Review
Medicine, General & Internal
Qian Yao, Qiuliang Ji, Ying Zhou
Summary: Pulmonary function tests play an important role in the diagnosis and treatment of sarcoidosis. While most patients have normal test results, some may experience a decline in lung function. A decrease in DLCO and FVC percentages can indicate clinically significant pathology and the need for treatment. During follow-up, changes in FVC and DLCO can reflect disease progression, and an improvement in FVC of more than 5% is considered an effective response to treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Dominique Valeyre, Michel Brauner, Jean-Francois Bernaudin, Etienne Carbonnelle, Boris Duchemann, Cecile Rotenberg, Ingrid Berger, Antoine Martin, Hilario Nunes, Jean-Marc Naccache, Florence Jeny
Summary: Diagnosing pulmonary sarcoidosis is challenging due to the absence of specific diagnostic criteria and its ability to mimic many other conditions. This review aims to help non-experts establish tailored differential diagnosis strategies. Granulomatous diseases like infections, chronic beryllium disease, hypersensitivity pneumonitis, and drug-induced granulomatosis must be ruled out. Epidemiological factors, clinical history, physical examination, and chest computed tomography guide further investigations. Differentiating sarcoidosis from lymphoproliferative disorders can be difficult. Continuous gathering of information may be necessary for a definite diagnosis. Chronic beryllium disease and drug-induced granulomatosis closely resemble sarcoidosis.
FRONTIERS IN MEDICINE
(2023)
Article
Critical Care Medicine
Stijn E. Verleden, Arno Vanstapel, Laurens De Sadeleer, Adriana Dubbeldam, Tinne Goos, Iwein Gyselinck, Vincent Geudens, Janne Kaes, Dirk E. Van Raemdonck, Laurens J. Ceulemans, Jonas Yserbyt, Robin Vos, Bart Vanaudenaerde, Birgit Weynand, Johny Verschakelen, Wim A. Wuyts
Summary: In pulmonary fibrotic sarcoidosis, different subtypes show varying levels of involvement in the large airways, but terminal bronchioles are universally lost. This suggests that small airways loss plays an important role in the pathophysiological features of fibrotic pulmonary sarcoidosis.
Article
Critical Care Medicine
Daniel A. Culver, Shambhu Aryal, Joseph Barney, Connie C. W. Hsia, Ennis James, Lisa A. Maier, Lucian T. Marts, Ogugua Ndili Obi, Peter H. S. Sporn, Nadera J. Sweiss, Sanjay Shukla, Nelson Kinnersley, Gennyne Walker, Robert Baughman
Summary: This study investigated the tolerability, safety, and effectiveness of Efzofitimod in pulmonary sarcoidosis. The results showed that Efzofitimod improved clinical outcomes and lung function in patients at different doses, with good tolerability. These findings support further evaluation of Efzofitimod in the treatment of pulmonary sarcoidosis.
Review
Critical Care Medicine
Rohit Gupta, Marc A. Judson, Robert P. Baughman
Summary: Advanced sarcoidosis is a form of sarcoidosis that poses a significant risk of organ function loss or death, with the lung being the most commonly affected organ. It can lead to complications such as pulmonary fibrosis and bronchiectasis. Although it affects a small proportion of patients, it is the leading cause of poor outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Marc A. Judson
Summary: This manuscript provides a comprehensive review of the etiology, measurement, and treatment of common pulmonary symptoms associated with sarcoidosis. It emphasizes the importance of thorough assessment of symptoms, as they serve as useful tools in diagnosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Yun Li, Zhixin Liang, Yiqiong Zheng, Juan Qiao, Ping Wang
Summary: Sarcoidosis is a multisystem disease with unknown causes, characterized by non-necrotizing epithelioid cell granuloma formation. Diagnosis relies on clinical symptoms, imaging observations, and characteristic histopathological findings.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Oncology
Zixin Guo, Liwen Hu, Qiongrong Chen, Junwei Hu, Jun Liu, Weidong Hu
Summary: This article introduces a rare case of a 63-year-old male patient with pulmonary marginal zone lymphoma combined with lung squamous carcinoma. The patient presented with a dry cough and CT imaging showed nodules in the lung and suspicious lesions. After MDT discussion, surgical resection was performed and postoperative pathology confirmed the diagnosis. Management of mixed tumors of the lung requires individualized treatment plans based on the patient's actual condition.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Pathology
Takashi Tasaki, Kazuhito Hatanaka, Ikumi Kitazono, Hirotsugu Noguchi, Kazuhiro Tabata, Michiyo Higashi, Kouki Maeda, Tomoyuki Yokose, Toshimasa Uekusa, Akihide Tanimoto
Summary: Sarcoidosis is a systemic granulomatous disease that can affect pulmonary blood vessels and lead to complications such as infarction, although this is extremely rare. Sarcoidosis is a significant risk factor for cardiovascular events, and our case suggests that it may cause vascular events in the lungs.
PATHOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Jan C. Grutters
Summary: Pulmonary sarcoidosis is the most common manifestation of sarcoidosis and poses challenges for diagnosis. Clinical presentation, evidence of granuloma formation, and exclusion of other diseases are the three criteria to consider. Multiple diagnostic tools are available, but the invasiveness and risk to the patient should be evaluated. In specific situations, a working diagnosis of sarcoidosis can be made without further invasive procedures, but close follow-up is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Michelle Sharp, Kevin J. Psoter, Aparna Balasubramanian, Anuhya Pulapaka, Edward S. Chen, Stacey-Ann Whittaker Brown, Stephen C. Mathai, Nisha A. Gilotra, Jonathan Chrispin, Rebecca Bascom, Richard Bernstein, Michelle N. Eakin, Robert A. Wise, David R. Moller, Meredith C. McCormack
Summary: This study investigated the pulmonary function phenotypes of a large and diverse cohort of patients with sarcoidosis. Less than half of the patients with pulmonary involvement demonstrated a restrictive phenotype. There were significant differences in pulmonary function phenotypes by race and sex.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Medicine, General & Internal
John A. Belperio, Faisal Shaikh, Fereidoun G. Abtin, Michael C. Fishbein, S. Samuel Weigt, Rajan Saggar, Joseph P. Lynch
Summary: Sarcoidosis is an inflammatory granulomatous disease that affects 2 to 160 people per 100,000 worldwide and can involve any organ. Approximately 10% to 30% of patients with pulmonary sarcoidosis develop progressive disease, and over 60% of deaths are due to advanced pulmonary sarcoidosis.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Medicine, General & Internal
Nicol Bernardinello, Simone Petrarulo, Elisabetta Balestro, Elisabetta Cocconcelli, Marcel Veltkamp, Paolo Spagnolo
Summary: Sarcoidosis is a complex multisystem disorder with variable clinical presentations, making diagnosis challenging. While many patients are asymptomatic or have a benign course, a significant proportion may develop chronic or progressive disease requiring long-term therapy. Careful exclusion of alternative diagnoses is crucial in the diagnostic approach to sarcoidosis.
Article
Medicine, General & Internal
Evan Brydges, Matthew Cecchini, Sherman Lin, Michael Mitchell
Summary: This article presents a case of a patient with both pulmonary sclerosing pneumocytoma and pulmonary sarcoidosis, which is a rare condition with malignant potential. The diagnosis was made through lobectomy, and the patient remained asymptomatic with stable lymphadenopathy during the two-year follow-up period.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Health Care Sciences & Services
Silviu Vlasceanu, Andrei Bobocea, Cornel Adrian Petreanu, Ioana Anca Badarau, Horatiu Moldovan, Daniela Gheorghita, Iulian-Vasile Antoniac, Liliana Mirea, Camelia Cristina Diaconu, Cornel Savu
Summary: Crohn's disease and sarcoidosis are both granulomatous diseases with overlapping diagnostic elements. The diagnoses are based on clinical and paraclinical criteria, without specific exclusion criteria based on typical locations.
Letter
Physiology
Thomas Gille, Lucile Sese, Eric Aubourg, Jean-Francois Bernaudin, Jean-Paul Richalet, Carole Planes
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Respiratory System
V Cottin, P. Bonniaud, J. Cadranel, B. Crestani, S. Jouneau, S. Marchand-Adam, H. Nunes, L. Wemeau-Stervinou, E. Bergot, E. Blanchard, R. Borie, A. Bourdin, C. Chenivesse, A. Clement, E. Gomez, A. Gondouin, S. Hirschi, F. Lebargy, C-H Marquette, D. Montani, G. Prevot, S. Quetant, M. Reynaud-Gaubert, M. Salaun, O. Sanchez, B. Trumbic, K. Berkani, P-Y Brillet, M. Campana, L. Chalabreysse, G. Chatte, D. Debieuvre, G. Ferretti, J-M Fourrier, N. Just, M. Kambouchner, B. Legrand, F. Le Guillou, J-P Lhuillier, A. Mehdaoui, J-M Naccache, C. Paganon, M. Remy-Jardin, S. Si-Mohamed, P. Terrioux
Summary: This study establishes practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis in clinical practice, based on evidence and the collaboration of experts in France.
REVUE DES MALADIES RESPIRATOIRES
(2022)
Editorial Material
Respiratory System
V. Cottin, P. Bonniaud, J. Cadranel, S. Jouneau, S. Marchand-Adam, H. Nunes, L. Wemeau-Stervinou, B. Crestani
REVUE DES MALADIES RESPIRATOIRES
(2022)
Meeting Abstract
Oncology
C. Mehlman, A. Swalduz, I. Monnet, C. Morin, F. Guisier, H. Curcio, P. Du Rusquec, A. Cortot, V. Gounant, B. Abbar, B. Duchemann, E. Giroux-Leprieur, T. Pierret, F. M. Quilot, J. Cadranel, V. Fallet
ANNALS OF ONCOLOGY
(2022)
Article
Rheumatology
Paul Breillat, Kuberaka Mariampillai, Paul Legendre, Pauline Martins, Bertrand Dunogue, Jean Luc Charuel, Makoto Miyara, Claire Goulvestre, Romain Paule, Helene Vanquaethem, Felix Ackermann, Olivier Benveniste, Hilario Nunes, Luc Mouthon, Yves Allenbach, Yurdagul Uzunhan
Summary: This study identified three distinct clinical phenotypes and outcomes among patients with anti-PM-Scl-scleroderma antibodies positive autoimmune diseases. Skin thickening and non-specific interstitial pneumonia were crucial predictors in differentiating these subgroups.
Article
Oncology
Assya Akli, Nicolas Girard, Vincent Fallet, Gaelle Rousseau-Bussac, Valerie Gounant, Sylvie Friard, Jean Tredaniel, Cecile Dujon, Marie Wislez, Boris Duchemann, Etienne Giroux-Leprieur
Summary: This study confirms the efficacy of osimertinib in patients with advanced EGFR mutation-positive NSCLC. The most frequent histomolecular alterations at progression were MET amplification and EGFR C797S mutation.
Article
Oncology
Timothee Lambert, Kinan El Husseini, Maeva Zysman, Boris Duchemann, Andre Gillibert, Luca Campedel, Edouard Dantoing, Camille Rolland-Debord, Maxime Patout
Summary: This study aimed to assess the characteristics of lung cancer in patients receiving long-term oxygen therapy (LTOT) and compare them with lung cancer patients without LTOT. The results showed that the treatment outcomes and survival rates were similar between the two groups, suggesting that LTOT does not significantly affect lung cancer outcomes.
Article
Critical Care Medicine
Anne-Claire Toffart, Anne-Pascale Meert, Florent Wallet, Aude Gibelin, Olivier Guisset, Frederic Gonzalez, Amelie Seguin, Achille Kouatchet, Myriam Delaunay, Didier Debieuvre, Boris Duchemann, Gaelle Rousseau-Bussac, Martine Nyunga, David Grimaldi, Albrice Levrat, Elie Azoulay, Virginie Lemiale
Summary: This study describes immune-related adverse events (irAE) leading to ICU admissions in solid cancer patients treated with immune checkpoint inhibitors (ICI). The results show that half of the ICU admissions were associated with irAE and could be treated with steroids.
ANNALS OF INTENSIVE CARE
(2023)
Letter
Respiratory System
Thomas Gille, Lucile Sese, Carole Planes
RESPIRATORY MEDICINE AND RESEARCH
(2023)
Letter
Respiratory System
Jean-Francois Bernaudin, Jerome Le Pavec, Elie Fadel, Florence Jeny, Dominique Valeyre, Vincent Thomas de Montpreville
Review
Respiratory System
Ana Oliveira, Gaia Fabbri, Thomas Gille, Elena Bargagli, Boris Duchemann, Rachel Evans, Hilary Pinnock, Anne E. Holland, Elisabetta Renzoni, Magnus Ekstrom, Steve Jones, Marlies Wijsenbeek, Anh Tuan Dinh-Xuan, Guido Vagheggini
Summary: This article summarizes the main needs of patients with progressive pulmonary fibrosis (PF) and their caregivers and proposes a supportive care approach. Personalized care, education, emotional and psychological support, specialized treatments, and better access to information and resources are necessary. Treatment should start at diagnosis and be tailored to the patient's needs, including individualized pharmacological and non-pharmacological interventions such as oxygen therapy and pulmonary rehabilitation.
Article
Respiratory System
Florence Jeny, Violetta Vucinic, Ying Zhou, Dominique Valeyre, Parathasarathi Bhattacharyya, Alexandra N. Bickett, Marc A. Judson, Ogugua Ndili Obi, Jacques E. Denis, Deepak Talwar, Irina Strambu, Elyse E. Lower, Robert P. Baughman
Summary: This study confirms the diagnostic value of the Sarcoidosis Diagnostic Score (SDS) in differentiating sarcoidosis from alternative diagnoses such as infectious and noninfectious granulomatous diseases. The SDS Clinical and SDS Biopsy showed good to excellent performance in discriminating sarcoidosis from alternative diagnoses.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Boris Duchemann, Ana Maria Portela, Pascal Joudiou, Olivia Freynet, Laurent Zelek, Emmanuel Martinod, Marianne Kambouchner
Summary: In locally advanced non-small-cell lung cancer, mediastinal staging is crucial for therapeutic decision-making. This case report presents a rare case of endobronchial involvement by metastatic lymph node cells after endobronchial ultrasound. The need for careful endoscopic control before surgical resection is highlighted in cases of prior positive endobronchial ultrasound with a time interval.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Respiratory System
Sabina A. Guler, Sara Cuevas-Ocana, Mouhamad Nasser, Wim A. Wuyts, Marlies S. Wijsenbeek, Antoine Froidure, Elena Bargagli, Elisabetta A. Renzoni, Marcel Veltkamp, Paolo Spagnolo, Hilario Nunes, Cormac McCarthy, Maria Molina-Molina, Francesco Bonella, Venerino Poletti, Michael Kreuter, Katerina M. Antoniou, Catharina C. Moor
Summary: This article provides an overview of scientific highlights in the field of interstitial lung disease (ILD) presented at the virtual European Respiratory Society Congress 2021, covering a wide range of topics from translational and genetic aspects to potential innovations in patient care. Early Career Members and the leadership of Assembly 12 - Interstitial Lung Disease summarize selected interesting findings from various congress sessions.
Article
Respiratory System
Alan K. Y. Teoh, Anne E. Holland, Julie Morisset, Kevin R. Flaherty, Athol U. Wells, Simon L. F. Walsh, Ian Glaspole, Wim A. Wuyts, Tamera J. Corte
Summary: This study achieved consensus among international ILD experts on the essential and desirable features of an ILD MDM through the use of a Delphi methodology. The findings provide important data for potential collaborative research on the standardization of ILD MDMs in the future.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
