Article
Polymer Science
Gauri Shankar Shaw, Ricky A. Dash, Satyavrata Samavedi
Summary: The study demonstrates the protective role of microparticles in minimizing adverse effects of electrospinning on the secondary structure of incorporated protein.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Constantinos Voniatis, Dora Barczikai, Gergo Gyulai, Angela Jedlovszky-Hajdu
Summary: This manuscript presents the first attempt to fabricate and characterise electrospun polycaprolactone/poly(succinimide) composite meshes, which show great potential for diverse applications. Three different meshes were produced using different electrospinning configurations, and physical-chemical and mechanical characterisation confirmed the advantages of the composite meshes in terms of mechanical strength and wettability.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Materials Science, Multidisciplinary
Rosebin Babu, C. R. Reshmi, John Joseph, Binulal N. Sathy, Shantikumar Nair, Praveen Kerala Varma, Deepthy Menon
Summary: This study demonstrates the design and fabrication of woven electrospun nanotextile vascular patches with biodegradable polymers, meeting mechanical and biological requirements for vascular applications. The unique nanofibrous architecture of the nanotextile allows for exceptional anisotropic mechanical behavior and good biocompatibility. The integration of electrospinning and weaving techniques results in a novel biodegradable material suitable for vascular patch applications.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Jin-Oh Jeong, Young Min Ju, Hyun-Wook Kang, Anthony Atala, James J. Yoo, Sang Jin Lee
Summary: The development of innovative vascular substitutes is increasingly important due to the prevalence of vascular diseases. In this study, a biofunctionalized electrospun vascular scaffold was designed by chemically conjugating heparin molecules and an endothelial cell (EC)-specific antibody. The findings showed that a higher degree of heparin conjugation improved the antithrombotic properties of the vascular scaffold.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Bingcheng Yi, Lei Yu, Han Tang, Wenbo Wang, Wei Liu, Yanzhong Zhang
Summary: This study demonstrated the use of a lysine-doped polydopamine coating strategy to functionalize tissue-engineered vascular grafts, improving coating uniformity, wettability, and protein adsorption capacity, as well as enhancing anti-thrombogenic and endothelialization capabilities.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Physical
Krisztina Toth, Nora Fekete, Vivien Klaudia Simon, Bence Toth, Arpad Ferenc Kovacs, Eva Pallinger, Istvan Antal, Laszlo Kohidai, Angela Jedlovszky-Hajdu, David Juriga, Krisztina S. Nagy
Summary: Electrospinning is used to prepare nanofibers with high specific surfaces, improved bioavailability of poorly water-soluble drugs, and multiple administration routes. Poly(vinyl alcohol) (PVA), polysuccinimide (PSI), and epsilon-polycaprolactone (PCL) based implantable scaffolds were developed to enhance the bioavailability of prednisone (Pred) and doxorubicin (Dox). The drug release profile depended on the polymer's polarity and environmental pH. Prednisone-loaded meshes showed anti-inflammatory effects by measuring the release of cytokines, while doxorubicin conjugation to polysuccinimide fibers provided prolonged release and increased cellular uptake. These findings suggest that multi-layered drug-containing implantable scaffolds can be prepared using different fibrous meshes to provide both burst and prolonged release of prednisone and doxorubicin.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Biomedical
Yuehao Xing, Yongquan Gu, Lianrui Guo, Jianming Guo, Zeqin Xu, Yonghao Xiao, Zhiping Fang, Cong Wang, Zeng-Guo Feng, Zhonggao Wang
Summary: Gelatin coating on the internal surface of PCL grafts is a simple and effective way to promote endothelialization. Heparinized gelatin-coated grafts showed more rapid and complete endothelialization, inhibiting intimal hyperplasia in the long-term, and promoting smooth muscle cells and extracellular matrix regeneration.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Engineering, Biomedical
Yuan Gui, Kang Qin, Ye Zhang, Xiangyu Bian, Zhiguang Wang, Dianpeng Han, Yuan Peng, Hongyuan Yan, Zhixian Gao
Summary: The study developed a polycaprolactone vascular graft incorporated with quercetin and found that quercetin reduced pro-inflammatory gene expressions and increased anti-inflammatory gene expressions. In vivo experiments showed that quercetin enhanced the regeneration and remodeling of vascular tissue.
BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Jiajie Liu, Dian Chen, Xiaoqiang Zhu, Nan Liu, Haibo Zhang, Rui Tang, Zhengni Liu
Summary: This study developed a 1.8-mm-diameter vascular graft composed of a decellularized human amniotic membrane (HAM) and polycaprolactone/silk fibroin composite. In vitro and in vivo experiments demonstrated that the bioengineered graft promoted rapid endothelialization, resisted collagen deposition, and maintained patency with a stable remodeling structure. The findings suggest the potential application of this graft for small-diameter vascular regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Tonghe Zhu, Hongbing Gu, Hongmei Zhang, Hongsheng Wang, Huitang Xia, Xiumei Mo, Jinglei Wu
Summary: The study synthesized PEUU@PEG-Hep vascular graft with good biocompatibility and blood compatibility, and the covalent grafting of PEG and heparin significantly enhanced endothelial cell adhesion, spreading, and proliferation, as well as improved the grafts' ability to prevent platelet deposition.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Textiles
Yasaman Jahanmardi, Mohammad A. Tavanaie, Ali R. Tehrani-Bagha
Summary: Developing drug delivery systems that are biocompatible and offer controlled drug release is of great interest. In this study, the release of curcumin from electrospun meshes made from polycaprolactone, polylactic acid, or their blends was investigated. The physical-mechanical properties of the fabricated electrospun meshes could be adjusted by polymer blending, impacting the release of curcumin. Key factors affecting curcumin release included the type of polymers, average diameter of nanofibers, porosity, and hydrophilicity of the meshes.
JOURNAL OF INDUSTRIAL TEXTILES
(2021)
Article
Biotechnology & Applied Microbiology
Dengchao Xie, Panpan Ma, Xin Ding, Xiao Yang, Lian Duan, Bo Xiao, Shixiong Yi
Summary: PF127-CPT/CUR-meshes prepared by electrospun fibrous technology exhibited evenly distributed CPT and CUR in fibers, demonstrating strong in vitro anti-colon cancer activities. The combination index values of the meshes indicated synergistic anti-colon cancer effects, suggesting their potential as an efficient implantable system for colon cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Vera Chernonosova, Alexandr Gostev, Ivan Murashov, Boris Chelobanov, Andrey Karpenko, Pavel Laktionov
Summary: This study examined the properties and compatibility of electrospun 3D matrices for vascular grafts produced using different materials. The results showed good hemocompatibility of scaffolds with Gel and bivalirudin, as well as the advantages of Pel-80A grafts over ePTFE in terms of graft occlusion and calcification levels. Additionally, the introduction of bivalirudin into grafts inhibited platelet adhesion.
Article
Biochemistry & Molecular Biology
Kiran R. Adhikari, Inessa Stanishevskaya, Pablo C. Caracciolo, Gustavo A. Abraham, Vinoy Thomas
Summary: In this study, electrospun scaffolds based on a blend of PHH and PDO were characterized, showing high porosity and nanofiber structure. The mechanical properties of the blended scaffold, including elastic modulus, tensile strength, and maximum elongation, were comparable to materials currently used for soft tissue applications. This demonstrates the potential of electrospun PHH/PDO blend for cardiac patches or vascular graft applications mimicking native tissue.
Article
Chemistry, Multidisciplinary
Claudia Mouro, Ana P. Gomes, Merja Ahonen, Raul Fangueiro, Isabel C. Gouveia
Summary: This study successfully incorporated Chelidonium majus extract into nanofibrous meshes using a needleless emulsion electrospinning technique, demonstrating promising healing support properties for wound infections.
Review
Polymer Science
Stefan Baudis, Marc Behl
Summary: The high-throughput development of new multifunctional polymers is achieved through the combination of different high-throughput tools established in polymer sciences over the past decade. Important advances include robotic/high-throughput synthesis of polymer libraries, high-throughput characterization of polymers, and the application of spatially resolved polymer library formats. High-throughput polymer synthesis allows the generation of material libraries with combinatorial design motifs, while high-throughput characterization enables rapid assessment of complementary properties and determination of important surface parameters. Current methods and limitations of high-throughput robotic synthesis and characterization of multifunctional polymers are presented and discussed.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yue Liu, Oliver E. C. Gould, Karl Kratz, Andreas Lendlein
Summary: Polymeric devices capable of controlled release of submicron particles on demand have been demonstrated using a temperature-memory polymer sheet as a matrix to embed and release polystyrene subMP based on particle size and temperature. The technology allows for sequential release of subMPs based on their size and temperature-memory effect, showing potential applications in assembly, particle sorting, and release technologies in microtechnology, catalysis, and controlled release.
Article
Materials Science, Multidisciplinary
Hanieh Moradian, Manfred Gossen, Andreas Lendlein
Summary: This study investigates the effects of different payload designs on gene co-expression, and finds that co-delivery of individual monocistronic nucleic acids is more effective than a bicistronic design.
MRS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Lucile Tartivel, Anna M. Blocki, Steffen Braune, Friedrich Jung, Marc Behl, Andreas Lendlein
Summary: This study presents microporous hydrogels with an inverse shape-memory effect, which can change their shape through heating and cooling. These hydrogels can gently load bioactive components without causing activation, making them potential candidates for tissue regeneration.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Shuo Zhou, Xun Xu, Nan Ma, Friedrich Jung, Andreas Lendlein
Summary: Glycerol-based epoxy networks have great potential for surface functionalization, but the production process may lead to the presence of organochlorides, affecting cytotoxicity.
Article
Materials Science, Multidisciplinary
Shanshan Zhang, Yue Liu, Rainhard Machatschek, Andreas Lendlein
Summary: We report the successful production of cohesive and well-organized type I collagen ultrathin films of about 10 nm thickness using the Langmuir-Blodgett technique. Investigation of molecular behavior at the air-water interface reveals the existence and disappearance of a network structure in the protein nanosheet. Highly aligned and fibrillar structures are observed by atomic force microscopy and optical microscopy.
Review
Chemistry, Physical
Jingbo Shen, Yakai Feng
Summary: The encapsulation materials for LEDs play a crucial role in their reliability and performance. Traditional materials such as epoxy resins and organic silicone resins have limitations, while organic-inorganic nanocomposites show great potential and are gaining increasing attention.
Article
Polymer Science
Jian-Liang Jiang, Xiao Yang, Dongqi Zhao, Ya-kai Feng
Summary: Blending is an economical and feasible method to improve the properties of polymers. A series of hydrogenated nitrile butadiene rubber (HNBR)/AEM blends were prepared to improve the mechanical properties of ethylene acrylate rubber (AEM). The mechanical, thermal properties and compatibility of HNBR/AEM blends were investigated in detail. Carbon black filled HNBR/AEM blends exhibited excellent mechanical properties as well as good resistance to high and low temperature.
JOURNAL OF RUBBER RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Bin Gao, Xiaoyu Wang, Meiyu Wang, Wen Liu, Ying Li, Shihai Xia, Wencheng Zhang, Yakai Feng
Summary: Currently, the focus of therapeutic technology development is on antisense oligonucleotides (ASOs) that regulate cell behavior by inhibiting target gene expression. However, the delivery of ASOs to the nucleus of cells still faces challenges. Inspired by intercellular-mass-transport, researchers discovered that the cell membrane of endothelial cells (ECs) allows ASOs to rapidly enter the nucleus. By utilizing natural/off-the-shelf biomaterials, a nanosystem was created that effectively overcomes this challenge and demonstrates superior efficacy compared to previous delivery vehicles. Moreover, the nanosystem was successfully applied in vivo to enhance therapeutic outcomes in a mouse model of critical limb ischemia.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Jingbo Shen, Yang Wang, Yakai Feng
Summary: Polysiloxane functionalized carbon dots were prepared to improve the stability and photoluminescence of conventional carbon dots. The size of the functionalized carbon dots ranged from 2.2 to 6.4 nm, and their UV-visible absorption spectra shifted to shorter wavelengths with decrease in aminopropyl content in the polysiloxanes. The fluorescence intensities and cores of the functionalized carbon dots varied with the aminopropyl content in the polysiloxanes, indicating tunable photoluminescence. The polysiloxane modification effectively enhanced the stability of carbon dots and allowed for adjustable photoluminescence.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Meiyu Wang, Ye Wan, Wen Liu, Bin Gao, Xiaoyu Wang, Wenzhong Li, Shihai Xia, Wencheng Zhang, Kai Wang, Yakai Feng
Summary: The NiTi-PMAMPC/REDV stent, modified with zwitterion polymer PMAMPC and adhesion peptide REDV, exhibited satisfactory anticoagulation performance and enhanced endothelialization. In vitro studies showed excellent blood compatibility and promotion of HUVEC adhesion, proliferation, and migration on the NiTi-PMAMPC/REDV surface. In vivo studies demonstrated good blood patency and formation of a complete endothelial layer on the NiTi-PMAMPC/REDV stent surface.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Xiaoyu Wang, Bin Gao, Shihai Xia, Wencheng Zhang, Xumin Chen, Zequn Li, Xiangyan Meng, Yakai Feng
Summary: Therapeutic angiogenesis is a promising solution for critical limb ischemia. A nano-system based on metal-organic frameworks was developed for delivering zinc ion and hydrogen sulfide to promote endothelial cell morphogenesis and normalize the microenvironment, offering a potential treatment option for CLI.
APPLIED MATERIALS TODAY
(2023)
Review
Materials Science, Biomaterials
Wen Liu, Xiaoyu Wang, Yakai Feng
Summary: Complete endothelialization is crucial for the long-term success of cardiovascular stents, as it prevents complications and ensures proper functioning. Endothelial dysfunction, caused by factors like inflammation, oxidative stress, and altered hemodynamic shear stress, leads to stent failure. This review focuses on the molecular mechanisms and strategies to improve endothelial function, as well as introducing the design principles and potential improvements for next-generation stents.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Jianliang Jiang, Junxue Zhai, Lingxin Kong, Dongqi Zhao, Yakai Feng
Summary: CR/MCA vulcanizate exhibits high strength, high elongation at break, and excellent flame retardancy. The reaction between CR and cyanuric acid is achieved with the catalysis of MCA, resulting in the grafting of cyanuric acid molecules onto the molecular chain of CR and the formation of two types of crosslinking networks. This research will promote the industrial application of CR.
Article
Materials Science, Multidisciplinary
Jie Liu, Si-Yu Gao, Xin-Yi Zhang, Yakai Feng, Han-Chun Wu, Zhijian Chen, Maxim Bermeshev, Xiang-Kui Ren
Summary: In this study, a POSS-containing polynorbornene was synthesized and its supramolecular structure and photoluminescence properties were investigated. The experimental results demonstrated that the introduction of POSS cages led to a unique structure and enhanced photoluminescence properties. These findings are of great significance for understanding the structure-property relationship of optical polymers and designing polymer materials with controllable supramolecular structure and tunable luminescence properties.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)