Article
Allergy
Maryam Ghaedi, Fumio Takei
Summary: Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and play a regulatory role in tissue homeostasis and immunity. They are divided into 3 groups based on similar effector programs to T cells, and their development from lymphoid progenitors in adult mouse bone marrow has been extensively studied.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hung-Yu Shih, Chia-Wei Chang, Yi-Chieh Chen, Yi-Chuan Cheng
Summary: Bone morphogenetic protein (BMP) signaling plays a crucial role in the regulation of neural induction, neuronal specification, and neuronal differentiation. However, its role in neural progenitors is still not well understood. By manipulating BMP signaling in zebrafish embryos, researchers discovered that inhibiting BMP signaling during gastrulation can increase the proliferation of neural progenitors and decrease the number of neuronal precursors. This study also revealed that there is a fine balance between BMP and Notch signaling in regulating the proliferation of neural progenitor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sara A. Rubin, Chloe S. Baron, Cecilia Pessoa Rodrigues, Madeleine Duran, Alexandra F. Corbin, Song P. Yang, Cole Trapnell, Leonard I. Zon
Summary: This study provides insights into key aspects of zebrafish lymphocyte development and cellular diversity through single-cell RNA sequencing. It advances the understanding of zebrafish immunology and will facilitate future genetic and developmental studies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Immunology
Elsa Bourayou, Rachel Golub
Summary: Immune cells, including the innate lymphoid cells (ILCs), are important in the development and progression of hepatocellular carcinoma (HCC). ILCs are a family of lymphocytes, including Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s and lymphocytes tissue-inducer cells (LTi), that play significant roles in HCC. This overview highlights the importance of diverse signaling pathways in the regulation of ILCs' response to HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ahmed Kabil, Samuel B. Shin, Michael R. Hughes, Kelly M. McNagny
Summary: ILCs are frontline immune effectors that play crucial roles in tissue homeostasis and diseases. They exhibit a degree of plasticity, allowing them to adapt to different tissue environments. The plasticity of ILCs is important for immune responses and therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lian Narunsky-Haziza, Gregory D. Sepich-Poore, Ilana Livyatan, Omer Asraf, Cameron Martino, Deborah Nejman, Nancy Gavert, Jason E. Stajich, Guy Amit, Antonio Gonzalez, Stephen Wandro, Gili Perry, Ruthie Ariel, Arnon Meltser, Justin P. Shaffer, Qiyun Zhu, Nora Balint-Lahat, Iris Barshack, Maya Dadiani, Einav N. Gal-Yam, Sandip Pravin Patel, Amir Bashan, Austin D. Swafford, Yitzhak Pilpel, Rob Knight, Ravid Straussman
Summary: This study comprehensively characterizes the cancer mycobiome in cancer patients and finds low abundances of fungi in various human cancers. The composition of fungal communities differs among cancer types and they are frequently associated with cancer cells and macrophages spatially. Comparisons with bacterial and immune communities reveal co-occurring bi-domain ecologies and distinct immune responses. The tissue and plasma mycobiomes show prognostic and diagnostic capabilities even in early stage cancers, and synergistic predictive performance with bacterial communities.
Article
Immunology
Le Kang, Angelika Schmalzl, Tamara Leupold, Miguel Gonzalez-Acera, Raja Atreya, Markus F. Neurath, Christoph Becker, Stefan Wirtz
Summary: The complex immune cell network in intestinal inflammation involves the chemokine receptor CCR8, which plays a protective role in the gut through its interaction with the chemotactic ligand CCL1. This pathway is linked to the function of intestinal innate lymphoid cells producing IFN-gamma. Modulating this regulatory circuit may present a new strategy for treating inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Carla Belmonte-Mateos, Lydvina Meister, Cristina Pujades
Summary: Tissue growth and morphogenesis are tightly coordinated processes that determine cell fates and stem cell capacities. Studying the neurogenic commitment in the zebrafish embryonic brainstem, researchers discovered temporal and spatial differences in progenitor capacities and the decreased proliferative capacity of cells within center areas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rachel Golub
Summary: The Notch signaling pathway plays a crucial role in regulating the differentiation, plasticity, and functions of innate lymphoid cells (ILCs) by controlling the abundance and specificity of cytokine release, thus impacting both ILC cell fate decisions and immune responses.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Bing Liu, Tao Cheng, Bo O. Zhou, Hui Cheng, Zhaofeng Zheng, Han He, Xinyu Thomas Tang, Han Zhang, Fanglin Gou, Hua Yang, Jiaxuan Cao, Shujuan Shi, Zining Yang, Guohuan Sun, Xiaowei Xie, Yang Zeng, Aiqing Wen, Yu Lan, Jiaxi Zhou
Summary: This study used single-cell RNA sequencing to map the transcriptomic landscape of human fetal bone marrow and spleen hematopoietic stem/progenitor cells (HSPCs). It was found that functional HSCs do not emerge in the bone marrow until 12 post-conception weeks, while they are not detected in the spleen by 14 post-conception weeks.
Article
Cell & Tissue Engineering
Young-Woo Jo, Inkuk Park, Kyusang Yoo, Hyun-Young Woo, Ye Lynne Kim, Yea-Eun Kim, Ji-Hoon Kim, Young-Yun Kong
Summary: This study found that Notch1 and Notch2 play distinct roles in maintaining the population of myogenic progenitors (MPs) during fetal myogenesis, with Notch1 inducing cell cycle exit and Notch2 suppressing premature differentiation. The activation of Notch1 and Notch2 signaling in MPs is also shown to be distinctively regulated by interactions with Notch ligand-expressing myofibers and MP-lineage cells, respectively.
Article
Cell Biology
Mingzhu Zheng, Chen Yao, Gan Ren, Kairui Mao, Hyunwoo Chung, Xi Chen, Gangqing Hu, Lei Wang, Xuemei Luan, Difeng Fang, Dar Li, Chao Zhong, Xiaoxiao Lu, Nikki Cannon, Mingxu Zhang, Avinash Bhandoola, Keji Zhao, John J. O'Shea, Jinfang Zhu
Summary: This study reveals that T cell factor 1 (TCF-1) is essential for the development of non-lymphoid tissue inducer (LTi) cells, specifically for the organogenesis of Peyer's patches (PPs). TCF-1 regulates the expression of lymphotoxin in PP LTi cells, and it may do so through promoting the expression of GATA3. Thus, the TCF-1-GATA3 axis is crucial for the development and tissue-specific functions of LTi cells.
Article
Endocrinology & Metabolism
Di Wu, Luni Hu, Mengwei Han, Yichen Deng, Yime Zhang, Guanqun Ren, Xingyu Zhao, Zongxian Li, Peng Li, Yinlian Zhang, Shanwen Chen, Jun Li, Yanyan Shi, Jianxin Xue, Pengyuan Wang, Chao Zhong
Summary: In this study, the researchers found that a metabolic reconfiguration in colonic lymphoid tissue inducer (LTi) cells regulated by PD-1 signaling modulates inflammatory states in the gut during anti-PD-1 immunotherapy.
Article
Biochemistry & Molecular Biology
Hilman Nurmahdi, Mao Hasegawa, Elzava Yuslimatin Mujizah, Takeshi Sasamura, Mikiko Inaki, Shinya Yamamoto, Tomoko Yamakawa, Kenji Matsuno
Summary: Notch signaling is essential for cell-fate specification and involves direct cell-cell interactions. This study investigates the role of different epidermal growth factor (EGF)-like repeats in Notch receptor by analyzing 19 previously identified mutants. Findings suggest that certain EGF-like repeats may be crucial for proper folding and function of Notch protein.
Review
Immunology
Ana Cumano, Claire Berthault, Cyrille Ramond, Maxime Petit, Rachel Golub, Antonio Bandeira, Pablo Pereira
ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019
(2019)
Article
Biology
Jean-Francois Darrigrand, Mariana Valente, Glenda Comai, Pauline Martinez, Maxime Petit, Ryuichi Nishinakamura, Daniel S. Osorio, Gilles Renault, Carmen Marchiol, Vanessa Ribes, Bruno Cadot
Article
Immunology
Antonia O. Cuff, Thibaut Perchet, Simone Dertschnig, Rachel Golub, Victoria Male
Review
Immunology
Marie Cherrier, Gayetri Ramachandran, Rachel Golub
MUCOSAL IMMUNOLOGY
(2020)
Article
Cell Biology
Milesa Simic, Iris Manosalva, Lionel Spinelli, Rebecca Gentek, Raheleh R. Shayan, Carole Siret, Mathilde Girard-Madoux, Shuaiwei Wang, Lauriane de Fabritus, Janneke Verschoor, Yann M. Kerdiles, Marc Bajenoff, Ralf Stumm, Rachel Golub, Serge A. van de Pavert
Article
Endocrinology & Metabolism
C. Berthault, W. Staels, R. Scharfmann
MOLECULAR METABOLISM
(2020)
Article
Hematology
Ramy Elsaid, Sylvain Meunier, Odile Burlen-Defranoux, Francisca Soares-da-Silva, Thibaut Perchet, Lorea Iturri, Laina Freyer, Paulo Vieira, Pablo Pereira, Rachel Golub, Antonio Bandeira, Elisa Gomez Perdiguero, Ana Cumano
Summary: During embryonic development, multiple waves of hematopoietic progenitors are regulated differently, with the first wave of thymic progenitors comprising a unique population of bipotent T and innate lymphoid cells that play a crucial role in thymic organogenesis and the establishment of the immune system.
Article
Endocrinology & Metabolism
Fernanda M. C. Sodre, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aisha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Summary: In this study, systemic inhibition of peptidylarginine deiminases (PADs) through BB-Cl-amidine treatment prevented diabetes development in NOD mice by reducing citrullination levels in the pancreas, decreasing circulating autoantibody titers, and reducing neutrophil extracellular trap formation. Additionally, the treatment induced a shift in cytokine production and increased regulatory T cell frequency. This highlights the potential of PAD inhibition for treating autoimmune diseases like type 1 diabetes.
Review
Biochemistry & Molecular Biology
Rachel Golub
Summary: The Notch signaling pathway plays a crucial role in regulating the differentiation, plasticity, and functions of innate lymphoid cells (ILCs) by controlling the abundance and specificity of cytokine release, thus impacting both ILC cell fate decisions and immune responses.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Soumaya Karaki, Charlotte Blanc, Thi Tran, Isabelle Galy-Fauroux, Alice Mougel, Estelle Dransart, Marie Anson, Corinne Tanchot, Lea Paolini, Nadege Gruel, Laure Gibault, Francoise Lepimpec-Barhes, Elizabeth Fabre, Nadine Benhamouda, Cecile Badoual, Diane Damotte, Emmanuel Donnadieu, Sebastian Kobold, Fathia Mami-Chouaib, Rachel Golub, Ludger Johannes, Eric Tartour
Summary: This study demonstrates the in vivo role of the CXCR6-CXCL16 axis in the migration of CD8(+) resident memory T cells in lung mucosa after intranasal vaccination, leading to tumor growth control. Intranasal vaccination induces higher and more sustained concentrations of CXCL16, compared with other chemokines, showing superior efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Alicia Bellomo, Rebecca Gentek, Rachel Golub, Marc Bajenoff
Summary: This article discusses how macrophages interact with their cellular niches, focusing on the cellular circuits formed by splenic macrophages and fibroblasts and their molecular signals. The study finds that these cellular circuits are crucial for maintaining splenic function, especially as they may be affected in the elderly.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Immunology
Elsa Bourayou, Rachel Golub
Summary: Immune cells, including the innate lymphoid cells (ILCs), are important in the development and progression of hepatocellular carcinoma (HCC). ILCs are a family of lymphocytes, including Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s and lymphocytes tissue-inducer cells (LTi), that play significant roles in HCC. This overview highlights the importance of diverse signaling pathways in the regulation of ILCs' response to HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Marie Laviron, Maxime Petit, Eleonore Weber-Delacroix, Alexis J. Combes, Arjun Rao Arkal, Sandrine Barthelemy, Tristan Courau, David A. Hume, Christophe Combadiere, Matthew F. Krummel, Alexandre Boissonnas
Summary: Tumor-associated macrophages (TAMs) adapt to the tumor microenvironment and exhibit different functions based on their localization in the stroma or neoplastic epithelium. Single-cell RNA sequencing and imaging techniques reveal that TAM subsets in different tissue territories and tumor lesions have distinct capacities to activate T cells and phagocytose tumor cells.
Article
Biochemistry & Molecular Biology
Pietro Cacialli, Marie-Pierre Mailhe, Ingrid Wagner, Doron Merkler, Rachel Golub, Julien Y. Bertrand
Summary: This study reveals that the expansion of hematopoietic stem cells during vertebrate development is a result of the sequential and synergistic contribution of neutrophils, macrophages, and endothelial cells.
