Article
Virology
Misun Kim, Sang Taek Heo, Hyunjoo Oh, Suhyun Oh, Keun Hwa Lee, Jeong Rae Yoo
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is difficult to distinguish from other febrile diseases. This study identified climatic factors and clinical characteristics as predictors of SFTS, with factors like temperature and oral intake significantly associated with the SFTS-positive group. Physicians should consider ambient temperature and clinical features when suspecting SFTS.
Article
Microbiology
Mi-Young Moon, Hyeon Kyu Kim, Se-Jin Chung, Jae Hwan Byun, Ha-Na Kim, Woan Lee, Soon-Won Lee, Sezim Monoldorova, Sungkyeong Lee, Bo-Young Jeon, Eun-Joo Lim
Summary: This study investigated the clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome (SFTS) in Gangwon Province, Korea, from 2019 to 2021. The findings revealed that SFTS occurred throughout the province, with Hwacheon having the highest incidence density. Multiple genotypes of SFTS were identified, with B2 and A being the most common. These findings provide important insights for the understanding and management of SFTS in this region.
Article
Infectious Diseases
Sohyun Bae, Hyun-Ha Chang, Shin-Woo Kim, Yoonjung Kim, EunByeol Wang, Chi Kyeong Kim, Eunji Choi, Bohyun Lim, Sookkyung Park, Hwajin Chae, Hyeyoung Jeon
Summary: In August 2020, 17 healthcare workers in a university hospital in Daegu, Republic of Korea were diagnosed with severe fever with thrombocytopenia syndrome (SFTS). Risk factors for SFTS infection included operating a bag valve mask and cardiac massage during CPR, exposure to patient's body fluids, and shorter individual hospital work experience periods. Exposure to body fluids was identified as the most significant risk factor for SFTS infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Jeong Rae Yoo, Tae-Jin Kim, Sang Taek Heo, Kyung-Ah Hwang, Hyunjoo Oh, TaeHong Ha, Hye Kyung Ko, Seungjae Baek, Ju Eun Kim, Jun Hyeong Kim, Jiin Lee, Min Ji Kang, Mi Soo Yoo, Jung Mogg Kim, Kyung-Mi Lee, Keun Hwa Lee
Summary: In this study, it was found that various biomarkers and inflammatory factors were higher in patients with fatal SFTS than in those with nonfatal disease during the initial clinical course. Additionally, IL-6 and IL-10 levels were strongly correlated with outcomes in SFTSV-infected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Seok-Min Yun, Tae-Young Lee, Hee-Young Lim, Jungsang Ryou, Joo-Yeon Lee, Young-Eui Kim
Summary: The study established a T7 RNA polymerase-driven reverse genetics system for rescuing the infectious clone of Severe fever with thrombocytopenia syndrome virus (SFTSV). Through evaluating the biological properties of the rescued virus, it was confirmed to be similar to the parental virus, showing the effectiveness of the system for identifying viral determinants and facilitating vaccine and antiviral development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Yang Yuan, Qing-Bin Lu, Wen-Si Yao, Jing Zhao, Xiao-Ai Zhang, Ning Cui, Chun Yuan, Tong Yang, Xue-Fang Peng, Shou-Ming Lv, Jia-Chen Li, Ya-Bin Song, Dong-Na Zhang, Li-Qun Fang, Hong-Quan Wang, Hao Li, Wei Liu
Summary: Favipiravir (FPV) treatment significantly reduced the case fatality rate in SFTS patients, but showed heterogeneity in different age groups, onset-to-admission intervals, initial viral loads, and therapy durations. FPV was beneficial for patients aged <= 70 years with specific conditions, but did not benefit those aged >70 years.
Article
Immunology
Shilpa Chatterjee, Choon-Me Kim, Dong-Min Kim, Jun-Won Seo, Da Young Kim, Na-Ra Yun, Sook In Jung, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Kim, Jian Hur, Young Keun Kim, Hye Won Jeong, Jung Yeon Heo, Dong Sik Jung, Hyungdon Lee, Sun Hee Park, Yee Gyung Kwak, Sujin Lee, Rajendra Prasad Chatterjee
Summary: This study investigated the prevalence of coinfection with severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus in patients in South Korea. The results showed that 1.6% of SFTS patients were coinfected with SFTS virus and Orientia tsutsugamushi. This information adds to clinical diagnosis and public health management.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Hee-kyoung Nam, Kyung-Duk Min, Suyoung Jo, Sung-il Cho
Summary: Deforestation increases the risk of severe fever with thrombocytopenia syndrome (SFTS). An integrated approach that considers deforestation is necessary for SFTS surveillance.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Ying Xu, Mingran Shao, Ning Liu, Jian Tang, Qin Gu, Danjiang Dong
Summary: This study aimed to investigate the incidence and clinical characteristics of invasive pulmonary aspergillosis (IPA) in patients with severe fever with thrombocytopenia syndrome (SFTS). The findings showed that SFTS combined with IPA is associated with high morbidity and mortality, with wheezing identified as an independent predictor of IPA in SFTS patients. Further research is needed to determine the potential benefits of early antifungal prophylaxis in this patient population.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Virology
Tomoki Yoshikawa
Summary: The article discusses the establishment of small animal models for SFTS in order to evaluate vaccine candidates, develop these candidates, and establish practical animal models.
Article
Immunology
Lifen Hu, Qinxiang Kong, Chengcheng Yue, Xihai Xu, Lingling Xia, Tingting Bian, Yanyan Liu, Hui Zhang, Xuejiao Ma, Huafa Yin, Qiulin Sun, Yufeng Gao, Ying Ye, Jiabin Li
Summary: Patients with severe fever with thrombocytopenia syndrome (SFTS) infected by novel phlebovirus may have severe immune damage associated with Aspergillus-related disease. Lower CD4(+) and CD8(+) T-cell counts, higher levels of IL-6, TNF-alpha, IL-8, and IL-10 are important factors for predicting the occurrence of invasive pulmonary aspergillosis (IPA) in severe SFTS patients. Early diagnosis and antifungal treatment can improve the prognosis of SFTS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Zhenxing Li, Zhaoru Zhang, Chong Chen
Summary: This study developed two critical risk nomograms based on indicators for predicting mortality risk in SFTS patients, with the model incorporating viral load displaying better predictive accuracy. These models will provide frontline clinicians with a convenient tool for early identification of critically ill patients and initiation of better personalized treatment in a timely manner.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Li Song, Yingjie Zhao, Gang Wang, Wenlu Zou, Lintao Sai
Summary: Patients with severe fever with thrombocytopenia syndrome (SFTS) are at risk of developing invasive pulmonary aspergillosis (IPA), which is associated with increased mortality. This study aimed to identify predictors for IPA in SFTS patients, and the results can aid in early identification and treatment of IPA. The study reviewed laboratory confirmed SFTS patients in two tertiary hospitals in Shandong province and found that uncontrolled diabetes, low platelet count, and low CD4(+) and CD8(+) T cell counts were independent predictors for IPA in SFTS patients. IPA is a serious complication in SFTS patients and early identification of predictors is crucial for improving survival.
SCIENTIFIC REPORTS
(2023)
Article
Virology
Tsuyoshi Ando, Takeshi Nabeshima, Shingo Inoue, Mya Myat Ngwe Tun, Miho Obata, Weiyin Hu, Hiroshi Shimoda, Shintaro Kurihara, Koichi Izumikawa, Kouichi Morita, Daisuke Hayasaka
Summary: The study revealed that 33.1% of cats in Nagasaki were infected with SFTSV, with the main genotype being J1 and unique reassortant strains with J2 and unclassified genotypes present. SFTSV RNA was detected in the body fluids of cats, and some veterinary staff members showed seropositivity for SFTSV-specific antibodies.
Article
Parasitology
Xiao-Hu Han, Yue Ma, Hong-Yan Liu, Dan Li, Yan Wang, Feng-Hua Jiang, Qing-Tian Gao, Feng Jiang, Bao-Shan Liu, Guo-Shun Shen, Ze-Liang Chen
Summary: This study determines the genotypes of SFTSV in patients and ticks in Liaoning Province, PR China, providing a deeper understanding of the SFTS epidemic and information on the variability in mortality rate among genotypes.
PARASITES & VECTORS
(2022)
Correction
Immunology
Chang Kyung Kang, Minji Kim, Soojin Lee, Gwanghun Kim, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Chang-Han Lee, Ik Soo Kim, Keehoon Jung, Dong-Sup Lee, Hyun Mu Shin, Hang-Rae Kim, Myoung-don Oh
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Materials Science, Multidisciplinary
Jae-Eun Park, Ha-Neul Shin, Jihyuk Park, Juwon Suh, Young-Keun Kim
Summary: This paper focuses on developing a friction-variable rubber pad using magnetorheological elastomer (MRE) for robot gripper applications. Tribological experiments were conducted, showing that the frictional coefficient can be varied as much as 40% on different surfaces. The experiments with robot grippers validated the applicability of the proposed MRE pads in controlling the overall friction force by more than 48%.
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES
(2023)
Article
Hematology
Hyunji Kim, Daehyun Chu, Miyoung Kim, Young-uk Cho, Chan-jeoung Park, Seongman Bae, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Sung-Han Kim
Summary: This study suggests that Lupus anticoagulants (LA) are associated with disease severity in COVID-19 patients. The majority of LA-positive patients showed LA positivity within 10 days of SARS-CoV-2 infection, while a subgroup of patients initially tested negative for LA during the early stages of infection and became positive later.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Correction
Medicine, General & Internal
Jiwon Jung, Sun-Kyung Kim, Yumi Lee, Soyeon Park, Young-Ju Lim, Eun Ok Kim, Sung-Han Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Sungim Choi, Song Mi Moon, Ji-Soo Kwon, Sung-Han Kim, Seong Yeon Park
Summary: The study evaluated the diagnostic usefulness of varicella zoster virus (VZV) specific IgA and IgG antibodies in patients with herpes zoster (HZ). The results showed significant differences in the levels of VZV-specific IgA and IgG antibodies between HZ patients and healthy controls.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Jiyoung Lee, Euijin Chang, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Seongman Bae
Summary: This study evaluated the rate and composition of bacterial co-infection in COVID-19 patients and assessed the association between the use of empirical antibacterials and mortality. The results showed that bacterial co-infection was infrequent in the patients, and the co-infected organisms varied depending on the previous use of antibacterial drugs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Chemistry, Analytical
Jihwan You, Young-Keun Kim
Summary: This study proposes a simple and effective method to up-sample low-resolution point cloud input for 3D object detection, which reconstructs objects in the sparse point cloud data to produce more dense data. By converting the 3D point cloud dataset into a 2D range image and using interpolation based on pixel distance and range values of neighbor points, the proposed method enhances the detection accuracy and improves operational speed compared to deep-learning-based super-resolution methods.
Article
Engineering, Electrical & Electronic
Hyeong-Seok Song, Young-Keun Kim
Summary: In this study, an accurate automatic LiDAR alignment inspection system is proposed for manufacturing environments. It utilizes a single-shot, static method with a planar target and NIR camera. The system segments and locates laser beam spots on the target surface using NIR images, and matches them with corresponding feature points from the 3-D point cloud. The system exhibits high accuracy in rotation and translation alignment, with 0.02 degrees and 0.4 mm, respectively.
IEEE SENSORS JOURNAL
(2023)
Letter
Infectious Diseases
Song Hee Namgung, Jiwon Jung, Sun Kyung Kim, Eun Ok Kim, Kyung-Wook Jo, Tae Sun Shim, Sung-Han Kim
JOURNAL OF INFECTION
(2023)
Letter
Medical Laboratory Technology
Jeong Su Park, Yun Jung Choi, Kyungmi Kwon, Seong Jin Choi, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Kyoung Un Park, Hong Bin Kim
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Hong En Fu, Thomas Myeongseok Koo, Myeong Soo Kim, Min Jun Ko, Bum Chul Park, Kyuha Oh, Younhyung Cho, Jae-Wan Jung, Sungil Kim, Woong Sik Jang, Chae Seung Lim, Young Keun Kim
Summary: This study aimed to establish a magnetic-fluorescent nanocluster for high-sensitivity lateral flow assay (LFA) to detect rotavirus antigen. The results showed that the developed LFA platform outperformed commercial test kits, with the potential to inhibit virus propagation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Immunology
Jin Young Ahn, Jae-Hoon Ko, Kyong Ran Peck, Seongman Bae, Sung-Han Kim, Kyoung Hwa Lee, Young Goo Song, Yong Chan Kim, Yoon Soo Park, Kyoung-Ho Song, Eu Suk Kim, Hye Won Jeong, Shin-Woo Kim, Ki Tae Kwon, Won Suk Choi, Jun Yong Choi
Summary: This study investigated the long-term kinetics of immune responses after heterologous booster vaccination and the impact of Omicron breakthrough infection. The findings showed that participants who experienced breakthrough infection during the BA.1/BA.2 period had a more robust increase in neutralizing antibody titers against the wild-type virus compared to BA.1 and BA.5.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Gahee Kim, Ree Nar Yoo, Hyejin So, Jeong-Young Lee, Mi-Na Kim, Sung-Han Kim, Won Kyoung Jhang, Seong Jong Park, Jina Lee
Summary: Ralstonia mannitolilytica is a causative organism of nosocomial infections, particularly associated with contaminated water, and resistant to various antibiotics, including carbapenems. In this study, 18 patients with R. mannitolilytica infection were included, with 94.4% diagnosed with pneumonia and 5.6% with central line-associated bloodstream infection. The all-cause 30-day mortality rate was 61.1%, and environmental sampling identified R. mannitolylica at a cold-water tap of a water purifier and an exhalation circuit of a patient mechanical ventilator.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Yunsang Choi, Minsun Kang, Dong Hoon Shin, Jongtak Jung, Seong Jin Choi, Nak-Hyun Kim, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Jaehun Jung, Hong Bin Kim
Summary: This study aimed to analyze the prescription of antibiotics in patients with COVID-19 and factors influencing this prescription. The results showed that over a quarter of patients were prescribed antibiotics, with a higher proportion among those with severe and critical illness. The study emphasizes the importance of judicious use of antibiotics in patients with COVID-19, taking into consideration the severity of the disease and the risk of bacterial co-infection.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Nak-Hyun Kim, Yunjung Choi, Kyungmi Kwon, Jeong Su Park, Kyoung Un Park, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Wan Beom Park, Hong Bin Kim
Summary: This study aimed to investigate the association between serum anti-α-toxin antibody levels and clinical outcomes of Staphylococcus aureus bacteremia (SAB). The findings suggest that lower anti-α-toxin antibody responses before and during SAB are associated with more severe clinical presentations of infection.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)