Article
Integrative & Complementary Medicine
Dong-Sheng Wang, Jia-Mei Wang, Fu-Rui Zhang, Feng-Jie Lei, Xin Wen, Jia Song, Guang-Zhi Sun, Zhi Liu
Summary: This study demonstrates that malonyl-ginsenosides from Panax ginseng (PG-MGR) has the potential to improve glucose and lipid metabolism and insulin resistance by activating the IRS-1/PI3K/AKT and AMPK signal pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Lanchun Liu, Jun Hu, Qiyuan Mao, Chao Liu, Haoqiang He, Xiaoshan Hui, Guang Yang, Peirong Qu, Wenjing Lian, Lian Duan, Yan Dong, Juhua Pan, Yongmei Liu, Qingyong He, Jun Li, Jie Wang
Summary: This paper elaborates on the current pharmacological effects of ginseng functional components in treating cardiovascular diseases, summarizes the adverse reactions of ginseng, and provides a list of Chinese patent medicines containing ginseng formula for the treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoxue Fang, Manqi Wang, Xinteng Zhou, Huan Wang, Huaying Wang, Hongxing Xiao
Summary: This study investigated the effects of growth years on gene expression in cultivated ginseng and wild ginseng through transcriptome sequencing. The results showed that the growth years significantly affected gene expression in cultivated ginseng, especially in the MAPK signaling pathway and terpenoid backbone biosynthesis pathway. Moreover, the growth years had significant effects on genes related to ginsenoside synthesis in cultivated ginseng but had little influence on wild ginseng.
Review
Biochemistry & Molecular Biology
Xianmei Yin, Haoyu Hu, Xiaofeng Shen, Xiangyan Li, Jin Pei, Jiang Xu
Summary: Ginseng, known as the king of herbs, has been used as an important traditional medicine for thousands of years. Ginsenosides, bioactive compounds of ginseng, have posed challenges for research and development due to their complexity. In recent years, the emergence of new biological research tools, particularly omics and bioinformatic tools, has become a major trend in ginseng research.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Horticulture
Hong Chen, Xiangzhu Li, Yongjun Zheng, Mingming Liu, Kangyu Wang
Summary: Panax ginseng, an ancient and potent herb, contains ginsenosides which contribute to its medicinal effects. Wild and cultivated ginseng has insufficient saponin content to meet market demand, but ginseng adventitious root suspension culture can produce targeted ginsenosides. The length of culture time impacts plant growth, secondary metabolite accumulation, and gene expression. Extraction and analysis revealed increased total saponins, protopanaxadiol ginsenosides (specifically Rd and Rb1), and gene changes related to ginsenoside biosynthesis.
Article
Biotechnology & Applied Microbiology
Tao Zhang, Changbao Chen, Yuqiu Chen, Qinghe Zhang, Qiong Li, Weichen Qi
Summary: Short-term cold stress can reduce ginseng biomass and activate antioxidant mechanisms, leading to an increase in ginsenoside concentrations. Key enzyme genes involved in ginsenoside biosynthesis are positively correlated with ginsenoside accumulation trends. Manipulation of protopanaxadiol/protopanaxatriol ratios can be achieved through low-temperature storage or treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Wang, Shuai Zhang, Lu Zhai, Liwei Sun, Daqing Zhao, Zeyu Wang, Xiangyan Li
Summary: The study showed that total ginsenosides (TGS) can extend the lifespan of worms, improve mobility, have antioxidant and health benefits, and achieve these effects by activating signaling pathways related to antioxidant regulation and longevity.
Article
Agriculture, Multidisciplinary
Chunxia Zhang, Meiyu Liu, Xiaoyan Xu, Jia Wu, Xue Li, Hongda Wang, Xiumei Gao, Dean Guo, Xiaoxuan Tian, Wenzhi Yang
Summary: This research evaluated the coverage of data-dependent acquisition (DDA) in untargeted metabolite/component identification in the food sciences and pharmaceutical analysis. Using Panax ginseng flower buds as an example, DDA on a Q-Orbitrap mass spectrometer demonstrated higher coverage compared to other MS2 acquisition approaches. By predicting a large-scale molecular library and filtering based on mass defect, new component MS2 spectra were obtained and unknown ginsenosides were characterized. In conclusion, a molecular-prediction-oriented DDA approach can enable the discovery of potentially novel molecules for functional food and drug development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chang Liu, Kangyu Wang, Ziyi Yun, Wenbo Liu, Mingzhu Zhao, Yanfang Wang, Jian Hu, Tao Liu, Nan Wang, Yi Wang, Meiping Zhang
Summary: Ginseng, a well-known perennial herb, has been studied for the biosynthesis of ginsenosides. The involvement of GRAS transcription factors in ginsenoside biosynthesis was found, and the PgGRAS68-01 gene closely related to ginsenoside biosynthesis was identified and analyzed. The study revealed that the PgGRAS68-01 gene has spatio-temporal specific expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Zhaoqiang Chen, Zepeng Zhang, Jiaqi Liu, Hongyu Qi, Jing Li, Jinjin Chen, Qingxia Huang, Qing Liu, Jia Mi, Xiangyan Li
Summary: This review systematically summarizes the characteristics of ginseng in regulating gut microbiota diversity and the effects of gut microbiota on ginsenoside transformation. The findings suggest that ginseng treatment can modulate the composition of gut microbiota, promoting the growth of beneficial bacteria and inhibiting pathogenic bacteria. Key bacteria involved in the transformation of ginsenosides were also identified. The regulation of gut microbiota by ginseng has important implications for the prevention and treatment of metabolic diseases, colitis, neurological diseases, cancer, and other conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
Lei Zhu, Jian Hu, Ruiqi Li, Chang Liu, Yang Jiang, Tao Liu, Mingming Liu, Mingzhu Zhao, Yi Wang, Kangyu Wang, Meiping Zhang
Summary: In this study, the PgGT25-04 gene was identified as a negative regulator of ginsenoside synthesis in ginseng. The gene was found to respond to ABA signals and exhibited spatiotemporally specific expression patterns in ginseng. The results suggest that PgGT25-04 plays a role in the secondary metabolism of ginseng and provide a theoretical basis for further study of Trihelix transcription factors in Panax ginseng.
Article
Biotechnology & Applied Microbiology
Li Li, Yanfang Wang, Mingzhu Zhao, Kangyu Wang, Chunyu Sun, Lei Zhu, Yilai Han, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang
Summary: At least five PgOSC genes are involved in ginsenoside biosynthesis, including three newly identified genes and two published genes. These genes show significant correlations with ginsenoside contents and their mutations influence ginsenoside levels. The regulation analysis using MeJA further supports the role of these genes in ginsenoside biosynthesis.
Article
Biochemical Research Methods
Qinghai Dong, Yang An, Guangguang Du, Jia Wang, Jiayin Liu, Jun Su, Hongliu Xie, Chongyang Liang, Jihua Liu
Summary: In this study, the differential bioactivities of Panax notoginseng (PN) and Panax ginseng (PG) were investigated using a metabolomics approach. The results revealed the differences in metabolites and signaling pathways that contribute to the distinct bioactivities of PN and PG.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Review
Plant Sciences
Paul H. Goodwin, Madison A. Best
Summary: Ginsenosides have been widely studied for their medicinal benefits and their role in ginseng plant biology. They play a crucial role in ginseng's defense against biotic stresses, providing antimicrobial, antifeedant, and allelopathic activities. Ginsenosides also have roles in ginseng development and abiotic stress tolerance.
Article
Plant Sciences
Jaewook Kim, Yeongbae Yun, Jeonghoon Huh, Yurry Um, Donghwan Shim
Summary: Comparative transcriptome analysis between 7-year-old and 13-year-old wild-simulated ginseng identified differentially expressed genes involved in pentose-phosphate shunt, abscisic acid and defense responses. Up-regulated bacterial stimulation-induced gene expression in 13-year-old ginseng may contribute to minor ginsenoside biosynthesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wei Gao, Yu-shuai Wang, Zheng-yi Qu, Eunson Hwang, Hien T. T. Ngo, Ying-ping Wang, Jahyun Bae, Tae-hoo Yi
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Wei Gao, Xiu Wang, Yue Si, Jinlong Pang, Hao Liu, Shanshan Li, Qi Ding, Yushuai Wang
Summary: The study found that exosomes (Exo) derived from ADSCs have significant effects in preventing skin photoaging, by inhibiting DNA damage and overexpression of harmful substances through regulating multiple signaling pathways. Additionally, Exo can enhance the expression of procollagen type I and activate related pathways to protect the skin.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu-shuai Wang, Wei-han Yang, Wei Gao, Lu Zhang, Fang Wei, Hang Liu, Shu-ya Wang, Ying-ying Li, Wei-man Zhao, Tao Ma, Qingqing Wang
Summary: The combination of arbutin and vitamin C was found to be effective in inhibiting melanogenesis and tyrosinase activity, and the use of HA-based DMNA helped overcome skin barriers for better drug delivery. DMNA also improved the stability of vitamin C and synergistically suppressed UVB-induced hyperpigmentation in guinea pig skin.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wei Gao, Shengdao Zheng, Eunson Hwang, Tae-hoo Yi, Yu-shuai Wang
Summary: The study revealed that acteoside, isoacteoside, and 2 '-acetylacteoside in Orobanche cernua Loefling are effective in protecting against UV radiation-induced skin damage by reducing MMP-1 expression, increasing type I procollagen synthesis, and inhibiting ROS and TARC secretion. Crenatoside, however, did not show any significant effect on the regulation of these signal cascades.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Yu-shuai Wang, Min-zhe Fang, Sheng-dao Zheng, Jin-Gyeong Cho, Tae-Hoo Yi
Summary: This study identified 29 primary metabolites and 25 secondary metabolites in different varieties of green tea using metabolite analysis. PCA analysis showed distinct differences among the green tea varieties. The amounts of organic acids, amino acids, flavan-3-ols, and flavonol glycosides varied significantly, serving as important markers for evaluating and establishing tea quality standards.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Gao, Limin Yuan, Yue Zhang, Yue Si, Xuqing Wang, Tianci Lv, Yu-shuai Wang
Summary: In this study, the effects of miR-221/222 overexpression/silence in ADSCs on endothelial differentiation were investigated. The results showed that transfection with miR-221/222 promoted the expression of endothelial markers, LDL uptake, and tube-like formation. It was found that the PI3K/AKT signaling pathway was activated during endothelial differentiation. Injection of miR-221/222 transfected ADSCs significantly improved rat hindlimb ischemia, indicating its potential for vascular formation and tissue regeneration.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Gao, Yue Zhang, Limin Yuan, Fangzhou Huang, Yu-shuai Wang
Summary: This study demonstrates that lncRNA H19 can protect against UVB-induced skin photoaging by upregulating SIRT1 via miR-138, providing a potential therapeutic target for treating UVB-induced photodamage.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-shuai Wang, Jin-Gyeong Cho, Eun-Son Hwang, Jung-Eun Yang, Wei Gao, Min-zhe Fang, Sheng-dao Zheng, Tae-Hoo Yi
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2018)
