Review
Medicine, General & Internal
Robert Ossendorff, Alessandra Menon, Frank A. Schildberg, Pietro S. Randelli, Sebastian Scheidt, Christof Burger, Dieter C. Wirtz, Davide Cucchi
Summary: The global distribution and quality of studies using adipose tissue derivates in orthopedics were assessed through a systematic review. Among the 82 included studies, 70% focused on knee disorders, mainly osteoarthritis. Approximately 26% of the studies investigated expanded adipose-derived stem/stromal cells (ADSCs), with 72% of these using stromal vascular fraction (SVF). The overall quality of the studies varied, with a higher score found in studies involving expanded ADSCs compared to SVF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Article
Veterinary Sciences
Khan Sharun, Kaveri Jambagi, Rohit Kumar, Mudasir Bashir Gugjoo, Abhijit M. Pawde, Hardeep Singh Tuli, Kuldeep Dhama, Amarpal
Summary: Adipose tissue-derived stromal vascular fraction (AdSVF) is a heterogeneous cell population with therapeutic potential for various conditions, including osteoarthritis, wound healing, and orthopaedic disorders. Compared to in vitro expanded adipose tissue-derived mesenchymal stem cells (AdMSCs), AdSVF has several advantages.
VETERINARY QUARTERLY
(2022)
Article
Biochemistry & Molecular Biology
Nicolo Costantino Brembilla, Ali Modarressi, Dominik Andre-Levigne, Estelle Brioudes, Florian Lanza, Hubert Vuagnat, Stephane Durual, Laurine Marger, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: This study evaluates the influence of a gelatin sponge on adipose-derived stromal cells (ASC). The results show that the gelatin sponge strongly influences the transcriptome of ASC and acted as a concentrator and reservoir of the regenerative ASC secretome. The gelatin sponge also increased angiogenesis in vivo and promoted wound healing.
Review
Cell & Tissue Engineering
Xiuyi Huang, Yunchong Liu, Zilun Li, Lilach O. Lerman
Summary: Mesenchymal stem/stromal cells (MSCs) have therapeutic potential in treating metabolic syndrome (MetS) by inhibiting inflammation, improving insulin resistance, regulating glycolipid metabolism, and protecting organ function. However, several challenges remain to overcome, such as the unclear merits of autologous versus allogeneic MSCs sources, the distinct characteristics and relative efficacy of MSCs harvested from different tissue sources, and the potential safety concerns of approaches to improve therapeutic efficacy. Larger-scale studies are needed to determine the therapeutic efficacy and safety of MSCs for clinical application.
Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ivana Roberta Romano, Floriana D'Angeli, Nunzio Vicario, Cristina Russo, Carlo Genovese, Debora Lo Furno, Giuliana Mannino, Serena Tamburino, Rosalba Parenti, Rosario Giuffrida
Summary: This review discusses the osteogenic and chondrogenic differentiation ability of adipose-derived mesenchymal stromal cells (ASCs) and their potential therapeutic applications in bone and cartilage defects. ASCs can easily differentiate into chondrocyte-like and osteocyte-like elements and they can be used for tissue repair. Various strategies involving ASCs, such as transplantation of freshly harvested cells, in vitro expanded cells, or predifferentiated cells, are being developed globally. Combining ASCs with scaffolds can further enhance their positive effects and contribute to their osteogenic or chondrogenic differentiation.
Article
Agriculture, Dairy & Animal Science
Gabriele Scattini, Martina Pellegrini, Giulio Severi, Monica Cagiola, Luisa Pascucci
Summary: Adipose-derived MSCs are commonly isolated by collagenase digestion, but waste tissue fragments contain cells that adhere belatedly to the plastic. In this study, three sets of cells that adhered at different time points were analyzed for their properties, and no significant differences were found between the three subpopulations. This procedure improves MSCs yield and shortens the time required for clinical applications.
Article
Surgery
Francisca Frias, Beatriz Matos, Mariana Jarnalo, Sara Freitas-Ribeiro, Rui L. Reis, Rogerio P. Pirraco, Ricardo Horta
Summary: This study investigates the correlation between age, body mass index (BMI), history of obesity and massive weight loss, and harvest site with the expression of stromal vascular fraction (SVF) cell markers in human adipose tissue. The results indicate that ex-obese patients have a higher percentage of SVF cells expressing CD90. BMI, harvest site, and age do not appear to be associated with SVF subpopulations.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Bong-Sung Kim, Shih-Heng Chen, Mauro Vasella, Marco Guidi, Epameinondas Gousopoulos, Nicole Lindenblatt, Huang-Kai Kao
Summary: This study investigates the in vivo fate of mechanically processed stromal vascular fraction (mSVF) for regenerative purposes. By establishing an arteriovenous (AV) shunt model in rats, the study shows that vascularized mSVF can proliferate and express adipocyte-specific markers.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Kevin Arnke, Dalia Dranseikiene, Elia Guzzi, Francesca Melega, Gregory Reid, Holger Jan Klein, Riccardo Schweizer, Mark W. Tibbitt, Bong-Sung Kim
Summary: In this study, the feasibility of using methacrylated gelatin (GelMA) as a scaffold for mechanically processed stromal vascular fraction (mSVF) was investigated. The results showed that GelMA maintained cell viability and proliferation, and released growth factors, which had a promoting effect on both mSVF and dermal fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Anna Boada-Pladellorens, Merce Avellanet, Esther Pages-Bolibar, Anna Veiga
Summary: Adipose-derived stromal vascular fraction (SVF) therapy is considered a potential treatment for knee osteoarthritis (KOA). The studies reviewed showed that SVF treatment improved pain, functionality and anatomical structures in patients with KOA, and was considered a safe treatment. However, standardization of SVF products, homogenization of cell numbers, and reduction of concomitant treatments are needed for proper comparisons.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Review
Cell & Tissue Engineering
Nicolo C. Brembilla, Hubert Vuagnat, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: Chronic wounds have a significant impact on quality of life and healthcare costs. Adipose-derived stromal cells (ASC) have emerged as a promising therapy for chronic wounds. Studies have shown the clinical efficacy of ASC-based therapies in treating chronic wounds.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Dayanand Deo, Misty Marchioni, Prakash Rao
Summary: Organ transplantation is crucial for saving lives, but faces challenges such as organ shortage and rejection. Cellular therapy using MSC can address these issues, and advances in tissue engineering and regenerative medicine offer potential solutions for generating new organs and improving organ availability.
Article
Surgery
Kevin M. Urlaub, Kavitha Ranganathan, Jeremy V. Lynn, Alexandra O. Luby, Lauren N. Patrick, Noah S. Nelson, Alexis Donneys, Steven R. Buchman
Summary: Stromal vascular fraction therapy has shown significant efficacy in enhancing bone healing in irradiated fracture repair, improving union rates and bone vascularization metrics while restoring bone cellularity and maturity despite preoperative irradiation. This study provides a promising foundation for the development of noncultured, cell-based therapies for clinical implementation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Anatomy & Morphology
Trenton M. Gause, Wesley N. Sivak, Kacey G. Marra
CELLS TISSUES ORGANS
(2014)
Article
Immunology
Wakako Tsuji, Jonas T. Schnider, Meghan M. McLaughlin, Riccardo Schweizer, Wensheng Zhang, Mario G. Solari, J. Peter Rubin, Kacey G. Marra, Jan A. Plock, Vijay S. Gorantla
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Engineering, Biomedical
J. J. Vennemeyer, T. Hopkins, M. Hershcovitch, K. D. Little, M. C. Hagen, D. Minteer, D. B. Hom, K. Marra, S. K. Pixley
JOURNAL OF BIOMATERIALS APPLICATIONS
(2015)
Editorial Material
Medicine, General & Internal
J. Peter Rubin, Kacey G. Marra
Article
Biochemistry & Molecular Biology
Chibueze A. Ihunnah, Taira Wada, Brian J. Philips, Sudheer K. Ravuri, Robert B. Gibbs, Levent Kirisci, J. Peter Rubin, Kacey G. Marra, Wen Xie
MOLECULAR AND CELLULAR BIOLOGY
(2014)
Article
Medicine, Research & Experimental
Faina Linkov, Lauren Kokai, Robert Edwards, M. Aamir Sheikh, Kyle E. Freese, Kacey G. Marra, J. Peter Rubin
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2014)
Article
Cell & Tissue Engineering
Arta Kelmendi-Doko, Kacey G. Marra, Natasa Vidic, Huaping Tan, J. Peter Rubin
TISSUE ENGINEERING PART A
(2014)
Article
Cell & Tissue Engineering
Han-Tsung Liao, Kacey G. Marra, J. Peter Rubin
TISSUE ENGINEERING PART B-REVIEWS
(2014)
Review
Medical Laboratory Technology
Lauren E. Kokai, Kacey Marra, J. Peter Rubin
TRANSLATIONAL RESEARCH
(2014)
Article
Cell Biology
Brian J. Philips, Kacey G. Marra, J. Peter Rubin
WOUND REPAIR AND REGENERATION
(2014)
Article
Engineering, Biomedical
Evangelia Bellas, Tim J. Lo, Eric P. Fournier, Joseph E. Brown, Rosalyn D. Abbott, Eun S. Gil, Kacey G. Marra, J. Peter Rubin, Gary G. Leisk, David L. Kaplan
ADVANCED HEALTHCARE MATERIALS
(2015)
Article
Chemistry, Applied
P. Zhang, S. K. Ravuri, J. Wang, K. G. Marra, R. E. Kling, J. Chai
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2014)
Article
Clinical Neurology
Benjamin K. Schilling, M. Asher Schusterman, Deok-Yeol Kim, Alexander J. Repko, Katarina C. Klett, George J. Christ, Kacey G. Marra
Article
Cell & Tissue Engineering
Benjamin K. Schilling, Jocelyn S. Baker, Chiaki Komatsu, Kacey G. Marra
Summary: Peripheral nerve injury and muscle atrophy have a significant healthcare burden in the United States, partly due to the lack of specific preventative therapies. Injecting skeletal muscle-derived ECM directly into denervated muscle can promote muscle regeneration and improve muscle function.
JOURNAL OF TISSUE ENGINEERING
(2021)
Article
Surgery
Dennis J. Hurwitz, Dani Kruchevsky
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Fabio Xerfan Nahas, Lydia Masako Ferreira
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Evgeni Vanyov Sharkov
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Armando A. Davila
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Peter Wirth, Ahmed M. Afifi
Summary: The oblique flankplasty is a surgical procedure aimed at narrowing the waist and flank. It is suitable for patients who are primarily concerned with trunk contouring and achieving a narrow waist, as well as having prominent flank rolls. The procedure also aims to better define the upper border of the buttock and improve upper abdominal laxity.
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Joshua A. David, Jeffrey A. Gusenoff
Summary: Surgical intervention is usually required to correct upper back rolls, and one technique involves transverse excision. The surgery will create a near-circumferential scar that can be concealed within the brassiere line.
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Osvaldo Saldanha, Osvaldo Saldanha Filho, Cristianna Bonetto Saldanha, Karin Luiza Mokarzel, Aline Curado Machado Borges, Eduar Arnaldo Murcia Bonilla
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Luccie M. Wo, Onelio Garcia Jr
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Emmanuel De La Cruz
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Flavio Henrique Mendes, Fausto Viterbo, Weber Ribolli Moragas
CLINICS IN PLASTIC SURGERY
(2024)
Article
Surgery
Dennis J. Hurwitz, Dani Kruchevsky
CLINICS IN PLASTIC SURGERY
(2024)
