An affinity-directed protein missile system for targeted proteolysis

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

(2015) Michael Zengerle et al.   ACS Chemical Biology

Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting

(2015) Christoph H. Emmerich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

(2015) Emil Bulatov et al.   BIOCHEMICAL JOURNAL

Nanobodies and recombinant binders in cell biology

(2015) Jonas Helma et al.   JOURNAL OF CELL BIOLOGY

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16to trigger its nuclear localization

(2015) Lina Herhaus et al.   Science Signaling

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

(2015) Alejandro Rojas-Fernandez et al.   Scientific Reports

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16to trigger its nuclear localization

(2015) Lina Herhaus et al.   Science Signaling

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

A robust pipeline for rapid production of versatile nanobody repertoires

(2014) Peter C Fridy et al.   NATURE METHODS

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

(2014) J. Vogt et al.   Open Biology

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

(2014) L. Herhaus et al.   Open Biology

Cullin-RING Ligases as Attractive Anti-cancer Targets

(2013) Yongchao Zhao et al.   CURRENT PHARMACEUTICAL DESIGN

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

(2013) Lina Herhaus et al.   Nature Communications

Specificity of the E1-E2-E3 Enzymatic Cascade for Ubiquitin C-Terminal Sequences Identified by Phage Display

(2012) Bo Zhao et al.   ACS Chemical Biology

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

(2012) Dennis L. Buckley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

E2s: structurally economical and functionally replete

(2010) Dawn M. Wenzel et al.   BIOCHEMICAL JOURNAL

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

Cullin-RING ubiquitin ligases: global regulation and activation cycles

(2008) Dimple R Bosu et al.   Cell Division