Ebola vaccines in clinical trial: The promising candidates

Chimpanzee Adenovirus Vector Ebola Vaccine

(2017) Julie E. Ledgerwood et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Recombinant Vesicular Stomatitis Virus Ebola Vaccine

(2017) Jason A. Regules et al.   NEW ENGLAND JOURNAL OF MEDICINE

Viral vectors as vaccine platforms: from immunogenicity to impact

(2016) Katie J Ewer et al.   CURRENT OPINION IN IMMUNOLOGY

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

(2016) Iain D. Milligan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial

(2016) Milagritos D Tapia et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study

(2016) Olga De Santis et al.   LANCET INFECTIOUS DISEASES

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

(2016) Selidji T. Agnandji et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

(2016) Katie Ewer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent advances in the development of vaccines for Ebola virus disease

(2016) Elijah Ige Ohimain   VIRUS RESEARCH

Emergency Postexposure Vaccination With Vesicular Stomatitis Virus–Vectored Ebola Vaccine After Needlestick

(2015) Lilin Lai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

(2015) Oleg V. Pyankov et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial

(2015) Hannah Kibuuka et al.   LANCET

Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial

(2015) Feng-Cai Zhu et al.   LANCET

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

(2015) Ana Maria Henao-Restrepo et al.   LANCET

The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial

(2015) Angela Huttner et al.   LANCET INFECTIOUS DISEASES

An Ebola whole-virus vaccine is protective in nonhuman primates

(2015) A. Marzi et al.   SCIENCE

Immune Evasion in Ebolavirus Infections

(2015) Jonathan Audet et al.   VIRAL IMMUNOLOGY

Homologous and Heterologous Protection of Nonhuman Primates by Ebola and Sudan Virus-Like Particles

(2015) Kelly L. Warfield et al.   PLoS One

Epidemiological Investigation and Seroprevalence of Human Parainfluenza Virus in Mie Prefecture in Japan during 2009^|^ndash;2013

(2014) Takuya Yano et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial

(2014) U. N. Sarwar et al.   JOURNAL OF INFECTIOUS DISEASES

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

(2014) Daphne A Stanley et al.   NATURE MEDICINE

Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents

(2014) Gary Wong et al.   VACCINE

Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice

(2013) Guangwu Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus

(2013) A. S. Herbert et al.   JOURNAL OF VIROLOGY

NTDs in the Heart of Darkness: The Democratic Republic of Congo's Unknown Burden of Neglected Tropical Diseases

(2013) Anne W. Rimoin et al.   PLoS Neglected Tropical Diseases

Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine

(2013) Joseph E. Blaney et al.   PLoS Pathogens

A Cytomegalovirus-based Vaccine Expressing a Single Tumor-specific CD8+ T-cell Epitope Delays Tumor Growth in a Murine Model of Prostate Cancer

(2012) Elena N. Klyushnenkova et al.   JOURNAL OF IMMUNOTHERAPY

A Syrian Golden Hamster Model Recapitulating Ebola Hemorrhagic Fever

(2012) Hideki Ebihara et al.   JOURNAL OF INFECTIOUS DISEASES

The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy

(2012) Daniel R. Beniac et al.   PLoS One

Ad35 and Ad26 Vaccine Vectors Induce Potent and Cross-Reactive Antibody and T-Cell Responses to Multiple Filovirus Species

(2012) Roland Zahn et al.   PLoS One

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

(2012) E. Barnes et al.   Science Translational Medicine

A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice

(2012) Rob Tierney et al.   VACCINE

A replication-deficient rabies virus vaccine expressing Ebola virus glycoprotein is highly attenuated for neurovirulence

(2012) Amy B. Papaneri et al.   VIROLOGY

A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge

(2012) Rebecca J. Grant-Klein et al.   Human Vaccines & Immunotherapeutics

Minigenomes, transcription and replication competent virus-like particles and beyond: Reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses

(2011) Thomas Hoenen et al.   ANTIVIRAL RESEARCH

Impact of Imitation Processes on the Effectiveness of Ring Vaccination

(2011) Chad R. Wells et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Protective Efficacy of a Bivalent Recombinant Vesicular Stomatitis Virus Vaccine in the Syrian Hamster Model of Lethal Ebola Virus Infection

(2011) Yoshimi Tsuda et al.   JOURNAL OF INFECTIOUS DISEASES

Kunjin Virus Replicon-Based Vaccines Expressing Ebola Virus Glycoprotein GP Protect the Guinea Pig Against Lethal Ebola Virus Infection

(2011) O. Reynard et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

(2011) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

Inactivated or Live-Attenuated Bivalent Vaccines That Confer Protection against Rabies and Ebola Viruses

(2011) J. E. Blaney et al.   JOURNAL OF VIROLOGY

CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

(2011) Nancy J Sullivan et al.   NATURE MEDICINE

A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus

(2011) Yoshimi Tsuda et al.   PLoS Neglected Tropical Diseases

A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults

(2010) J.E. Ledgerwood et al.   VACCINE

Replication-Deficient Ebolavirus as a Vaccine Candidate

(2009) P. Halfmann et al.   JOURNAL OF VIROLOGY

Single-Injection Vaccine Protects Nonhuman Primates against Infection with Marburg Virus and Three Species of Ebola Virus

(2009) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

Mucosal Immunization of Cynomolgus Macaques with the VSVΔG/ZEBOVGP Vaccine Stimulates Strong Ebola GP-Specific Immune Responses

(2009) Xiangguo Qiu et al.   PLoS One

Recombinant Vesicular Stomatitis Virus Vector Mediates Postexposure Protection against Sudan Ebola Hemorrhagic Fever in Nonhuman Primates

(2008) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

Generation of biologically contained Ebola viruses

(2008) P. Halfmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge

(2008) Alexander Bukreyev et al.   VIROLOGY

Protection against lethal challenge by Ebola virus-like particles produced in insect cells

(2008) Yuliang Sun et al.   VIROLOGY

Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

(2008) Jonathan S. Towner et al.   PLoS Pathogens

Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates

(2008) Thomas W. Geisbert et al.   PLoS Pathogens