Human Adipose-Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia

(2014) Alessandra Bura et al.   CYTOTHERAPY

Mesenchymal stem cells and hypoxia: Where are we?

(2014) L.B. Buravkova et al.   MITOCHONDRION

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility and tropism to brain cancer

(2014) Y Feng et al.   Cell Death & Disease

A role for DNA polymerase θ in the timing of DNA replication

(2014) Anne Fernandez-Vidal et al.   Nature Communications

Data-based filtering for replicated high-throughput transcriptome sequencing experiments

(2013) Andrea Rau et al.   BIOINFORMATICS

Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells

(2013) Qiuwei Pan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Adipose-derived stem cells: Fatty potentials for therapy

(2013) Wee Kiat Ong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The level of origin firing inversely affects the rate of replication fork progression

(2013) Yuan Zhong et al.   JOURNAL OF CELL BIOLOGY

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy

(2013) Nazmul Haque et al.   TheScientificWorldJOURNAL

Platelet Lysate as Replacement for Fetal Bovine Serum in Mesenchymal Stromal Cell Cultures

(2013) Karen Bieback   TRANSFUSION MEDICINE AND HEMOTHERAPY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants

(2012) Jianming Tan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Impact of hypoxia and long-term cultivation on the genomic stability and mitochondrial performance of ex vivo expanded human stem/stromal cells

(2012) Pedro H. Oliveira et al.   Stem Cell Research

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow-Derived Mouse Mesenchymal Stem Cells via a p53-Dependent Mechanism: Implications for Long-Term Culture Expansion

(2012) Siddaraju V. Boregowda et al.   STEM CELLS

Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift

(2012) Pablo Cingolani et al.   Frontiers in Genetics

Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix

(2011) Guokuan Fan et al.   BMC CELL BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

(2011) J C Estrada et al.   CELL DEATH AND DIFFERENTIATION

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions

(2011) Hanae Ueyama et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

(2011) Peter Connick et al.   Trials

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

(2010) A. Torsvik et al.   CANCER RESEARCH

Platelet Lysate Consisting of a Natural Repair Proteome Supports Human Mesenchymal Stem Cell Proliferation and Chromosomal Stability

(2010) Ruben Crespo-Diaz et al.   CELL TRANSPLANTATION

Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells

(2010) S. Garcia et al.   EXPERIMENTAL CELL RESEARCH

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA