☆ 4.5 Article

A 6-Year-Old Child with Severe Ebola Virus Disease: Laboratory-Guided Clinical Care in an Ebola Treatment Center in Guinea

PLOS NEGLECTED TROPICAL DISEASES (2016)

Journal

PLOS NEGLECTED TROPICAL DISEASES

Volume 10, Issue 3, Pages -

Publisher

PUBLIC LIBRARY SCIENCE

DOI: 10.1371/journal.pntd.0004393

Keywords

-

Categories

Infectious Diseases Parasitology Tropical Medicine

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Environmental Sciences

Associations between surrounding residential greenness and intelligence quotient in 6-year-old children

Kyung-Shin Lee, Bung-Nyun Kim, Jinwoo Cho, Yoon-Young Jang, Yoon-Jung Choi, Woo-Seok Lee, Changwoo Han, Hyun Joo Bae, Youn-Hee Lim, Johanna Inhyang Kim, Choong Ho Shin, Young Ah Lees, Yun-Chul Hong

Summary: This study found that 6-year-old children tend to score higher on total IQ if they live in greener neighborhoods, with a stronger association between children's total IQ and built greenness. This provides further evidence of the health benefits of greenness and supports urban planning and public health efforts to create healthy cities for children and pregnant women.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Sustainable Laboratory Capacity Building After the 2014 Ebola Outbreak in the Republic of Guinea

Jean Ndjomou, Scott Shearrer, Brendan Karlstrand, Carmen Asbun, Jesse Coble, Jane S. Alam, Mar P. Mar, Lance Presser, Scott Poynter, Julia M. Michelotti, Nadia Wauquier, Casey Ross, Sharon Altmann

Summary: The West Africa Ebola virus outbreak from 2014 to 2016 revealed the weaknesses in the public health systems of Guinea, Sierra Leone, and Liberia, including inadequate training and equipment. Affected countries urgently sought international assistance to strengthen their public health systems. A successful laboratory capacity building program in Guinea improved bio-surveillance capabilities.

FRONTIERS IN PUBLIC HEALTH (2021)

Add to Collection

Article Infectious Diseases

Presentation of severe brucellosis in 5-year-old boy-challenges and results

Yulia Dinikina, Uliana Tsoy, Andrey Dyachkov, Roman Grozov, Aleksandr Mushkin, Vyacheslav Zorin, Irina Nikitina, Elena Grineva

Summary: Brucellosis is a highly contagious bacterial disease caused by gram-negative genus, with a wide variety of clinical manifestations and difficult diagnostics. This article presents a clinical case of severe chronic brucellosis in a 5-year-old boy with long-term disease and multiorgan involvement, and discusses different complications including syndrome of inappropriate ADH secretion. Despite the severity of the disease, the patient achieved significant clinical improvement through a multidisciplinary approach and optimal etiotropic and pathogenetic treatment.

BMC INFECTIOUS DISEASES (2023)

Add to Collection

Article Immunology

Structured Immune Workup in Healthy Children With a First Episode of Severe Bacterial Infection: A 7-year Single-Center Study

Sophie Strasser, Christa Relly, Christoph Berger, Johannes Truck

Summary: A retrospective analysis found that a substantial proportion of children with severe bacterial infections (SBIs) had immune function impairments. Routine immunological testing can help identify these abnormalities and optimize preventive measures to avoid future SBI episodes.

JOURNAL OF INFECTIOUS DISEASES (2023)

Add to Collection

Article Infectious Diseases

Child mortality after the Ebola virus disease outbreak across Guinea, Liberia, and Sierra Leone

Young Eun Kim

Summary: This study assessed the impact of the Ebola virus disease outbreak on child mortality in Guinea, Liberia, and Sierra Leone from 2014 to 2016. The results showed that the child mortality rate decreased significantly for children born after the outbreak, but the association with the increase in Ebola cases remained strong. Additionally, there were variations in the utilization of maternal health services after the outbreak.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Add to Collection

Article Medicine, General & Internal

Endoscopic Ultrasound-guided Hepaticogastrostomy in a Seven-year-old Girl

Shigeto Ishii, Hiroyuki Koga, Hiroaki Saito, Shogo Seo, Mako Ushio, Sho Takahashi, Yusuke Takasaki, Akinori Suzuki, Koichi Ito, Kazushige Ochiai, Ko Tomishima, Toshio Fujisawa, Atsuyuki Yamataka, Shuichiro Shiina, Hiroyuki Isayama

Summary: EUS-HGS is an effective biliary drainage procedure in adults, but its application in pediatric cases is limited. We successfully performed this procedure in a pediatric case with a surgically altered anatomy, avoiding the use of a difficult-to-maintain percutaneous tube.

INTERNAL MEDICINE (2022)

Add to Collection

Article Endocrinology & Metabolism

Relationship of iodine excess with thyroid function in 6-year-old children living in an iodine-replete area

Yun Jeong Lee, Sun Wook Cho, Youn-Hee Lim, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Young Joo Park, Choong Ho Shin, Young Ah Lee

Summary: Excessive iodine intake is common in 6-year-old Korean children and is associated with decreased thyroid function. Further research is needed to investigate the long-term effects of iodine excess on thyroid function and health outcomes.

FRONTIERS IN ENDOCRINOLOGY (2023)

Add to Collection

Article Psychology, Multidisciplinary

Reliability and Validation of the Child Eating Behavior Questionnaire in 3-to 6-Year-Old Spanish Children

Andrea Jimeno-Martinez, Ivie Maneschy, Luis A. Moreno, Gloria Bueno-Lozano, Pilar De Miguel-Etayo, Katherine Flores-Rojas, Jose Manuel Jurado-Castro, Carmela de Lamas, Rocio Vazquez-Cobela, Raul Martinez-Lacruz, Olga Portoles, J. Alfredo Martinez, Santiago Navas-Carretero, Helmut Schroeder, Montserrat Fito, Nancy Babio, Jordi Salas-Salvado, Rosaura Leis, Mercedes Gil-Campos, Azahara I. Ruperez

Summary: The CEBQ questionnaire has been validated for high reliability and internal consistency in Spanish children. Positive associations were found between pro-intake scales like Food Responsiveness, Emotional Overeating, and Enjoyment of food, and children's BMI, while negative associations were observed between anti-intake scales like Satiety Responsiveness, Slowness in Eating, and Emotional Undereating, and BMI.

FRONTIERS IN PSYCHOLOGY (2022)

Add to Collection

Article Obstetrics & Gynecology

Assessing the cognitive and behavioral development of 3-year-old children born from fathers with severe male infertility

Stephanie Cheung, Queenie V. Neri, Jane Squires, Zev Rosenwaks, Gianpiero D. Palermo

Summary: Despite concerns, children conceived via intracytoplasmic sperm injection and in vitro fertilization generally develop well, with the latter showing slightly impaired developmental characteristics. Surprisingly, children conceived from surgically retrieved spermatozoa via intracytoplasmic sperm injection had lower risk of abnormal development and behavior compared to those conceived from ejaculated specimens. Further studies on outcomes of children from fathers with severe male factor infertility are needed due to limited data.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

Add to Collection

Article Environmental Sciences

Dynamics of skin microvascular blood flow in 4-6-year-old children in association with pre- and postnatal black carbon and particulate air pollution exposure

Katrien Witters, Yinthe Dockx, Jos Op't Roodt, Wouter Lefebvre, Charlotte Vanpoucke, Michelle Plusquin, Jaco Vangronsveld, Bram G. Janssen, Tim S. Nawrot

Summary: The study reveals that prenatal exposure to BC, particulate air pollution, and NO2, even at low concentrations, may have long-lasting consequences on the microvasculature, especially during childhood.

ENVIRONMENT INTERNATIONAL (2021)

Add to Collection

Article Medicine, General & Internal

A Case Report for Severe COVID-19 in a 9-Year-Old Child Treated with Remdesivir and Dexamethasone

Yoon Hee Jo, Yosub Hwang, Soo-Han Choi

Summary: A previously healthy but obese 9-year-old boy with severe COVID-19 was successfully treated with remdesivir and dexamethasone, showing significant improvement before discharge on day 21. No adverse effects of remdesivir therapy were observed in this case.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Validation of the illustrated questionnaire on food consumption for Brazilian schoolchildren (QUACEB) for 6-to 10-year-old children

Giovanna Angela Leonel Oliveira, Daniela Oliveira Llorente Barrio, Giovanna Soutinho Araujo, Marina Pimentel Saldanha, Raquel Machado Schincaglia, Muriel Bauermann Gubert, Natacha Toral

Summary: The objective of this study was to develop and validate an illustrated questionnaire on food consumption for Brazilian schoolchildren aged 6 to 10 years old. The results showed that the questionnaire had high sensitivity and specificity, substantial agreement with the parents' responses, and the illustrations were validated by the children.

FRONTIERS IN PUBLIC HEALTH (2023)

Add to Collection

Article Pediatrics

Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl

Ya Bin Zhou, Jia Feng Yao, Zi Gang Xu, Rui Hui Wu

Summary: In this article, a case of CNL in a 6-year-old Chinese girl with leukemia cutis as the first manifestation is described. The skin rashes failed to attract the attention of dermatologists in the early stages, leading to misdiagnosis.

FRONTIERS IN PEDIATRICS (2022)

Add to Collection

Article Nursing

The relationship between caregiver burden and self-care agency of pregnant women with 0-6-year-old children

Sibel Ergun

Summary: The study found that mothers with two or more children between the ages of 0-6 had lower self-care ability scores and higher caregiver burden scores, and there was a negative correlation between the self-care ability and caregiver burden of pregnant women. These results provide valuable insights into the caregiver burden and self-care ability of pregnant women with young children.

NURSING OPEN (2022)

Add to Collection

Article Pediatrics

Fulminant Infective Endocarditis Due to Kingella Kingae and Several Complications in a 6-Year-Old Girl: A Case Report

Raphael Joye, Dimitri Ceroni, Maurice Beghetti, Yacine Aggoun, Tornike Sologashvili

Summary: Kingella kingae is a common oropharyngeal colonizer in healthy young children, often causing mild osteoarticular infections. However, it can also lead to severe invasive infections like infective endocarditis. Treatment may include emergency cardiac surgery and antibiotic therapy.

FRONTIERS IN PEDIATRICS (2021)

Add to Collection

Article Immunology

Kinetics of Archived M184V Mutation in Treatment-Experienced Virally Suppressed HIV-Infected Patients

Romain Palich, Elisa Teyssou, Sophie Sayon, Basma Abdi, Cathia Soulie, Lise Cuzin, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Sophie Seang, Marc Wirden, Valerie Pourcher, Christine Katlama, Vincent Calvez, Anne-Genevieve Marcelin

Summary: The presence of drug-resistant viral variants (DRVs) with the M184V mutation decreases over time in HIV DNA, but it persists more frequently in patients with longer treatment experience and past replication under 3TC/FTC.

JOURNAL OF INFECTIOUS DISEASES (2022)

Add to Collection

Article Infectious Diseases

Household transmission of SARS-CoV-2 infection in the Paris/Ile-de-France area

Christine Katlama, Yasmine Dudoit, Julien Huyard, Christine Blanc, Cathia Soulie, Luminita Schneider, Antoine Faycal, Ludovic Lenclume, Naima Hamani, Naoual Qatib, Roland Tubiana, Sophie Seang, Baptiste Sellem, Dominique Costagliola, Romain Palich, Marc-Antoine Valantin, Lambert Assoumou

Summary: This study found a high transmission rate of SARS-CoV-2 within households, with a significant portion of infected contacts being asymptomatic. Independent predictors of virus transmission included housing surface area and the number of family members.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2022)

Add to Collection

Article Infectious Diseases

Distribution of HIV self-tests by men who have sex with men attending a French sexual health centre: results of the OTO study

Daniel Gosset, Marine Plathey, France Lert, Stephane Lasry, Thibaut Jedrzejewski, Philippe Gazalet, Thomas L'Yavanc, Nadege Pierre, Abdessamad Kachal, Marc Fremondiere, Michel Ohayon, Romain Palich

Summary: This study aimed to assess the proportion and characteristics of MSMs attending sexual health centers who distributed HIV self-tests (HSTs), as well as the characteristics of people who received HSTs. The results showed that most participants were willing to distribute HSTs themselves, and the majority of recipients were MSMs who had not been tested for a long time. This study demonstrates the potential of MSMs in promoting HIV self-testing.

SEXUALLY TRANSMITTED INFECTIONS (2023)

Add to Collection

Article Immunology

Birth Country Influences the Choice of Antiretroviral Therapy in HIV-Infected Individuals: Experience From a French HIV Centre

Romain Palich, Rachid Agher, Dimoke J. Wetshikoy, Lise Cuzin, Sophie Seang, Cathia Soulie, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Valerie Pourcher, Anne-Genevieve Marcelin, Lambert Assoumou, Christine Katlama

Summary: This study aims to explore the differences in antiretroviral therapy (ART) prescriptions between naive and virally suppressed HIV patients born in France and Sub-Saharan Africa. The findings suggest that the differences in ART prescriptions between these two groups cannot solely be explained by different clinical and virologic situations.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2023)

Add to Collection

Article Infectious Diseases

Viral loads in clinical samples of men with monkeypox virus infection: a French case series

Romain Palich, Sonia Burrel, Gentiane Monsel, Agathe Nouchi, Alexandre Bleibtreu, Sophie Seang, Vincent Berot, Cecile Brin, Ariane Gavaud, Yara Wakim, Nagisa Godefroy, Antoine Faycal, Yanis Tamzali, Thomas Grunemwald, Michel Ohayon, Eve Todesco, Valentin Leducq, Stephane Marot, Vincent Calvez, Anne-Genevieve Marcelin, Valerie Pourcher

Summary: This study describes the distribution of Monkeypox virus (MPXV) in the human body, and the results show that the virus is more frequently detected and has higher viral loads in the skin, anus, and throat. These findings suggest that transmission most likely occurs through direct body contact.

LANCET INFECTIOUS DISEASES (2023)

Add to Collection

Article Immunology

Is There a Reduction in Chemsex Practice in Men Who Have Sex With Men During COVID-19 Lockdown? Results of the CheRRLock Study

Thomas L'Yavanc, Daniel Gosset, Marine Plathey, Thibaut Jedrzejewski, Philippe Gazalet, Stephane Lasry, Nadege Pierre, Abdessamad Kachal, Marc Fremondiere, Michel Ohayon, Romain Palich

Summary: This study investigated changes in chemsex practices during COVID-19 lockdown among MSM in France and factors associated with maintaining or increasing chemsex practice. The results showed an overall increase in chemsex practice, but a decrease in the number of sexual partners. Feeling lonely, craving, and working during lockdown were significantly associated with maintaining or increasing chemsex practice, whereas fear of COVID-19 was associated with a decrease in chemsex practice.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2023)

Add to Collection

Letter Dermatology

Prospective cohort of 70 consecutive cases of human monkeypox: Clinical description with focus on dermatological presentation

Agathe Nouchi, Cecile Brin, Abigail Martin, Marion Favier, Romain Palich, Yara Wakim, Ariane Gavaud, Sophie Seang, Marc-Antoine Valantin, Alexandre Bleibtreu, Sonia Burrel, Vincent Berot, Valerie Pourcher, Gentiane Monsel

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

Add to Collection

Article Immunology

Country of birth is associated with antiretroviral therapy choice in treatment-naive persons with HIV in France

Romain Palich, Maxime Hentzien, Laurent Hocqueloux, Claudine Duvivier, Clotilde Allavena, Thomas Huleux, Pierre Delobel, Alain Makinson, David Rey, Lise Cuzin

Summary: This study aimed to describe factors associated with the choice of first antiretroviral therapy (ART) in persons with HIV (PWH) in France, including the country of birth, as well as the time to undetectable viral load and treatment discontinuation. The results showed that, regardless of HIV disease parameters, PWH born abroad were less likely to choose integrase strand transfer inhibitors (INSTI) as a first-line therapy compared to those born in France. Therefore, qualitative data are needed to better understand physicians' prescribing practices.

AIDS (2023)

Add to Collection

Article Immunology

Psychosocial factors involved in the very rare use of HIV testing among French MSM: a cross-sectional study

Renaud Mabire-Yon, Marion Di Ciaccio, Herve Picard, Romain Palich, Virginie Supervie, Marie Preau

Summary: Among MSM in France, the average time between HIV infection and testing is too long, leading to late diagnosis. Understanding the psychosocial factors associated with infrequent HIV testing can help reach MSM who are unknowingly infected for a long time.

INTERNATIONAL JOURNAL OF STD & AIDS (2023)

Add to Collection

Article Infectious Diseases

Doravirine plus lamivudine two-drug regimen as maintenance antiretroviral therapy in people living with HIV: a French observational study

Pascale Perfezou, Nolwenn Hall, Jean-Charles Duthe, Basma Abdi, Sophie Seang, Cedric Arvieux, Isabelle Lamaury, Amelie Menard, Anne-Genevieve Marcelin, Christine Katlama, Romain Palich

Summary: This study reports the experience of using doravirine/lamivudine as maintenance therapy in HIV patients. The results showed that this treatment regimen can effectively suppress viral replication and improve CD4+ T cell count.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

Add to Collection

Article Infectious Diseases

Low-level viral loads and virological failure in the integrase strand transfer era

Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Helene Laroche, Pascal Pugliese, Andre Cabie, Dat'AIDS Study Grp

Summary: This study analyzed the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years and its relationship with previous episodes of low-level viral load (LLVL). The results showed that LLVL was associated with VF, and even in the absence of subsequent failure, LLV episodes have a cost. Therefore, any viral load value above 50 copies/mL should lead to enhanced adherence counseling.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

Add to Collection

Article Infectious Diseases

Four days/week antiretroviral maintenance strategy (ANRS 170 QUATUOR): substudies of reservoirs and ultrasensitive drug resistance

Sidonie Lambert-Niclot, Basma Abdi, Jonathan Bellet, Djeneba Fofana, Pierre De Truchis, Karine Amat, Jean-Claude Alvarez, Laure Surgers, Clothilde Allavena, Olivia Zaegell-Faucher, Philippe Morlat, Romain Palich, Severine Gibowski, Dominique Costagliola, Pierre-Marie Girard, Roland Landman, Lambert Assoumou, Laurence Morand-Joubert

Summary: The ANRS-170 QUATUOR trial found that a 4 days/week maintenance strategy can effectively suppress viral replication and resistance, resulting in positive virological outcomes for patients.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

Add to Collection

Article Medicine, General & Internal

Mpox in people with advanced HIV infection: a global case series

Oriol Mitja, Andrea Alemany, Michael Marks, Jezer I. Lezama Mora, Juan Carlos Rodriguez-Aldama, Mayara Secco Torres Silva, Ever Arturo Corral Herrera, Brenda Crabtree-Ramirez, Jose Luis Blanco, Nicolo Girometti, Valentina Mazzotta, Aniruddha Hazra, Macarena Silva, Juan Jose Montenegro-Idrogo, Kelly Gebo, Jade Ghosn, Maria Fernanda Pena Vazquez, Eduardo Matos Prado, Uche Unigwe, Judit Villar-Garcia, Noah Wald-Dickler, Jason Zucker, Roger Paredes, Alexandra Calmy, Laura Waters, Cristina Galvan-Casas, Sharon Walmsley, Chloe M. Orkin

Summary: In the 2022 multicountry mpox outbreak, 38-50% of those affected were people living with HIV. Clinical outcomes and mortality were worse in people with more advanced HIV.

LANCET (2023)

Add to Collection

Letter Infectious Diseases

Hepatitis A, hepatitis B and HPV vaccine needs and coverage in MSM initiating HIV PrEP in a sexual health clinic in Paris

Vincent Berot, Anton Eremin, Antoine Fauchois, Jeanne Dechamp, Luminita Schneider, Aziza Chermak, Antoine Faycal, Baptiste Sellem, Thibault Orriere, Marion Favier, Roland Tubiana, Marc-Antoine Valantin, Valerie Pourcher, Eve Todesco, Gentiane Monsel, Rachid Agher, Romain Palich, Christine Katlama

SEXUALLY TRANSMITTED INFECTIONS (2023)

Add to Collection

Article Health Care Sciences & Services

Intermittent Bictegravir/Emtricitabine/Tenofovir Alafenamide Treatment Maintains High Level of Viral Suppression in Virally Suppressed People Living with HIV

Baptiste Sellem, Basma Abdi, Minh Le, Roland Tubiana, Marc-Antoine Valantin, Sophie Seang, Luminita Schneider, Antoine Faycal, Gilles Peytavin, Cathia Soulie, Anne-Genevieve Marcelin, Christine Katlama, Valerie Pourcher, Romain Palich

Summary: In this observational study, researchers evaluated the effectiveness of administering bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) 5 or 4 days a week in maintaining viral suppression in people living with HIV. The study included 85 patients who started intermittent B/F/TAF between November 28, 2018, and July 30, 2020. The results showed a high success rate in terms of both virological success and strategy success, indicating that the intermittent dosing of B/F/TAF could effectively control HIV replication while reducing exposure to antiretroviral therapy (ART).

JOURNAL OF PERSONALIZED MEDICINE (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.