Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ole Kristian Lobekk, Ward Dijkstra, Torbjorn O. Pedersen
Summary: The study compared the outcomes of surgical and conservative treatment for medication-related osteonecrosis of the jaw, with slightly better results reported after surgical treatment. However, there are issues with poor quality of evidence and high risk of bias in the research.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Takuma Watanabe, Keita Asai, Shizuko Fukuhara, Ryuji Uozumi, Kazuhisa Bessho
Summary: This study evaluated the variables associated with treatment outcomes in patients with ARONJ at a single center, finding that surgery and HBO therapy were effective treatment approaches for both stage 2 and 3 ARONJ. Extensive surgery was more effective in healing than conservative surgery for stage 2 ARONJ, while >= 46 sessions of HBO therapy was less associated with healing in the same stage.
Article
Multidisciplinary Sciences
Yuki Sakamoto, Shunsuke Sawada, Yuka Kojima
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a refractory osteonecrosis caused by antiresorptive agents. In some recent cases, no abnormal findings were detected on computed tomography (CT), leading to the need for clarification of the characteristics of MRONJ without osteolysis.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Biology
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J. Campagna, Nicholas A. Lentini, Eric C. Sung, Samantha Chiang, Yi-Ling Lin, Frank H. Ebetino, Varghese John, Shuting Sun, Charles E. McKenna, Ichiro Nishimura
Summary: This study presents a novel method to elucidate the pathological mechanism of BRONJ and demonstrates the potential of HMDP-DNV as an effective therapy. The results show that the intra-oral application of HMDP-DNV can selectively remove legacy N-BP from the jawbone and accelerate wound healing and bone socket healing, while attenuating osteonecrosis development. Single cell RNA sequencing reveals the resolution of chronic inflammation by increasing the expression of anti-inflammatory signature genes. This research suggests that BRONJ pathology is related to N-BP levels in jawbones.
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Chemistry, Medicinal
Ken Matsunaka, Mikio Imai, Koma Sanda, Noriyuki Yasunami, Akihiro Furuhashi, Ikiru Atsuta, Hiroko Wada, Yasunori Ayukawa
Summary: This study found that a single injection of benidipine near MRONJ-like lesions can promote healing of osteonecrotic extraction socket, reducing the area of necrotic bone and recovering soft tissue continuity.
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Dentistry, Oral Surgery & Medicine
Sven Otto, Eva Maria Schnoedt, Selgai Haidari, Teresa Franziska Brunner, Suad Aljohani, Mohamed Mosleh, Oliver Ristow, Matthias Troeltzsch, Christoph Pautke, Michael Ehrenfeld, Riham Fliefel
Summary: This study evaluated the efficacy of minimally invasive autofluorescence-guided resection in MRONJ, showing it to be a safe and successful treatment option for all stages of the condition.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sven Zittel, Julius Moratin, Dominik Horn, Karl Metzger, Oliver Ristow, Michael Engel, Jan Mrosek, Kolja Freier, Jurgen Hoffmann, Christian Freudlsperger
Summary: Survival outcomes for radiotherapy-naive patients with recurrent oral squamous cell carcinoma were evaluated, with surgical therapy showing significantly better disease-free survival and overall survival compared to other treatment modalities. Presence of regional metastases and short disease-free interval between primary and recurrent cancer were significant predictors for adverse outcomes.
CLINICAL ORAL INVESTIGATIONS
(2022)
Correction
Otorhinolaryngology
Karl Metzger, Julius Moratin, Kolja Freier, Jurgen Hofmann, Karim Zaoui, Michaela Plath, Fabian Stogbauer, Christian Freudlsperger, Jochen Hess, Dominik Horn
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Oliver Ristow, Gregor Schnug, Maximilian Smielowksi, Julius Moratin, Maximilian Pilz, Michael Engel, Christian Freudlsperger, Jurgen Hoffmann, Thomas Ruckschloss
Summary: This study compared the diagnostic accuracy of orthopantomography (OPT) and cone-beam computed tomography (CBCT) in detecting early non-vital bone changes before tooth extractions in patients with antiresorptive (AR) intake. The results showed that CBCT had higher sensitivity and specificity in detecting non-vital bone changes compared to OPT.
Article
Oncology
Ann-Kristin Struckmeier, Anne Radermacher, Michael Fehrenz, Tamara Bellin, Dalia Alansary, Philipp Wartenberg, Ulrich Boehm, Mathias Wagner, Anja Scheller, Jochen Hess, Julius Moratin, Christian Freudlsperger, Juergen Hoffmann, Lorenz Thurner, Klaus Roemer, Kolja Freier, Dominik Horn
Summary: IDO1-expressing immune cells, especially macrophages, are more abundant in advanced stages of oral squamous cell carcinoma (OSCC) and are associated with reduced progression-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Reinald Kuehle, Medea Kuebler, Jennifer Fuchs, Frederic Weichel, Julius Moratin, Kolja Freier, Michael Engel, Juergen Hoffmann, Oliver Ristow, Christian Freudlsperger
Summary: Prebent reconstruction plates on 3D printed models can improve the accuracy of condylar position after mandibular resection. However, the recent changes in the European Medical Device Regulation affect the use of 3D printing in hospitals, raising the need for discussion on its legitimization. This retrospective observational case-control study found that prefabricated osteosynthesis significantly reduced rotational deviations in the coronal and sagittal planes, with Jewer class-L defects benefiting more.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Infectious Diseases
Oliver Ristow, Thomas Rueckschloss, Gregor Schnug, Julius Moratin, Moritz Bleymehl, Sven Zittel, Maximilian Pilz, Caroline Sekundo, Christian Mertens, Michael Engel, Juergen Hoffmann, Maximilian Smielowski
Summary: This study compared the success rates of three different antibiotic regimes in patients undergoing preventive tooth extraction during or after antiresorptive therapy. Retrospective analysis included patients who had tooth extraction from 2009 to 2019 according to specified preventive conditions. Three antibiotic regimens were distinguished: intravenous for 7 days, oral for 14 days, and oral for 7 days. The primary endpoint was the occurrence of medication-related osteonecrosis of the jaw at 12 weeks after surgery. The study found no significant difference in the development of medication-related osteonecrosis among the different antibiotic groups, suggesting that a reduced, oral administration of antibiotics may be sufficient for preventive tooth extraction.
Article
Dentistry, Oral Surgery & Medicine
Christian Mertens, Christopher Buesch, Konrad Goldenbaum, Oliver Ristow, Juergen Hoffmann, Hom-Lay Wang, Korbinian Jochen Hoffmann
Summary: This study evaluated radiographic bone gain after alveolar ridge augmentation with two different designs of autogenous block grafts harvested from the mandible. The results showed that the split-block technique resulted in greater bone gain than the full-block technique in both the vertical and horizontal dimensions.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Medicine, General & Internal
Sven Zittel, Julius Moratin, Sinclair Awounvo, Thomas Rueckschloss, Kolja Freier, Oliver Ristow, Michael Engel, Juergen Hoffmann, Christian Freudlsperger, Dominik Horn
Summary: Salvage surgery can improve health-related quality of life (HRQoL) in patients with recurrent oral squamous cell carcinoma (OSCC), despite a decrease in swallowing function. Significant pain relief can be observed as early as 3 months after surgery in patients with advanced recurrent tumors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Reinald Kuehle, Mats Scheurer, Frederic Bouffleur, Jennifer Fuchs, Michael Engel, Juergen Hoffmann, Christian Freudlsperger
Summary: This retrospective study compared the positioning and fixation effects of traditional miniplates and patient-specific implants in virtually planned segmental maxillary osteotomy. The results showed that the patient-specific implant group had lower deviation differences and positive influences on pitch and inward rotation of the lateral segments compared to the conventional group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Julius Moratin, Sven Zittel, Dominik Horn, Rouven Behnisch, Oliver Ristow, Michael Engel, Juergen Hoffmann, Kolja Freier, Christian Freudlsperger
Summary: This study evaluated the oncological outcome and quality of life in patients with early oral squamous cell carcinoma treated with surgical resection and free-flap reconstruction, and concluded that free-flap reconstruction is a safe and effective procedure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Julius Moratin, Philip Dao Trong, Karl Semmelmayer, Jan Mrosek, Sven Zittel, Moritz Bleymehl, Oliver Ristow, Christian Freudlsperger, Juergen Hoffmann, Michael Engel
Summary: This study compared the use of antero-lateral thigh flaps (ALT) and vastus lateralis muscle flaps for the reconstruction of extensive scalp defects. The study found no significant differences in flap success rate, complication rate, or duration of hospitalization between the two groups. Both ALT flaps and vastus lateralis flaps are suitable options for large scalp defect closure, with high success rates and short surgery times.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Julius Moratin, Dominik Horn, Karl Semmelmayer, Oliver Ristow, Michael Engel, Juergen Hoffmann, Moritz Bleymehl, Thomas Held, Sven Zittel, Christian Freudlsperger
Summary: Carcinomas of the minor salivary glands of the oral cavity are a rare and heterogeneous group of malignant tumors. In this study, we compared clinical and pathological features and oncological outcomes in patients with different kinds of minor salivary gland cancer who received primary surgical therapy. We found different rates of cervical metastases and disease recurrence in dependence on the tumor entity, suggesting the need for different treatment approaches for each tumor entity.
Article
Oncology
Christian Freudlsperger, Reinald Kuehle, Sebastian Adeberg, Julius Moratin, Jennifer Fuchs, Sameena Sandhu, Sebastian Regnery, Jochen Hess, Juergen Hoffmann
Summary: Personalized oncologic therapy of head and neck tumours can achieve remarkable therapeutic success through interdisciplinary collaboration between surgeons, pathologists, and radiation oncologists. Virtual surgical planning, prefabricated surgical guides, and patient-specific implants improve accuracy and predict reconstructive outcomes. Intraoperative assistance systems enhance safe oncological resection and navigation data sets contribute to individualized postoperative radiotherapy. The determination of molecular characteristics enables personalized adjuvant therapy. Overall, the importance of this approach in optimizing therapy management is rated 8 out of 10.
Article
Dentistry, Oral Surgery & Medicine
Christian Freudlsperger, Frederic Weichel, Mats Scheurer, Reinald Kuehle, Juergen Hoffmann
Summary: Recent decades have witnessed significant advancements in orthognathic surgery techniques and the application of new osteosynthesis methods. Virtual 3D planning has become a routine practice in clinics, offering higher accuracy compared to conventional planning, particularly for patients with asymmetry. Soft tissue simulation has greatly influenced the planning process and improved communication between practitioners and patients. The trend is shifting towards orthofacial surgery, emphasizing facial harmony as well as function. The use of patient-specific implants enables precise implementation of the 3D plan without the need for positioning splints. However, close cooperation between orthodontists and surgeons remains crucial for successful treatment.
Article
Dentistry, Oral Surgery & Medicine
Korbinian Jochen Hoffmann, Christopher Buesch, Julius Moratin, Oliver Ristow, Juergen Hoffmann, Christian Mertens
Summary: The type of graft and peri-implant tissue do not significantly affect peri-implant inflammatory parameters and implant survival. Further studies are needed to assess long-term success more comprehensively.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
