Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types

NDRG1 attenuates epithelial–mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling

(2015) Zhi-Yan Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer

(2015) Yunhui Hu et al.   BREAST CANCER RESEARCH AND TREATMENT

In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities

(2015) Carlota Rubio-Perez et al.   CANCER CELL

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

(2015) Erik S Knudsen et al.   CELL CYCLE

Keap1–Nrf2 signalling in pancreatic cancer

(2015) Alastair J. Hayes et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells

(2015) Zhike Chen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf–Mdm2–p53 and RP–Mdm2–p53 pathways

(2015) X Meng et al.   ONCOGENE

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response

(2015) K. Hein et al.   Science Signaling

COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human invasive carcinoma-associated stromal cells and carcinoma progression

(2015) Fernando Vázquez-Villa et al.   TUMOR BIOLOGY

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

(2015) Özgün Babur et al.   GENOME BIOLOGY

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response

(2015) K. Hein et al.   Science Signaling

OncodriveROLE classifies cancer driver genes in loss of function and activating mode of action

(2014) Michael P. Schroeder et al.   BIOINFORMATICS

The Anti-proliferative Function of the TGF-β1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3

(2014) Jarod Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Arf-Egr-C/EBPβ Pathway Linked to Ras-Induced Senescence and Cancer

(2014) Jacqueline Salotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

Overexpression of HepaCAM inhibits cell viability and motility through suppressing nucleus translocation of androgen receptor and ERK signaling in prostate cancer

(2014) Xuedong Song et al.   PROSTATE

S100A2 protein and non-small cell lung cancer. The dual role concept

(2014) Panagiotis Hountis et al.   TUMOR BIOLOGY

Protumorigenic actions of S100A2 involve regulation of PI3/Akt signaling and functional interaction with Smad3

(2013) Sarwat Naz et al.   CARCINOGENESIS

Decreased EGR3 expression is related to poor prognosis in patients with gastric cancer

(2013) Fei Liao et al.   JOURNAL OF MOLECULAR HISTOLOGY

Synergetic regulatory networks mediated by oncogene-driven microRNAs and transcription factors in serous ovarian cancer

(2013) Min Zhao et al.   Molecular BioSystems

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

Age-Specific Gene Expression Signatures for Breast Tumors and Cross-Species Conserved Potential Cancer Progression Markers in Young Women

(2013) Dilek Colak et al.   PLoS One

NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells

(2013) Kristine Misund et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Comprehensive identification of mutational cancer driver genes across 12 tumor types

(2013) David Tamborero et al.   Scientific Reports

Regulation of Tcf7l1 DNA Binding and Protein Stability as Principal Mechanisms of Wnt/β-Catenin Signaling

(2013) Brian R. Shy et al.   Cell Reports

The mutational landscape of chromatin regulatory factors across 4,623 tumor samples

(2013) Abel Gonzalez-Perez et al.   GENOME BIOLOGY

HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions

(2012) Luiz A Bovolenta et al.   BMC GENOMICS

Control of Breast Cancer Growth and Initiation by the Stem Cell-Associated Transcription Factor TCF3

(2012) M. Slyper et al.   CANCER RESEARCH

The transcription factor NF-E2-related Factor 2 (Nrf2): a protooncogene?

(2012) Phillip Shelton et al.   FASEB JOURNAL

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

Sample-level enrichment analysis unravels shared stress phenotypes among multiple cancer types

(2012) Gunes Gundem et al.   Genome Medicine

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mutual exclusivity analysis identifies oncogenic network modules

(2011) G. Ciriello et al.   GENOME RESEARCH

Gitools: Analysis and Visualisation of Genomic Data Using Interactive Heat-Maps

(2011) Christian Perez-Llamas et al.   PLoS One

Acetylation of the Proto-Oncogene EVI1 Abrogates Bcl-xL Promoter Binding and Induces Apoptosis

(2011) Anjan Kumar Pradhan et al.   PLoS One

Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM

(2010) Charles J. Vaske et al.   BIOINFORMATICS

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Pathway Commons, a web resource for biological pathway data

(2010) E. G. Cerami et al.   NUCLEIC ACIDS RESEARCH

Automated Network Analysis Identifies Core Pathways in Glioblastoma

(2010) Ethan Cerami et al.   PLoS One

The role of S100 genes in breast cancer progression

(2010) Eadaoin McKiernan et al.   TUMOR BIOLOGY

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

(2009) Tatsuya Kawase et al.   CELL

A census of human transcription factors: function, expression and evolution

(2009) Juan M. Vaquerizas et al.   NATURE REVIEWS GENETICS

MYC in breast tumor progression

(2008) Yinghua Chen et al.   Expert Review of Anticancer Therapy

The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences

(2008) Elodie Portales-Casamar et al.   NUCLEIC ACIDS RESEARCH