Review
Medicine, General & Internal
Jeannette Widmer, Janina Eden, Mauricio Flores Carvalho, Philipp Dutkowski, Andrea Schlegel
Summary: The renaissance of dynamic preservation techniques has brought extended criteria donor (ECD) livers back into the transplantable organ pool. However, there is ongoing debate about the advantages and disadvantages of different perfusion strategies and their best applications for specific categories of marginal livers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Eunsung Jang, Su Young Hong, Suk Kyun Hong, Sola Lee, Jeong-Moo Lee, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: This study retrospectively analyzed patients who underwent living donor liver transplantation and compared the incidence of biliary complications between those who underwent external biliary drainage (EBD) and those who did not. The results showed that EBD implementation is effective in preventing biliary leakage after liver transplantation, but caution should be taken to prevent EBD-related complications.
LIVER TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Michel Rayar, Jean-Marie Beaurepaire, Emma Bajeux, Stephanie Hamonic, Thomas Renard, Clara Locher, Veronique Desfourneaux, Aude Merdrignac, Damien Bergeat, Mohamed Lakehal, Laurent Sulpice, Pauline Houssel-Debry, Caroline Jezequel, Christophe Camus, Edouard Bardou-Jacquet, Bernard Meunier
Summary: The use of HOPE in liver transplantation can effectively lower AST and ALT levels, reduce ICU and hospital stay, without increasing the incidence of early allograft dysfunction or affecting graft and patient survival rates. The additional cost of HOPE per patient is estimated, but the overall cost and revenue balance does not significantly differ from the control group. These findings need further validation in a randomized trial.
LIVER TRANSPLANTATION
(2021)
Article
Multidisciplinary Sciences
Julie M. Steinbrink, Cameron Miller, Rachel A. Myers, Scott Sanoff, Anna Mazur, Thomas W. Burke, Jennifer Byrns, Annette M. Jackson, Xunrong Luo, Micah T. McClain
Summary: Renal transplantation from HCV NAAT-positive donors to uninfected recipients increases the organ donation pool but may cause adverse outcomes due to dysregulated immunologic activation. In this study, gene expression patterns in circulating leukocytes were evaluated to understand the immune dysregulation and predict clinical outcomes. HCV infection incited a marked transcriptomic response in renal transplant recipients, reflecting antiviral immune pathways, which resolved after sustained viral response. Differential gene expression was noted in patients with CMV DNAemia or allograft rejection, although accurate predictive classifiers were not developed. Acute HCV infection induces immune activation in the presence of immunosuppression, which resolves after antiviral therapy. Changes in gene expression patterns are associated with clinical outcomes, but larger studies are needed for accurate predictions.
Article
Gastroenterology & Hepatology
Viniyendra Pamecha, Shridhar Vasantrao Sasturkar, Piyush Kumar Sinha, Nihar Mohapatra, Nilesh Patil
Summary: The use of the AKOT technique for biliary reconstruction in adult LDLT significantly reduces the incidence of BCs. Changes such as standardization of surgery, preferential use of the left hepatic artery for right lobe arterial reconstruction, reduction in the number of anastomoses, and the use of AKOT all contribute to the decrease in BCs.
LIVER TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Shengqiao Zhao, Zhixin Zhang, Zhuyuan Si, Chong Dong, Chao Sun, Kai Wang, Wei Zhang, Weiping Zheng, Xinzhe Wei, Wei Gao, Zhongyang Shen
Summary: Biliary stricture (BS) is a significant complication after pediatric living donor liver transplantation (LDLT) for biliary atresia (BA). This study found that longer arterial ischemia time (AIT) was the only independent risk factor for the development of BS. AIT ≥40 minutes increased the 5-year cumulative risk of BS, highlighting the importance of minimizing AIT to reduce BS.
LIVER TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Ian G. Christie, Ernest G. Chan, John P. Ryan, Takashi Harano, Matthew Morrell, James D. Luketich, Pablo G. Sanchez
Summary: This study examined trends in the use of extended criteria donor lungs for lung transplantation and found that the use of extended criteria lungs has increased over time. However, the use of extended criteria donor lungs did not compromise recipient survival outcomes, with both ECD and standard criteria organs showing similar 1-year survival rates.
ANNALS OF THORACIC SURGERY
(2021)
Article
Surgery
Peri Husen, Catherine Boffa, Ina Jochmans, Christina Krikke, Lucy Davies, Laura Mazilescu, Aukje Brat, Simon Knight, Daniel Wettstein, Orsolya Cseprekal, Neal Banga, Maria Irene Bellini, Laszlo Szabo, Elijah Ablorsu, Tom Darius, Isabel Quiroga, Michel Mourad, Johann Pratschke, Vassilios Papalois, Zoltan Mathe, Henri G. D. Leuvenink, Thomas Minor, Jacques Pirenne, Rutger J. Ploeg, Andreas Paul
Summary: In this randomized clinical trial, preimplantation short-term reconditioning of kidney grafts using oxygenated hypothermic machine perfusion did not lead to an improvement in 1-year graft survival compared to kidneys that underwent static cold storage alone, suggesting that this approach is not beneficial in kidneys retrieved from expanded criteria donors.
Article
Gastroenterology & Hepatology
Jordyn Silverstein, Francis Y. Yao, Joshua D. Grab, Hillary J. Braun, John Roberts, Jennifer L. Dodge, Neil Mehta
Summary: Living donor liver transplantation (LDLT) is an attractive option for hepatocellular carcinoma (HCC) patients, but its utilization has remained low in recent years. LDLT is an underutilized but valuable option for high-risk patients at risk of waitlist dropout.
LIVER TRANSPLANTATION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ismail Vokshi, Stephen Large, Marius Berman, Steven Tsui
Summary: This article reports a successful heart transplantation from a high-risk DCD donor, in which the donor heart was reconditioned using thoraco-abdominal normothermic regional perfusion. The recipient required brief mechanical circulatory support post-transplant but eventually made a good recovery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Zhitao Chen, Xitao Hong, Shanzhou Huang, Tielong Wang, Yihao Ma, Yiwen Guo, Changjun Huang, Qiang Zhao, Zhiyong Guo, Xiaoshun He, Weiqiang Ju, Maogen Chen
Summary: The technique of continuous normothermic machine perfusion without recooling in liver transplantation with extended criteria donor livers was found to be effective and safe in two cases, with no early allograft dysfunction or primary graft non-function observed. Further research is needed to confirm these promising results.
FRONTIERS IN SURGERY
(2021)
Article
Gastroenterology & Hepatology
Christoph Schultheiss, Silja Steinmann, Edith Willscher, Lisa Paschold, Ansgar W. Lohse, Mascha Binder
Summary: This study found that variant syndromes of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) share some immunological characteristics. Discriminative markers between AIH and PBC included T and B cell receptor repertoires, as well as soluble immune checkpoint molecules such as sCD25, sLAG-3, sCD86, and sTim-3. Another set of immune factors associated with AIH included TNF, IFN gamma, IL12p70, sCTLA-4, sPD-1, and sPD-L1. Clustering analysis revealed two pathological immunotypes consisting predominantly of either AIH or PBC cases. Overall, variant syndromes may represent an immunological spectrum from PBC to AIH-like disease rather than separate entities.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Surgery
Zoltan Czigany, Johann Pratschke, Jiri Fronek, Markus Guba, Wenzel Schoening, Dimitri Aristotle Raptis, Joachim Andrassy, Matthijs Kramer, Pavel Strnad, Rene Hany Tolba, Wenjia Liu, Theresa Keller, Hannah Miller, Sandra Pavicevic, Deniz Uluk, Matej Kocik, Isabella Lurje, Christian Trautwein, Arianeb Mehrabi, Irinel Popescu, Florian Wolfgang Rudolf Vondran, Cynthia Ju, Frank Tacke, Ulf Peter Neumann, Georg Lurje
Summary: This study demonstrates that HOPE significantly reduces early allograft injury and improves post-transplant outcomes in ECD-DBD liver transplantation compared to SCS.
Article
Medicine, General & Internal
Yuhong Zhang, Zhijun Zhu
Summary: This study aimed to explore the effect of the short Roux limb and standard limb on pediatric living donor liver transplantation (LDLT) biliary reconstruction. The study concluded that there was no significant difference in postoperative biliary complications between the short limb and the routine limb in children with LDLT.
Article
Surgery
Vladimir J. Lozanovski, Pascal Probst, Ali Ramouz, Alireza Arefidoust, Omid Ghamarnejad, Ehsan Aminizadeh, Elias Khajeh, Arianeb Mehrabi
Summary: The study found that extended right lobe liver transplantation (ERLT) had lower graft survival rates at 3 months, 1 year, and 3 years compared to whole liver transplantation (WLT), while WLT was less associated with retransplantation, vascular complications, and biliary complications.
TRANSPLANT INTERNATIONAL
(2021)
Editorial Material
Gastroenterology & Hepatology
Bas Groot Koerkamp, Pierre-Alain Clavien, Wojciech G. Polak
JOURNAL OF HEPATOLOGY
(2023)
Review
Surgery
Anne-Marleen van Keulen, Stefan Buttner, Joris I. Erdmann, Jeroen Hagendoorn, Frederik J. H. Hoogwater, Jan N. M. IJzermans, Ulf P. Neumann, Wojciech G. Polak, Jeroen De Jonge, Pim B. Olthof, Bas Groot Koerkamp
Summary: A systematic review and meta-analysis revealed that the risk of major complications and mortality after resection of intrahepatic cholangiocarcinoma was assessed. The study found that in-hospital, 30-day, and 90-day mortality rates were 5.9%, 4.6%, and 6.1% respectively, while the proportion of major complications was 22.2%.
Article
Gastroenterology & Hepatology
David M. de Jong, Sanne van de Vondervoort, Roy S. Dwarkasing, Michael Doukas, Rogier P. Voermans, Robert C. Verdonk, Wojciech G. Polak, Jeroen de Jonge, Bas Groot Koerkamp, Marco J. Bruno, Lydi M. J. W. van Driel
Summary: This study investigates the added value of preoperative endoscopic ultrasound (EUS) with or without tissue acquisition (TA) for the detection of MLNs in patients with resectable pCCA. The results show that EUS-TA can effectively detect MLNs and prevent unnecessary surgeries.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Gastroenterology & Hepatology
Takuya Minagawa, Osamu Itano, Shinichiro Hasegawa, Hiroshi Wada, Yuta Abe, Minoru Kitago, Yoshiteru Katsura, Yutaka Takeda, Tomohiko Adachi, Susumu Eguchi, Go Oshima, Satoshi Aiko, Yusuke Ome, Toshiki Kobayashi, Kazuki Hashida, Satoshi Nara, Minoru Esaki, Jota Watanabe, Hiromi Ohtani, Yutaka Endo, Takashi Shirobe, Yukio Tokumitsu, Hiroaki Nagano
Summary: This study evaluated the surgical and oncological outcomes of laparoscopic procedures for suspected gallbladder carcinoma. The data of 129 patients with suspected GBC who underwent laparoscopic radical cholecystectomy before 2020 in Japan were analyzed. The results showed that laparoscopic radical cholecystectomy has favorable outcomes in selected patients with suspected GBC.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Pediatrics
Taiichiro Kosaka, Akihiko Soyama, Takuro Fujita, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Tomohiko Adachi, Masaaki Hidaka, Susumu Eguchi
Summary: This study reports the first case of a pediatric patient undergoing a hybrid procedure for living donor liver transplantation. The surgery was successful and the patient achieved a rapid recovery, with normal liver function and restored secondary sexual characteristics.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Bastian N. Ruijter, Akin Inderson, Aad P. van den Berg, Herold J. Metselaar, Jeroen Dubbeld, Maarten E. Tushuizen, Robert J. Porte, Wojciech Polak, Danny van der Helm, Marjolein van Reeven, Mar Rodriguez-Girondo, Bart van Hoek
Summary: This study compared the efficacy of cyclosporine and tacrolimus after liver transplantation, and found that tacrolimus (T0) had a lower incidence of acute rejection, higher patient and graft survival rates, and similar tolerability and safety compared to cyclosporine (C2). Therefore, tacrolimus might be a better choice after liver transplantation.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yusuke Takemura, Masahiro Shinoda, Yasushi Hasegawa, Yohei Yamada, Hideaki Obara, Minoru Kitago, Mureo Kasahara, Koji Umeshita, Susumu Eguchi, Yuko Kitagawa, Hideki Ohdan, Hiroto Egawa
Summary: This study investigated liver allografts from brain-dead donors that were declined and not transplanted due to various marginal factors in Japan. The results showed that pathological abnormalities of steatosis and fibrosis were the most common factors leading to transplant rejection. Although allografts with moderate steatosis were highly declined, they achieved promising outcomes after transplantation.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Yoshiki Kajiwara, Arata Takahashi, Hideki Ueno, Yoshihiro Kakeji, Hiroshi Hasegawa, Susumu Eguchi, Takanori Goi, Akio Saiura, Akira Sasaki, Shuji Takiguchi, Hiroya Takeuchi, Chie Tanaka, Masaji Hashimoto, Naoki Hiki, Akihiko Horiguchi, Satoru Matsuda, Tsunekazu Mizushima, Shigeru Marubashi, Mitsukazu Gotoh, Hiroyuki Konno, Hiroyuki Yamamoto, Hiroaki Miyata, Yasuyuki Seto, Yuko Kitagawa
Summary: This study summarizes the data of gastroenterological surgery in the National Clinical Database (NCD) of Japan from 2011 to 2020. It found that the number of surgeries has been increasing in the past decade, except for a decrease in 2020 due to the COVID-19 pandemic. The average age of surgical patients is steadily increasing, with more than 20% of patients aged 80 years or older. Overall, Japanese gastroenterological surgeries have shown good safety.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Hidefumi Shiroshita, Hideki Endo, Masafumi Inomata, Tomonori Akagi, Hiroyuki Yamamoto, Shigeki Yamaguchi, Susumu Eguchi, Norihito Wada, Yukinori Kurokawa, Yosuke Seki, Yoshiharu Sakai, Hiroaki Miyata, Yoshihiro Kakeji, Yuko Kitagawa, Akinobu Taketomi, Masaki Mori
Summary: This study evaluated the impact of COVID-19 on elective endoscopic surgeries in Japan. The number of surgeries, including laparoscopic cholecystectomy, laparoscopic distal gastrectomy, and laparoscopic low anterior resection, decreased in 2020 compared to previous years. Although the use of robot-assisted surgeries increased, the growth rate was lower than in 2019. The infection rate in different prefectures did not significantly affect the surgery numbers. The surgeries decreased from May to June but gradually recovered.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Surgery
Frederik J. H. Hoogwater, Hendrien Kuipers, Vincent E. de Meijer, Charlotte Maulat, Fabrice Muscari, Wojciech G. Polak, Bart van Hoek, Caroline Jezequel, Ian P. J. Alwayn, Jan N. M. Ijzermans, Kayvan Mohkam, Jean-Yves Mabrut, Frederike G. Van Vilsteren, Jean-Philippe Adam, Laurence Chiche, Alexandre Chebaro, Emmanuel Boleslawski, Jeroen Dubbeld, Sarwa Darwish Murad, Michel Rayar, Robert J. Porte
Summary: This study compared outcomes after liver transplantation for perihilar cholangiocarcinoma using strict selection criteria, with or without neoadjuvant chemoradiotherapy. The results showed that patients who received neoadjuvant chemoradiotherapy had lower post-transplant survival rates but lower tumor recurrence rates. Adjustments in neoadjuvant chemoradiotherapy may improve outcomes in these patients. Rating: 7 out of 10.
Article
Surgery
Sarah Bouari, Wojciech G. Polak, Jacqueline van de Wetering, Herold J. Metselaar, Jan N. M. IJzermans, Robert C. Minnee
Summary: This article presents a rare case of combined liver-kidney transplantation, highlighting the importance of considering the differences in peri-and postoperative care for liver and kidney transplant recipients. The delayed kidney transplantation in this case resulted in a successful recovery for the patient.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Gastroenterology & Hepatology
Hajime Matsushima, Akihiko Soyama, Takanobu Hara, Yasuhiro Maruya, Takuro Fujita, Hajime Imamura, Tomohiko Adachi, Masaaki Hidaka, Susumu Eguchi
Summary: This study retrospectively analyzed 280 cases of adult living donor liver transplantation (LDLT) and found that a graft-to-recipient weight ratio (GRWR) of less than 0.6% was associated with an increased risk of small-for-size syndrome (SFSS). Although overall graft survival rates were similar, appropriate donor and recipient selection is crucial for successful LDLT with very small grafts.
LIVER TRANSPLANTATION
(2023)
Article
Immunology
Varvara A. Kirchner, Sadhana Shankar, David W. Victor, Tomohiro Tanaka, Nicolas Goldaracena, Roberto I. Troisi, Kim M. Olthoff, Jong Man Kim, Elizabeth A. Pomfret, Nigel Heaton, Wojtek G. Polak, Akash Shukla, Ravi Mohanka, Deniz Balci, Mark Ghobrial, Subash Gupta, Daniel Maluf, John J. Fung, Susumu Eguchi, John Roberts, Bijan Eghtesad, Markus Selzner, Raj Prasad, Mureo Kasahara, Hiroto Egawa, Jan Lerut, Dieter Broering, Marina Berenguer, Mark S. Cattral, Pierre-Alain Clavien, Chao-Long Chen, Samir R. Shah, Zhi-Jun Zhu, Nancy Ascher, Toru Ikegami, Prashant Bhangui, Ashwin Rammohan, Jean C. Emond, Mohamed Rela
Summary: Small-for-size syndrome (SFSS) following living donor liver transplantation is a serious complication that may result in poor graft function and graft loss. Portal hyperperfusion of a small graft and hyperdynamic splanchnic circulation are the main causes of this syndrome. The initial treatment focuses on pharmacological therapy and supportive care, while interventional radiology and/or surgery may be considered if medical management fails. Retransplantation should be considered if postoperative laboratory parameters are abnormal.
Article
Gastroenterology & Hepatology
Gautam Mehta, Antonio Riva, Maria Pilar Ballester, Eva Uson, Montserrat Pujadas, Angela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Vigano, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Annelotte Broekhoven, Marjolein Kikkert, Shessy P. Torres Morales, Sebenzile K. Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Desamparados Escudero-Garcia, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara di Benedetto, Yolanda Sanchez-Torrijos, Ana Lucena-Varela, Eva Roman, Elisabet Sanchez, Ruben Sanchez-Aldehuelo, Julia Lopez-Cardona, Itzel Canas-Perez, Christine Eastgate, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Diaz, Antonio Madejon, Helena Degroote, Javier Fernandez, Marko Korenjak, Xavier Verhelst, Javier Garcia-Samaniego, Raul J. Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C. Patel, Amir Gander, Agustin Albillos, German Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G. Polak, Massimo Puoti, Anna Bosch-Comas, Luca Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, Jose Luis Calleja, Giovanni Perricone, Marina Berenguer, Joan Claria, Richard Moreau, Vicente Arroyo, Paolo Angeli, Cristina Sanchez, Javier Ampuero, Salvatore Piano, Shilpa Chokshi, Rajiv Jalan
Summary: This study aimed to measure humoral responses to COVID-19 vaccine among liver patients and determine the factors predicting breakthrough infection. The results showed that liver transplant patients had the lowest response to the vaccine, while reduced response in cirrhosis patients was associated with age, stage of liver disease, and systemic inflammation.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Surgery
Paolo Angelo Cortesi, Raffaella Vigano, Sara Conti, Ilaria Lenci, Riccardo Volpes, Silvia Martini, Mario Angelico, James Fung, Maria Buti, Audrey Coilly, Francois Durand, Constantino Fondevila, Pascal Lebray, Frederik Nevens, Wojciech G. Polak, Mario Rizzetto, Fabien Zoulim, Giovanni Perricone, Marina Berenguer, Lorenzo Giovanni Mantovani, Christophe Duvoux, Luca Saverio Belli
Summary: The European Liver and Intestine Transplant Association (ELITA) held a Consensus Conference involving experts worldwide to update guidelines on HBV prophylaxis in liver transplant candidates and recipients. A simulation model was developed to compare the economic impact of implementing the new ELITA guidelines. The model showed that the guidelines could save around euro 235.65 million after 5 years and euro 540.73 million after 10 years. These savings could be used to allocate resources to different needs.
TRANSPLANT INTERNATIONAL
(2023)
