Article
Environmental Sciences
Wenjun Du, Weidong Zhang, Hongyu Hu, Miaoyun Zhang, Yiling He, Zhiming Li
Summary: The study analyzed AECOPD hospitalization cases in Jinhua City in 2019 and found a significant spatial clustering between six pollutants and AECOPD hospitalizations. The research showed that residential exposure to increased concentrations of sulfur dioxide, nitrogen dioxide, and ozone were significantly associated with AECOPD hospitalizations.
Review
Medicine, General & Internal
Irene Prediletto, Gilda Giancotti, Stefano Nava
Summary: Chronic obstructive pulmonary disease (COPD) is a major global cause of morbidity and mortality. Acute exacerbations of COPD (AECOPD) leading to hospitalization are a significant health issue with implications for disease outcomes and healthcare resources. Severe AECOPD can result in acute respiratory failure (ARF) requiring admission to the intensive care unit (ICU) for invasive mechanical ventilation. AECOPD also poses comorbidity risks in critically ill patients, which are associated with poorer prognoses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Wen-tao Ding, Xue-xiu Chen, Zun-jiang Chen, Wei Chen, Cheng-feng Pan, Xing-ken Fan
Summary: This study analyzed the relationship between the frequency of hospitalizations and anxiety and depression in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The results showed a significant positive correlation between anxiety and depression, and depression was affected by the frequency of hospitalization earlier and gradually. It suggests that anxiety should be prioritized in the acute phase.
FRONTIERS IN GENETICS
(2022)
Editorial Material
Respiratory System
Ruth E. Barker, Samantha S. C. Kon, Stuart F. Clarke, Jenni Wenneberg, Claire M. Nolan, Suhani Patel, Jessica A. Walsh, Oliver Polgar, Matthew Maddocks, Morag Farquhar, Nicholas S. Hopkinson, Derek Bell, Jadwiga A. Wedzicha, William D-C. Man
Summary: Pulmonary rehabilitation following hospitalisation for AECOPD is beneficial for patients' exercise capacity and quality of life. This study suggests that COPD discharge bundles delivered by PR practitioners can significantly increase the referral and uptake of post-hospitalisation PR. Closer integration between hospital and PR services may help improve the rates of post-hospitalisation PR referral and uptake.
Article
Multidisciplinary Sciences
Kentaro Hyodo, Hironori Masuko, Hisayuki Oshima, Rie Shigemasa, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Hiroichi Ishikawa, Takahide Kodama, Akihiro Nomura, Katsunori Kagohashi, Hiroaki Satoh, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
Summary: This study aimed to investigate the exacerbation-prone phenotypes beyond disease labels in asthma and COPD using shared risk factors and to examine the role of the IL4RA gene polymorphism related to type 2 inflammation. The results showed common exacerbation-prone endotypes in chronic inflammatory airway diseases, supporting the use of a treatable traits approach for prevention.
Article
Medicine, General & Internal
Yun Su Sim, Jin Hwa Lee, Eung Gu Lee, Joon Young Choi, Chang-Hoon Lee, Tai Joon An, Yeonhee Park, Young Soon Yoon, Joo Hun Park, Kwang Ha Yoo
Summary: We evaluated the association between COPD medications used in the 6 months before acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the pathogens identified during AE-COPD. Medical records of 1177 patients diagnosed with AE-COPD were analyzed retrospectively. The use of inhaled corticosteroid (ICS) and systemic steroid was analyzed in relation to the microorganisms identified during AE-COPD. Bacteria were more frequently identified in patients using ICS and systemic steroids, and the risk of Pseudomonas aeruginosa infection increased in patients who used systemic steroids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Critical Care Medicine
Sarath Raju, Han Woo, Kirsten Koehler, Ashraf Fawzy, Chen Liu, Nirupama Putcha, Aparna Balasubramanian, Roger D. Peng, Cheng Ting Lin, Chantal Lemoine, Jennifer Wineke, Ronald D. Berger, Nadia N. Hansel, Meredith C. McCormack
Summary: Indoor air pollution is a modifiable risk factor for respiratory morbidity in chronic obstructive pulmonary disease (COPD). This study found an association between indoor particulate matter and heart rate variability, which is tied to cardiovascular morbidity and mortality. The use of household air purifiers can improve heart rate variability and have cardiovascular health benefits.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Environmental Sciences
Bellipady Shyam Prasad Shetty, George D'Souza, Mahesh Padukudru Anand
Summary: This study found that long-term exposure to indoor pollution significantly affects COPD mortality and symptoms. There is a significant correlation between exposure to solid fuel smoke and COPD mortality and prevalence in South Asian countries.
Review
Medicine, General & Internal
Omar Ammous, Walid Feki, Tamara Lotfi, Assem M. Khamis, Rik Gosselink, Ahmed Rebai, Samy Kammoun
Summary: Inspiratory muscle training (IMT) may not improve dyspnea, functional exercise capacity, and life quality when combined with pulmonary rehabilitation (PR) for chronic obstructive pulmonary disease (COPD) patients. However, IMT is likely to improve these outcomes when provided alone. The effects of both interventions may be greater in participants with respiratory muscle weakness and longer training durations, but further confirmation is needed.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Plant Sciences
Vahideh Ghorani, Mohammad Reza Khazdair, Majid Mirsadraee, Omid Rajabi, Mohammad Hossein Boskabady
Summary: The study suggests that Zataria multiflora may have therapeutic effects on chronic obstructive pulmonary disease (COPD) patients by reducing inflammatory cytokines, improving pulmonary function test values, and alleviating respiratory symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Respiratory System
Min Xiao, Xiaoyu Wang, Hanchao Wang, Fawang Du, Yu Yao, Xiaochuan Wang, Jiajia Wang, Juan Yang, Wei Xiong, Qin Wang, Xubin Ren, Tao Zhu
Summary: The aim of this study was to explore the risk factors and underlying etiologies of hyponatremia in patients with acute exacerbation of COPD (AECOPD). A total of 586 AECOPD patients were enrolled, and smoking status, rate of community-acquired pneumonia (CAP), anion gap (AG), erythrocyte sedimentation rate (ESR), and serum magnesium (Mg2+) were identified as independent risk factors for hyponatremia. The underlying etiologies of hyponatremia in AECOPD patients were found to be pneumonia, metabolic acidosis, and hypomagnesemia.
BMC PULMONARY MEDICINE
(2023)
Article
Environmental Sciences
Qi Tian, Lan Qiu, Zhaoyu Fan, Tingting Liu, Jiayi Li, Yingxin Li, Yaqi Wang, Chunxiang Shi, Yuewei Liu, Yun Zhou
Summary: The study investigated the impact of the Three-Year Action Plan to Win the Battle for a Blue Sky (TYAP) on COPD hospitalizations due to ambient air pollution in Guangdong province, China. Results showed that implementation of TYAP led to a significant reduction in COPD hospitalizations related to air pollution among the elderly.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Critical Care Medicine
Manaka Shibuya, Shuhei Yamamoto, Shuken Kobayashi, Kenichi Nishie, Takayoshi Yamaga, Shohei Kawachi, Atsuhiko Matsunaga
Summary: Pulmonary rehabilitation can reduce readmission rates for COPD patients within 3-6 months, even if initiated within 1 week of hospital admission. However, it has no significant effect on mortality rates after 1 year, more research is needed.
Article
Multidisciplinary Sciences
Ewert Ralf, Alexander Heine, Anne Obst, Karoline Koerner, Veit Hustig-Kittler, Michael Boesche, Mohamed Elhadad, Beate Stubbe, Michael Westhoff
Summary: The establishment of guidelines for long-term noninvasive ventilation treatment in acute hypercapnic exacerbations of chronic obstructive pulmonary disease (AECOPD) has been elusive. Most studies have shown no mortality benefit of this treatment. However, our retrospective analysis of patient data from 2012 to 2019 demonstrated higher survival rates in the group receiving long-term noninvasive ventilation compared to those who didn't. This study provides evidence of the mortality benefit of long-term NIV therapy for AECOPD patients in real-world conditions.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ethan I. Huang, Yu-Ching Lin, Shu-Yi Huang, Chin-Kuo Lin, Chieh-Mo Lin
Summary: The study showed that modified ZPP with one-layer closure in a one-stage multilevel surgery significantly reduced AHI in patients with very severe OSA, shifting the breathing disturbances by reducing more apnea than hypopnea and possibly converting some apnea to hypopnea.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Min-Chun Chuang, Jr-Hau Lung, Yi-Chuan Chen, Yu-Ching Lin, Ya-Chin Li, Ming-Szu Hung
Summary: The study revealed that ANXA1 plays critical roles in chemosensitivity to Osimertinib in lung cancer cells with EGFR mutations. Knockdown of ANXA1 increased chemosensitivity to Osimertinib and decreased tumorigenesis, invasion and migration of lung cancer cells with EGFR mutations. The research may have implications for the development of future lung cancer treatment strategies.
Article
Immunology
Chin-Chou Wang, Li-Chung Chiu, Jia-Shiuan Ju, Yu-Ching Lin, Yueh-Fu Fang, Cheng-Ta Yang, Ping-Chih Hsu
Summary: The study found that consolidation durvalumab is effective and safe for post-CCRT unresectable stage III NSCLC in clinical practice, but EGFR mutation is an unfavorable factor for consolidation durvalumab therapy. Therefore, it is necessary to search for a better consolidation therapy for patients with EGFR mutations.
Article
Environmental Sciences
Chieh-Mo Lin, Tzu-Hsiung Huang, Miao-Chig Chi, Su-Er Guo, Chiang-Wen Lee, Su-Lun Hwang, Chung-Sheng Shi
Summary: This study found that PM2.5-induced lung injury is caused by oxidative stress leading to the recruitment of neutrophils and Ly6C(high) monocytes, and production of inflammatory proteins. Treatment with NAC alleviated PM2.5 induced lung injury by attenuating the ROS-mediated recruitment of neutrophils and Ly6C(high) monocytes and lung inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Su-Er Guo, Mei-Yen Chen, Chizimuzo Okoli, Yi-Fan Chiang
Summary: The high smoking prevalence among adolescents in rural Taiwan may be due to a lack of anti-smoking education. Increasing access to such education could help reduce smoking initiation and promote cessation, especially in rural areas. This study assessed the effectiveness of a school-based prevention program in enhancing knowledge, attitudes, and self-efficacy in seventh-grade non-smoking students. The results showed significant improvements in knowledge about smoking and secondhand smoke, as well as in avoiding secondhand smoke exposure. However, modification of the intervention may be necessary to further enhance its effect on smoking-related attitudes and self-efficacy, considering cultural and other factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jrhau Lung, Ming-Szu Hung, Ting-Yao Wang, Kuan-Liang Chen, Chi-Wen Luo, Yuan-Yuan Jiang, Shin-Yi Wu, Li-Wen Lee, Paul-Yann Lin, Fen-Fen Chen, Hui-Fen Liao, Yu-Ching Lin
Summary: Cancer cells require large quantities of lipids for rapid growth and proliferation. Different lung cancer cells adopt different proteins to acquire sufficient lipids, and the lipid supply frequently exceeds the demand, leading to significant storage of lipids in lipid droplets. These lipid droplets are crucial for the progression and survival of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Education, Scientific Disciplines
Tzu-Jung Tseng, Su-Er Guo, Hui -Wen Hsieh, Kao-Wen Lo
Summary: This study explored the effectiveness of a teaching model combining the 5E learning model and self-efficacy in enhancing self-efficacy and critical thinking dispositions in a child-friendly care course. The results showed that this multidimensional teaching strategy was more effective than conventional teaching methods in improving students' self-efficacy and the overall reflective thinking aspect of critical thinking disposition.
NURSE EDUCATION TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Meng-Chin Ho, Ying-Shan Chung, Yu-Ching Lin, Ming-Szu Hung, Yu-Hung Fang
Summary: The concurrent use of proton-pump inhibitors (PPIs) with first-line afatinib treatment was associated with a significantly lower overall survival in patients with EGFR-mutant lung cancer. The combination use of PPIs and afatinib also reduced the chances of receiving second-line therapy.
ONCOTARGETS AND THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Ying-Shan Chung, Yu-Ching Lin, Ming-Szu Hung, Meng -Chin Ho, Yu -Hung Fang
Summary: This study evaluated Clostridioides difficile infection (CDI) among lung cancer patients receiving EGFR-TKIs through a retrospective cohort study. Results showed that patients with CDI had higher ICU admission rates and mortality rates than those without CDI, and concurrent use of antibiotics and systemic steroids were risk factors for CDI.
ONCOTARGETS AND THERAPY
(2022)
Article
Health Care Sciences & Services
Ching-Feng Huang, Fan-Hao Chou, Chia-Hao Chang, Su-Er Guo
Summary: This preliminary study examined the associations between Body Mass Index (BMI), body image, perceived stress, mental health, dietary habits, and exercise participation among 310 female college nursing students. The study found that BMI correlated with body image, but not with diet, exercise, stress, and mental health. The underweight group had the highest satisfactory score on appearance evaluation, while there was no difference between the overweight and obese groups. Attention should be given to underweight, overweight, obesity, high perceived stress, and poor mental health among nursing students.
Article
Environmental Sciences
Su-Er Guo, Pamela A. Ratner, Sung-Chih Tseng, Chieh-Mo Lin, Miao-Ching Chi, Chiang-Wen Lee, Ying-Chun Yu
Summary: Burning incense releases harmful particles and gases that can cause respiratory diseases. This study investigated the impact of incense burning exposure on the health of temple workers and volunteers in Taiwan. The researchers found that exposure to incense burning was associated with increased levels of inflammatory cytokines in the participants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Su-Er Guo, Pamela A. Ratner, Sung-Chih Tseng, Chieh-Mo Lin, Miao-Ching Chi, Chiang-Wen Lee, Ying-Chun Yu
Summary: Incense burning releases particulate matter and nitrogen dioxide that have adverse effects on human health. This study examined the association between incense burning exposure and the health status, particularly inflammatory biomarkers, of temple workers and volunteers. The study found that long-term exposure to incense burning was associated with respiratory issues and elevated levels of inflammatory cytokines.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, General & Internal
Li-Ping Wang, Li-Hwa Tsai, Hisang-Yun Huang, Chizimuzo Okoli, Su-Er Guo
Summary: This systematic review and meta-analysis found that buttonhole (BH) cannulation significantly reduces the risk of aneurysm formation, stenosis, thrombosis formation, and hematoma compared to rope ladder (RL) cannulation for arteriovenous fistula (AVF) in hemodialysis patients. There were no significant differences in AVF infection between BH and RL cannulation. BH cannulation should be recommended as a routine procedure for hemodialysis, but staff knowledge and skills should be strengthened to reduce the risk of AVF infection.
Article
Health Care Sciences & Services
Ethan Huang, Shu-Yi Huang, Yu-Ching Lin, Chieh-Mo Lin, Chin-Kuo Lin, Chia-Yu Hsu, Ying-Chih Huang, Jian-An Su
Summary: Respiratory arousal refers to the transition from sleep to wakefulness following a period of apnea or hypopnea. In patients with obstructive sleep apnea (OSA), respiratory arousal can both activate upper airway muscles and restore airflow, as well as contribute to greater ventilatory instability and exacerbate OSA. In this study, researchers investigated the presentation and associations of respiratory arousal in patients with very severe OSA, as well as the effects of a non-framework multilevel surgery on respiratory arousal. They found that respiratory arousal index was correlated with AHI, mean oxyhemoglobin saturation, mean desaturation, and desaturation index, but not with BMI or ESS. The study also demonstrated that the respiratory arousal index can be significantly reduced by approximately half after a non-framework multilevel surgery in these patients.
Article
Environmental Sciences
Meiman Maggie Chen, Su-Er Guo, Chi-Pin Yuan, Chizimuzo Okoli, Yen-Chi Liao
Summary: Self-reported questions regarding instances of smoking in front of the individual and subjective perceived frequency of SHS exposure in past 7 days are feasible items to assess SHS exposure in pregnant women, showing medium-strength correlations with urine cotinine levels. These simple questions can help pregnant women reduce the harm associated with SHS exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
