Article
Physiology
Yujie Liu, Yuncan Xia, Tian Yue, Fengya Li, Aiyi Zhou, Xiaoxiao Zhou, Yibing Yao, Yihong Zhang, Yan Wang
Summary: This study investigated the effects of 4 weeks of high-intensity interval training (HIIT) on physical fitness and oxygen uptake kinetics of individuals with different physical activity backgrounds. The results showed that HIIT improved fitness and oxygen uptake kinetics, with peripheral adaptations contributing to the improvements. The training effects were similar between groups, indicating that HIIT is effective for reaching higher fitness levels.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Cell Biology
Martin J. Gibala, Martin J. MacInnis
Summary: Brief, intense interval training improves V_O2max through various physiological changes, including increased maximal cardiac output and blood volume, as well as changes in capillary and mitochondrial density. However, the specific mechanisms underlying these improvements are still unclear and require further investigation using contemporary technologies.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Physiology
Tiago Andre Freire Almeida, Dalton Muller Pessoa Filho, Mario Cunha Espada, Joana Filipa Reis, Andrei Sancassani, Danilo Alexandre Massini, Fernando Jorge Santos, Francisco Besone Alves
Summary: This study compared the effects of 100- and 200-m interval training in swimming on temporal, perceptual, and physiological responses. The results showed that there were no significant differences in oxygen uptake, blood lactate, and perceived exertion between the two protocols. Both protocols were effective for aerobic power enhancement, but swimmers perceived the 100-m interval training as less difficult than the 200-m training.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Miguel Alvarez Villela, Sophia A. A. Dunworth, Bryan D. D. Kraft, Nicole P. P. Harlan, Michael J. J. Natoli, Hagir B. B. Suliman, Richard E. E. Moon
Summary: The study aimed to investigate the effects of hyperbaric oxygen in combination with high-intensity interval training on aerobic capacity and mitochondrial biogenesis. Results showed that HBO2 did not significantly enhance aerobic capacity, but displayed potential effects on glucose utilization and mitochondrial biogenesis when combined with HIIT.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takashi Yamada, Iori Kimura, Yuki Ashida, Katsuyuki Tamai, Hiroyori Fusagawa, Noritsugu Tohse, Hakan Westerblad, Daniel C. Andersson, Tatsuya Sato
Summary: Interval training with high-intensity contractions improves fatigue resistance in skeletal muscle by increasing mitochondrial function, specifically through increased expression of mitochondrial respiratory chain complexes.
Article
Multidisciplinary Sciences
Johannes Laessing, Tom Maudrich, Rouven Kenville, Zarah Uyar, Christian Bischoff, Sven Fikenzer, Martin Busse, Roberto Falz
Summary: This study examined acute cardiopulmonary responses in strength training. The results showed that at 75% of the 3-RM intensity, heart rate and cardiac output were higher compared to other intensities. During the post-exercise period, there were significant differences in respiratory parameters. The findings suggest that strength training intensity affects cardiopulmonary responses and post-exercise recovery effects.
SCIENTIFIC REPORTS
(2023)
Article
Sport Sciences
Patcharin Tangchaisuriya, Napasakorn Chuensiri, Hirofumi Tanaka, Daroonwan Suksom
Summary: This study investigated the effects of combining HIIT and BFR training on masters road cyclists. The results showed that adding HIIT and BFR to continuous training may be more effective in enhancing performance and physiological functions in masters road cyclists.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Physiology
Jessica Maria Norrbom, Mia Ydfors, Alen Lovric, Christopher G. R. Perry, Helene Rundqvist, Eric Rullman
Summary: High-intensity interval training induces profound metabolic adaptations in skeletal muscle, with a nonlinear pattern of performance improvements. This study found that the attenuation of acute exercise response is pathway-specific and driven by changes in steady-state expression and specific transcriptional regulation over time. The targeted regulation of specific pathways suggests a modulation of muscular adaptation after a period of training.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Norita Gildea, Adam McDermott, Joel Rocha, Donal O'Shea, Simon Green, Mikel Egana
Summary: This study compared the effects of low-volume high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on oxygen uptake and muscle deoxygenation kinetics in patients with type 2 diabetes. The results showed that both training methods improved oxygen uptake kinetics, but had no significant effect on muscle deoxygenation kinetics.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Victoria L. Wyckelsma, Ada Trepci, Lilly Schwieler, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Henrikas Paulauskas, Helena Gapeyeva, Mati Paasuke, Stefano Gastaldello, Sophie Imbeault, Hakan Westerblad, Sophie Erhardt, Daniel C. Andersson
Summary: In elderly men, three weeks of sprint interval training shifted KP metabolism towards neuroprotection, but this shift was blocked by antioxidant treatment.
Article
Veterinary Sciences
Kazutaka Mukai, Hajime Ohmura, Yuji Takahashi, Yusaku Ebisuda, Koki Yoneda, Hirofumi Miyata
Summary: The study found that high-intensity interval exercise and sprint interval exercise cause more severe arterial hypoxemia and lactic acidosis compared to moderate-intensity continuous exercise.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biology
Morten Hostrup, Anders Krogh Lemminger, Ben Stocks, Alba Gonzalez-Franquesa, Jeppe Kjaergaard Larsen, Julia Prats Quesada, Martin Thomassen, Brian Tate Weinert, Jens Bangsbo, Atul Shahaji Deshmukh, David E. James
Summary: Exercise is effective in preventing and treating metabolic diseases. High-intensity interval training (HIIT) can induce changes in the proteome and acetylome of human skeletal muscle, leading to metabolic adaptations. Furthermore, HIIT increases the acetylation of mitochondrial proteins.
Article
Nutrition & Dietetics
James B. Tincknell, Benjamin A. Kugler, Haley Spicuzza, Nicolas Berger, Huimin Yan, Tongjian You, Kai Zou
Summary: The study aimed to examine the effects of high-intensity interval training (HIIT) on skeletal muscle mitochondrial quality control and glucose homeostasis in diet-induced obese mice. The results showed that 10 weeks of HIIT improved mitochondrial respiration and regulatory protein machinery of mitochondrial quality control, and enhanced autophagy regulation.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Amane Hori, Ryuji Saito, Kenichi Suijo, Michael R. Kushnick, Daisuke Hasegawa, Koji Ishida, Norio Hotta
Summary: This study aimed to investigate whether blood flow restriction (BFR) during moderate-intensity aerobic training can accelerate the adaptation of the time constant (tau) of phase II oxygen uptake (<(V) over dot>O-2) kinetics in the moderate-intensity exercise domain. The results showed that tau significantly decreased in the BFR group at the mid-point of training, while the CON group showed a decrease at the end of training. The BFR group had significantly lower tau than the CON group at the mid-point, but there was no significant difference between the two groups at the end of training.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Yoshinao Kobayashi, Akiko Eguchi, Yasuyuki Tamai, Sanae Fukuda, Mina Tempaku, Kiyora Izuoka, Motoh Iwasa, Yoshiyuki Takei, Kenji Togashi
Summary: The study found that a short duration of high-intensity interval training (HIIT) can immediately change the circulating extracellular vesicles (EV) composition, indicating that EVs may rapidly communicate and transfer information across various organs in response to HIIT.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nynke H. Kooistra, Valent M. P. Intan-Goey, Francesca Ziviello, Geert E. Leenders, Adriaan O. Kraaijeveld, Pieter A. Doevendans, Nicolas M. Van Mieghem, Michiel Voskuil, Pieter R. Stella
Summary: The study compared the outcomes of patients undergoing transfemoral TAVI with ACURATE neo and Sapien 3 valves, finding that both devices showed comparable device success and clinical safety outcomes. Over a follow-up period of up to 6 months, the clinical outcomes and mortality rate remained excellent for both groups. The NEO group demonstrated a lower mean aortic gradient.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, Research & Experimental
Marijn C. Peters, Sofia Di Martino, Thomas Boelens, Jiabin Qin, Alain van Mil, Pieter A. Doevendans, Steven A. J. Chamuleau, Joost P. G. Sluijter, Klaus Neef
Summary: This study investigates the effects of FSTL1 on human iPSC-CM proliferation in a human cardiac in vitro hypoxia damage model. The study also explores the intercellular communication between different cardiac cell types under hypoxic conditions.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Medicine, General & Internal
Mochamad Yusuf Alsagaff, Louisa Fadjri Kusuma Wardhani, Iswanto Pratanu, Dian Paramita Kartikasari, Pieter A. Doevendans
Summary: A rise and/or fall in troponin level indicates myocardial infarction. Our retrospective review found that the presence of an "N-wave" pattern on the ECG during a non-diagnostic examination can suggest total occlusion in high-risk non-ST-segment myocardial infarction patients.
OXFORD MEDICAL CASE REPORTS
(2022)
Article
Medicine, General & Internal
Michelle Simons, Marijn H. A. Groen, Gert J. de Borst, Tim Leiner, Pieter A. F. Doevendans, Emad Ebbini, Fons J. B. Slieker, Rene van Es, Constantijn E. V. B. Hazenberg
Summary: This study protocol describes an investigation into a new non-invasive technique for treating atherosclerosis in the femoral artery using robot-assisted high-intensity focused ultrasound (HIFU). The study aims to assess the safety and feasibility of this therapy and evaluate its potential to improve long-term patency in patients with peripheral arterial disease.
Article
Cardiac & Cardiovascular Systems
Marijn H. A. Groen, Vincent J. H. M. van Driel, Kars Neven, Harry van Wessel, Jacques M. T. de Bakker, Pieter A. F. Doevendans, Fred H. M. Wittkampf, Peter Loh, Rene van Es
Summary: The multielectrode impedance system (MEIS) shows promise in predicting long-term success of electrical pulmonary vein (PV) isolation. Both the preclinical study and clinical experience support the effectiveness of MEIS in guiding the ablation procedure.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Y. Appelman, P. Doevendans
NETHERLANDS HEART JOURNAL
(2022)
Article
Cell & Tissue Engineering
Marijn C. Peters, Renee G. C. Maas, Iris van Adrichem, Pieter A. M. Doevendans, Mark Mercola, Tomo Saric, Jan W. Buikema, Alain van Mil, Steven A. J. Chamuleau, Joost P. G. Sluijter, Anna P. Hnatiuk, Klaus Neef
Summary: Developing new cardioprotective approaches using in vivo models is challenging due to differences between humans and animals. However, the development of human-induced pluripotent stem cell-derived cardiomyocytes provides new opportunities for in vitro studies. Metabolic maturation enhances the susceptibility of these cells to hypoxia and allows for better modeling of ischemic heart disease.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Philippe C. Wouters, Rutger R. van de Leur, Melle B. Vessies, Antonius M. W. van Stipdonk, Mohammed A. Ghossein, Rutger J. Hassink, Pieter A. Doevendans, Pim van der Harst, Alexander H. Maass, Frits W. Prinzen, Kevin Vernooy, Mathias Meine, Rene van Es
Summary: This study utilizes an explainable deep learning algorithm to predict the outcome of cardiac resynchronization therapy (CRT) using electrocardiogram (ECG) features. The algorithm outperforms current guideline ECG criteria and QRS(AREA) in predicting clinical endpoints. FactorECG, derived from a large dataset of ECGs, demonstrates superior discriminative ability without requiring additional clinical variables.
EUROPEAN HEART JOURNAL
(2023)
Article
Biology
Patricia van den Hoogen, Manon M. H. Huibers, Floor W. van den Dolder, Roel de Weger, Erica Siera-de Koning, Marish I. F. Oerlemans, Nicolaas de Jonge, Linda W. van Laake, Pieter A. Doevendans, Joost. P. G. Sluijter, Aryan Vink, Saskia C. A. de Jager
Summary: Heart transplantation is the gold standard for patients with end-stage heart failure, but immune responses to the transplanted heart can lead to complications and graft failure. Elevated levels of antibodies prior to transplantation are associated with poor outcomes after transplantation. Specifically, higher levels of IgG1 and IgG2 antibodies are associated with increased rejection of the transplanted heart and remain elevated after transplantation. This suggests that heart transplant patients with a more active antibody-mediated immune response might benefit from expanded immunosuppressive therapy.
Article
Medicine, General & Internal
Estu Rudiktyo, Annemieke Wind, Pieter Doevendans, Bambang Budi Siswanto, Maarten-Jan Cramer, Amiliana Mardiani Soesanto
Summary: This study found that isolated mitral stenosis was the most common valve lesion in RHD patients, who were predominantly female, younger, had preserved left ventricular function, reduced right ventricular function, and high prevalence of atrial fibrillation.
MEDICAL JOURNAL OF INDONESIA
(2022)
Article
Engineering, Biomedical
Selma E. Kaffka Genaamd E. Dengler, Mudit Mishra, Sjoerd van Tuijl, Saskia C. A. de Jager, Joost P. G. Sluijter, Pieter A. Doevendans, Niels. P. van der Kaaij
Summary: The aim of this study was to investigate the impact of cold oxygenated machine perfusion on functional myocardial survival in slaughterhouse porcine hearts compared to static cold storage. The results of this study showed that the survival rate in the cold oxygenated machine perfusion group was significantly higher than that in the static cold storage group.
Editorial Material
Cardiac & Cardiovascular Systems
Pieter A. A. Doevendans
NETHERLANDS HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Estu Rudiktyo, Emir Yonas, Maarten J. Cramer, Bambang B. Siswanto, Pieter A. Doevendans, Amiliana M. Soesanto
Summary: This study aimed to evaluate whether rheumatic mitral regurgitation (MR) is associated with ventricular dysfunction. The study found that patients with rheumatic MR had more impaired left ventricular function compared to patients with degenerative MR. However, rheumatic etiology was not associated with reduced right ventricular systolic function in patients with significant chronic MR.
Article
Cardiac & Cardiovascular Systems
Qianliang Yuan, Renee G. C. Maas, Ellen C. J. Brouwer, Jiayi Pei, Christian Snijders Blok, Marko A. Popovic, Nanne J. Paauw, Niels Bovenschen, Jesper Hjortnaes, Magdalena Harakalova, Pieter A. Doevendans, Joost P. G. Sluijter, Jolanda van der Velden, Jan W. Buikema
Summary: This study investigates the disassembly of sarcomeres during mitosis in cardiomyocytes and the effects of CHIR99021 on hiPSC-CMs. The study reveals the activation of Wnt and Hippo signaling in proliferative hiPSC-CMs and the increased efficiency of non-viral vector incorporation by CHIR99021. The findings provide a valuable tool for gene manipulation studies in hiPSC-CMs and engineered cardiac tissue.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Marijn H. A. Groen, Rene van Es, Bas R. van Klarenbosch, Marco Stehouwer, Peter Loh, Pieter A. Doevendans, Fred H. Wittkampf, Kars Neven
Summary: Anodal IRE applications result in significantly less gas formation compared to cathodal IRE applications and RF applications, which is supported by transoesophageal echocardiography observations.