Role of renin-angiotensin system in liver diseases: an outline on the potential therapeutic points of intervention

Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out

(2015) D. Zablocki et al.   CIRCULATION

Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3

(2015) Zhexue Qin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

(2015) Kai Y Mak et al.   MOLECULAR THERAPY

Diabetes, oxidative stress and therapeutic strategies

(2014) Luc Rochette et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

(2014) Petr Kujal et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease

(2014) George B Goh et al.   LIVER INTERNATIONAL

Proteomic white adipose tissue analysis of obese mice fed with a high-fat diet and treated with oral angiotensin-(1–7)

(2014) João Marcus Oliveira Andrade et al.   PEPTIDES

The role of renin-angiotensin system modulation on treatment and prevention of liver diseases

(2014) Simone Moreira de Macêdo et al.   PEPTIDES

Oxidative stress as a crucial factor in liver diseases

(2014) Halina Cichoż-Lach   WORLD JOURNAL OF GASTROENTEROLOGY

Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE-knockout mice

(2013) Analina R. Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling

(2013) Hiroshi Akazawa et al.   CURRENT PHARMACEUTICAL DESIGN

Role of oxidative stress in the pathogenesis of alcohol-induced liver disease

(2013) B. Sid et al.   FREE RADICAL RESEARCH

Activation of the Mas Receptor by Angiotensin-(1–7) in the Renin–Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis

(2013) Josephine A. Grace et al.   GASTROENTEROLOGY

Development of Nonalcoholic Hepatopathy: Contributions of Oxidative Stress and Advanced Glycation End Products

(2013) Juliana Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Phenytoin-Induced Toxicity in Freshly Isolated Rat Hepatocytes and the Protective Effects of Taurine and/or Melatonin

(2013) Mohammad Ali Eghbal et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The role of renin-angiotensin system in cellular differentiation: Implications in pancreatic islet cell development and islet transplantation

(2013) Lin Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Cationic solid lipid nanoparticles derived from apolipoprotein-free LDLs for target specific systemic treatment of liver fibrosis

(2012) Won Ho Kong et al.   BIOMATERIALS

The intracrine renin–angiotensin system

(2012) Rajesh Kumar et al.   CLINICAL SCIENCE

Possible Involvement of Angiogenesis in Chronic Liver Diseases: Interaction Among Renin-Angiotensin-Aldosterone System, Insulin Resistance and Oxidative Stress

(2012) K. Kaji et al.   CURRENT MEDICINAL CHEMISTRY

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

Inflammation and fibrogenesis in steatohepatitis

(2012) Hideki Fujii et al.   JOURNAL OF GASTROENTEROLOGY

The role of angiotensin II in nonalcoholic steatohepatitis

(2012) E. Matthew Morris et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing

(2011) Jean-Marc Tadié et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Angiotensin-(1–7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1

(2011) LaTronya T. McCollum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes

(2011) Sho-ichi Yamagishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondria as Possible Pharmaceutical Targets for the Effects of Vitamin E and its Homologues in Oxidative Stress-Related Diseases

(2011) Hideyuki J. Majima et al.   CURRENT PHARMACEUTICAL DESIGN

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

(2011) Wenhao Cui et al.   HEPATOLOGY

Portal Hypertension: Pathophysiology, Diagnosis, and Treatment

(2011) S. Buob et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

On the local cardiac renin angiotensin system. Basic and clinical implications

(2011) Walmor C. De Mello et al.   PEPTIDES

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy

(2010) Michael Bader   Annual Review of Pharmacology and Toxicology

Endothelial Damage and Regeneration: The Role of the Renin-Angiotensin-Aldosterone System

(2010) Ulrich M. Becher et al.   CURRENT HYPERTENSION REPORTS

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress and steatosis are cofactors of liver injury in primary biliary cirrhosis

(2010) Paolo Sorrentino et al.   JOURNAL OF GASTROENTEROLOGY

Atrial natriuretic peptide and oxidative stress

(2010) Paolo De Vito et al.   PEPTIDES

Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease

(2010) Ariel Feldstein   SEMINARS IN LIVER DISEASE

Oxidative Stress-Mediated Mitochondrial Dysfunction Contributes to Angiotensin II-Induced Nonalcoholic Fatty Liver Disease in Transgenic Ren2 Rats

(2009) Yongzhong Wei et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor α-converting enzyme

(2009) Michikado Iwata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2

(2009) Chandana B. Herath et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin-(1–7), an alternative metabolite of the renin–angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat

(2009) John S. Lubel et al.   CLINICAL SCIENCE

Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice

(2009) Christoph H. Österreicher et al.   HEPATOLOGY

Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver

(2009) Elango Kathirvel et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The angiotensin II type 2 receptor in cardiovascular disease

(2009) Catherine A Lemarié et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Maillard Reaction, mitochondria and oxidative stress: Potential role of antioxidants

(2009) M. Edeas et al.   PATHOLOGIE BIOLOGIE

Regulation of cell proliferation by NADPH oxidase-mediated signaling: Potential roles in tissue repair, regenerative medicine and tissue engineering

(2009) Elsa C. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src-Regulated Redox-Sensitive RhoA Pathways

(2008) A.C. Montezano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cytokines and Renin-Angiotensin System Signaling in Hepatic Fibrosis

(2008) Montserrat Moreno et al.   Clinics in Liver Disease

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

(2008) V. P. Singh et al.   DIABETES

Renin–angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression

(2008) Elena M.V. de Cavanagh et al.   EXPERIMENTAL GERONTOLOGY

Liver disease and the renin-angiotensin system: Recent discoveries and clinical implications

(2008) John S Lubel et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats

(2008) Yongzhong Wei et al.   JOURNAL OF HEPATOLOGY

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY