Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Mauricio Ivan Garcia-Rubio, Maria Elisa Otero-Cerdeira, Christian Gabriel Toledo-Lozano, Sofia Lizeth Alcaraz-Estrada, Juan Antonio Suarez-Cuenca, Ramon Mauricio Coral-Vazquez, Paul Mondragon-Teran, Juan Antonio Pineda-Juarez, Luis Fernando Diaz-Lopez, Silvia Garcia
Summary: This study identified dopamine agonists as being associated with the development of ICDs in PD patients, while the tremorgenic form may have a protective effect. Positive associations were found between the rigid-akinetic form and compulsive shopping, and between males and hypersexuality. Binge eating, compulsive shopping, and hypersexuality were the most common ICDs observed.
Article
Neuroimaging
Teresa Esteban-Penalba, Pedro M. Paz-Alonso, Irene Navalpotro-Gomez, Maria C. Rodriguez-Oroz
Summary: Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Linxi Chen, Xinwei He, Taotao Tao, Linkao Chen, Yun Chen, Lingqun Mao, Peng Liu
Summary: This study examined the profiles of impulse control disorders (ICDs) in Parkinson's disease (PD) patients and found that compulsive eating was the most common symptom. The study also revealed a significant association between poor blood glucose control and ICDs in PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan
Summary: Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Johann Faouzi, Baptiste Couvy-Duchesne, Samir Bekadar, Olivier Colliot, Jean-Christophe Corvol
Summary: This study aimed to investigate the genetic risk factors associated with impulse control disorders in Parkinson's disease by analyzing genetic risk scores for various known or putative risk factors. However, after testing in two large PD cohorts and conducting a meta-analysis, no significant associations were found. Despite the lack of success, this approach may prove useful in future studies as genotypic data becomes more available.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Xiaopeng Zhu, Langsha Liu, Yan Xiao, Fan Li, Yongkai Huang, Deqing Han, Chun Yang, Sian Pan
Summary: The study found that PD-ICD patients had increased clustering coefficient and characteristic path length, while decreased small-world index compared with PD-nICD patients. Furthermore, the abnormality of the small-world network parameters of PD-ICD patients was accompanied by the change of nodal centrality in the default mode network, control network, and dorsal attention network.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Lenise G. Soileau, Norris C. Talbot, Nicholas R. Storey, Noah J. Spillers, James V. D'antoni, Peter C. Carr, Connor M. Galardo, Patil Shilpadevi, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye
Summary: This study is the first systematic review and meta-analysis to assess the occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) patients treated with oral dopamine agonists (DAs): ropinirole (ROP) and pramipexole (PRX). The results show that the usage of PRX or ROP significantly increases the risk of developing ICDs in PD patients. Compared to the transdermal patch rotigotine (RTG), PRX has a significantly higher relative risk (P < 0.0001) of 3.46 (95% CI 2.07-5.76), and ROP has a significantly higher relative risk (P < 0.0001) of 2.98 (95% CI 1.77-5.02). The data collected indicates that RTG is approximately three times less likely to cause ICDs than oral PRX and ROP.
NEUROLOGICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Diego Santos-Garcia, Fonticoba T. De Deus, Bartolome C. Cores, Aymerich L. Valdes, Castro E. Suarez, Angel Aneiros, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Caldente J. Garcia, Nuria Caballol, Ines Legarda, Vara J. Hernandez, Iria Cabo, Manzanares L. Lopez, Aramburu I. Gonzalez, Rivera M. A. Avila, Catalan M. Jose, Victor Nogueira, Victor Puente, Moreno J. M. Garcia, Carmen Borrue, Vila B. Solano, Sauco M. Alvarez, Lydia Vela, Sonia Escalante, Esther Cubo, Padilla F. Carrillo, Castrillo J. C. Martinez, Alonso P. Sanchez, Losada M. G. Alonso, Ariztegui N. Lopez, Itziar Gaston, Jaime Kulisevsky, Estrada M. Blazquez, Manuel Seijo, Martinez J. Ruiz, Caridad Valero, Monica Kurtis, Oriol de Fabregues-Boixar, Ardura J. Gonzalez, Jurczynska C. Prieto, Diaz L. Lopez, Darrian McAfee, Pablo Mir
Summary: This study investigated the frequency of depression, mood related factors, and the contribution of mood to a Parkinson's disease patient's quality of life perception. It found that the impact of mood on QoL perception is greater in patients with longer disease duration.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Santos-Garcia Diego, De Deus Teresa, Carlos Cores, Hector Canfield, Jose M. Paz Gonzalez, Cristina Martinez Miro, Lorena Valdes Aymerich, Ester Suarez, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez-Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. avila Rivera, Maria J. Catalan, Victor Nogueira, Victor Puente, Julio Dotor, Carmen Borrue, Berta Solano, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Gemma Alonso, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Ardura, Ruben Alonso, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: The study found a significant increase in NMS burden in Parkinson's disease patients over 2 years, while no change was observed in the control group. Worsening sleep problems and neuropsychiatric symptoms were identified as significant independent predictors of this NMS progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
D. Santos-Garcia, T. de Deus Fonticoba, C. Cores Bartolome, E. Suarez Castro, S. Jesus, P. Mir, B. Pascual-Sedano, J. Pagonabarraga, J. Kulisevsky, J. Hernandez-Vara, L. L. Planellas, I. Cabo-Lopez, M. Seijo-Martinez, I. Legarda, F. Carrillo Padilla, N. Caballol, E. Cubo, V. Nogueira, M. G. Alonso Losada, N. Lopez Ariztegui, I. Gonzalez Aramburu, J. Garcia Caldentey, C. Borrue, C. Valero, P. Sanchez Alonso
Summary: The study found that Parkinson's disease patients with impulsive-compulsive behaviors are more likely to suffer from depression, particularly in relation to pathological gambling, compulsive eating behavior, and hobbyism-punding.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Ahmad Neyazi, Bijaya K. Padhi, Ab Qadim Mohammadi, Mahsa Ahmadi, Adiba Erfan, Bahara Bashiri, Mehrab Neyazi, Marjina Ishaqzada, Morteza Noormohammadi, Mark D. Griffiths
Summary: This study examined the association of depression and anxiety with quality of life among Afghan women living in urban areas under the rule of the Taliban government. The prevalence of depression was high and it had significant impacts on the quality of life. Therefore, the international health organizations should implement screening programs for depression and anxiety and provide psychological counseling services.
Article
Clinical Neurology
S. Jesus, M. T. Perinan, C. Cortes, D. Buiza-Rueda, D. Macias-Garcia, A. Adarmes, L. Munoz-Delgado, M. a. Labrador-Espinosa, C. Tejera-Parrado, M. P. Gomez-Garre, P. Mir
Summary: Impulse control disorders are common in patients with Parkinson's disease, with 25.1% of cases experiencing them. Younger patients with higher rates of anxiety are more likely to have ICDs. Genetic studies suggest that polymorphisms in the DDC gene may modulate the risk of ICDs in PD, with genotype data increasing predictability by 11%.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Tatiana Usnich, Bjoern Hauptmann, Henrike Hanssen, Jannik Prasuhn, Alexander Balck, Max Borsche, Vera Tadic, Annika Klee, Greta Noblejas-Sanchez, Eva-Juliane Vollstedt, Christine Klein, Norbert Brueggemann, Meike Kasten, EPIPARK Study Grp
Summary: Depressive symptoms in Parkinson's disease (PD) are multifactorial, including both dopaminergic deficit and chronic illness-related reactions. The prevalence and severity of depressive symptoms are similar between PD patients and disease controls (DC), though PD patients use antidepressants, especially Mirtazapine, more frequently. However, a significant proportion of patients in both groups with clinically significant depressive symptoms were not receiving medication. The diagnosis and treatment of depressive symptoms in both PD and DC should be improved.
NPJ PARKINSONS DISEASE
(2023)
Review
Psychiatry
Jun-Fang Zhang, Xi-Xi Wang, Ya Feng, Robert Fekete, Joseph Jankovic, Yun-Cheng Wu
Summary: ICDs in PD refer to aberrant behaviors such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically result from dopaminergic therapy. Research has focused on the broad spectrum of ICDs-related behaviors and their significant impact on patients and their families, with recent advances improving our understanding of this issue.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Amer Jaradat, Andreas Nowacki, Matteo Montalbetti, Ines Debove, Katrin Petermann, Janine -Ai Schlaeppi, Lenard Lachenmayer, Gerd Tinkhauser, Paul Krack, Thuy-Anh Khoa Nguyen, Claudio Pollo
Summary: This study integrated a previously validated probabilistic STN sweet spot into a commercially available software to evaluate its predictive value for clinically effective DBS programming in patients with Parkinson disease. The results showed a certain level of match between the image-based prediction and clinical evaluation in terms of stimulation effect and side-effect thresholds, indicating the potential of this integrated image-based programming approach in optimizing DBS programming for PD patients.
Article
Medicine, Research & Experimental
Ashesh Shah, Thuy-Anh Khoa Nguyen, Katrin Peterman, Saed Khawaldeh, Ines Debove, Syed Ahmar Shah, Flavie Torrecillos, Huiling Tan, Alek Pogosyan, Martin Lenard Lachenmayer, Joan Michelis, Peter Brown, Claudio Pollo, Paul Krack, Andreas Nowacki, Gerd Tinkhauser
Summary: In this study, the advantage of algorithmic selection and combination of multiple electrophysiological and imaging markers is investigated to predict relevant clinical deep brain stimulation (DBS) parameters. The results show that the combination of resting and movement-state features from multiple frequency bands can accurately predict the clinical outcome of DBS treatment. The use of both electrophysiological and imaging markers improves the prediction accuracy.
Article
Psychology, Clinical
Charlotte Manceau, Emilie Constant, Elodie Brugalle, Emilie Wawrziczny, Celine Sokolowski, Berengere Flinois, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Pascal Antoine
Summary: This qualitative study aims to understand the experience and functioning of couples during the honeymoon period of Parkinson's disease. The results highlight different dynamics between couples, with some adjusting flexibly and positively while others oscillate between rigid hyperprotection and control/avoidance.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Clinical Neurology
Serge Pinto, Adelheid Nebel, Jorn Rau, Robert Espesser, Pauline Maillochon, Oliver Niebuhr, Paul Krack, Tatiana Witjas, Alain Ghio, Marie-Charlotte Cuartero, Lars Timmermann, Alfons Schnitzler, Helke Hesekamp, Niklaus Meier, Julia Muellner, Thomas D. Haelbig, Bettina Moeller, Steffen Paschen, Laura Paschen, Jens Volkmann, Michael T. Barbe, Gereon R. Fink, Johannes Becker, Paul Reker, Andrea A. Kuehn, Gerd-Helge Schneider, Valerie Fraix, Eric Seigneuret, Andrea Kistner, Olivier Rascol, Christine Brefel-Courbon, Fabienne Ory-Magne, Christian J. Hartmann, Lars Wojtecki, Anne Fradet, David Maltete, Philippe Damier, Severine Le Dily, Friederike Sixel-Doering, Petra Benecke, Daniel Weiss, Tobias Waechter, Marcus O. Pinsker, Jean Regis, Stephane Thobois, Gustavo Polo, Jean-Luc Houeto, Andreas Hartmann, Karina Knudsen, Marie Vidailhet, Michael Schuepbach, Gunther Deuschl
Summary: This study compared speech intelligibility assessment and other outcomes between subthalamic nucleus deep brain stimulation (STN-DBS) and best medical treatment (BMT) in early-stage Parkinson's disease patients over a 2-year period. The results showed no significant differences in speech intelligibility and patient-reported outcomes between the STN-DBS and BMT groups, but there was a trend towards worsening in both groups.
MOVEMENT DISORDERS
(2023)
Article
Nutrition & Dietetics
Jean-Baptiste Bouillon-Minois, Louisa Khaled, Florence Vitte, Ludovic Miraillet, Romain Eschalier, Matthieu Jabaudon, Vincent Sapin, Lucas Derault, Samy Kahouadji, Marina Brailova, Julie Durif, Jeannot Schmidt, Fares Moustafa, Bruno Pereira, Emmanuel Futier, Damien Bouvier
Summary: The study establishes the reference values for ionized magnesium (iMg) and finds a strong correlation between plasmatic magnesium (pMg) and iMg. The interpretation of iMg is not influenced by pH and albumin variations. The incidencce of ionized hypomagnesemia among de novo atrial fibrillation patients is 8.5%.
Article
Environmental Sciences
Alicia Fillon, Nicole Fearnbach, Stephanie Vieira, Jade Gelinier, Sarah Bagot, Melina Bailly, Audrey Boscaro, Lena Pelissier, Julie Siroux, Vincent Grasteau, Jean Bertsch, Bruno Pereira, Martine Duclos, Celine Lambert, David Thivel
Summary: This study evaluates the effects of the Globe Trotter Initiative on physical activity level, sedentary time, physical fitness, and activity preferences in primary school children. The findings suggest that the intervention had beneficial effects on reducing sedentary time and increasing preference for physical activities among the participating students.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Randy Coupet, Martin Schlaepfer, Thomas A. Neff, Pierre Boucher, Pierre Bailly, Martin Bellgardt, Rafael Badenes, Jose Carbonell, Tobias Becher, Caroline Varillon, Dominique Morand, Raiko Blondonnet, Jean-Michel Constantin, Bruno Pereira, Brian O'Gara, Matthieu Jabaudon
Summary: This study investigated 196 COVID-19 ARDS patients from 10 intensive care units in Europe and the US in 2021. The results showed that inhaled sedation did not significantly improve the number of ventilator-free days compared to intravenous sedation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Eve Faugeras, Lauren Veronese, Gaelle Jeannin, Henri Janicot, Sebastien Bailly, Jacques-Olivier Bay, Bruno Pereira, Anne Cayre, Frederique Penault-Llorca, Florent Cachin, Patrick Merle, Andrei Tchirkov
Summary: In patients with advanced non-small cell lung cancer (NSCLC), short telomeres, high levels of telomerase, and aberrant expression of shelterin genes TRF2, RAP1, and TIN2 are significantly associated with shorter survival. The determination of telomere parameters in NSCLC could be useful for individualized treatment decisions.
Article
Biochemistry & Molecular Biology
Xavier Poirot-Seynaeve, Perrine Smets, Bruno Pereira, Louis Olagne, Julien Stievenart, Vincent Sapin, Olivier Aumaitre, Marc Andre, Ludovic Trefond
Summary: Procalcitonin (PCT) may be useful for differentiating between infections and flare in patients suffering from antineutrophil-cytoplasmic-antibody (ANCA)-associated vasculitides (AAV). The study found that PCT levels were significantly higher in the infected group compared to the relapsing group. C-reactive protein (CRP) levels were also higher in cases of infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Charlene Gouhier, Hanae Pons-Rejraji, Sandra Dollet, Laure Chaput, Celine Bourgne, Marc Berger, Bruno Pereira, Andrei Tchirkov, Florence Brugnon
Summary: No significant impact of slow freezing on sperm telomere length (STL) was observed, despite increased sperm DNA oxidation and fragmentation. These findings are important for ensuring the safety of assisted reproductive techniques, fertility preservation, and sperm donation.
Article
Medicine, General & Internal
Amandine Puissegur, Marie Accoceberry, Marion Rouzaire, Bruno Pereira, Marie Herault, Clement Bruhat, Amelie Delabaere, Denis Gallot
Summary: We conducted a retrospective case-control study to identify risk factors for early perineal suture breakdown in patients with perineal tear or episiotomy complication. Instrumental delivery and a longer second phase of labor were confirmed as risk factors for early perineal suture breakdown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Julie Maraud, Sabrina Bedhomme, Bruno Pereira, Sophie Trevis, Marine Jary, David Balayssac
Summary: Self-medication practices by cancer patients and survivors, including the use of dietary supplements and pain medications, were assessed in this French observational study. The study found that self-medication was commonly practiced to manage the adverse effects of anticancer therapies and to improve their efficacy. Patients had high confidence in the safety of self-medication, but it was associated with altered social functioning, pain, insomnia, and financial difficulties. These findings highlight the potential undermanagement of cancer and treatment-related adverse effects.
Article
Oncology
Nicolas Saroul, Nicolas Tardif, Bruno Pereira, Alexis Dissard, Laura Montrieul, Phelipe Sanchez, Jerome Salles, Jens Erik Petersen, Towe Jakobson, Laurent Gilain, Thierry Mom, Yves Boirie, Olav Rooyakers, Stephane Walrand
Summary: Cancer cachexia, particularly muscle loss, in head and neck cancer (HNC) is not solely attributed to decreased food intake. The exact role of secreted factors from tumor cells in driving cancer cachexia is still unknown. This study used conditioned media from HNC cell lines and mix of sera from HNC patients to analyze their impact on skeletal muscle protein catabolism, and found similar metabolic responses in both cases. These findings suggest that muscle atrophy in HNC patients is not solely caused by reduced food intake.
Article
Pediatrics
Justine Paysal, Charlotte Oris, Ugo Troin, Pierre-Nicolas Limeri, Jeanne Allard, Marie Tadrent, Bruno Pereira, Etienne Merlin, Emmanuelle Rochette, Bertrand Evrard, Julie Durif, Vincent Sapin, Maguelonne Pons
Summary: This study aimed to compare the levels of blood tryptase and fecal calprotectin in newborns according to their term, trophicity, and sex. The results showed that blood tryptase levels were higher in premature newborns and in situations of antenatal use of corticosteroids and non-exclusive use of human milk. However, only prematurity significantly influenced tryptase levels according to regression analyses. Fecal calprotectin levels were much higher in female newborns compared to male newborns. The differences in tryptase levels could be due to early aggression of the still-immature digestive wall in premature newborns, while the influence of sex on fecal calprotectin levels remains unexplained.
Article
Health Care Sciences & Services
Michael Single, Lena C. Bruhin, Narayan Schuetz, Aileen C. Naef, Heinz Hegi, Pascal Reuse, Kaspar A. Schindler, Paul Krack, Roland Wiest, Andrew Chan, Tobias Nef, Stephan M. Gerber
Summary: This paper presents the development of a novel sensor recording software system that supports the integration of heterogeneous sensor technologies and can reliably record longitudinal sensor measurements in research settings. Through qualitative and quantitative tests and evaluations, the feasibility and reliability of the software system were demonstrated. Conclusion: This software can be used to test sensor devices, develop and validate algorithms for extracting digital measures, and reduce barriers in sensor-enhanced biomedical research.
JMIR FORMATIVE RESEARCH
(2023)
