Article
Cell Biology
Wei Sun, Hong Cheng, Yang Yang, Dongxin Tang, Xiaolian Li, Lei An
Summary: The study found that the precursor pro-brain-derived neurotrophic factor (proBDNF) plays a crucial role in spatial cognition in adult rodent brains. Blocking proBDNF expression disrupted spatial memory consolidation without affecting learning or memory retrieval. The results underscore the importance of proBDNF in synaptic and cognitive functions in postnatal brains.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Eduarda G. Nachtigall, Jociane de C. Myskiw, Ivan Izquierdo, Cristiane R. G. Furini
Summary: This article investigates the molecular mechanisms involved in the reconsolidation of contextual fear conditioning memory in the hippocampus. The findings highlight the necessity of SFKs, GluN2B-containing NMDAR, and TrkBR in the reconsolidation process.
PSYCHOPHARMACOLOGY
(2023)
Article
Toxicology
Wei Sun, Yang Yang, Yazi Mei, Yuanhua Wu, Xiao Chen, Lei An
Summary: The study revealed that prenatal exposure to cyanuric acid (CA) impairs learning and memory function in a dose-dependent manner. It affects synaptic function in the hippocampal circuitry, with a decrease in NMDA-GluN2A levels. These findings support the hypothesis that CA treatment can negatively impact spatial cognition in fetuses.
TOXICOLOGY LETTERS
(2022)
Article
Psychiatry
Lisa Rebecca Otto, Vera Clemens, Berk Uesekes, Nicoleta Carmen Cosma, Francesca Regen, Julian Hellmann-Regen
Summary: This study investigates the link between retinoid homeostasis and depression in a well-matched cohort of 109 patients with major depressive disorder (MDD) and healthy controls. The results show altered retinoid homeostasis in MDD, with higher levels of retinol and greater synthesis activity of all-trans RA in MDD patients compared to healthy controls. Furthermore, the MDD-associated alterations in retinoid homeostasis differ between men and women.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biology
Maximilian Lenz, Amelie Eichler, Pia Kruse, Julia Muellerleile, Thomas Deller, Peter Jedlicka, Andreas Vlachos
Summary: The study demonstrates that the vitamin A metabolite all-trans retinoic acid (atRA) induces synaptic plasticity in mouse dentate granule cells, particularly in the dorsal hippocampus, leading to an increase in excitatory postsynaptic current frequencies and synapse numbers. AtRA treatment improved the ability of dentate granule cells to express LTP, with this plasticity-promoting effect being dependent on synaptopodin. These findings highlight the role of atRA in mediating synaptopodin-dependent metaplasticity in mouse dentate granule cells.
Article
Neurosciences
Bethany E. Frost, Sean K. Martin, Matheus Cafalchio, Md Nurul Islam, John P. Aggleton, Shane M. O'Mara
Summary: Lesions affecting the anterior thalamic nuclei may be responsible for diencephalic amnesia, similar to how hippocampal lesions cause temporal lobe amnesia. The core element of diencephalic amnesia seems to be the loss of information in hippocampal output regions following anterior thalamic pathology, possibly due to the direct connections between the two areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Mohsen Shamsi, Maliheh Soodi, Shirin Shahbazi, Ameneh Omidi
Summary: The study found that Acetamiprid reduces glutamate levels, affects the expression of NMDA receptor subunits in the hippocampus, leading to impaired memory consolidation at low doses, and loss of neural cells in the dentate gyrus area at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Valentin Penaloza-Sancho, Catherine Perez-Valenzuela, Celindo Gonzalez, German Jujihara, Paulina Bustos, Alexies Dagnino-Subiabre
Summary: Our study reveals that in stressed rats, the expression of CB1 receptors in the hippocampus is up-regulated, and only n-3 PUFAs can counteract this effect. Memory improvement in stressed rats depends on the supplementation of n-3 PUFAs and the modulation of CB1 receptors.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Psychology, Experimental
Xing Xing, Jeffrey A. Saunders
Summary: This study tested whether connections between non-spatial properties can distort judgments about spatial distance. The results showed that similar houses were drawn closer on reconstructed maps, and pairwise distance judgments were smaller for similar houses. These findings support theories that space is represented with other properties, suggesting that the mechanism for encoding space in the hippocampal-entorhinal system has a broader function.
Article
Neurosciences
M. Asada-Utsugi, K. Uemura, M. Kubota, Y. Noda, Y. Tashiro, T. M. Uemura, H. Yamakado, M. Urushitani, R. Takahashi, S. Hattori, T. Miyakawa, N. Ageta-Ishihara, K. Kobayashi, M. Kinoshita, A. Kinoshita
Summary: The study demonstrated that knock-in GD mice with resistance to ADAM10-mediated cleavage of N-cadherin exhibited improved performance in memory tests, enhanced fear conditioning responses, and increased complexity in dendritic spines in the hippocampal CA3 region. This indicates that ADAM10-mediated cleavage of N-cadherin is crucial for synaptic structure and function, impacting memory function.
Article
Neurosciences
Cai-Yan Xue, Tian Gao, E. Mao, Zhen-Zhen Kou, Ling Dong, Feng Gao
Summary: This study demonstrates the crucial role of Insulin receptors (InsRs) in episodic and spatial memory in the hippocampus. InsRs affect the activity and excitatory/inhibitory balance of GABAergic and glutamatergic neurons in the hippocampus.
Article
Behavioral Sciences
Siamak Beheshti, Hadi Dehestani
Summary: Ghrelin, a peptide primarily secreted from the stomach, has been shown to have a positive impact on memory formation. However, studies have not measured the expression levels of ghrelin or its receptors in the brain during memory formation. This study found that in fear memory formation, mRNA levels of ghrelin significantly increased 24 hours post-training while its receptors were down-regulated; in spatial memory consolidation, ghrelin expression levels remained unchanged but its receptors showed a significant increase 24 hours post-training.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Marcus K. Benna, Stefano Fusi
Summary: The study proposes a memory model of the hippocampus, suggesting that the hippocampus is a memory device that compresses correlations between sensory experiences into compressed representations of episodes stored in memory. This model naturally produces place cells similar to those observed in experiments, with predictions that the activity of these cells is variable.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Multidisciplinary Sciences
Donovan K. Galvez-Marquez, Mildred Salgado-Menez, Perla Moreno-Castilla, Luis Rodriguez-Duran, Martha L. Escobar, Fatuel Tecuapetla, Federico Bermudez-Rattoni
Summary: This study found that decreasing catecholamine release from the locus coeruleus terminals in the hippocampus can impact the updating of spatial contextual memory. Photoinhibtion of these terminals impaired the consolidation of object location memory and led to a decrease in both dopamine and noradrenaline levels. This data suggests that dopamine plays a role in the mechanisms of spatial contextual memory updating.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Gregoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Laye, A. Nadjar
Summary: Maternal immune activation (MIA) and poor maternal nutritional habits are risk factors for the occurrence of neurodevelopmental disorders (NDD). Low maternal n-3 PUFA intake exacerbates MIA-induced early gut dysfunction and inflammation, leading to long-lasting effects on microglia-neuron crosstalk pathways and behavior. The perinatal period is critical for understanding the link between MIA, poor nutritional habits, and NDD through the gut-brain axis.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Immunology
M. Chataigner, P. Mortessagne, C. Lucas, V. Pallet, S. Laye, A. Mehaignerie, E. Bouvret, AL. Dinel, C. Joffre
Summary: This study aims to determine the combined effect of n-3 LC-PUFAs and low molecular weight peptides on cognitive functions and their mechanism of action. The researchers found that a dietary supplementation with a fish hydrolysate containing n-3 LC-PUFAs and low molecular weight peptides prevented age-related spatial short-term memory deficits and modulated navigation strategies during spatial learning. Additionally, the fish hydrolysate displayed anxiolytic activities and modulated the hypothalamic stress response, indicating its potential role in preventing age-related cognitive decline.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Fabien Dumetz, Rachel Ginieis, Corinne Bure, Anais Marie, Serge Alfos, Veronique Pallet, Clementine Bosch-Bouju
Summary: This study investigates the effects of vitamin A deficiency on memory and neuronal plasticity in the hippocampus of rats. The findings suggest that vitamin A deficiency leads to abnormal morphology and synaptic function in hippocampal cells, and moderate-dose vitamin A supplementation can alleviate these abnormalities.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Maryse Khoury, Santa Chamsine, Camil Merheb, Edouard Arfoul, Maria Rached, Farah Younes, Nada El Osta, Sophie Laye, Carla Aoun, Tatiana Papazian, Lydia Rabbaa Khabbaz
Summary: The study found significant associations between higher BMI, total energy intake, negative urgency, and positive urgency scores with binge eating behavior (BE); participants with high dietary n-6:n-3 ratio were more at risk of having BE; the relationship between BE and impulsivity was not mediated by BMI.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Essi F. Biyong, Serge Alfos, Fabien Dumetz, Jean-Christophe Helbling, Agnes Aubert, Julie Brossaud, Aline Foury, Marie-Pierre Moisan, Sophie Lay, Emmanuel Richard, Elaine Patterson, Kiera Murphy, Kieran Rea, Catherine Stanton, Harriet Schellekens, John F. Cryan, Lucile Capuron, Veronique Pallet, Guillaume Ferreira
Summary: The study revealed that dietary vitamin A supplementation in mice can prevent some of the metabolic, microbiota, neuronal and cognitive alterations induced by early consumption of obesogenic diets, and protect hippocampal function.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Nutrition & Dietetics
Mathilde Chataigner, Marie Martin, Celine Lucas, Veronique Pallet, Sophie Laye, Alexis Mehaignerie, Elodie Bouvret, Anne-Laure Dinel, Corinne Joffre
Summary: Neuroinflammation, which can lead to neuronal damage and cognitive impairments, is regulated by microglial cells. Dietary n-3 long chain polyunsaturated fatty acids and low molecular weight peptides found in fish hydrolysate have anti-inflammatory properties, making them promising candidates for preventing and counteracting neuroinflammation.
Article
Neurosciences
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Briere, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony-Lee Sterley, Clementine Bosch-Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie-Kim St-Pierre, Maude Bordeleau, Veronique De Smedt-Peyrusse, Alexandran Sere, Leslie Schwendimann, Stephane Gregoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie-Eve Tremblay, Sophie Laye, Agnes Nadjar
Summary: Westernized dietary habits leading to reduced intake of n-3 PUFAs may be associated with neurodevelopmental disorders and disruptions in brain functional connectivity. Lifelong n-3 PUFA deficiency can interfere with oligodendrocyte maturation and myelination processes, resulting in long-term detrimental effects on white matter organization and hippocampus-prefrontal functional connectivity. Promoting developmental myelination through clemastine could rescue memory deficits in n-3 PUFA deficient animals.
Article
Biochemistry & Molecular Biology
Alessia Costa, Barbara Rani, Thomaz F. S. Bastiaanssen, Francesco Bonfiglio, Eoin Gunnigle, Gustavo Provensi, Moira Rossitto, Marcus Boehme, Conall Strain, Clara S. Martinez, Patrizio Blandina, John F. Cryan, Sophie Laye, Renato Corradetti, Maria Beatrice Passani
Summary: Exposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. This study found that brain histamine plays a role in the protective effects of a diet enriched with polyunsaturated fatty acids and vitamin A on chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Laye, Marie-Eve Tremblay, Agnes Nadjar
Summary: The westernization of dietary habits has led to a decrease in the intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnant and lactating women, resulting in defects in the formation of brain myelin in infants. This study found that these deficits may be related to alterations in the structure and function of microglial cells in the white matter of the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mathieu Di Miceli, Maud Martinat, Moira Rossitto, Agnes Aubert, Shoug Alashmali, Clementine Bosch-Bouju, Xavier Fioramonti, Corinne Joffre, Richard P. Bazinet, Sophie Laye
Summary: Long-chain (LC) n-3 polyunsaturated fatty acids (PUFAs) have been studied in the field of neuropsychiatric disorders, particularly depression. The effect of LC n-3 PUFA supplementation on behavior and synaptic plasticity was investigated in mice exposed to chronic social defeat stress (CSDS). The results showed that LC n-3 PUFA supplementation influenced the fatty acid profile in the NAc, altered emotional behavior and synaptic plasticity, and promoted resilience, independently of CSDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Karkkainen, Sophie Laye, Nathalie Delzenne, Kati Hanhineva
Summary: Alterations in gut microbiota composition have been linked to various neurological disorders, and the gut-brain axis plays a crucial role in this communication. While the specific mechanisms are not fully understood, existing data suggests that metabolites from gut microbiota may be key factors in the gut-brain axis communication. Further research is needed to understand the molecular mechanisms and explore intervention approaches for prevention and treatment of neurological disorders.
Article
Biochemistry & Molecular Biology
Hugo Martin, Sebastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Penicaud, Sophie Laye, Bruno P. Guiard, Xavier Fioramonti
Summary: Insulin directly modulates the activity of DR 5-HT neurons to dampen 5-HT neurotransmission and control emotional behaviors. However, in T2D animal models, the anxiolytic effect of intranasal insulin and the response of 5-HT neurons to insulin are both blunted.
MOLECULAR PSYCHIATRY
(2022)
Article
Immunology
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Laye, Cristina Limatola, Marie-Eve Tremblay, Agnes Nadjar
Summary: Sleep is regulated by various neuroanatomical and neurochemical systems, with microglia playing a significant role in sleep regulation. Depletion of microglia in female mice results in longer NREM sleep duration and increased number of sleep episodes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Valentine Turpin, Maud Schaffhauser, Mathieu Thabault, Agnes Aubert, Corinne Joffre, Eric Balado, Jean-Emmanuel Longueville, Maureen Francheteau, Christophe Burucoa, Maxime Pichon, Sophie Laye, Mohamed Jaber
Summary: This study compared the effects of n-3 long-chain polyunsaturated fatty acid (PUFA) dietary supplementation from fatty fish with n-3 PUFA precursor diet from plant oils in an autism spectrum disorder (ASD) mouse model. The results showed that regardless of the diet, n-3 PUFA-based diets can prevent certain behavioral and cellular symptoms related to ASD.
SCIENTIFIC REPORTS
(2023)
Review
Environmental Sciences
Boushra Dalile, Curie Kim, Andy Challinor, Lucie Geurts, Eileen R. Gibney, Marcelo Galdos, Giorgio La Fata, Sophie Laye, John C. Mathers, David Vauzour, J. Martin Verkuyl, Sandrine Thuret
Summary: This review assesses the evidence for the impact of diet on cognitive function and finds that the current evidence base is weak with mixed conclusions. Long-term intervention and prospective cohort studies are needed to fill this knowledge gap and revise dietary recommendations for maintaining healthy cognitive function across the life course.
LANCET PLANETARY HEALTH
(2022)
