Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Dose Schedules Inspired by Evolutionary Concepts Lengthen Progression-Free Survival in Mice

(2016) Charlie Schmidt   JNCI-Journal of the National Cancer Institute

Cancer therapy: an evolved approach

(2016) Cassandra Willyard   NATURE

Identification of neutral tumor evolution across cancer types

(2016) Marc J Williams et al.   NATURE GENETICS

Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

(2016) Pierre Martinez et al.   Nature Communications

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness

(2016) Alexander Nguyen et al.   Nature Communications

Dose Schedules Inspired by Evolutionary Concepts Lengthen Progression-Free Survival in Mice

(2016) Charlie Schmidt   JNCI-Journal of the National Cancer Institute

Pathology to Enhance Precision Medicine in Oncology

(2015) Mark C. Lloyd et al.   ADVANCES IN ANATOMIC PATHOLOGY

Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus

(2015) X. Li et al.   Cancer Prevention Research

Precision oncology for patients with advanced cancer: the challenges of malignant snowflakes

(2015) Razelle Kurzrock et al.   CELL CYCLE

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Evolutionary perspective of cancer: myth, metaphors, and reality

(2015) Audrey Arnal et al.   Evolutionary Applications

Rapid and convergent evolution in the Glioblastoma multiforme genome

(2015) Max Shpak et al.   GENOMICS

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

(2015) Lucy R Yates et al.   NATURE MEDICINE

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

(2015) Shaoping Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cannibalism by malignant neoplastic cells: three cases in dogs and a literature review

(2015) Antonio Meléndez-Lazo et al.   VETERINARY CLINICAL PATHOLOGY

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

(2015) Michal Kovac et al.   Nature Communications

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

(2015) Sandra Misale et al.   Nature Communications

The reverse evolution from multicellularity to unicellularity during carcinogenesis

(2015) Han Chen et al.   Nature Communications

Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

(2015) N. Murugaesu et al.   Cancer Discovery

Construction and analysis of dynamic transcription factor regulatory networks in the progression of glioma

(2015) Yongsheng Li et al.   Scientific Reports

Changes in Intake of Fruits and Vegetables and Weight Change in United States Men and Women Followed for Up to 24 Years: Analysis from Three Prospective Cohort Studies

(2015) Monica L. Bertoia et al.   PLOS MEDICINE

Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing

(2014) E. Helman et al.   GENOME RESEARCH

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Copy number alteration burden predicts prostate cancer relapse

(2014) H. Hieronymus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

(2014) Mariam Jamal-Hanjani et al.   PLOS BIOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

NSAIDs Modulate Clonal Evolution in Barrett's Esophagus

(2013) Rumen L. Kostadinov et al.   PLoS Genetics

Long Interspersed Element–1 (LINE-1): Passenger or Driver in Human Neoplasms?

(2013) Nemanja Rodić et al.   PLoS Genetics

Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization

(2012) A. Sottoriva et al.   CANCER RESEARCH

Drugs that target pathogen public goods are robust against evolved drug resistance

(2012) John W. Pepper   Evolutionary Applications

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Dispersal Evolution in Neoplasms: The Role of Disregulated Metabolism in the Evolution of Cell Motility

(2011) C. A. Aktipis et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Does the cell number 109still really fit one gram of tumor tissue?

(2011) Ugo Del Monte   CELL CYCLE

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

The genomic complexity of primary human prostate cancer

(2011) Michael F. Berger et al.   NATURE

Solving the Puzzle of Metastasis: The Evolution of Cell Migration in Neoplasms

(2011) Jun Chen et al.   PLoS One

A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma

(2010) L. M. F. Merlo et al.   Cancer Prevention Research

The role of genetic diversity in cancer

(2010) Lauren M.F. Merlo et al.   JOURNAL OF CLINICAL INVESTIGATION

BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review

(2010) Xin An et al.   LEUKEMIA RESEARCH

Genetic variegation of clonal architecture and propagating cells in leukaemia

(2010) Kristina Anderson et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Somatic expression of LINE-1 elements in human tissues

(2010) Victoria P. Belancio et al.   NUCLEIC ACIDS RESEARCH

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Resistance to Imatinib and Second-Generation Tyrosine Inhibitors in Chronic Myeloid Leukemia

(2009) D. Milojkovic et al.   CLINICAL CANCER RESEARCH

Embryonic vaccines against cancer: An early history

(2009) Bradley G. Brewer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Probabilistic Cross-Species Inference of Orthologous Genomic Regions Created by Whole-Genome Duplication in Yeast

(2008) G. C. Conant et al.   GENETICS

Comparative lesion sequencing provides insights into tumor evolution

(2008) S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-specific incidence of cancer: Phases, transitions, and biological implications

(2008) R. Meza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Retrotransposon-Mediated Gene Duplication Underlies Morphological Variation of Tomato Fruit

(2008) H. Xiao et al.   SCIENCE