Article
Cardiac & Cardiovascular Systems
Baruch Vainshelboim, Khin Chan, Zhongming Chen, Jonathan Myers
Summary: This study found that higher cardiorespiratory fitness is independently associated with lower risk of cancer mortality and extended survival time in men with cardiovascular disease, although it is not associated with cancer incidence. Improving cardiorespiratory fitness through supervised exercise rehabilitation programs could serve as a cost-effective public-health strategy for secondary prevention and survivorship in men with cardiovascular disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Serge C. Harb, Paul C. Cremer, Yuping Wu, Bo Xu, Leslie Cho, Venu Menon, Wael A. Jaber
Summary: Estimating patients' age based on exercise stress testing performance (A-BEST) is a better predictor of mortality compared to chronological age. Higher exercise capacity and chronotropic reserve index are associated with improved survival, while abnormal heart rate recovery and higher A-BEST are associated with higher mortality. Prediction models using A-BEST show significantly higher accuracy and improvement in predicting mortality compared to chronological age.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Physiology
J. Alberto Neder, Devin B. Phillips, Mathieu Marillier, Anne-Catherine Bernard, Danilo C. Berton, Denis E. O'Donnell
Summary: Interpretation of CPET has limitations that should be recognized, with a focus on identifying dysfunction based on variable clusters, avoiding prolixity and redundancy in graphical data display, and understanding the relationship between submaximal dyspnea ratings, work rate and ventilatory demand. Additionally, measuring dynamic inspiratory capacity is crucial in uncovering abnormalities related to exertional dyspnea.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Pablo Jimenez-Martinez, Carlos Alix-Fages, Danica Janicijevic, Sergio Miras-Moreno, Sara Chacon-Ventura, Juan J. Martin-Olmedo, Juan Carlos de la Cruz-Marquez, Francisco J. Osuna-Prieto, Lucas Jurado-Fasoli, Francisco J. Amaro-Gahete, Amador Garcia-Ramos, Juan C. Colado
Summary: This study assessed the effects of phenylcapsaicin (PC) on aerobic capacity, substrate oxidation, energy metabolism, and exercise physiological variables in young males. The results showed that PC can increase aerobic capacity through the improvement of fat oxidation, maximum heart rate, and perceptual responses during exercise.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Multidisciplinary Sciences
Martin Ackah, Mohammed Gazali Salifu, Cynthia Osei Yeboah
Summary: Studies from Sub-Saharan Africa have found that the incidence of Traumatic Brain Injury in children aged 0-18 years is 18%, with a case fatality rate of approximately 8%. The major causes of TBI in this population were Road Traffic Accidents and falls.
Article
Medicine, General & Internal
Fernanda Maria Vendrusculo, Gabriela Sabino Bueno, Mailise Fatima Gheller, Natalia Evangelista Campos, Daniele Schiwe, Ingrid Silveira de Almeida, Nicolas Acosta Becker, Joao Paulo Heinzmann-Filho, Marcio Vinicius Fagundes Donadio
Summary: This study found that peripheral muscle strength in patients with cystic fibrosis is associated with aerobic fitness and the use of antibiotics. Biceps strength was positively correlated with VO(2)peak, while quadriceps and hamstrings strength were negatively correlated with antibiotic use.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Antonella Bianco, Francesco Russo, Isabella Franco, Giuseppe Riezzo, Rossella Donghia, Ritanna Curci, Caterina Bonfiglio, Laura Prospero, Benedetta D'Attoma, Antonia Ignazzi, Angelo Campanella, Alberto Ruben Osella
Summary: Moderate-intensity aerobic exercise improves gastrointestinal health and alleviates irritable bowel syndrome symptoms, while also enhancing physical capacity. Monitoring physical capacity levels in IBS patients can provide insights into the effectiveness of exercise on symptom severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Ori Hochwald, Lea Bentur, Yara Haddad, Moneera Hanna, Merav Zucker-Toledano, Gur Mainzer, Julie Haddad, Michal Gur, Liron Borenstein-Levin, Amir Kugelman, Ronen Bar-Yoseph
Summary: This study found that exercise capacity is lower in late preterm children compared to term children, but within the normal range, and comparable to that of early preterm children, with and without bronchopulmonary dysplasia (BPD). Lung function is only lower than normal in early preterm children.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Surgery
Gozde In, Halit Eren Taskin, Muzaffer Al, Hasan Kerem Alptekin, Kagan Zengin, Volkan Yumuk, Baris Ikitimur
Summary: This pilot study compared the effects of two post-bariatric surgery home-based exercise programs, finding that patients who underwent aerobic exercise combined with progressive resistance conditioning achieved greater weight loss, functional capacity, muscle mass, and upper-body strength compared to those who only did aerobic exercise.
Article
Physiology
Ji He, Jiayu Fu, Wei Zhao, Chuan Ren, Ping Liu, Lu Chen, Dan Li, Lequn Zhou, Lu Tang, Xiangyi Liu, Shan Ye, Xiaolu Liu, Yan Ma, Yixuan Zhang, Xinran Ma, Linjing Zhang, Gaoqi Zhang, Nan Li, Dongsheng Fan
Summary: This study evaluated the clinical value of cardiopulmonary exercise testing (CPET) in amyotrophic lateral sclerosis (ALS). The results showed that ALS patients had significantly decreased exercise capacity, and the peak oxygen consumption (VO2 peak) and peak heart rate (HR peak) were closely correlated with disease severity and predicted a worse prognosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Devin B. Phillips, Matthew D. James, Conor D. O'Donnell, Sandra G. Vincent, Katherine A. Webb, Juan P. de-Torres, J. Alberto Neder, Denis E. O'Donnell
Summary: Low resting inspiratory capacity (IC) is closely associated with exertional dyspnea, exercise limitation, and poor survival in COPD. Meanwhile, maximal inspiratory pressure (MIP) has no significant impact on these variables. Resting IC is a stronger predictor of peak oxygen uptake (VO2peak) compared to MIP. Low resting IC remains independently associated with worse survival in COPD after accounting for airway obstruction, inspiratory muscle strength, and diffusing capacity.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Elizabeth Granier, Madaniah O. Zakari, Musaad B. Alsahly, Lauren G. Koch, Steven Britton, Laxmansa C. Katwa, Robert M. Lust
Summary: The study found that low capacity running (LCR) rats have an increased risk of ischemic injury and exhibit a delayed and less effective adaptive response to ischemic stress. LCR showed significantly reduced exhaustion time, more severe immediate decrease in blood flow, lower gene expression levels, and decreased capillary density compared to high capacity running (HCR) rats in response to ischemia. The results suggest that intrinsic exercise capacity plays a significant role in vascular adaptive responses to hind limb ischemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Mon-Chien Lee, Yi-Ju Hsu, Hsin-Ching Sung, Ya-Ting Wen, Li Wei, Chi-Chang Huang
Summary: Women during pregnancy and the postpartum period, especially those with excessive caloric intake, have a higher risk of obesity and metabolic diseases. This study found that mice with low-fitness phenotype were more likely to develop metabolic abnormalities and obesity after dietary induction following delivery, while mice with high-fitness phenotype had a protective mechanism.
Article
Medicine, General & Internal
Daniel J. Mcdonough, Mahesh Mathew, Zachary C. Pope, Pamela J. Schreiner, David R. Jacobs Jr, Lisa B. Vanwagner, John Jeffrey Carr, James G. Terry, Kelley Pettee Gabriel, Jared P. Reis, Mark A. Pereira
Summary: This study examined the association between lifestyle factors and NAFLD and found that regular moderate-vigorous aerobic and muscle-strengthening activities, along with reduced television viewing time, significantly reduce the risk of NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Goncalo Mendonca, Ines Santos, Bo Fernhall, Tracy Baynard
Summary: This study developed prediction models for peak absolute oxygen uptake and peak heart rate in individuals with and without Down syndrome (DS), using retrospective data. Results showed that it is possible to estimate absolute peak oxygen uptake and peak heart rate in individuals with DS using nonexercise variables, but caution is advised when using these equations for individual estimations.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Mikael Dellborg, Zacharias Mandalenakis
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Silvana Kontogeorgos, Erik Thunstrom, Carmen Basic, Per-Olof Hansson, You Zhong, Constantinos Ergatoudes, David Morales, Zacharias Mandalenakis, Annika Rosengren, Kenneth Caidahl, Michael Fu
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Anna Bjork, Zacharias Mandalenakis, Kok Wai Giang, Annika Rosengren, Peter Eriksson, Mikael Dellborg
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Gustaf Lernfelt, Zacharias Mandalenakis, Bjorn Hornestam, Bodil Lernfelt, Annika Rosengren, Valter Sundh, Per-Olof Hansson
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Pigi Dikaiou, Lena Bjorck, Martin Adiels, Christina E. Lundberg, Zacharias Mandalenakis, Karin Manhem, Annika Rosengren
Summary: This study found a significant association between body mass index in young women and the risk for early cardiovascular disease and mortality, with overweight and obese women showing a markedly increased risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Neurosciences
Alexia Karagianni, Zacharias Mandalenakis, Mikael Dellborg, Naqibullah Mirzada, Magnus Carl Johansson, Peter Eriksson
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Medicine, General & Internal
Xiaojing Chen, Salim Bary Barywani, Per-Olof Hansson, Annika Rosengren, Erik Thunstrom, You Zhong, Constantinos Ergatoudes, Zacharias Mandalenakis, Kenneth Caidahl, Michael Fu
Article
Cardiac & Cardiovascular Systems
Kristofer Skoglund, Joel Heimdahl, Zacharias Mandalenakis, Ulf Thilen, Bengt Johansson, Christina Christersson, Peder Sorensson, Mikael Dellborg
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Xiaotong Cui, Zacharias Mandalenakis, Erik Thunstrom, Michael Fu, Kurt Svardsudd, Per-Olof Hansson
Summary: In this study involving middle-aged male cohort, it was found that an RHR of 60-70 bpm was associated with the lowest cardiovascular mortality. Time-updated RHR could potentially serve as a useful long-term prognostic index in the general population.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Fedchenko, Zacharias Mandalenakis, Kok Wai Giang, Annika Rosengren, Peter Eriksson, Mikael Dellborg
Summary: Patients with congenital heart disease have a higher risk of myocardial infarction compared to controls, and also a higher risk of developing new-onset heart failure, recurrent MI, or death after the index MI. Proper management of modifiable cardiovascular risk factors is crucial in reducing morbidity and mortality in these patients.
EUROPEAN HEART JOURNAL
(2021)
Article
Immunology
Ulrika Snygg-Martin, Kok Wai Giang, Mikael Dellborg, Josefina Robertson, Zacharias Mandalenakis
Summary: Patients with congenital heart disease have a higher cumulative incidence of infective endocarditis compared to controls, and this incidence increases with age. The incidence of infective endocarditis varies by age but not by birth year.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Kok Wai Giang, Maria Fedchenko, Mikael Dellborg, Peter Eriksson, Zacharias Mandalenakis
Summary: Patients with congenital heart disease have a 5-fold higher risk of developing index ischemic stroke compared with controls, but they have a 34% lower risk of recurrent stroke and a 47% lower risk of all-cause mortality after index stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mikael Dellborg, Kok Wai Giang, Peter Eriksson, Hans Liden, Maria Fedchenko, Anders Ahnfelt, Annika Rosengren, Zacharias Mandalenakis
Summary: In recent decades, the survival rate of children with congenital heart disease (CHD) has greatly increased. However, this study found that adult survivors with CHD have a higher risk of mortality compared to the general population, although at least 75% of patients can live past middle age and become sexagenerians.
Letter
Cardiac & Cardiovascular Systems
Niklas Bergh, Kristofer Skoglund, Maria Fedchenko, Entela Bollano, Peter Eriksson, Mikael Dellborg, Kok Wai Giang, Zacharias Mandalenakis
Article
Cardiac & Cardiovascular Systems
Filip Eckerstrom, Peter Eriksson, Mikael Dellborg, Georgios Lappas, Annika Rosengren, Vibeke Elisabeth Hjortdal, Zacharias Mandalenakis
Summary: The overall all-cause mortality for patients with EA declined dramatically from 64 times to 20 times that of controls without EA, from the 1970s to the early 1990s. Unoperated patients with EA had better survival than did operated patients, possibly reflecting the higher severity of disease or more severe associated cardiac defects in patients undergoing surgery.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2021)