Article
Biotechnology & Applied Microbiology
Genmei Lin, Dong Gao, Jianguo Lu, Xiaowen Sun
Summary: This study investigated the gene expression patterns during gonad differentiation in the half-smooth tongue sole, revealing differentially expressed genes associated with sex differentiation and gonad development. Trend analysis showed that gene expression patterns varied over time, with either common features or significant sexual dimorphism. Transcript structure analyses identified both sex and time differences among samples, clarifying the significant sexual differences during early development and providing insight into sex differentiation and development mechanisms.
MARINE BIOTECHNOLOGY
(2021)
Article
Fisheries
Wenwen Wang, Qian Xu, Xinbao Liu, Hongning Liu, Zhujun Li, Qingxin Fan, Suxu Tan, Kunpeng Shi, Yanting Xia, Zhenxia Sha
Summary: This study explored the relationship between bacterial concentrations and host mortality, inflammatory reaction, and immune response in half-smooth tongue sole after infection with Vibrio anguillarum. The results indicated that the 24-48 hour period post-infection was a key time node for early detection and intervention of vibriosis. Excessive activation of the complement system and inflammatory reaction may contribute to mass death in fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Chunguang Gong, Yaotong Hao, Yating Liu, Yaxian Zhao, Yufeng Liu, Guixing Wang, Zhongwei He, Jiaqi Liu, Bo An, Yanling Zhang, Qinghai Yu, Yufeng Wang, Jilun Hou
Summary: The study found that the immune system of the half-smooth tongue sole is not sensitive to moderate- or low-dose Vibrio vulnificus infection, while leukocytes, ALP, and complement primarily play a role in resisting high-dose infection. A variety of intestinal microbial taxa are important in inhibiting Vibrio vulnificus growth.
Article
Microbiology
Yaotong Hao, Yaxian Zhao, Yitong Zhang, Yufeng Liu, Guixing Wang, Zhongwei He, Wei Cao, Tian Han, Xun Zhang, Ziying Zhang, Yufen Wang, Chunguang Gong, Jilun Hou
Summary: This study investigated the intestinal microbial response to different doses of Vibrio alginolyticus infection in half-smooth tongue sole. The results showed that high-dose infection significantly altered the intestinal microbiota, decreased microbial diversity, and increased the number of potential pathogens such as Vibrio and Shewanella.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongning Liu, Suxu Tan, Yadong Chen, Xuejie Chen, Xinbao Liu, Zhujun Li, Ningning Wang, Sen Han, Zhendong Wu, Jie Ma, Kunpeng Shi, Wenwen Wang, Zhenxia Sha
Summary: This study elucidated the regulatory mechanism of Cse-miR-722 on CsC5aR1 and demonstrated its important role in immune response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhujun Li, Suxu Tan, Longjiang Qi, Yadong Chen, Hongning Liu, Xinbao Liu, Zhenxia Sha
Summary: The study identified and characterized a set of 28 ITG genes in half-smooth tongue sole, most of which are involved in immune function. The selection pressure analysis showed that these ITG genes were under purifying selection, with the exception of ITG alpha11b and ITG alphaL. Expression analysis of eight selected ITG genes in healthy tissues and after bacterial infection revealed their significant role in immune response.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2023)
Article
Fisheries
Lei Wang, Fumiao Zhang, Yadong Chen, Shuangyan Wang, Zhangfan Chen, Qian Zhou, Songlin Chen
Summary: In this study, the membrane-bound and secretory IgT of the half-smooth tongue sole were identified for the first time. Transcript levels of IgT showed significant induction upon Vibrio Harveyi infection. This study provides insights into the immune response of marine fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Na Yao, Yaqun Zhang, Yangzhen Li, Yuanri Hu, Hengde Li
Summary: In this study, genomic markers in Chinese tongue sole were identified and their association with hypermelanosis area was analyzed. Hypermelanosis was found to be a complicated quantitative trait with a certain degree of predictability, indicating the existence of complex genetic mechanisms.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Medicine, General & Internal
Tamar Sofer, Nuzulul Kurniansyah, Michael Murray, Yuk-Lam Ho, Erik Abner, Tonu Esko, Jennifer E. Huffman, Kelly Cho, Peter W. F. Wilson, Daniel J. Gottlieb
Summary: This study conducted a genome-wide association study (GWAS) of obstructive sleep apnea (OSA) using the Million Veteran Program (MVP), revealing multiple novel genetic loci associated with OSA. The study also demonstrated widespread sex differences in genetic associations and shared genetic underpinnings between OSA and other sleep phenotypes.
Article
Fisheries
Xihong Li, Qian Yang, Rui Shi, Xiwen Xu, Zhangfan Chen, Songlin Chen, Na Wang
Summary: In this study, the researchers found differential expression of igfbp genes in Chinese tongue sole, which is an economically important marine flatfish. These genes play a role in growth and development, and interact with key molecules involved in these processes. The study also revealed differences in gene expression and DNA methylation patterns in different tissues, as well as the differential effects of estradiol and testosterone on igfbp gene expression.
Article
Medicine, General & Internal
Shun Li, C. M. Schooling
Summary: In addition to their well-known cardiovascular disease prevention benefits, statins have sex-specific pleiotropic effects. Genetically mimicking statins was found to have inverse associations with lipid traits, especially in women, and was also related to platelet attributes, serum calcium, and sex hormone-binding globulin.
Article
Biochemistry & Molecular Biology
Anastasia Levchenko, Sergey Malov, Alexey Antonik, Anastasia Protsvetkina, Kseniya V. Rybakova, Alexander Kanapin, Alexey N. Yakovlev, Anna Y. Nenasteva, Anton E. Nikolishin, Nikolay Cherkasov, Natalia A. Chuprova, Anna S. Blagonravova, Angelica V. Sergeeva, Tatyana V. Zhilyaeva, Maria K. Denisenko, Raul R. Gainetdinov, Alexander O. Kibitov, Evgeny M. Krupitsky
Summary: This study identifies a significant association between a genetic variant and alcohol dependence (AD) in female patients. Other genetic variants previously associated with psychiatric and addiction traits show different associations with AD and related clinical measures in male and female patients. Bioinformatic analysis reveals that the associated genetic variants control the expression of 80 protein-coding genes, many of which directly interact with previously published genes associated with alcohol phenotypes, with BDNF being the most important hub gene.
Article
Genetics & Heredity
Jin Gao, Yongbo Wang, Jinye Liu, Fuxiao Chen, Yilan Guo, Hongji Ke, Xulei Wang, Ming Luo, Shuyuan Fu
Summary: This study identified multiple genomic loci associated with sex differentiation and gonadal development traits in Plectropomus leopardus using genome-wide association study (GWAS). It also identified candidate genes related to sex differentiation and gonadal development, providing valuable resources for further research on the genetic mechanism and sex control in P. leopardus.
FRONTIERS IN GENETICS
(2023)
Article
Clinical Neurology
Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, Saori Sakaue, Hideaki Imai, Masahiro Shimizu, Hiroki Hongo, Yuki Shinya, Kenta Ohara, Yu Teranishi, Atsushi Okano, Hideaki Ono, Hirofumi Nakatomi, Akira Teraoka, Kenichi Yamamoto, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Ken Suzuki, Jun Hirata, Meiko Takahashi, Koichi Matsuda, Atsushi Kumanogoh, Fumihiko Matsuda, Yukinori Okada, Nobuhito Saito
Summary: This study conducted the first genome-wide association study (GWAS) of intracranial artery stenosis (ICAS) in a Japanese population. They identified a functional variant of RNF2J3, rs112735431, that was significantly associated with ICAS. Furthermore, they found that this variant was also associated with high blood pressure and angina.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Biology
Hong-Yan Wang, Xiang Liu, Jian-Yang Chen, Yingyi Huang, Yifang Lu, Fujian Tan, Qun Liu, Mingming Yang, Shuo Li, Xianghui Zhang, Yating Qin, Wenxiu Ma, Yingming Yang, Liang Meng, Kaiqiang Liu, Qian Wang, Guangyi Fan, Rafael H. Nobrega, Shanshan Liu, Francesc Piferrer, Changwei Shao
Summary: This study provides insights into the regulatory mechanisms of spermatogenesis in female-to-male sex-reversed individuals (pseudomales) in Chinese tongue sole. The researchers identified key genes and signaling pathways involved in spermatogenesis, as well as abnormalities in germ cells and somatic cells in pseudomales. The study also highlights the importance of Z chromosome-specific genes in spermatogenesis.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Genetics & Heredity
Changwei Shao, Yongchao Niu, Pasi Rastas, Yang Liu, Zhiyuan Xie, Hengde Li, Lei Wang, Yong Jiang, Shuaishuai Tai, Yongsheng Tian, Takashi Sakamoto, Songlin Chen
Article
Genetics & Heredity
Hengde Li, Jingwei Wang, Zhenmin Bao
Article
Ecology
Shi Wang, Jinbo Zhang, Wenqian Jiao, Ji Li, Xiaogang Xun, Yan Sun, Ximing Guo, Pin Huan, Bo Dong, Lingling Zhang, Xiaoli Hu, Xiaoqing Sun, Jing Wang, Chengtian Zhao, Yangfan Wang, Dawei Wang, Xiaoting Huang, Ruijia Wang, Jia Lv, Yuli Li, Zhifeng Zhang, Baozhong Liu, Wei Lu, Yuanyuan Hui, Jun Liang, Zunchun Zhou, Rui Hou, Xue Li, Yunchao Liu, Hengde Li, Xianhui Ning, Yu Lin, Liang Zhao, Qiang Xing, Jinzhuang Dou, Yangping Li, Junxia Mao, Haobing Guo, Huaiqian Dou, Tianqi Li, Chuang Mu, Wenkai Jiang, Qiang Fu, Xiaoteng Fu, Yan Miao, Jian Liu, Qian Yu, Ruojiao Li, Huan Liao, Xuan Li, Yifan Kong, Zhi Jiang, Daniel Chourrout, Ruiqiang Li, Zhenmin Bao
NATURE ECOLOGY & EVOLUTION
(2017)
Article
Genetics & Heredity
Wenqian Jiao, Xiaoteng Fu, Jinzhuang Dou, Hengde Li, Hailin Su, Junxia Mao, Qian Yu, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Yangfan Wang, Shi Wang, Zhenmin Bao
Article
Ecology
Yu Cui, Weifeng Wang, Liyong Ma, Jinhua Jie, Yanhong Zhang, Huanling Wang, Hengde Li
Article
Agriculture, Dairy & Animal Science
H. D. Li, M. S. Lund, O. F. Christensen, V. R. Gregersen, P. Henckel, C. Bendixen
JOURNAL OF ANIMAL SCIENCE
(2010)
Article
Genetics & Heredity
Hengde Li
JOURNAL OF GENETICS
(2011)
Article
Biotechnology & Applied Microbiology
Yan Zhang, Peng Xu, Cuiyun Lu, Youyi Kuang, Xiaofeng Zhang, Dingchen Cao, Chao Li, Yumei Chang, Ning Hou, Hengde Li, Shu Wang, Xiaowen Sun
MARINE BIOTECHNOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Li Jiang, Shu Wang, Huijie Li, Guoxin Zhang, Hengde Li
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Biotechnology & Applied Microbiology
Yaqun Zhang, Zhanjiang Liu, Hengde Li
MARINE BIOTECHNOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
Hengde Li, Guosheng Su, Li Jiang, Zhenmin Bao
GENETICS SELECTION EVOLUTION
(2017)