Concise Review: Paracrine Functions of Vascular Niche Cells in Regulating Hematopoietic Stem Cell Fate

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo

(2015) M. F. Ciuculescu et al.   BLOOD

Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells

(2015) B.-S. Ding et al.   JOURNAL OF CELL SCIENCE

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

(2015) J Huan et al.   LEUKEMIA

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

(2015) Christopher N. Inra et al.   NATURE

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Fetal liver hematopoietic stem cell niches associate with portal vessels

(2015) J. A. Khan et al.   SCIENCE

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

(2015) Bo O Zhou et al.   eLife

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

(2014) B. Saez et al.   BLOOD

Vasculature-Associated Cells Expressing Nestin in Developing Bones Encompass Early Cells in the Osteoblast and Endothelial Lineage

(2014) Noriaki Ono et al.   DEVELOPMENTAL CELL

Pleiotrophin mediates hematopoietic regeneration via activation of RAS

(2014) Heather A. Himburg et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein tyrosine phosphatase–σ regulates hematopoietic stem cell–repopulating capacity

(2014) Mamle Quarmyne et al.   JOURNAL OF CLINICAL INVESTIGATION

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells

(2014) Süleyman Coşkun et al.   Cell Reports

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells

(2013) C. K. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release

(2012) K. Golan et al.   BLOOD

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

(2012) J. Huan et al.   CANCER RESEARCH

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

The hematopoietic stem cell niche-home for friend and foe?

(2012) Daniela S. Krause et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Tie2+Bone Marrow Endothelial Cells Regulate Hematopoietic Stem Cell Regeneration Following Radiation Injury

(2012) Phuong L. Doan et al.   STEM CELLS

Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

(2012) Heather A. Himburg et al.   Cell Reports

Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures

(2012) Kyung-Dal Choi et al.   Cell Reports

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

(2011) Andrejs Ivanovs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

(2011) Kana Miyamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal-Derived Factor-1 and Its Receptor, CXCR4, Are Constitutively Expressed by Mouse Liver Sinusoidal Endothelial Cells: Implications for the Regulation of Hematopoietic Cell Migration to the Liver During Extramedullary Hematopoiesis

(2011) Mayela Mendt et al.   STEM CELLS AND DEVELOPMENT

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

(2010) M. Tesio et al.   BLOOD

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

(2010) Heather A Himburg et al.   NATURE MEDICINE

Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo

(2009) A. B. Salter et al.   BLOOD

Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis

(2009) Sachin Malhotra et al.   Cell Stem Cell

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells

(2009) Dmitry O. Traktuev et al.   CIRCULATION RESEARCH

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Liver Sinusoidal Endothelial Cells Promote B Lymphopoiesis From Primitive Hematopoietic Cells

(2009) Olga Wittig et al.   STEM CELLS AND DEVELOPMENT

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation

(2008) S. Chunduri et al.   HAEMATOLOGICA

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Endochondral ossification is required for haematopoietic stem-cell niche formation

(2008) Charles K. F. Chan et al.   NATURE

Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing

(2008) Liwen Chen et al.   PLoS One

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE