Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Article
Microbiology
Mohamad Hamad, Farah Al-Marzooq, Vunnam Srinivasulu, Hany A. Omar, Ashna Sulaiman, Dana M. Zaher, Gorka Orive, Taleb H. Al-Tel
Summary: We report the discovery of a new class of potent antimicrobial compounds effective against Gram-positive bacteria, including MRSA. These compounds exhibit low minimum inhibitory concentrations and rapid killing ability, without inducing bacterial resistance. Furthermore, they show minimal toxicity to human red blood cells. The study suggests that these small molecules hold promise as new antibacterial agents against MRSA infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Amar Deep Sharma, William G. Gutheil
Summary: New strategies are urgently needed to address antimicrobial resistance. Synergistic agent combinations provide a potential approach to combating this problem. In this study, a screening of an FDA-approved drug library identified several beta-lactam antibiotics with synergistic effects with ceftobiprole.
MICROBIOLOGY SPECTRUM
(2023)
Review
Materials Science, Multidisciplinary
Shreya Kanth, Akshatha Nagaraja, Yashoda Malgar Puttaiahgowda
Summary: The current global death rate is threatened by deadly unknown infections and the emergence of multidrug-resistant bacteria. Combatting drug-resistant bacteria, such as MRSA, has become a daunting challenge globally, with polymer synthesis being explored as a significant approach in preventing the spread of infections.
JOURNAL OF MATERIALS SCIENCE
(2021)
Review
Chemistry, Medicinal
Yujie Gao, Yuan Chen, Yubin Cao, Anchun Mo, Qiang Peng
Summary: The abuse of antibiotics has led to the emergence of drug-resistant pathogens, such as MRSA, which presents a significant challenge in treatment. Nanotechnology offers a promising solution, utilizing functional nanomaterials as drug carriers or antibacterial agents for therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Andrade, Maria J. Ramalho, Silvio B. Santos, Luis D. R. Melo, Rita S. Santos, Nuno Guimaraes, Nuno F. Azevedo, Joana A. Loureiro, Maria C. Pereira
Summary: Antimicrobial resistance (AMR) poses a significant threat to global health, with Methicillin-resistant Staphylococcus aureus (MRSA) being a major concern. Nanoparticles (NPs) have emerged as a promising approach for treating MRSA infections, acting as antibacterial agents or drug delivery systems. The targeted delivery of NPs to the infection site is crucial for effective treatment, allowing for high concentrations of therapeutics while minimizing toxicity to healthy cells and reducing AMR emergence and disruption of the healthy microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Infectious Diseases
Martyna Kasela, Mateusz Ossowski, Ewelina Dzikon, Katarzyna Ignatiuk, Lukasz Wlazlo, Anna Malm
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of infectious diseases in humans and animals, resulting in economic losses in human healthcare and the farming sector. The changing epidemiology of MRSA globally affects animal welfare and public health concerns. Livestock have high rates of MRSA colonization, raising questions about reservoirs and transmission, while companion animals vary in MRSA colonization and infection rates, impacting human health. This article highlights the circulation of animal-associated MRSA (AA-MRSA) in the environment and factors influencing its transmission, as well as successful strategies to limit its spread among animals and humans.
Article
Biochemistry & Molecular Biology
Hanbeen Kim, Jakyeom Seo
Summary: Two potential endolysins were identified, with one showing better efficacy against MRSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Abdelbagi Elfadil, Ahmad Mandeel Alzahrani, Hani Abdullah, Hamoud Alsamhan, Turki S. Abujamel, Hafsa Elawd Ahmed, Asif Jiman-Fatani
Summary: This study aims to evaluate the antibacterial activity of a quinoxaline derivative compound against MRSA in comparison with vancomycin as a reference drug. The results showed that the quinoxaline derivative compound had lower minimal inhibitory concentrations (MICs) for most MRSA isolates, indicating a promising effectiveness against MRSA.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Isabel Guthridge, Simon Smith, Matthew Law, Enzo Binotto, Josh Hanson
Summary: Lincosamides, particularly when used as a predominant therapy, show potential efficacy in the treatment of MRSA bacteremia, especially in young, clinically stable patients with few comorbidities. Patients receiving lincosamide-predominant therapy had lower in-hospital mortality and a lower incidence of renal complications compared to those receiving an alternative regimen. Prospective studies are needed to further define the optimal role of lincosamides in the treatment of MRSA bacteremia.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Bingqian Yuan, Xiaoyu Lu, Min Yang, Qiyi He, Zhuocen Cha, Yaqun Fang, Yan Yang, Lei Xu, Jingting Yan, Ren Lai, Aili Wang, Xiaodong Yu, Zilei Duan
Summary: Staphylococcus aureus (S. aureus) is a common pathogenic bacterium with increasing drug resistance. The antimicrobial peptide GW18 shows excellent activity against various strains of S. aureus and significantly reduces infection in animal models.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yachen Hou, Sikai Zhu, Yamiao Chen, Moxi Yu, Yongsheng Liu, Mingkai Li
Summary: A series of thiourea derivatives (TDs) were prepared and tested for their antibacterial activities, and TD4 exhibited the most potent antibacterial activity against various strains of Staphylococcus aureus (S. aureus), including methicillin-resistant Staphylococcus aureus (MRSA). It disrupted the integrity of the MRSA cell wall and showed efficacy in reducing bacterial numbers and lesion size in MRSA-induced infection in mice. These findings suggest that TD4 has potential as a lead compound for the development of novel antibacterial agents against MRSA infections.
Article
Microbiology
Pengfei She, Shijia Li, Linying Zhou, Yaqian Liu, Lanlan Xu, Zubair Hussain, Yimin Li, Zehao Li, Shasha Liu, Yong Wu
Summary: This study found that eltrombopag exhibits potential antimicrobial and anti-biofilm activities against Staphylococcus aureus, and interferes with the proton motive force in the bacteria. The in vivo anti-infective efficacy of the drug was confirmed in multiple infection models, with no observed cytotoxicity or in vivo toxicity. These findings suggest that eltrombopag could be a potential novel antimicrobial agent against MRSA infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Hamidreza Houri, Abbas Yadegar, Mohammad Reza Zali
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mohadeseh Naseri, Fahimeh Palizban, Abbas Yadegar, Mohsen Khodarahmi, Hamid Asadzadeh Aghdaei, Hamidreza Houri, Javad Zahiri
Summary: Liver cirrhosis is a major public health problem with high rates of morbidity and mortality. Gut microbiome alterations have been found to play a vital role in the development and progression of cirrhosis. This study analyzed the taxonomic structure and functional attributes of the gut phageome in patients with advanced liver cirrhosis of different etiologies.
Article
Biotechnology & Applied Microbiology
Samira Zamani, Anis Mohammadi, Bahareh Hajikhani, Parnaz Abiri, Maryam Fazeli, Mohammad Javad Nasiri, Masoud Dadashi, Mehdi Goudarzi, Mehrdad Haghighi
Summary: The genetic features of high-level mupirocin-resistant S. aureus isolates in Tehran were investigated. The study found that these isolates had multidrug resistance, toxinogenicity, and strong biofilm production ability. Various clonal complexes and sequence types were identified, with CC/ST22 being the most prevalent.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Parisa Asadollahi, Iraj Pakzad, Sobhan Ghafourian, Hossein Kazemian, Roohollah Fatahi, Nourkhoda Sadeghifard, Behrooz Sadeghi Kalani
Summary: Considering the widespread occurrence of antibiotic resistance, the need for new therapeutic strategies is inevitable. This study focuses on the crucial role of Lon protease in the regulation of toxin-antitoxin systems in E. coli and designs inhibitory peptides against the action of this protease. The results show that Lon protease plays a central role in controlling these systems and is a conserved protein.
Article
Microbiology
Pouya Amiri, Jalil Kardan-Yamchi, Hossein Kazemian, Faranak Rezaei
Summary: Chitosan, a biocompatible and non-toxic material, shows excellent application prospects in wound dressing conjugate compounds. This study evaluated the antibacterial activity of six different chitosan-based nanohybrid membranes against multidrug-resistant bacterial isolates. The results suggest that chitosan/montmorillonite/ciprofloxacin nanocomposite has the strongest antibacterial effect.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Microbiology
Hamidreza Houri, Hamid Asadzadeh Aghdaei, Sepideh Firuzabadi, Babak Khorsand, Fatemeh Soltanpoor, Maedeh Rafieepoor, Mohammad Tanhaei, Ghazal Soleymani, Masoumeh Azimirad, Amir Sadeghi, Nasser Ebrahimi Daryani, Farhad Zamani, Ramin Talaei, Abbas Yadegar, Seyed Reza Mohebi, Ghazal Sherkat, Mehrdad Hagh Azalli, Habib Malekpour, Gholamreza Hemmasi, Mohammad Reza Zali
Summary: Understanding the extent of inadequate reprocessing of gastrointestinal (GI) endoscopes is crucial due to severe outbreaks caused by multidrug-resistant microorganisms. This multicenter study in Tehran, Iran, evaluated the microbial contamination of reprocessed GI endoscopes and found a higher-than-expected contamination rate. The results suggest a potential risk of deadly outbreaks associated with endoscopy procedures in Iran.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Mehdi Goudarzi, Simasadat Seyedjavadi, Parmida Bagheri, Masoud Dadashi, Mohammad Javad Nasiri
Summary: This descriptive cross-sectional study provides insights into the molecular characteristics and antimicrobial resistance of fusidic acid resistant Staphylococcus aureus strains isolated from hospitalized patients in Iran. The prevalence of fusidic acid resistance in S. aureus isolates was found to be 15.1%, with fusB being the most predominant acquired gene. The study highlights the importance of understanding the local prevalence of FA-resistant MRSA for effective treatment, control, and reduction of these isolates.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2023)
Article
Medical Laboratory Technology
Shirin Ghasemian, Morteza Karami-Zarandi, Hamid Heidari, Saeed Khoshnood, Ebrahim Kouhsari, Sobhan Ghafourian, Abbas Maleki, Hossein Kazemian
Summary: Burn wounds are often colonized by Pseudomonas aeruginosa, which produces biofilms and exhibits antibiotic resistance. This study identified carbapenem resistance in 40% of the P. aeruginosa isolates, with bla(TEM) being the most common beta-lactamase gene. High resistance was observed to cefotaxime, ceftazidime, meropenem, imipenem, and piperacillin.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Review
Infectious Diseases
Fatemeh Sodeifian, Moein Zangiabadian, Erfan Arabpour, Naghmeh Kian, Fartous Yazarlou, Mehdi Goudarzi, Rosella Centis, Zahra Sadat Seghatoleslami, Mahdis Chahar Kameh, Bardia Danaei, Hossein Goudarzi, Mohammad Javad Nasiri, Giovanni Sotgiu, Giovanni Battista Migliori
Summary: This systematic review and meta-analysis aimed to explore the safety and efficacy of tigecycline for the treatment of multi drug-resistant Acinetobacter baumannii. The results showed that tigecycline had similar efficacy compared to other antibiotics, but it had a higher mortality rate and lower microbiological eradication rate. Therefore, the use of tigecycline for the treatment of multi drug-resistant A. baumannii is not recommended.
MICROBIAL DRUG RESISTANCE
(2023)
Review
Nutrition & Dietetics
Mohammad Rostami-Nejad, Nastaran Asri, Meysam Olfatifar, Babak Khorsand, Hamidreza Houri, Kamran Rostami
Summary: This study investigated the association between different gluten doses administered and the risk of coeliac disease (CD) relapse. It found that even a very low dose of gluten can lead to CD relapse and the duration of gluten exposure is also an important factor. More randomized clinical trials are needed to confirm these findings.
Correction
Microbiology
Hamidreza Houri, Hamid Asadzadeh Aghdaei, Sepideh Firuzabadi, Babak Khorsand, Fatemeh Soltanpoor, Maedeh Rafieepoor, Mohammad Tanhaei, Ghazal Soleymani, Masoumeh Azimirad, Amir Sadeghi, Nasser Ebrahimi Daryani, Farhad Zamani, Ramin Talaei, Abbas Yadegar, Seyed Reza Mohebbi, Ghazal Sherkat, Mehrdad Hagh Azalli, Habib Malekpour, Gholamreza Hemmasi, Mohammad Reza Zali
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Chakameh Amini, Maryam Fazeli, Mohammad Javad Nasiri, Sara Bahonar, Masoud Dadashi, Mehrdad Haghighi, Mirmohammad Miri, Mehdi Goudarzi
Summary: This study investigated the genetic characteristics of PVL-positive S. aureus strains isolated from clinical samples. The emergence of vancomycin-resistant S. aureus strains among PVL-positive S. aureus strains in Iran is a serious alarm and poses the greatest concern in the treatment of staphylococcal infections in the healthcare setting. Direct transfers between community and nosocomial PVL-positive S. aureus types were observed.
ARCHIVES OF CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Zahra Rahmani, Sareh Sadat Hosseini, Parmida Bagheri, Mehdi Goudarzi
Summary: The study investigated the antibiotic resistance profile and genetic variability of Staphylococcus aureus isolates from ear infections in adult patients in Tehran, Iran. The results showed high resistance to antibiotics and strong biofilm formation ability in these strains. Different genetic differences were observed in strains from different types of ear infections.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2023)
Article
Microbiology
Narjes Feizabadi, Javad Sarrafzadeh, Mojtaba Fathali, Behnoosh Vasaghi-Gharamaleki, Mahdi Dadgoo, Jalil Kardan-Yamchi, Hossein Kazemian, Sonia Hesam-Shariati, Mohammad Mehdi Feizabadi
Summary: This study investigated the use of therapeutic ultrasound in the treatment of chronic rhinosinusitis (CRS) patients. The results showed that both continuous and pulsed ultrasound could significantly reduce the quantity of clinically important bacteria in CRS patients. CT scan and questionnaire scores also supported the effectiveness of therapeutic ultrasound in promoting patient recovery.
IRANIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Fatemeh Yarkarami, Hossein Kazemian, Nourkhoda Sadeghifard, Reza Pakzad, Farid Azizi Jalilian, Parisa Asadollahi, Ali Hematian, Iraj Pakzad
Summary: The study demonstrates that carvacrol extract exhibits significant antimicrobial and anti-biofilm properties against E. faecalis, even against vancomycin resistant isolates.
CLINICAL LABORATORY
(2022)
