Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT)
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT)
Authors
Keywords
Cilia, Sensory neurons, Caenorhabditis elegans, Genetic screens, Phenotypes, Mutant strains, Mutation, Missense mutation
Journal
PLoS Genetics
Volume 12, Issue 8, Pages e1006235
Publisher
Public Library of Science (PLoS)
Online
2016-08-11
DOI
10.1371/journal.pgen.1006235
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration
- (2015) Xiangming Wang et al. DEVELOPMENTAL BIOLOGY
- Efficient Genome Editing inCaenorhabditis eleganswith a Toolkit of Dual-Marker Selection Cassettes
- (2015) Adam D. Norris et al. GENETICS
- Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design
- (2015) Behnom Farboud et al. GENETICS
- High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes
- (2015) A. Paix et al. GENETICS
- Efficient Genome Editing inCaenorhabditis eleganswith a Toolkit of Dual-Marker Selection Cassettes
- (2015) Adam D. Norris et al. GENETICS
- Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design
- (2015) Behnom Farboud et al. GENETICS
- The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium
- (2014) Weiping Wang et al. eLife
- Striated Rootlet and Nonfilamentous Forms of Rootletin Maintain Ciliary Function
- (2013) Swetha Mohan et al. CURRENT BIOLOGY
- The million mutation project: A new approach to genetics in Caenorhabditis elegans
- (2013) O. Thompson et al. GENOME RESEARCH
- Missense mutations in β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker–Warburg syndrome
- (2013) Karen Buysse et al. HUMAN MOLECULAR GENETICS
- SQL-1, homologue of the Golgi protein GMAP210, modulates intraflagellar transport in C. elegans
- (2013) J. R. Broekhuis et al. JOURNAL OF CELL SCIENCE
- The roles of evolutionarily conserved functional modules in cilia-related trafficking
- (2013) Ching-Hwa Sung et al. NATURE CELL BIOLOGY
- A truncating mutation in B3GNT1 causes severe Walker–Warburg syndrome
- (2013) Ranad Shaheen et al. NEUROGENETICS
- TATES: Efficient Multivariate Genotype-Phenotype Analysis for Genome-Wide Association Studies
- (2013) Sophie van der Sluis et al. PLoS Genetics
- Rab35 regulates Arf6 activity through centaurin- 2 (ACAP2) during neurite outgrowth
- (2012) H. Kobayashi et al. JOURNAL OF CELL SCIENCE
- MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS
- (2012) Paul F. O’Reilly et al. PLoS One
- Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
- (2011) Michael C. Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Dye-filling of the amphid sheath glia: Implications for the functional relationship between sensory neurons and glia in Caenorhabditis elegans
- (2011) Kiyotaka Ohkura et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dystroglycanopathies: coming into focus
- (2011) Caroline Godfrey et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates
- (2011) Tatsuo Miyamoto et al. HUMAN MOLECULAR GENETICS
- Ciliopathies
- (2011) Friedhelm Hildebrandt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Testing for an Unusual Distribution of Rare Variants
- (2011) Benjamin M. Neale et al. PLoS Genetics
- Whole-Genome Profiling of Mutagenesis in Caenorhabditis elegans
- (2010) S. Flibotte et al. GENETICS
- The Glia of Caenorhabditis elegans
- (2010) Grigorios Oikonomou et al. GLIA
- A method and server for predicting damaging missense mutations
- (2010) Ivan A Adzhubei et al. NATURE METHODS
- New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0
- (2010) Stéphane Guindon et al. SYSTEMATIC BIOLOGY
- Comprehensive Screening for Novel Rab-Binding Proteins by GST Pull-Down Assay Using 60 Different Mammalian Rabs‡
- (2010) Eiko Kanno et al. TRAFFIC
- Making sense of cilia in disease: The human ciliopathies
- (2009) Kate Baker et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- Association of -1,3-N-acetylglucosaminyltransferase 1 and -1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis
- (2009) P. L Lee et al. GLYCOBIOLOGY
- Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
- (2009) Prateek Kumar et al. Nature Protocols
- Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease
- (2009) Iben R. Veland et al. NEPHRON PHYSIOLOGY
- Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data
- (2008) Bingshan Li et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A multivariate test of association
- (2008) Manuel A. R. Ferreira et al. BIOINFORMATICS
- Impaired sexual behavior in male mice deficient for the β1–3N-Acetylglucosaminyltransferase-I gene
- (2007) Franziska Biellmann et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now