Article
Environmental Sciences
Hua Zhang, Kui Shen, Ruan Wu, Zhiyong Li, Xiao Wang, Desheng Wang, Meixiao Zhan, Weiguo Xu, Yunfei Gao, Ligong Lu
Summary: The study investigated the presence of neonicotinoid insecticides (NEOs) and their metabolites in paired urine and indoor dust samples from young adults in China. Results showed that females had higher exposure to NEOs than males, highlighting the importance of addressing potential health risks in female adults in future studies. This study provides valuable insights into the levels of NEOs and their metabolites in indoor environments in China.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Miaomiao Xu, Zhanpeng Zhang, Zhiyong Li, Shunyan Kan, Zhaoxiang Liu, Desheng Wang, Qihui Liu, Hua Zhang
Summary: This study analyzed NEOs and their metabolites in paired urine and blood samples collected from young adults in China. The results showed widespread detection of NEOs and their metabolites in both urine and blood samples, with gender-related differences in concentrations. Urinary levels were found to be good predictors of human exposure to NEOs and their metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Naomi Lejeune, Fabien Mercier, Cecile Chevrier, Nathalie Bonvallot, Barbara Le Bot
Summary: This study aimed to assess the exposure of pregnant women in Brittany to pesticides, and results show the detection of organophosphate and pyrethroid residues, providing valuable insights into the exposure situation.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Wojciech Rodzaj, Malwina Wilenska, Anna Klimowska, Emila Dziewirska, Joanna Jurewicz, Renata Walczak-Jedrzejowska, Jolanta Slowikowska-Hilczer, Wojciech Hanke, Bartosz Wielgomas
Summary: Pyrethroid insecticides are widely used and may pose a threat to human health. A study in Lodz, Poland found that non-dietary factors such as owning a dog, using pesticides on household pets, and dietary sources like seeds and nuts can significantly contribute to pyrethroid exposure in young men.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Zhangjian Chen, Shuo Han, Jiahe Zhang, Pai Zheng, Xiaodong Liu, Yuanyuan Zhang, Guang Jia
Summary: This study identified potential biomarkers of occupational exposure to low concentrations of TiO2 NPs in urine samples of workers through metabolomics analysis. A total of 1760 differentially expressed metabolites were found, with 60 confirmed as potential biomarkers. Among these biomarkers, 10 showed good sensitivity and specificity, including compounds like dibenzyl ether and quassimarin. Pathway enrichment analysis revealed significant alterations in the metabolic pathway related to long chain acyl-coa dehydrogenase deficiency. These findings provide insights into early health effects of TiO2 NPs exposure.
Article
Environmental Sciences
Antonela Santillan Deiu, Karina S. B. Miglioranza, Paola M. Ondarza, Fernando R. de la Torre
Summary: The study revealed that exposure to environmental concentrations of Fipronil could induce oxidative stress in Prochilodus lineatus fish, affecting their defense system and antioxidant capacity, especially in the liver and brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Pan Yan, Lingfei Kong, Tuo Qin, Zhonggeng Luo, Xiaona Zhang, Cai Tie
Summary: Using ultra-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS), this study identified the monohydroxyl metabolites of naphthalene, phenanthrene, pyrene, and 9-fluorenone in the urine of low-dose PAH-exposed individuals. The concentrations of these metabolites were monitored for 15 consecutive days, and the results showed that they were strongly correlated with their parent PAH exposure and may serve as potential biomarkers of PAH internal exposure at low doses. This study provides methodological and data support for further health risk studies involving internal exposure to PAHs and other organic pollutants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Jing-hong Liang, Mei-ling Liu, Ying-qi Pu, Shan Huang, Nan Jiang, Shao-yi Huang, Xue-ya Pu, Guang-hui Dong, Ya-jun Chen
Summary: This study found an association between exposure to organophosphate insecticides (OPIs) and asthma in US adults. Specifically, we observed that dimethyl phosphate (DMP), diethyl phosphate (DEP), dimethyl thiophosphate (DMTP), and dimethyl dithiophosphate (DMDTP) were positively correlated with asthma. Furthermore, females, non-Hispanic White populations, and individuals with lower levels of physical activity were more vulnerable to developing asthma when exposed to OPIs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Gisela H. Degen, Joerg Reinders, Martin Kraft, Wolfgang Voelkel, Felicia Gerull, Rafael Burghardt, Silvia Sievering, Jennifer Engelmann, Yvonni Chovolou, Jan G. Hengstler, Hermann Fromme
Summary: This study investigated the exposure of German residents to the mycotoxin citrinin. The results showed evidence of significant exposure, particularly in children. Further biomonitoring studies and investigations into the major sources of citrinin exposure in food commodities are needed.
Article
Environmental Sciences
Hannes Reinwald, Julia Alvincz, Gabriela Salinas, Christoph Schafers, Henner Hollert, Sebastian Eilebrecht
Summary: This study characterized the transcriptomic responses to six insecticides in zebrafish embryos, aiming to identify biomarker candidates for specific modes of action. Abamectin showed the most unique signature related to lipid metabolic processes. Differentially expressed genes after imidacloprid exposure were primarily associated with immune system and inflammation. The findings provide insights into early molecular events in response to the analyzed modes of action.
Article
Environmental Sciences
Shihua Zhong, Xiaoling Wu, Duo Zhang, Sijin Du, Junchun Shen, Lehan Xiao, Ying Zhu, Yuanyuan Xu, Yuli Lin, Liuyi Yin, Manting Rao, Shaoyou Lu
Summary: This study examined the presence of four classes of widely-used antibiotics in urine samples from adult residents in Shenzhen, China. The results showed that antibiotics were detected in 30.8% of all urine samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Chengyu Pan, Jinxia Yu, Qian Yao, Nan Lin, Zhenping Lu, Yan Zhang, Shasha Zhao, Zixia Wang, Xiaoning Lei, Ying Tian, Yu Gao
Summary: This study investigated the prenatal exposure to neonicotinoid insecticides (NEOs) in pregnant women in China and assessed its association with birth outcomes. The study found that exposure to NEOs may have an impact on the head circumference and ponderal index of newborns, and this association may be mediated by urinary 8-OHdG. These findings are important for understanding the effects of NEOs on human health.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Lili Long, Yuedi Tang
Summary: Studies on the association between urinary caffeine metabolites and hearing threshold shifts in US adults found no significant relationship after adjusting for various factors.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Nadejda Tsvetkov, Victoria J. MacPhail, Sheila R. Colla, Amro Zayed
Summary: In this study, a conservation genomics approach was used to investigate the vulnerable Bombus terricola, with transcriptional and metatranscriptomic analysis revealing signs of pesticide exposure and pathogen infections. These findings suggest that pesticides and pathogen spillover may contribute to the decline of B. terricola populations.
Article
Food Science & Technology
Dionisia Carballo, Noelia Pallares, Emilia Ferrer, Francisco J. Barba, Houda Berrada
Summary: The study found that 72.5% of the urine samples analyzed contained at least one mycotoxin, with de-epoxy DON (DOM-1), ZEA, and alpha ZOL being the most prevalent. Although some mycotoxins had potential daily intakes higher than the established tolerable daily intakes, the low urine excretion rate should be noted.
Article
Biochemical Research Methods
Seth R. Newton, Jon R. Sobus, Elin M. Ulrich, Randolph R. Singh, Alex Chao, James McCord, Sarah Laughlin-Toth, Mark Strynar
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Environmental Sciences
Shaza Gaballah, Adam Swank, Jon R. Sobus, Xia Meng Howey, Judith Schmid, Tara Catron, James McCord, Erin Hines, Mark Strynar, Tamara Tal
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Article
Environmental Sciences
Dimitri Panagopoulos Abrahamsson, Jon R. Sobus, Elin M. Ulrich, Kristin Isaacs, Christoph Moschet, Thomas M. Young, Deborah H. Bennett, Nicolle S. Tulve
Summary: The study aimed to develop a workflow to identify and rank organic chemicals as tracers for calculating children's dust ingestion rates. Despite proposing criteria and conducting related research, no individual compound was found to fully meet all criteria as a suitable tracer for dust ingestion rates. Future studies should consider larger datasets and refinements to selection criteria for identifying robust and defensible tracer compounds.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Engineering, Environmental
Charles N. Lowe, Katherine A. Phillips, Kristin A. Favela, Alice Y. Yau, John F. Wambaugh, Jon R. Sobus, Antony J. Williams, Ashley J. Pfirrman, Kristin K. Isaacs
Summary: The study found that many consumer products contain recycled materials with their chemical content generally uncharacterized, and the number and types of chemicals in recycled products were significantly greater than in virgin materials; products made from recycled materials contained higher quantities of fragrances, flame retardants, etc.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Allison L. Phillips, Antony J. Williams, Jon R. Sobus, Elin M. Ulrich, Jennifer Gundersen, Christina Langlois-Miller, Seth R. Newton
Summary: Unknown chemical releases are a major focus of rapid response scenarios for the US Environmental Protection Agency. Recent advancements in high-resolution mass spectrometry and non-targeted analysis have significantly improved the ability to identify unknown compounds quickly and effectively, making them highly relevant in rapid response situations. This article advocates for the consideration of high-resolution mass spectrometry-based non-targeted analysis approaches to support future rapid response needs.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Biochemical Research Methods
Charles N. Lowe, Kristin K. Isaacs, Andrew McEachran, Christopher M. Grulke, Jon R. Sobus, Elin M. Ulrich, Ann Richard, Alex Chao, John Wambaugh, Antony J. Williams
Summary: With the increasing availability of high-resolution mass spectrometers, suspect screening and non-targeted analysis have become popular compound identification tools for environmental researchers. Using a chromatography method to separate chemicals before injecting them into the mass spectrometer, different compounds can be observed based on the type of instrument used. This study utilized experimental datasets to predict the amenability of chemical compounds to detection with liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS).
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Katherine T. Peter, Allison L. Phillips, Ann M. Knolhoff, Piero R. Gardinali, Carlos A. Manzano, Kelsey E. Miller, Manuel Pristner, Lyne Sabourin, Mark W. Sumarah, Benedikt Warth, Jon R. Sobus
Summary: Non-targeted analysis (NTA) workflows using mass spectrometry are becoming increasingly popular in various disciplines, but there is still a lack of universally accepted reporting standards. To address this issue, researchers have developed the NTA Study Reporting Tool (SRT), which has been shown to be effective in guiding study design, manuscript writing, and evaluating NTA reporting quality through analysis of published articles.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Benjamin J. Place, Elin M. Ulrich, Jonathan K. Challis, Alex Chao, Bowen Du, Kristin Favela, Yong-Lai Feng, Christine M. Fisher, Piero Gardinali, Alan Hood, Ann M. Knolhoff, Andrew D. McEachran, Sara L. Nason, Seth R. Newton, Brian Ng, Jamie Nunez, Katherine T. Peter, Allison L. Phillips, Natalia Quinete, Ryan Renslow, Jon R. Sobus, Eric M. Sussman, Benedikt Warth, Samanthi Wickramasekara, Antony J. Williams
Summary: Non-targeted analysis (NTA) is a rapidly evolving set of mass spectrometry techniques aimed at characterizing complex samples' chemical composition, identifying unknown compounds, and classifying samples. Recent advances are due to improved instrumentation and accessible data analysis tools, with a growing need for community-wide method reporting guidelines. This has led to the formation of the Benchmarking and Publications for Non-Targeted Analysis Working Group (BP4NTA) to address challenges and establish consensus in NTA-related terms and reporting practices.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
James P. McCord, Louis C. Groff, Jon R. Sobus
Summary: Chemical risk assessments traditionally rely on hazard, dose-response, and exposure data, but with the development of non-targeted analysis (NTA) methods, there is potential for identifying unknown compounds and improving risk-based decision making. Efforts have been made to bridge the quantitative gap of NTA data, which can contribute to contemporary risk assessment frameworks along with other high-throughput data streams and predictive models.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Louis C. Groff, Jarod N. Grossman, Anneli Kruve, Jeffrey M. Minucci, Charles N. Lowe, James P. McCord, Dustin F. Kapraun, Katherine A. Phillips, S. Thomas Purucker, Alex Chao, Caroline L. Ring, Antony J. Williams, Jon R. Sobus
Summary: In this study, new statistical methods for quantitative NTA (qNTA) using HRMS data were presented and evaluated. The methods successfully estimated chemical concentrations and confidence limits. The study demonstrated the feasibility of using qNTA for chemical risk characterization.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Christine M. Fisher, Katherine T. Peter, Seth R. Newton, Andrew J. Schaub, Jon R. Sobus
Summary: Non-targeted analysis using high-resolution mass spectrometry enables the detection and identification of unknown compounds in various sample matrices. However, standardized procedures for assessing the performance of non-targeted analysis methods are lacking. This article summarizes existing performance assessment metrics and discusses promising approaches for evaluating non-targeted analysis methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Kristin K. Isaacs, Jonathan T. Wall, Ashley R. Williams, Kevin A. Hobbie, Jon R. Sobus, Elin Ulrich, David Lyons, Kathie L. Dionisio, Antony J. Williams, Christopher Grulke, Caroline A. Foster, Josiah McCoy, Charles Bevington
Summary: Direct monitoring of chemical concentrations in different media is crucial for understanding the mechanisms of exposure to exogenous chemicals. This study curated and harmonized public monitoring data from 20 sources to support exposure assessments in a sustainable machine-readable format.
Article
Environmental Sciences
Alex Chao, Jarod Grossman, Celeste Carberry, Yunjia Lai, Antony J. Williams, Jeffrey M. Minucci, S. Thomas Purucker, John Szilagyi, Kun Lu, Kim Boggess, Rebecca C. Fry, Jon R. Sobus, Julia E. Rager
Summary: This study analyzes placental tissues to identify chemical-biological interactions associated with preeclampsia. The findings suggest that human metabolites are closely related to biological processes involved in preeclampsia, while exogenous chemicals may impact select transcriptomic/epigenomic processes.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Gabrielle Black, Charles Lowe, Tarun Anumol, Jessica Bade, Kristin Favela, Yong-Lai Feng, Ann Knolhoff, Andrew Mceachran, Jamie Nunez, Christine Fisher, Kathy Peter, Natalia Soares Quinete, Jon Sobus, Eric Sussman, William Watson, Samanthi Wickramasekara, Antony Williams, Tom Young
Summary: Non-targeted analysis (NTA) using high-resolution mass spectrometry enables the detection and identification of compounds in diverse matrices without prior chemical knowledge. However, there is a need for accessible approaches to map the chemical space in NTA studies. The proposed ChemSpaceTool can help improve method transparency and communication in NTA workflows.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
Kristin K. Isaacs, Peter Egeghy, Kathie L. Dionisio, Katherine A. Phillips, Angelika Zidek, Caroline Ring, Jon R. Sobus, Elin M. Ulrich, Barbara A. Wetmore, Antony J. Williams, John F. Wambaugh
Summary: To rapidly assess the risk of exogenous chemicals to humans and ecosystems, it is important to consider both hazard and exposure. The ToxCast program and Tox21 initiative by the U.S. Environmental Protection Agency have screened thousands of chemicals for bioactivity in high-throughput assays. The ExpoCast program aims to develop new methods for characterizing human and ecological exposures, complimenting the hazard data obtained through ToxCast and Tox21. By analyzing the landscape of exposure data, this study demonstrates the improvement in coverage compared to traditional approaches and suggests further research activities to enhance the development of high-throughput exposure data for risk characterization.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
