics. Data from medical records of patients who underwent right hemicolectomy for cancer were collected, and it was found that the length of the terminal ileum specimen varied and was positively correlated with BMI. Additionally, the length of colon specimens differed naturally depending on the cancer location.
ANZ JOURNAL OF SURGERY
(2023)
Review
Emergency Medicine
Anders Peter Skovsen, Jakob Burcharth, Ismail Gogenur, Mai-Britt Tolstrup
Summary: This systematic review aimed to evaluate if an entero-entero/entero-colonic anastomosis is safe in patients with peritonitis undergoing abdominal acute care surgery. The review did not find evidence to support the idea that peritonitis is a risk factor for anastomotic leakage.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Surgery
M. Kvist, N. A. Henriksen, J. Burcharth, Y. W. Nielsen, T. K. Jensen
Summary: This study found a significant association between rectus diastasis and burst abdomen in patients undergoing emergency midline laparotomy. Rectus diastasis was identified as an important risk factor for burst abdomen after emergency midline laparotomy.
Article
Emergency Medicine
Lorenzo Cobianchi, Daniele Piccolo, Francesca Dal Mas, Vanni Agnoletti, Luca Ansaloni, Jeremy Balch, Walter Biff, Giovanni Butturini, Fausto Catena, Federico Coccolini, Stefano Denicolai, Belinda De Simone, Isabella Frigerio, Paola Fugazzola, Gianluigi Marseglia, Giuseppe Roberto Marseglia, Jacopo Martellucci, Mirko Modenese, Pietro Previtali, Federico Ruta, Alessandro Venturi, Haytham M. Kaafarani, Tyler J. Loftus
Summary: This study investigates trauma and emergency surgeons' knowledge and perception of using AI-based tools in clinical decision-making processes. The results show that there are technology enthusiasts and skeptics among surgeons, with a preference towards more classical decision-making aids. Lack of knowledge about AI and mistrust are also observed.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Review
Emergency Medicine
Binyamin Sikander, Jacob Rosenberg, Siv Fonnes
Summary: This scoping review included 65 biomarkers from 52 studies, involving 14,312 patients. Routine biomarkers had poor diagnostic accuracy, with sensitivity ranging from 15% to 100% and specificity between 27% and 100%. Novel biomarkers are still in the early stage of study and lack accuracy and cost-benefit analysis.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Immunology
Siv Fonnes, Tilde Rasmussen, Barbara Juliane Holzknecht, Christoffer Skov Olesen, Joachim Hjalde Halmsted Olsen, Line Schmidt, Rasmus Alder, Sara Gamborg Sorensen, Sengul Gulen, Louise Laurberg Klarskov, Karen Angeliki Krogfelt, Henrik Westh, Jacob Rosenberg
Summary: This study investigated the presence of diarrhoea-causing bacteria in patients undergoing surgery for suspected appendicitis. The findings suggest that infection with Yersinia spp. and other diarrhoea-causing microorganisms is rare in these patients.
Article
Endocrinology & Metabolism
Dennis Zetner, Claus Kamby, Camilla Christophersen, Sengul Gulen, Cecilie B. Paulsen, Emily Piga, Bodil Hoffmeyer, Faisal Mahmood, Jacob Rosenberg
Summary: This double-blind, placebo-controlled randomized study investigated whether melatonin can protect against radiation dermatitis in women receiving radiation therapy for primary breast cancer. The results showed no difference in RTOG-scores and pixel analyses at 2 weeks follow-up between the melatonin and placebo groups. However, the melatonin group demonstrated a protective effect based on RTOG-scores over the entire duration of the study.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Bodil Hoffmeyer, Siv Fonnes, Kristoffer Andresen, Jacob Rosenberg
Summary: This study evaluated the usage of long-term inactive reviews in the Cochrane Database of Systematic Reviews in academia. The findings showed that these reviews continue to be cited even though they are not updated, which may lead to the dissemination of outdated evidence or misinformation.
Article
Emergency Medicine
Lorenzo Cobianchi, Francesca Dal Mas, Vanni Agnoletti, Luca Ansaloni, Walter Biffl, Giovanni Butturini, Stefano Campostrini, Fausto Catena, Stefano Denicolai, Paola Fugazzola, Jacopo Martellucci, Maurizio Massaro, Pietro Previtali, Federico Ruta, Alessandro Venturi, Sarah Woltz, Haytham M. Kaafarani, Tyler J. Loftus, Team Dynamics Study Grp
Summary: This study explores the understanding, barriers, and facilitators of shared decision-making (SDM) in trauma and emergency surgery. Findings show that less than half of the surgeons understand SDM and 30% still see value in exclusively engaging multidisciplinary provider teams without involving the patient. The inclusion of SDM practices in clinical guidelines is recommended.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Cell Biology
Kirsten L. Wahlstrom, Hannah F. Hansen, Madeline Kvist, Jakob Burcharth, Jens Lykkesfeldt, Ismail Gogenur, Sarah Ekeloef
Summary: Endothelial dysfunction occurs due to inflammation and excessive reactive oxygen species production during surgical stress. Remote ischemic preconditioning (RIPC) may have anti-oxidative and anti-inflammatory properties, but it did not affect endothelial function or markers of nitric oxide (NO) bioavailability until 24 hours after sub-acute laparoscopic cholecystectomy. Surgical removal of the inflamed gallbladder reduced markers of NO bioavailability and oxidative stress caused by acute cholecystitis.
Article
Surgery
Nadir Noureldin Abdella Bahta, Philine Zeinert, Jacob Rosenberg, Siv Fonnes
Summary: This bibliometric analysis investigates the citation pattern of studies on diagnostic tools for appendicitis. The Alvarado score has been the most cited and impactful study in this field since 1999. Additionally, there are differences in citations between English and non-English studies, as well as studies focusing on diagnostic tools for children.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Marie R. Mortensen, Mohammad Alouda, Zara Bond, Jakob Burcharth, Katrine F. Finne, Thomas K. Jensen, Ida Lolle, Talha Malik, Loan Ngo-Stuyt, Liv B. J. Nielsen, Maria Olausson, Anders P. Skovsen, Mette A. Tolver, Henry G. Smith
Summary: This study aimed to compare recurrence rates and survival in patients with adhesional small bowel obstruction treated operatively or non-operatively. The results showed that patients who underwent operative treatment had significantly better 1-year recurrence-free survival compared with patients managed non-operatively. However, operative treatment was associated with an increased all-cause mortality rate in the first year after admission.
Article
Oncology
Birthe Thing Oggesen, Marie Louise Sjodin Hamberg, Thordis Thomsen, Jacob Rosenberg
Summary: This qualitative study explored patients' experiences and coping strategies in relation to late complications following treatment for colorectal and anal cancer. Findings revealed that patients commonly feel abandoned after their surgical and oncological treatments are completed and turn to the internet for guidance. Stool-related issues significantly impact patients' personal and professional lives, while additional troublesome symptoms further affect their daily lives.
Article
Oncology
Birthe Thing Oggesen, Momena Akbar, Marie Louise Sjodin Hamberg, Thordis Thomsen, Anne Kjaergaard Danielsen, Jacob Rosenberg
Summary: In this study, 14 cancer patients were interviewed to explore their experiences with treatment and care in a late complication clinic. The results showed that patients benefited from the clinic, but also had some confusion and recommendations. They wished for more information on late complications and patient-friendly treatment options. Patients were satisfied with telephone consultations as it provided convenience and ease of expression.
EUROPEAN JOURNAL OF CANCER CARE
(2023)
Review
Surgery
Hugin Reistrup, Kristoffer Andresen, Jacob Rosenberg
Summary: This systematic review evaluated the use of mesh versus non-mesh repair for groin hernia in adolescents and assessed the incidence of recurrence and chronic pain. The findings showed that both mesh and non-mesh repairs had low recurrence rates and low rates of postoperative chronic pain.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
