Article
Cell & Tissue Engineering
Lucas Guillo, Fanny Grimaud, Fanny Houser, Caroline Prost, Elisabeth Jouve, Cecile Philandrianos, Maxime Abellan, Julie Veran, Carine Visee, Laura Beyer-Berjot, Ariadne Desjeux, Francoise Dignat-George, Marc Leone, Jean-Charles Grimaud, Florence Sabatier, Melanie Serrero, Jeremy Magalon
Summary: This study evaluated the long-term efficacy of combined treatment with autologous adipose-derived stromal vascular fraction (ADSVF) and microfat in Crohn's disease perianal fistulas. The results showed that the safety and efficacy of this treatment were maintained at 3 years, leading to long-lasting healing effect.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biology
Ariel Berl, Ofir Shir-az, Noa Perk, Abraham Levy, Yair Levy, Avshalom Shalom
Summary: This study describes the experience and results of using total facial autologous fat grafting to treat patients with systemic sclerosis. The procedure successfully increased patients' oral openings and improved facial manifestations, leading to improvement in their quality of life.
Article
Surgery
Sophie Menkes, Mounia SidAhmed-Mezi, Jean Paul Meningaud, Laurent Benadiba, Guy Magalon, Barbara Hersant
Summary: The study evaluated the safety and efficacy of microfat and nanofat grafting for vulvovaginal rejuvenation in women with GSM. The results showed significant improvement in vaginal health index and female sexual distress scores, particularly in dryness and dyspareunia. Around 80% of patients showed normalized data after 6 months posttreatment, with stable results at 18 months.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Surgery
Zhibin Yang, Shengyang Jin, Yu He, Xinyu Zhang, Xuefeng Han, Facheng Li
Summary: The study aimed to investigate the therapeutic potential of microfat, nanofat, and extracellular matrix/stromal vascular fraction gel (SVF-gel) in skin rejuvenation. Results showed that microfat preserved histologic structure integrity and presented advantages in subcutaneous volumetric restoration and skin quality improvement compared to nanofat and SVF-gel. Clinical application of microfat led to marked improvement in skin wrinkles.
AESTHETIC SURGERY JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Gretel S. Major, Jeremy W. Simcock, Tim B. F. Wood, Khoon S. Lim
Summary: Autologous fat grafting shows promise in repairing soft tissue deformities, but engineered solutions are needed to improve adipose tissue survival due to high resorption rates. Advances in material development and biofabrication have laid the foundation for functional adipose tissue constructs, but a balance is required between clinically feasible delivery and enhanced graft structural integrity. A new approach that combines clinical and research objectives can assist in developing mature adipose tissue constructs with controlled spatial arrangement and increased potential for neovascularization.
TRENDS IN BIOTECHNOLOGY
(2022)
Letter
Surgery
Rosita Pensato, Rasmieh Al-Amer, Simone La Padula
Summary: We reviewed a highly intriguing article on the rheological properties of PRP/microfat mixtures in fat grafting procedure. Fat grafting is widely used in plastic surgery, but the issue of inconsistent fat resorption remains a challenge. PRP has been incorporated to enhance fat revascularization, but the ideal fat-to-PRP ratio is still unknown. This study focused on analyzing the rheological properties of microfat combined with different proportions of PRP. The lack of standardized preparation protocol for PRP and absence of specific platelet and leukocyte information raise concerns, requiring further analysis for reliable conclusions on PRP applications.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Surgery
Liang Cao, Xiaoming Feng, Qiang Zhang, Junbiao Fang, Chunhua Chu, Jinlong Lv, Yuyuan Ma, Gang Lu, Kaichuang Yang, Ruolang Pan
Summary: This study establishes an efficient procedure for SVF isolation, examines its application in fat grafting, and explores the potential underlying mechanisms. The results show that freshly harvested adipose tissue is better for SVF isolation and that isolated SVF should be used promptly. SVF may promote revascularization after fat grafting and inhibit adipose cell apoptosis when co-transplanted.
AESTHETIC PLASTIC SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Ibrahim Vargel, Ali Tuncel, Nilsu Baysal, Irem Hartuc-Cevik, Feza Korkusuz
Summary: SVF has the potential to modulate inflammation and initiate regeneration in joint tissues, making it a potential approach for treating knee osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Zhibin Yang, Liangyan Dong, Shengyang Jin, Xuefeng Han, Facheng Li
Summary: This study evaluated the effects of microfat, nanofat, and SVF-gel on UV-induced photoaged skin injury. The results showed that microfat promoted skin cell proliferation and improved photoaged skin, while nanofat and SVF-gel led to inflammation and fibrosis, which did not improve the photoaged skin.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Paul Girard, Joelle Dulong, Jerome Duisit, Camille Mocquard, Simon Le Gallou, Benoit Chaput, Elise Lupon, Eric Watier, Audrey Varin, Karin Tarte, Nicolas Bertheuil
Summary: This study optimized the nanofat grafting technique to increase the yield of adipose-derived stem cells (ASCs) extraction. The results showed that the stromal vascular fraction (SVF) obtained by 20 inter-syringe passages contained more cells, including ASCs, and had better anti-inflammatory properties. This study provides an important foundation for decellularized tissue methods that can provide the required quantity and quality of cells in a clinical setting.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Surgery
B. J. Langridge, S. Jasionowska, H. Khan, L. Awad, B. R. H. Turner, J. Varghese, P. E. M. Butler
Summary: This systematic review examines the processing methods of autologous fat grafting and evaluates the long-term patient outcomes. The results suggest that processing the fat through washing and filtration, especially when combined with commercial devices, leads to better long-term outcomes compared to centrifugation and decantation methods. In facial fat grafting, ASC enrichment methods and commercial devices seem to have superior long-term volume retention.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Oncology
Rawan Al-kharboosh, Jonathan Jude Perera, Alexandra Bechtle, Guojun Bu, Alfredo Quinones-Hinojosa
Summary: Neurodegenerative disorders are characterized by the irreversible loss of cognitive functions and CNS structures, and the lack of preventive and regenerative measures has led to traditional symptomatic management as the only available therapeutic recourse. However, recent research suggests that the adipose-derived stromal vascular fraction (SVF) may hold promise as a cellular treatment for neurodegenerative diseases, with improvements seen in clinical applications for conditions such as Multiple Sclerosis, Alzheimer's disease, and Parkinson's disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Letter
Surgery
Bishara Atiyeh, Ahmad Oneisi
Summary: This journal requires authors to assign a level of evidence to each article.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Orthopedics
Marie Laure Louis, Robinson Gravier Dumonceau, Elisabeth Jouve, Michel Cohen, Rym Djouri, Nathalie Richardet, Emmanuelle Jourdan, Laurent Giraudo, Chloe Dumoulin, Fanny Grimaud, Francoise Dignat George, Julie Veran, Florence Sabatier, Jeremy Magalon
Summary: The study aimed to compare single abdominal microfat (MF) injections with or without platelet-rich plasma (PRP) Low Dose (LD) or High Dose (HD) in knee osteoarthritis patients. The results showed significant improvements in knee functional status and symptom relief with these treatments, although there was no significant change in T2max parameter.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Medicine, General & Internal
Antonio Arena, Umberto Committeri, Fabio Maglitto, Giovanni Salzano, Giovanni Dell'Aversana Orabona, Luigi Angelo Vaira, Pasquale Piombino, Michela Apolito, Gianluca Renato De Fazio, Luigi Califano
Summary: Systemic sclerosis is a connective tissue disease that affects various organs including the skin, lungs, heart, and gastrointestinal tract. Orofacial manifestations of the disease can have significant psychological implications. Fat grafting has shown to improve facial volume loss and elasticity in patients with systemic sclerosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Dennis J. Hurwitz, Dani Kruchevsky
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Fabio Xerfan Nahas, Lydia Masako Ferreira
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Evgeni Vanyov Sharkov
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Armando A. Davila
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Peter Wirth, Ahmed M. Afifi
Summary: The oblique flankplasty is a surgical procedure aimed at narrowing the waist and flank. It is suitable for patients who are primarily concerned with trunk contouring and achieving a narrow waist, as well as having prominent flank rolls. The procedure also aims to better define the upper border of the buttock and improve upper abdominal laxity.
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Joshua A. David, Jeffrey A. Gusenoff
Summary: Surgical intervention is usually required to correct upper back rolls, and one technique involves transverse excision. The surgery will create a near-circumferential scar that can be concealed within the brassiere line.
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Osvaldo Saldanha, Osvaldo Saldanha Filho, Cristianna Bonetto Saldanha, Karin Luiza Mokarzel, Aline Curado Machado Borges, Eduar Arnaldo Murcia Bonilla
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Luccie M. Wo, Onelio Garcia Jr
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Emmanuel De La Cruz
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Flavio Henrique Mendes, Fausto Viterbo, Weber Ribolli Moragas
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Dennis J. Hurwitz, Dani Kruchevsky
CLINICS IN PLASTIC SURGERY
(2024)
