Enhanced Immunosuppression of T Cells by Sustained Presentation of Bioactive Interferon-γ Within Three-Dimensional Mesenchymal Stem Cell Constructs

Topographical cues regulate the crosstalk between MSCs and macrophages

(2015) Gema Vallés et al.   BIOMATERIALS

Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2

(2014) Marian H. Hettiaratchi et al.   BIOMATERIALS

Chondroitin Sulfate Microparticles Modulate Transforming Growth Factor-β1-Induced Chondrogenesis of Human Mesenchymal Stem Cell Spheroids

(2014) Melissa C. Goude et al.   CELLS TISSUES ORGANS

IDO-Independent Suppression of T Cell Effector Function by IFN- -Licensed Human Mesenchymal Stromal Cells

(2014) R. Chinnadurai et al.   JOURNAL OF IMMUNOLOGY

Materials as stem cell regulators

(2014) William L. Murphy et al.   NATURE MATERIALS

Human Adipose-Derived Stromal/Stem Cells Induce Functional CD4+CD25+FoxP3+CD127− Regulatory T Cells Under Low Oxygen Culture Conditions

(2014) Trivia P. Frazier et al.   STEM CELLS AND DEVELOPMENT

Matrix Composition and Mechanics Direct Proangiogenic Signaling from Mesenchymal Stem Cells

(2014) Amr A. Abdeen et al.   TISSUE ENGINEERING PART A

Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study

(2014) Dandan Wang et al.   ARTHRITIS RESEARCH & THERAPY

The interaction between mesenchymal stem cells and steroids during inflammation

(2014) X Chen et al.   Cell Death & Disease

Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

(2014) James A. Ankrum et al.   Scientific Reports

A microparticle approach to morphogen delivery within pluripotent stem cell aggregates

(2013) Andrés M. Bratt-Leal et al.   BIOMATERIALS

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion

(2013) Joshua A. Zimmermann et al.   CYTOTHERAPY

Insights into the Mechanism by Which Interferon-γ Basic Amino Acid Clusters Mediate Protein Binding to Heparan Sulfate

(2013) Els Saesen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

(2013) Ratti Ram Sharma et al.   TRANSFUSION

Mesenchymal stem cells: a double-edged sword in regulating immune responses

(2012) W Li et al.   CELL DEATH AND DIFFERENTIATION

Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis

(2012) Kentaro Akiyama et al.   Cell Stem Cell

Spherical Bullet Formation via E-cadherin Promotes Therapeutic Potency of Mesenchymal Stem Cells Derived From Human Umbilical Cord Blood for Myocardial Infarction

(2012) Eun Ju Lee et al.   MOLECULAR THERAPY

Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype

(2012) Joni H. YlÖstalo et al.   STEM CELLS

Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells

(2011) Suk Ho Bhang et al.   BIOMATERIALS

Systematic engineering of 3D pluripotent stem cell niches to guide blood development

(2011) Kelly A. Purpura et al.   BIOMATERIALS

Differentiation of mesenchymal stem cells in heparin-containing hydrogels via coculture with osteoblasts

(2011) Song P. Seto et al.   CELL AND TISSUE RESEARCH

Mesenchymal stromal cell ‘licensing’: a multistep process

(2011) M Krampera   LEUKEMIA

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

Pretreatment with Interferon-γ Enhances the Therapeutic Activity of Mesenchymal Stromal Cells in Animal Models of Colitis

(2011) Marjolijn Duijvestein et al.   STEM CELLS

Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources

(2010) Mehdi Najar et al.   CELLULAR IMMUNOLOGY

Umbilical Cord-Derived Mesenchymal Stromal Cells Modulate Monocyte Function to Suppress T Cell Proliferation

(2010) A. J. Cutler et al.   JOURNAL OF IMMUNOLOGY

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

(2010) T. J. Bartosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules

(2009) Richard L. Carpenedo et al.   BIOMATERIALS

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Cell contact, prostaglandin E2and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+regulatory T cells

(2009) K. English et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

(2009) Moutih Rafei et al.   JOURNAL OF IMMUNOLOGY

Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-β

(2009) Qing-fei Kong et al.   JOURNAL OF NEUROIMMUNOLOGY

Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis

(2009) Gabriela Constantin et al.   STEM CELLS

Requirement of IFN-γ–Mediated Indoleamine 2,3-Dioxygenase Expression in the Modulation of Lymphocyte Proliferation by Human Adipose–Derived Stem Cells

(2009) Olga DelaRosa et al.   TISSUE ENGINEERING PART A

Mesenchymal Stem Cells Require a Sufficient, Ongoing Immune Response to Exert Their Immunosuppressive Function

(2009) P. Renner et al.   TRANSPLANTATION PROCEEDINGS

The CD34-like protein PODXL and  6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice

(2008) R. H. Lee et al.   BLOOD

The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology

(2008) A. Curti et al.   BLOOD

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

IFN-γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease

(2008) David Polchert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS