Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway

Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

(2016) Eleftherios Ouzounoglou et al.   BMC Systems Biology

Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

(2016) Yuki Shindo et al.   Nature Communications

Control of Transcript Variability in Single Mammalian Cells

(2015) Nico Battich et al.   CELL

Noise Facilitates Transcriptional Control under Dynamic Inputs

(2015) Ryan A. Kellogg et al.   CELL

Cellular noise and information transmission

(2014) Andre Levchenko et al.   CURRENT OPINION IN BIOTECHNOLOGY

A comprehensive transcriptional portrait of human cancer cell lines

(2014) Christiaan Klijn et al.   NATURE BIOTECHNOLOGY

Determinants of Cell-to-Cell Variability in Protein Kinase Signaling

(2013) Matthias Jeschke et al.   PLoS Computational Biology

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

(2012) Marc R Birtwistle et al.   BMC Systems Biology

Cell Size Control in Yeast

(2012) Jonathan J. Turner et al.   CURRENT BIOLOGY

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

(2012) René Meyer et al.   Frontiers in Physiology

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells

(2011) Alexander Loewer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Activation Kinetics of RAF Protein in the Ternary Complex of RAF, RAS-GTP, and Kinase on the Plasma Membrane of Living Cells

(2011) Kayo Hibino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processive phosphorylation of ERK MAP kinase in mammalian cells

(2011) K. Aoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Information Transduction Capacity of Noisy Biochemical Signaling Networks

(2011) R. Cheong et al.   SCIENCE

Phosphorylation of nucleoporins

(2011) Hidetaka Kosako et al.   Nucleus

Mathematical modeling of cell cycle regulation in response to DNA damage: Exploring mechanisms of cell-fate determination

(2010) Kazunari Iwamoto et al.   BIOSYSTEMS

Multiple Decisive Phosphorylation Sites for the Negative Feedback Regulation of SOS1 via ERK

(2010) Yuji Kamioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

A RasGTP-Induced Conformational Change in C-RAF Is Essential for Accurate Molecular Recognition

(2009) Kayo Hibino et al.   BIOPHYSICAL JOURNAL

Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation

(2009) Roberta Alfieri et al.   BMC BIOINFORMATICS

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

(2009) Nikolay Borisov et al.   Molecular Systems Biology

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

(2009) Hidetaka Kosako et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exploring the roles of noise in the eukaryotic cell cycle

(2009) S. Kar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA