Journal
CLINICS IN LIVER DISEASE
Volume 19, Issue 2, Pages 239-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2015.01.003
Keywords
Hepatocellular carcinoma; Liver biopsy; Dysplastic nodule; lmmunohistochemistry; Glypican-3; Glutamine synthetase; Arginase-1; Biphenotypic
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Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.
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