Journal
SILICON
Volume 8, Issue 4, Pages 525-531Publisher
SPRINGER
DOI: 10.1007/s12633-015-9397-1
Keywords
Porous silicon; Drug delivery; Antibacterial; Nanomaterial
Funding
- NIH [R21EY021583]
- Robert A. Welch Foundation [P-1212]
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In this work, nanostructured porous silicon (pSi) prepared by a metal-assisted stain etched route is investigated for its ability to act as a carrier for sustained delivery of the antibacterial drug triclosan. The morphology, analyzed by transmission electron microscopy, reveals a rather different microstructure than traditional anodized porous silicon; as a consequence, such morphology manifests a different loaded drug crystallinity, triclosan release behavior, and associated antibacterial activity versus Staphococcus aureus relative to high porosity anodized porous silicon. In addition to electron microscopies and antibacterial disk diffusion assays, a combination of x-ray diffraction, thermogravimetric analyses, and UV/Vis spectrophotometric analysis of triclosan release are employed to carry out the above investigations.
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