The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts

The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division

(2015) Alyona Keder et al.   CURRENT BIOLOGY

Warts Phosphorylates Mud to Promote Pins-Mediated Mitotic Spindle Orientation in Drosophila , Independent of Yorkie

(2015) Evan B. Dewey et al.   CURRENT BIOLOGY

The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye

(2015) E. Wittkorn et al.   DEVELOPMENT

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4

(2015) Birgit L. Aerne et al.   PLoS One

Localization of Hippo signalling complexes and Warts activation in vivo

(2015) Shuguo Sun et al.   Nature Communications

Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling

(2015) Shuangxi Li et al.   Cell Discovery

The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAP

(2015) Katherine Striedinger et al.   NEOPLASIA

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

(2014) M. Diepenbruck et al.   JOURNAL OF CELL SCIENCE

Molecular Evolution of the Yap/Yorkie Proto-Oncogene and Elucidation of Its Core Transcriptional Program

(2014) Aissam Ikmi et al.   MOLECULAR BIOLOGY AND EVOLUTION

α-Tubulin K40 acetylation is required for contact inhibition of proliferation and cell–substrate adhesion

(2014) Andrea Aguilar et al.   MOLECULAR BIOLOGY OF THE CELL

Combover/CG10732, a Novel PCP Effector for Drosophila Wing Hair Formation

(2014) Jeremy K. Fagan et al.   PLoS One

Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer

(2013) Z. Smole et al.   CANCER RESEARCH

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

The Hippo pathway polarizes the actin cytoskeleton during collective migration ofDrosophilaborder cells

(2013) Eliana P. Lucas et al.   JOURNAL OF CELL BIOLOGY

Drosophila rae1 is required for male meiosis and spermatogenesis

(2013) S. Volpi et al.   JOURNAL OF CELL SCIENCE

Alcohol Interacts with Genetic Alteration of the Hippo Tumor Suppressor Pathway to Modulate Tissue Growth in Drosophila

(2013) Anoj Ilanges et al.   PLoS One

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes

(2013) Hyangyee Oh et al.   Cell Reports

Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat

(2012) E. Marcinkevicius et al.   DEVELOPMENT

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Hippo signaling inDrosophila: Recent advances and insights

(2011) Binnaz Kucuk Staley et al.   DEVELOPMENTAL DYNAMICS

Polyglutamine Atrophin provokes neurodegeneration inDrosophilaby repressingfat

(2011) Francesco Napoletano et al.   EMBO JOURNAL

Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit

(2011) B. N. Nicolay et al.   GENES & DEVELOPMENT

Oncogene addiction in gliomas: Implications for molecular targeted therapy

(2011) Wei Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer therapy based on oncogene addiction

(2011) Frank McCormick   JOURNAL OF SURGICAL ONCOLOGY

Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons

(2011) Xiaolin Tian et al.   NATURE NEUROSCIENCE

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zyxin Links Fat Signaling to the Hippo Pathway

(2011) Cordelia Rauskolb et al.   PLOS BIOLOGY

CD44 Attenuates Activation of the Hippo Signaling Pathway and Is a Prime Therapeutic Target for Glioblastoma

(2010) Y. Xu et al.   CANCER RESEARCH

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

(2010) Ricardo M. Neto-Silva et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

(2010) Y. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants

(2010) L. B. Bensenor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

(2010) Marcello Ziosi et al.   PLoS Genetics

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

The MST1 and hMOB1 Tumor Suppressors Control Human Centrosome Duplication by Regulating NDR Kinase Phosphorylation

(2009) Alexander Hergovich et al.   CURRENT BIOLOGY

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

(2009) Hyangyee Oh et al.   DEVELOPMENTAL BIOLOGY

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

(2009) Caroline Badouel et al.   DEVELOPMENTAL CELL

In vivo analysis of Yorkie phosphorylation sites

(2009) H Oh et al.   ONCOGENE

Dual functions ofNicotiana benthamianaRae1 in interphase and mitosis

(2009) Jae-Yong Lee et al.   PLANT JOURNAL

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

(2008) Qi Zeng et al.   CANCER CELL

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway

(2008) J. Zhang et al.   CANCER RESEARCH

Warts Is Required for PI3K-Regulated Growth Arrest, Autophagy, and Autophagic Cell Death in Drosophila

(2008) Sudeshna Dutta et al.   CURRENT BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

The mob as tumor suppressor Gene Is Essential for Early Development and Regulates Tissue Growth in Drosophila

(2008) T. Shimizu et al.   GENETICS

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

Retinoic acid downregulates Rae1 leading to APCCdh1 activation and neuroblastoma SH-SY5Y differentiation

(2008) J Cuende et al.   ONCOGENE