Article
Neurosciences
Lauren M. Patrick, Kevin M. Anderson, Avram J. Holmes
Summary: The study shows that the brain responds to variations in effort expenditure, reflecting the efforts individuals put in pursuit of their goals. These findings are important for understanding how the brain processes behavior in complex real-world environments, with implications for health and disease research.
Article
Neurosciences
Tingting Wu, Melissa-Ann Mackie, Chao Chen, Jin Fan
Summary: The study found that overt and covert attention orientations are represented by interdependent functional clusters of neuronal populations in regions of the frontoparietal network, which may reflect a generalizable principle in the nervous system for the functional organization of closely associated processes.
Article
Clinical Neurology
Chenglong Cao, Yu Wang, Jia Liu, Aobo Chen, Jinjiang Lu, Guozheng Xu, Jian Song
Summary: This study identified deficits in attention processing in prolactinoma patients, with larger frontoparietal theta and alpha coherence compared to healthy controls. The positive correlation between frontoparietal coherence and altered prolactin levels suggests the significance of prolactin for adaptive brain compensation in prolactinomas. The coherence between frontal and parietal regions may serve as a possible electrophysiological biomarker for detecting deficient attention processing in prolactinomas.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Roger E. Beaty, Robert A. Cortes, Daniel C. Zeitlen, Adam B. Weinberger, Adam E. Green
Summary: Recent research has found distinct connectivity dynamics between frontoparietal subnetworks and the default network during creative cognition, with one subnetwork showing positive coupling and another subnetwork showing negative coupling with the default network. These findings suggest a behavioral benefit to the cooperation of typically anticorrelated brain networks.
Article
Neurosciences
Hang Zhang, Shi-You Yang, Yang Qiao, Qiu Ge, Yi-Yuan Tang, Georg Northoff, Yu-Feng Zang
Summary: The study found that neural fluctuation in sustained attention is mediated by the default-mode network (DMN) and is correlated with behavioral fluctuation in the frequency range of 0.01-0.1 Hz, highlighting the temporal dynamic of the brain-behavior relationship.
HUMAN BRAIN MAPPING
(2022)
Article
Anatomy & Morphology
Shouhang Yin, Yilu Li, Antao Chen
Summary: The frontoparietal control network (FPCN) serves as a bridge between internally oriented introspective processes and externally oriented perceptual attention, and this interaction is facilitated by the coupling between FPCNa and FPCNb.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Mats W. J. van Es, Tom R. Marshall, Eelke Spaak, Ole Jensen, Jan-Mathijs Schoffelen
Summary: Sustained attention affects perception in a discrete, rhythmic way, with modulations of decoding performance by frequency-specific top-down brain activity, suggesting a potential link between attentional sampling rate and visual stimulus representation modulations in the brain, particularly in the frontoparietal attention network. However, the behavioral relevance of these effects remains to be established.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Bryan D. Conklin, Steven L. Bressler
Summary: The study introduces a new connectivity matrix for the monkey frontoparietal network, revealing its utilization of small-world architecture and the M9 motif. The network exhibits relatively homogeneous connectivity and its M9 dynamical relay motif supports cognition by enabling near-zero and non-zero phase synchrony. These findings have implications for the treatment of neurological disorders affecting the cognitive functions supported by the frontoparietal network.
Article
Neurosciences
Xiao Chen, Chao-Gan Yan
Summary: This study found that during rumination, the stability of the brain's functional architecture showed similar but slightly different characteristics compared to distraction and resting states. Key regions of the default mode network (DMN), such as the medial prefrontal cortex and bilateral parahippocampal gyrus, exhibited decreased stability, while regions of the frontoparietal control network, such as the inferior parietal lobule and dorsal lateral prefrontal cortex, showed significantly enhanced stability during rumination. Additionally, stability in the medial prefrontal cortex and inferior parietal lobule was related to individual differences in rumination traits.
Article
Neurosciences
Svenja Kuechenhoff, Christian Sorg, Sebastian C. Schneider, Oliver Kohl, Hermann J. Mueller, Natan Napiorkowski, Aurore Menegaux, Kathrin Finke, Adriana L. Ruiz-Rizzo
Summary: The study found a negative association between inter-FC of the right-frontoparietal network and visual networks with visual processing speed in certain frequency ranges. This suggests that direct connectivity between occipital and right frontoparietal regions supports visual processing speed.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Takeshi Ogawa, Hideki Shimobayashi, Jun-Ichiro Hirayama, Motoaki Kawanabe
Summary: The study focuses on directed functional connectivity among multiple regions of the frontoparietal motor network during motor imagery or motor execution. It was found that there is higher directed functional connectivity from the contralateral dorsal premotor cortex (dPMC) to the primary motor cortex (M1) in motor execution compared to motor imagery. Direct effects from dPMC and ventral premotor cortex (vPMC) to parietal regions were also identified.
Article
Neurosciences
Luyao Wang, Chunlin Li, Ziteng Han, Qiong Wu, Liwei Sun, Xu Zhang, Ritsu Go, Jinglong Wu, Tianyi Yan
Summary: The frontoparietal network (FPN) is a brain network associated with attention processing that can handle attention tasks in different spatiotemporal and sensory modality domains. The activation patterns of brain areas within the FPN are reorganized according to specific attentional demands, suggesting distinct regional neural representations associated with specific attention processes within the FPN.
Article
Psychiatry
Xinglin Zeng, Xinyang Han, Fei Gao, Yinghao Sun, Zhen Yuan
Summary: This study identifies significantly abnormal large-scale brain systems in behavioral addictions (BA) through analyzing structural alterations and resting-state functional connectivity (rs-FC) changes. The results suggest dysconnectivity in response to inhibition, salience attribution, self-referential mental process, and reward-driven behaviors in BA. Additionally, there are overlapping dysfunctions in structure and rs-FC in the cingulate cortex and anterior thalamus regions. This study provides novel insights into the neural biomarkers for clinical diagnoses and treatment targets for BA.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Article
Mathematics, Applied
Melvyn Tyloo
Summary: This paper investigates the impact of noise on the first escape time of nonlinearly coupled oscillators and finds that both the amplification of fluctuations and the spatial and temporal correlations of noise pose a threat to the proper functioning of the network.
Article
Multidisciplinary Sciences
Majd Abdallah, Valentin Iovene, Gaston Zanitti, Demian Wassermann
Summary: In this study, we expand the scope of neuroimaging meta-analysis by designing a domain-specific language, NeuroLang, and using probabilistic first-order logic programming to test hypotheses. Through use-case examples, the paper demonstrates the language's capability in conducting comprehensive neuroimaging meta-analysis and provides some findings on structure-function associations.
SCIENTIFIC REPORTS
(2022)
Letter
Clinical Neurology
Flavio Frohlich, Justin Riddle
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Justin Riddle, Morgan L. Alexander, Crystal Edler R. Schiller, David R. Rubinow, Flavio Frohlich
Summary: This study aimed to replicate the successful target engagement of a single session of bifrontal tACS at the individualized alpha frequency (IAF-tACS) on alpha oscillations in patients with MDD. The results showed that a single session of bifrontal IAF-tACS reduced left frontal alpha power during the resting state when compared with placebo. Furthermore, the reduction of left frontal alpha oscillation by tACS was specific for stimuli with positive valence. However, these effects on left frontal alpha power were not found in healthy control participants.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Letter
Clinical Neurology
Mengsen Zhang, Justin Riddle, Flavio Frohlich
Article
Clinical Neurology
Mengsen Zhang, Flavio Frohlich
Summary: This study reveals the critical role of alpha oscillations in controlling input to the posterior parietal cortex in a phase-dependent manner. Pyramidal cells are more responsive to optogenetic stimulation at specific phases of the alpha oscillation, while presumed fast-spiking inhibitory interneurons do not show such dependency.
Article
Clinical Neurology
Justin Riddle, Flavio Frohlich
Summary: In this study, the researchers propose a neurobehavioral model for psychiatric illness, aiming to identify potential endophenotypes and treatment targets. By investigating the relationship between the severity of psychiatric symptoms, associated mental activity, and neural activity signatures, a deeper understanding of the patient experience and therapeutic effects can be achieved. Causal testing through direct enhancement or suppression of neural activity patterns provides evidence for biomarkers. Non-invasive brain stimulation techniques offer precise manipulation of spatial and temporal activity patterns.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Letter
Clinical Neurology
Justin Riddle, David R. Rubinow, Flavio Frohlich
Article
Psychiatry
Julie A. Clancy, Justin Riddle, Paolo Cassano, Flavio Frohlich
Summary: The 21st century has seen significant advancements in device-based treatments for psychiatric disorders, including transcranial alternating current stimulation (tACS). Although further refinement of device parameters for treating major depressive disorder is needed, tACS is expected to have a significant impact on psychiatric treatment in the future.
PSYCHIATRIC ANNALS
(2022)
Article
Neurosciences
Lauren Sidelinger, Mengsen Zhang, Flavio Frohlich, Stacey B. Daughters
Summary: The study found that the individual alpha frequency (IAF) within the 8-12 Hz alpha frequency band is a unique neural signature, but its day-to-day variability is unknown. Using the Muse 2 headband, participants recorded their brain activity daily at home and high-density EEG was also collected in lab. The results showed that the IAF extracted from the Muse 2 was comparable to that of the HD-EEG electrodes, and there was no significant difference in IAF values before and after the at-home recording period.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Joline M. Fan, A. Moses Lee, Kristin K. Sellers, Kai Woodworth, Ghassan S. Makhoul, Tony X. Liu, Catherine Henderson, Daniela A. Astudillo Maya, Rebecca Martinez, Hashem Zamanian, Benjamin A. Speidel, Ankit N. Khambhati, Vikram R. Rao, Leo P. Sugrue, Katherine W. Scangos, Edward F. Chang, Andrew D. Krystal
Summary: This study investigated the effects of direct electrical stimulation on the corticolimbic network in humans and found that stimulation of the orbitofrontal cortex, subgenual cingulate, and ventral capsule modulated sleep-wake levels. Stimulation at 100Hz increased wakefulness, while 1Hz stimulation increased sleepiness. Sleep-wake levels were correlated with gamma activity in various brain regions.
Article
Neurosciences
Weronika Potok, Onno van der Groen, Sahana Sivachelvam, Marc Bachinger, Flavio Frohlich, Laszlo B. B. Kish, Nicole Wenderoth
Summary: Stochastic resonance refers to the phenomenon where the transmission of signals in a nonlinear system is enhanced by the presence of additive noise. In the nervous system, nonlinear properties exist at different levels and seem to contribute to stochastic resonance. This study demonstrates that high-frequency, deterministic, periodic signals can yield resonance-like effects and improve visual contrast detection, suggesting that similar mechanisms can emerge when deterministic electrical waveforms are applied.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Review
Neurosciences
Kristin K. Sellers, Joshua L. Cohen, Ankit N. Khambhati, Joline M. M. Fan, A. Moses Lee, Edward F. Chang, Andrew D. Krystal
Summary: Despite the lack of effective treatments for psychiatric diseases, recent research on the neurobiology of these diseases has provided insights into their complex nature. Neurostimulation has gained renewed interest as a potential treatment approach, with closed-loop stimulation showing promise in providing more personalized therapy. The use of biomarkers and specific symptom-correlated stimulation during symptomatic periods allows for targeted intervention. This review discusses the background, foundational studies, and key considerations in designing and implementing closed-loop neurostimulation for psychiatric disorders.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Qi Fang, Flavio Frohlich
Summary: Attention deficits are common in psychiatric and neurological disorders, and there is a lack of circuit-based treatments. To better treat attentional deficits, a comprehensive functional dissection of neural circuits underlying attention is imperative. Animal models and well-designed behavioral assays can help achieve this goal and translate findings into novel interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Meeting Abstract
Neurosciences
Justin Riddle, Moria Smoski, Crystal Schiller, David Rubinow, Flavio Frohlich
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Mengsen Zhang, Rachel B. B. Force, Christopher Walker, Sangtae Ahn, L. Fredrik Jarskog, Flavio Frohlich
Summary: People with schizophrenia show reduced alpha oscillations and decreased frontotemporal coordination of brain activity. The reduced alpha oscillations may lead to auditory hallucinations by failing to inhibit spurious endogenous activity. Transcranial alternating current stimulation (tACS) at the alpha frequency has been proven to enhance alpha oscillations in people with schizophrenia, suggesting its potential as a network-based treatment for auditory hallucinations.
Article
Neurosciences
Justin Riddle, Morgan L. Alexander, Crystal Edler Schiller, David R. Rubinow, Flavio Frohlich
Summary: The prefrontal cortex controls sensory and motor systems through cross-frequency coupling. This study investigates whether these signals are involved in reward-based decision-making and whether this dynamic network configuration is changed in major depressive episodes. The results show that the amplitude of frontal-midline theta oscillations is highest in participants with the highest reward-evaluation. Additionally, the coupling between frontal theta phase and parieto-occipital gamma amplitude is positively correlated with reward-evaluation. Moreover, goal-directed behavior is positively correlated with coupling between frontal delta phase and motor beta amplitude. Finally, mood symptoms positively correlate with reward-evaluation, while motivation symptoms negatively correlate with goal-directed behavior. These findings indicate that different modes of prefrontal top-down control are involved in different aspects of reward-based decision-making and are modulated in different symptom dimensions of depression.
