Article
Cardiac & Cardiovascular Systems
Patrizio Sarto, Alessandro Zorzi, Laura Merlo, Teresina Vessella, Cinzia Pegoraro, Flaviano Giorgiano, Francesca Graziano, Cristina Basso, Jonathan A. Drezner, Domenico Corrado
Summary: This study aimed to report the long-term findings of the Italian programme of cardiovascular preparticipation screening (PPS) in young, competitive athletes. The study assessed the diagnostic yield for diseases at risk of sudden cardiac death (SCD), the costs of serial evaluations, and the long-term outcomes of PPS in a large population of Italian children. Over an 11-year study period, 69 children (0.3%) were identified with cardiovascular diseases at risk of SCD, and one child with normal PPS findings experienced an episode of resuscitated cardiac arrest during sports activity.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Paolo Zeppilli, Massimiliano Bianco, Salvatore F. Gervasi, Michela Cammarano, Riccardo Monti, Fabrizio Sollazzo, Gloria Modica, Lorenzo Morra, Francesco M. Nifosi, Vincenzo Palmieri
Summary: The anomalous origin of a coronary artery (AOCA) is a rare condition that presents challenges in terms of diagnosis and management, especially in the context of sports participation where the risk of acute cardiovascular events is heightened. This paper provides a comprehensive review of current knowledge on AOCAs in athletes, including epidemiology, pathophysiology, diagnostic approaches, individual risk assessment, treatment options, and considerations for returning to sports after surgery.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander C. Razavi, S. M. Iftekhar Uddin, Zeina A. Dardari, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Albert D. Osei, Olufunmilayo H. Obisesan, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee J. Shaw, Laurence S. Sperling, Seamus P. Whelton, Martin Bodtker Mortensen, Michael J. Blaha, Omar Dzaye
Summary: Coronary artery calcium (CAC) is associated with the risk of incident sudden cardiac death (SCD), particularly among primary prevention patients with low-intermediate risk. Stratification of SCD risk through CAC measurement can identify patients who are most likely to benefit from further downstream testing in the early stages of coronary heart disease (CHD).
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Gentile, Vincenzo Castiglione, Raffaele De Caterinao
Summary: CAAs are a group of congenital conditions characterized by abnormal origin or course of the 3 main epicardial coronary arteries. While they have been identified as a common underlying condition in young athletes, their recognition among adults has increased with the widespread use of invasive and noninvasive coronary imaging. The clinical correlates and therapeutic choices for CAAs remain poorly understood, with studies suggesting that multimodality imaging may play a key role in management.
Article
Cardiac & Cardiovascular Systems
Orianne Weizman, Jean-Philippe Empana, Marieke Blom, Hanno L. Tan, Martin Jonsson, Kumar Narayanan, Mattias Ringh, Eloi Marijon, Xavier Jouven
Summary: This study assessed the incidence, characteristics, and outcomes of women presenting with sudden cardiac arrest during sports (Sr-SCA) using data from 3 European registries. The results showed a significantly lower risk of Sr-SCA in women compared with men, emphasizing the need to consider this in future preparticipation screening strategies.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Benji Lim, Baoying Lim, Fadzil Hamzah, Ang Tee Lim, Chung Sien Ng, Benedict Tan, Khim Leng Tong
Summary: Sudden cardiac death is rare in athletes, with the most common cause being hypertrophic cardiomyopathy. This study compared four different ECG criteria and found that the 2017 International Criteria performed the best in detecting cardiac abnormalities in athletes.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2023)
Article
Sport Sciences
Nicole M. Panhuyzen-Goedkoop, Hein J. Wellens, Andre L. M. Verbeek, Jan J. Piek, Ron J. G. Peters
Summary: The analysis of internet videos shows that immediate bystander CPR for non-traumatic sudden cardiac arrest during sports is associated with improved survival rates. It emphasizes the importance of timely chest compressions and early defibrillation during sports activities to enhance the chances of survival for victims of sudden cardiac arrest.
SPORTS MEDICINE-OPEN
(2021)
Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Review
Cardiac & Cardiovascular Systems
Stefania Rizzo, Monica De Gaspari, Carla Frescura, Massimo Padalino, Gaetano Thiene, Cristina Basso
Summary: This chapter explores the wide spectrum of congenital coronary artery anomalies (CAA), ranging from asymptomatic cases to those with a risk of sudden cardiac death (SCD). It discusses normal coronary artery anatomy, pathology of CAA at risk of SCD, and shares experiences with young individuals and athletes who have succumbed to SCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Steve Bibevski, Mark Ruzmetov, Immanuel I. Turner, Frank G. Scholl
Summary: Anomalous aortic origin of right coronary artery (AAORCA) is a congenital heart lesion that can lead to coronary ischemia and sudden death. This study analyzed patients with AAORCA managed at the center, finding that 30% underwent surgical management while 70% were monitored nonsurgically. The outcomes in the midterm were excellent with functional testing showing no evidence of ischemia in the surgical patients.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Linfeng Li, Xiangwang He, Min Liu, Libing Yun, Bin Cong
Summary: This study found that cardiac miR-126-5p and miR-499a-5p were downregulated in CAD-SCD patients, and their combination had good diagnostic capabilities. These miRNAs are expected to serve as novel biomarkers for CAD-SCD and help differentiate the detailed causes in SCD cases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jenni J. Hekkanen, Tuomas Kentta, Mikko P. Tulppo, Antti M. Kiviniemi, Olavi H. Ukkola, M. Juhani Junttila, Heikki Huikuri, Juha S. Perkiomaki
Summary: This study evaluated the prognostic significance of temporal variability of P-wave morphology in relation to cardiac autonomic regulation. The results showed that the variability of P-wave morphology, when combined with cardiac autonomic regulation, independently predicts the risk of sudden cardiac death in patients with coronary artery disease.
Article
Cardiac & Cardiovascular Systems
Nicole Karam, Louis Pechmajou, Kumar Narayanan, Wulfran Bougouin, Ardalan Sharifzadehgan, Soraya Anys, Orianne Weizman, David Perrot, Victor Waldmann, Frankie Beganton, Marie-Cecile Perier, Julien Rischard, Thomas Loeb, Jean-Marc Agostinucci, Eric Lecarpentier, Patricia Jabre, Daniel Jost, Florence Dumas, Alain Cariou, Xavier Jouven, Eloi Marijon
Summary: This study assessed the temporal trends in incidence, management, and survival of sports-related sudden cardiac arrest (SrSCA). The results showed that SrSCA incidence remained stable over time, but improvements in on-field resuscitation and public automated external defibrillator use led to a significant increase in survival.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Pietro Amedeo Modesti, Giancarlo Casolo, Iacopo Olivotto, Alessio Pellegrino
Summary: Sudden death in young athletes is a rare but dramatic condition. Prevention measures include pre-participation screening and promoting the use of automated external defibrillators. The impact of pre-participation screening on mortality needs further evaluation, while the reactive strategy of using defibrillators appears to be considerably effective and should be implemented globally.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hoang Nhat Pham, Lauri Holmstrom, Harpriya Chugh, Audrey Uy-Evanado, Kotoka Nakamura, Zijun Zhang, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, Sumeet S. Chugh
Summary: This study investigates the importance and prevalence of dynamic electrocardiogram (ECG) remodeling in sudden cardiac death (SCD) and finds that dynamic ECG remodeling improves SCD risk prediction.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Fu Guan, Ardan M. Saguner, Daniel Hofer, Thomas Wolber, Alexander Breitenstein, Nazmi Krasniqi, Urs Eriksson, Jan Steffel, Corinna Brunckhorst, Firat Duru
Summary: This study aimed to investigate the characteristics of His bundle potentials in patients with symptomatic atrioventricular nodal reentrant tachycardia (AVNRT) and to determine whether they can provide clues for the identification of slow pathway (SP). The study found that the amplitude and duration of HBmax were higher and longer, respectively, in patients with AVNRT compared to those with atrioventricular reentrant tachycardia (AVRT).
CARDIOLOGY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Martijn Scherrenberg, Nastasia Marinus, Francesco Giallauria, Maarten Falter, Hareld Kemps, Matthias Wilhelm, Eva Prescott, Carlo Vigorito, Ed De Kluiver, Gerson Cipriano Jr, Paul Dendale, Dominique Hansen
Summary: Due to advancements in cardiovascular medicine, patients with significant disease burden now have a better prognosis. However, aging-related syndromes like frailty become more common among these patients. Frailty leads to exercise intolerance and compromised adherence to cardiovascular rehabilitation. Recent technological advancements in telemedicine have made it possible to remotely monitor and supervise cardiovascular patients, providing promising benefits. This article aims to provide a framework for developing and implementing a tele-rehabilitation program for managing prevention and rehabilitation in cardiovascular disease patients with frailty.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Elena Elchinova, Yara Banz, Stephan Zbinden, Federico Caobelli, Christoph Graeni
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marius Reto Bigler, Christoph Grani
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dominik C. Benz, Michinobu Nagao, Christoph Grani
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Bernhard, Aaron Schnyder, Davide Garachemani, Kady Fischer, Giulin Tanner, Yasaman Safarkhanlo, Anselm W. Stark, Jonathan Schutze, Maryam Pavlicek-Bahlo, Simon Greulich, Caroline Johner, Andreas Wahl, Dominik C. Benz, Raymond Y. Kwong, Christoph Graeni
Summary: This study analyzed the prognostic value of right ventricular involvement in myocarditis and found that it has independent and incremental prognostic value.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Dobner, Benedikt Bernhard, Babken Asatryan, Stephan Windecker, Stefan Stortecky, Thomas Pilgrim, Christoph Grani, Lukas Hunziker
Summary: This study aimed to evaluate the tolerability, clinical outcomes, and changes in NT-proBNP levels and glomerular filtration rate (GFR) in transthyretin amyloid cardiomyopathy (ATTR-CM) patients treated with dapagliflozin. After 3 months of follow-up, a numerical decrease in NT-proBNP levels was observed in some patients in the dapagliflozin treatment group, while other disease parameters remained stable and no adverse events occurred.
Article
Cardiac & Cardiovascular Systems
Alessandro Spirito, Alessandro Sticchi, Fabien Praz, Christoph Grani, Franz Messerli, George C. M. Siontis
Summary: CCTA is associated with a decreased risk of myocardial infarction (MI) compared to non-invasive functional testing in patients with chronic coronary syndromes (CCS), but this benefit is not significant in studies with clinical outcome definition, central outcome assessment/adjudication, or low-risk of bias.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Christian-H Heeger, Sorin Stefan Popescu, Christian Sohns, Alexander Pott, Andreas Metzner, Osamu Inaba, Florian Straube, Malte Kuniss, Arash Aryana, Shinsuke Miyazaki, Serkan Cay, Joachim R. Ehrlich, Ibrahim El-Battrawy, Martin Martinek, Ardan M. Saguner, Verena Tscholl, Kivanc Yalin, Evgeny Lyan, Wilber Su, Giorgi Papiashvili, Maichel Sobhy Naguib Botros, Alessio Gasperetti, Riccardo Proietti, Erik Wissner, Daniel Scherr, Masashi Kamioka, Hisaki Makimoto, Tsuyoshi Urushida, Tolga Aksu, Julian K. R. Chun, Kudret Aytemir, Ewa Jedrzejczyk-Patej, Karl-Heinz Kuck, Tillman Dahme, Daniel Steven, Philipp Sommer, Roland Richard Tilz
Summary: CB-based PVI is an effective treatment for AF, but the most common complication is PNI. Our study found a high rate of reconnection during repeat procedures. These findings can help identify the optimal dosing protocol in CB-based PVI procedures.
Editorial Material
Cardiac & Cardiovascular Systems
Christoph Graeni
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Alper Gok, Mehmet Altan, Ahmet Emin Dogan, Asir Eraslan, Fahrettin Samil Uysal, Ufuk Ozturk, Ardan Muammer Saguner, Muhammet Abdurrahim Imamoglu
Summary: This study aimed to examine the changes in the frequency of erectile dysfunction after COVID-19 and whether the condition improves over time. The results showed that there may be a deterioration in erectile function after COVID-19, but it tends to improve, especially from the first year after the initial infection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tolga Cimen, Argelia Medeiros-Domingo, Antonios Kolios, Deniz Akdis, Shehab Anwer, Felix C. C. Tanner, Corinna Brunckhorst, Firat Duru, Ardan M. M. Saguner
Summary: In this case report, a 58-year-old male patient with cardiomyopathy and palmoplantar keratosis is described. Genetic testing revealed a novel variant in the desmoplakin gene, suggesting the presence of Cardiocutaneous syndrome. Repeated genetic testing is clinically significant, especially in patients with a high probability of a specific inherited cardiac disease, to improve diagnostic accuracy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Andreas A. Giannopoulos, Basil Bolt, Dominik C. Benz, Michael Messerli, Elia Von Felten, Dimitri Patriki, Catherine Gebhard, Aju P. Pazhenkottil, Christoph Grani, Philipp A. Kaufmann, Ronny R. Buechel, Oliver Gaemperli
Summary: Myocardial bridging (MB) is a segment of coronary arteries that is usually free from atherosclerosis, while the adjacent proximal segment is prone to it due to local endothelial shear stress (ESS). This study used coronary computed tomography angiography and computational fluid dynamics to analyze the ESS in coronary arteries with MBs and investigate the association between atherosclerosis and hemorheological characteristics. The results showed that there was no significant difference in ESS between the proximal 5 mm to MBs and the region within MBs. No significant ESS variances were observed around the MB entrance in arteries with plaques, regardless of the morphological features of the bridged segment. MBs have homogeneous, atheroprotective ESS, which may explain the absence of atherosclerosis within bridged segments. The interplay between ESS and atherosclerosis is potentially similar in arteries with MB compared to those without bridges.
Article
Cardiac & Cardiovascular Systems
Claudia Herrera Siklody, Luis Schiappacasse, Raphael Jumeau, Tobias Reichlin, Ardan M. Saguner, Nicolaus Andratschke, Olgun Elicin, Frederic Schreiner, Boldizsar Kovacs, Michael Mayinger, Adrian Huber, Joost J. C. Verhoeff, Patrizio Pascale, Jorge Solana Munoz, Adrian Luca, Giulia Domenichini, Raphael Moeckli, Jean Bourhis, Esat M. Ozsahin, Etienne Pruvot
Summary: This study analyzed recurrences in patients after Stereotactic Arrhythmia Radioablation (STAR) treatment. It was found that VT recurrences were common, but no recurrences were observed inside the planning target volume (PTV), indicating the local efficacy of STAR.
Article
Biochemistry & Molecular Biology
Stephanie M. van der Voorn, Esmee van Drie, Virginnio Proost, Kristina Dimitrova, Robert F. Ernst, Cynthia A. James, Crystal Tichnell, Brittney Murray, Hugh Calkins, Ardan M. Saguner, Firat Duru, Patrick T. Ellinor, Connie R. Bezzina, Sean J. Jurgens, J. Peter van Tintelen, Toon A. B. van Veen
Summary: This study investigated the impact of the p.(Ser96Ala) polymorphism in the HRC gene on cardiomyopathy and found no association with life-threatening arrhythmias or heart failure-related events, suggesting a lack of evidence supporting its role as a modifier in cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
