Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Article
Ophthalmology
Arantxa Acera, Beatriz Abad, Xandra Pereiro, Francisco David Rodriguez, Noelia Ruzafa, Juan Antonio Duran, Elena Vecino
Summary: The tear film lipid layer (TFLL) plays a crucial role in maintaining high-quality vision, protecting the cornea, and promoting wound healing. Plasma rich in growth factor (PRGF) eye drops have emerged as a new treatment for aqueous deficient dry eye. This study compared the lipid profiles of PRGF eye drops with tears and found that the lipids in PRGF eye drops could be used as a supplement for altered tear lipid composition.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Zhenyu Wei, Yuandong Su, Guanyu Su, Christophe Baudouin, Antoine Labbe, Qingfeng Liang
Summary: This study aimed to investigate the change in dynamic optical quality in dry eye patients after the use of artificial tears. The study found that optical quality indices were significantly higher in dry eye patients compared to the control group, but decreased significantly after 5 minutes of artificial tear instillation in severe dry eye patients. There were no significant differences in optical quality parameters among the three groups after 30 minutes.
Article
Medicine, General & Internal
Wan-Lin Wu, Shu-Wen Chang
Summary: This study aimed to investigate the relationships between subjective symptoms, objective signs, and dermatochalasis severity in dry-eye patients and the effects of lid hygiene on dry-eye parameters. The results showed that patients with more severe dermatochalasis had less severe symptoms and poorer meibomian gland expressibility, higher meiboscale grades, and thicker lipid-layer thickness. Lid hygiene significantly improved subjective symptoms, lipid-layer thickness, and aqueous tear secretion, particularly in patients with less severe dermatochalasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Safal Khanal, Yuqiang Bai, William Ngo, Kelly K. Nichols, Landon Wilson, Stephen Barnes, Jason J. Nichols
Summary: The study found that some human meibum-derived OAHFAs were significantly associated with precorneal tear film thinning, potentially related to eye health. However, tear film-derived OAHFAs showed no association with the rate of precorneal tear film thinning.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Keisuke Watanabe, Masataka Yoshida, Takashi Okumura, Takayuki Sassa, Akio Kihara, Akira Uchiyama
Summary: This study evaluated the efficacy of a mineral oil-containing ophthalmic solution in mitigating evaporative dry eye symptoms in a mouse model with disrupted fatty acid elongase Elovl1. The results showed that mineral oil was effective in improving dry eye symptoms. This research provides new insights into the treatment of dry eye disease.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ching-Jen Hsiao, Hsiao-Ching Tung, Chuen-Lin Tien, Yu-Wen Chang, Ching-Ying Cheng
Summary: This study investigated the impact of large-diameter multifocal contact lenses on the ocular surface, visual quality, and visual function for presbyopic adults with dry eye syndromes. The results showed that while these lenses had a negative effect on the ocular surface and tear film, they significantly improved visual function and visual quality.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Hsin-Yu Weng, Wei-Ting Ho, Chiung-Yi Chiu, Tzu-Yun Tsai, Shu-Wen Chang
Summary: The study found that younger patients with dry eye disease (DED) had more severe subjective symptoms, higher SPEED and OSDI scores, thinner LLT, lower extent of meibomian gland dropout, and more blinks compared to older patients. This may be due to less impact on the structure and function of the meibomian glands in younger patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Ophthalmology
Leopoldo M. Baiza-Duran, Patricia Munoz-Villegas, Alejandra Sanchez-Rios, Oscar Olvera-Montano
Summary: This study evaluated the safety and efficacy of an ophthalmic nanoemulsion in patients with dry eye disease. The results showed that the nanoemulsion was as safe and effective as the control treatment. These findings support the use of ophthalmic nanoemulsion for improving clinical parameters and symptoms in patients with dry eye disease.
JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation-and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The study found that IL-10 and SP levels in tears were increased in patients with a history of corneal refractive surgery. IL-9 levels were associated with chronic ocular pain. These findings suggest that tear cytokines and neuromodulators could serve as biomarkers for chronic ocular pain, leading to improved therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation- and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The results showed that IL-9 tear levels were increased in patients with chronic ocular pain, IL-10, SP, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with previous surgery, and IL-8/CXCL8, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with DE-related inflammation. Higher NGF levels were related to chronic ocular pain and DE in patients with previous surgery. These findings are important for understanding biomarkers of chronic ocular pain and making better therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Naeimeh Monfared, Paul J. Murphy
Summary: Tear evaporation is a normal physiological process that regulates blink activity and tear production. Altered tear evaporation rate (TER) is a defining characteristic of evaporative dry eye disease (DED) and serves as a useful clinical diagnostic test. Understanding the normal range of TER, influenced by ocular, environmental and systemic factors, is crucial for improved disease diagnosis.
CONTACT LENS & ANTERIOR EYE
(2023)
Review
Biology
Norihiko Yokoi, Petar Eftimov, Georgi As. Georgiev
Summary: Soft contact lenses cause disturbances in the connection between the pre-lens tear film and the ocular surface, resulting in dry eye and discomfort. Factors such as decreased tear meniscus radius, attenuated spread of tear film lipid layer, limited wettability of contact lens surface, and increased friction with eyelid wiper contribute to these issues. This review examines the contributions of these factors to tear film breakup patterns and contact lens discomfort from a clinical and basic science perspective.
Article
Medicine, General & Internal
Antonio Ballesteros-Sanchez, Jose-Maria Sanchez-Gonzalez, Giovanni Roberto Tedesco, Carlos Rocha-De-Lossada, Gianluca Murano, Antonio Spinelli, Davide Borroni
Summary: This study evaluated the efficacy of 0.3% carboxymethylcellulose tear substitute in treating dry eye disease, as well as treatment compliance and adverse events. The results showed significant improvement in various clinical endpoints, including OSDI questionnaire, A-NIBUT, LLT, and ST. Treatment compliance was high and only minor transient adverse events were reported.
JOURNAL OF CLINICAL MEDICINE
(2023)