Article
Plant Sciences
Fengna Yan, Xinhui Wang, Yuqing Xie, Xiaoli Liu, Lihua Yu, Peng Wang, Tenghui Li, Shanshan Wang, Weihong Li, Zhiyun Yang
Summary: The study demonstrated that Yangyin Fuzheng Jiedu Prescription could effectively inhibit solid tumor growth in HCC mouse model, maintain high ratio of T cells, and decrease expression of inflammatory and immunosuppressive cytokines in tumor tissues.
Article
Oncology
Faisal Fa'ak, Maryam Buni, Adewunmi Falohun, Huifang Lu, Juhee Song, Daniel H. Johnson, Chrystia M. Zobniw, Van A. Trinh, Muhammad Osama Awiwi, Nourel Hoda Tahon, Khaled M. Elsayes, Kaysia Ludford, Emma J. Montazari, Julia Chernis, Maya Dimitrova, Sabina Sandigursky, Jeffrey A. Sparks, Osama Abu-Shawer, Osama Rahma, Uma Thanarajasingam, Ashley M. Zeman, Rafee Talukder, Namrata Singh, Sarah H. Chung, Petros Grivas, May Daher, Ala Abudayyeh, Iman Osman, Jeffrey Weber, Jean H. Tayar, Maria E. Suarez-Almazor, Noha Abdel-Wahab, Adi Diab
Summary: This retrospective study evaluated the safety and effectiveness of anti-interleukin-6 receptor (anti-IL-6R) therapy for immune-related adverse events (irAEs). The results showed that anti-IL-6R treatment can improve irAEs without hindering antitumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Plant Sciences
Xue Yang, Ying Feng, Yao Liu, Xieqiong Ye, Xiaomin Ji, Le Sun, Fangyuan Gao, Qun Zhang, Yuxin Li, Bingbing Zhu, XianBo Wang
Summary: Combining FZJDXJ with TACE therapy significantly prolonged the overall survival and progression-free survival of HCC patients, especially in early stages. FZJDXJ inhibited the proliferation and migration of liver cancer cells and exerted its effects through the AKT/CyclinD1/p21/p27 pathways.
Article
Oncology
Yuqing Xie, Fengna Yan, Xinhui Wang, Lihua Yu, Huiwen Yan, Qing Pu, Weihong Li, Zhiyun Yang
Summary: This study used network pharmacology to identify the key drugs in the Yangyin Fuzheng Jiedu prescription (YFJP) and investigate their therapeutic effects on hepatocellular carcinoma (HCC). The results showed that the Fuzheng prescription (FZP) of YFJP exhibited significant anti-tumor effects and improved immune response in H22 tumor-bearing mice. Network pharmacology and experimental validation identified PIK3CA, TP53, MAPK1, MAPK3, and EGFR as the key targets of FZP in HCC treatment. FZP was found to alleviate T cell exhaustion and improve the immunosuppressive microenvironment through HCC-related signaling pathways and biological processes.
Article
Integrative & Complementary Medicine
Hongshuo Shi, Sisheng Tian, Hu Tian
Summary: This study found that FJD can regulate cell proliferation, apoptosis, inflammation, and immunity through the PI3K-Akt signaling pathway to exert an anti-CRC effect.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Oncology
Rosemina Merchant, Carole Galligan, Manjunatha Ankathatti Munegowda, L. Bruce Pearce, Peter Lloyd, Paul Smith, Fahar Merchant, Minh D. To
Summary: MDNA11 is a next generation long-acting IL-2 immunotherapeutic that overcomes the limitations of current treatments by modifying receptor selectivity and extending the pharmacokinetic profile. It has been shown to control tumor growth and induce durable tumor clearance when used as a monotherapy or in combination with immune checkpoint inhibitors. Evaluation of MDNA11 in non-human primates demonstrates its good tolerability and the ability to stimulate a strong and durable immune response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Nasren Eiza, Ofra Kessler, Adi Sabag, Gera Neufeld, E. Yvonne Jones, Zahava Vadasz
Summary: Regulatory molecule sema3A has been found to be decreased in systemic lupus erythematosus (SLE) patients and its beneficial effects in treating lupus nephritis have been demonstrated. This study aimed to generate a stable and highly binding sema3A molecule. By synthesizing a truncated sema3A derivative, called T-sema3A, with higher binding ability to the CD72 receptor, it was shown to have regulatory effects on immune cells and reduce the secretion of pro-inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Wu Tong, Yang Zhiyun, Yang Yuying, Jiang Yuyong, Meng Peipei, Liu Huimin, Tian Yehong, Zhang Qiaoli
Summary: This study investigated the effect and underlying mechanism of Fuzheng Jiedu Xiaoji formula (FJXF) combined with chemoembolization (TACE) on primary liver cancer (PLC) patients. The combination therapy showed a better short-term clinical effect compared to TACE alone, possibly by alleviating multidrug resistance. Additionally, FJXF did not increase the risk of liver damage.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Review
Medicine, General & Internal
Michal Tomaszewski, Dominika Bebnowska, Rafal Hrynkiewicz, Jakub Dworzynski, Paulina Niedzwiedzka-Rystwej, Grzegorz Kopec, Ewelina Grywalska
Summary: Pulmonary arterial hypertension (PAH) is a relatively rare but increasingly incident disease, posing a significant diagnostic and therapeutic challenge due to its severe course and low patient survival rate. Research indicates that abnormalities within the immune system play a crucial role in the development of PAH, affecting the progression of the disease significantly. This review highlights the importance of understanding the immune system's role in PAH development to improve diagnosis and targeted immunotherapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Nami Yamashita, Mark Long, Atsushi Fushimi, Masaaki Yamamoto, Tsuyoshi Hata, Masayuki Hagiwara, Atrayee Bhattacharya, Qiang Hu, Kwok-Kin Wong, Song Liu, Donald Kufe
Summary: The study demonstrates that MUC1-C is a key regulator of the TNBC transcriptome through activation of the IFN-gamma pathway, leading to immunosuppression and depletion of TILs in the TNBC TIME. MUC1-C may be a potential target for improving TNBC treatment, especially in combination with ICIs, and is already being explored as a target for CAR T cells and ADCs in clinical development.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Naveed Pervaiz, Harjot Kaur, Davinder Parsad, Ravinder Kumar
Summary: The study investigated the effects of lenalidomide on vitiligo mouse models, showing that lenalidomide could suppress the development of vitiligo lesions by reducing levels of pro-inflammatory cytokines and increasing levels of anti-inflammatory cytokines, modulating the immune response towards an anti-inflammatory profile.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Valentina Rubino, Anna Teresa Palatucci, Giuliana La Rosa, Angela Giovazzino, Francesco Aruta, Simona Damiano, Flavia Carriero, Mariarosaria Santillo, Rosa Iodice, Paolo Mondola, Giuseppina Ruggiero, Giuseppe Terrazzano
Summary: Reactive oxygen species (ROS) play a role in T-cell activation, with SOD-1 production and secretion influenced by antigen-dependent activation. In patients with MS, SOD-1 levels are associated with T cell function and regulatory T cell populations, impacting cytokine secretion.
Article
Cell Biology
Jacqueline Unsinger, Andrew H. Walton, Teresa Blood, Daniel J. Tenney, Michael Quigley, Anne M. Drewry, Richard S. Hotchkiss
Summary: Protracted sepsis is characterized by the development of immunosuppression, which can be reversed by administration of agonistic antibodies to OX40, leading to restoration of T cell function and improved survival in animal models. This approach not only showed efficacy in murine sepsis but also improved T effector cell function in patients with sepsis, suggesting its potential as a new therapeutic strategy for treating this highly lethal disorder.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Plant Sciences
Gen Li, Jingwei Ma, Yang Yang, Caixia Zang, Cheng Ju, Fangyu Yuan, Jingwen Ning, Meiyu Shang, Qiuzhu Chen, Yueqi Jiang, Fangfang Li, Xiuqi Bao, Degui Mu, Dan Zhang
Summary: Yinma Jiedu Granule (YMJD) is a traditional Chinese patent medicine with anti-inflammatory effects and therapeutic effects on obstructive pulmonary disease. The study found that YMJD can alleviate acute lung injury induced by lipopolysaccharide in rats by suppressing inflammation and oxidative stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Allergy
Hui Li, Huaqi Wang, Leon Sokulsky, Shaoxia Liu, Rui Yang, Xiaojie Liu, Lujia Zhou, Juan Li, Chun Huang, Fangfang Li, Xu Lei, Hongxia Jia, Jiuling Cheng, Fuguang Li, Ming Yang, Guojun Zhang
Summary: This study identified significantly elevated levels of monocytes, CD8(+) T cells, and macrophages in the bronchoalveolar lavage fluid of patients with asthma exacerbation. Additionally, a complicated molecular framework involving a set of cytokines and intracellular transduction regulators shared across multiple cell clusters was discovered. Moreover, core exacerbation-associated modules activated included pathways such as eukaryotic initiation factor 2 signaling and C-X-C chemokine receptor type 4 signaling in specific cell populations associated with infection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)