Review
Obstetrics & Gynecology
Karoline Gundersen Sarmon, Troels Eliasen, Ulla Breth Knudsen, Bjorn Bay
Summary: The study identified an increased risk of stillbirth in pregnancies resulting from in vitro fertilization (IVF) and IVF with intracytoplasmic sperm injection (IVF-ICSI) compared to spontaneous conception, highlighting the potential risks associated with assisted reproductive technologies.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Anastasija Arechvo, Despoina A. Nikolaidi, Maria M. Gil, Valeria Rolle, Argyro Syngelaki, Ranjit Akolekar, Kypros H. Nicolaides
Summary: This study found that the independent predictor of stillbirth is higher for black women compared to other racial groups, with the risk being about two times higher than that for white women. This suggests that closer surveillance should be provided for black women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Samira Behboudi-Gandevani, Razieh Bidhendi-Yarandi, Mohammad Hossein Panahi, Abbas Mardani, Ingjerd Gare Kymre, Piret Paal, Mojtaba Vaismoradi
Summary: Immigrant women in host countries have a higher risk of stillbirth, perinatal, and neonatal mortality compared to native-origin women. This study emphasizes the need for healthcare providers and policymakers to improve maternal and neonatal healthcare for the immigrant population.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Review
Acoustics
W. Zhang, S. Geris, N. Al-Emara, G. Ramadan, A. Sotiriadis, R. Akolekar
Summary: A systematic review and meta-analysis of 21 studies involving 683 pregnancies with vasa previa showed a high perinatal survival rate of 98.6%. Lack of prenatal diagnosis significantly increased the risk of perinatal death and hypoxic morbidity. Further research into prenatal screening strategies for vasa previa is needed for improved outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Multidisciplinary Sciences
Fengming Tu, Aimei Fei
Summary: This study examines the impact of gestational diabetes mellitus (GDM) on maternal and neonatal outcomes in singleton and twin pregnancies. The results showed that singleton pregnancies with GDM had a lower risk of cesarean section, small-for-gestational age neonates, preterm delivery, respiratory morbidity, neonatal hyperbilirubinemia, and NICU admission compared to twin pregnancies with GDM. Therefore, interventions should be focused on twin pregnancies with GDM.
Review
Medicine, General & Internal
Mireia Bernal Claverol, Maria Ruiz Minaya, Irene Aracil Moreno, Santiago Garcia Tizon, Pilar Pintado Recarte, Melchor Alvarez-Mon, Coral Bravo Arribas, Miguel A. Ortega, Juan A. De Leon-Luis
Summary: Triplet pregnancies are rare events and associated with higher risks for both fetal and maternal outcomes compared to twins and singletons. This study aims to review and analyze the literature on triplet pregnancies and evaluate the influence of chorionicity on these outcomes. The results showed a variety of complications, with higher risks observed in non-TCTA pregnancies. More evidence is needed to fully assess certain outcome measures due to limitations in available publications and sample size.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Shashi B. Singh, Bijaya K. Padhi, Aravind P. Gandhi, Pallavi Lohani, Nisha Kumari, Geetu Singh, Prakasini Satapathy, Keerti Bhusan Pradhan, Sarvesh Rustagi, Alaa Hamza Hermis, Arkadiusz Dziedzic, Ranjit Sah
Summary: This study aims to estimate the global burden of stillbirths among pregnant women with COVID-19 vaccination. The systematic review and meta-analysis found a low prevalence of stillbirths among pregnant women vaccinated against COVID-19 infection.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Obstetrics & Gynecology
Danilo Buca, Daniele Di Mascio, Asma Khalil, Ganesh Acharya, Tim Van Mieghem, Karien Hack, Masaharu Murata, Olivia Anselem, Alice D'Amico, Ludovico Muzii, Marco Liberati, Luigi Nappi, Francesco D'Antonio
Summary: This study reports the incidence of neonatal morbidity in monochorionic monoamniotic (MCMA) twin pregnancies, with a focus on respiratory morbidity. The study finds that the incidence of respiratory morbidity decreases with increasing gestational age at delivery. Furthermore, the study suggests that the type of management (inpatient or outpatient) does not affect the occurrence of neonatal morbidity.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Review
Obstetrics & Gynecology
Filomena Giulia Sileo, Francesco D'antonio, Can Benlioglu, Amar Bhide, Asma Khalil
Summary: This systematic review and meta-analysis evaluated the outcomes of monochorionic-diamniotic twin pregnancies affected by late TTTS with different management options. The results indicated a need for further high-quality research to determine the optimal management of these pregnancies, as evidence on perinatal mortality and morbidity was of very low quality.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Obstetrics & Gynecology
Elizabeth J. Eggleton, Kate J. McMurrugh, Catherine E. Aiken
Summary: This study systematically assessed perinatal outcomes of pregnancies complicated by maternal cardiomyopathy. Thirteen studies were included, representing 2,291,024 pregnancies. It was found that women with cardiomyopathy had higher rates of perinatal death, preterm birth, and small-for-gestational-age neonates compared to those without cardiac disease. Therefore, detailed counseling and management by experienced multidisciplinary teams are recommended for pregnant women with cardiomyopathy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Clinical Neurology
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Gita D. Mishra
Summary: Miscarriage and stillbirth are associated with an increased risk of stroke among women, potentially influenced by underlying factors such as endocrine disorders, endothelial dysfunction, and chronic systemic inflammation.
Review
Obstetrics & Gynecology
S. Marleen, C. Dias, R. Nandasena, R. MacGregor, J. Allotey, J. Aquilina, A. Khalil, S. Thangaratinam
Summary: After analyzing 39 studies, it was found that monochorionicity is significantly associated with an increased risk of preterm birth in twin pregnancies, especially at all gestations.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Pediatrics
Wei Zhong, Xiaojiao Fan, Fang Hu, Meiqin Chen, Fanshu Zeng
Summary: Gestational weight gain in twin pregnancies significantly influences maternal and neonatal outcomes, with both insufficient and excessive gain associated with negative effects. Optimal weight gain during pregnancy is recommended to improve outcomes in twin pregnancies.
FRONTIERS IN PEDIATRICS
(2021)
Review
Endocrinology & Metabolism
Qiqi You, Qingqing Jiang, Irakoze Shani, Yiling Lou, Shen Huang, Shiqi Wang, Shiyi Cao
Summary: This study systematically assessed the association between a history of miscarriage or stillbirth and the risk of diabetes in women. It found that women who have ever experienced a miscarriage have an increased risk of non-gestational diabetes and gestational diabetes, and women with three or more miscarriages have a higher risk of non-gestational diabetes. Women with a history of stillbirth also have an increased risk of non-gestational diabetes. However, the study did not find a stable association between stillbirth and gestational diabetes risk.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Obstetrics & Gynecology
Maya Whittaker, Isabelle Greatholder, Mark D. D. Kilby, Alexander E. P. Heazell
Summary: Globally, the incidence of twin pregnancies is increasing due to assisted reproductive technologies, emigration, and advanced maternal age. Twin pregnancies have higher risks of adverse outcomes compared to singleton pregnancies, but the impact of specific risk factors may differ. Targeted evidence is needed to provide tailored care and prevent adverse outcomes in twin pregnancies.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Acoustics
S. Sorrenti, D. Di Mascio, A. Khalil, N. Persico, F. D'antonio, F. Zullo, V. D'ambrosio, G. Greenberg, J. Hasson, F. Vena, L. Muzii, R. Brunelli, A. Giancotti
Summary: This study evaluated outcomes of dichorionic twin pregnancies undergoing early vs late selective termination of pregnancy. The results showed that the risk of pregnancy loss prior to 24 weeks was lower in the early-ST group, and the risks of preterm birth and low birth weight were also lower. Therefore, the importance of early diagnosis of fetal anomalies in twin pregnancies was highlighted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Kelly Hughes, Heather Ford, Shakila Thangaratinam, Shaun Brennecke, Ben W. Mol, Rui Wang
Summary: This study conducted a systematic review of 14 papers and found that cervical length is associated with the risk of preterm birth. However, most of the systematic reviews analyzed the diagnostic test accuracy of cervical length rather than its predictive ability. It is recommended to perform individual participant data meta-analysis to better quantify the predictive capacity of transvaginal ultrasonographic cervical length for preterm birth.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Signe Milling Mortensen, Charlotte Kvist Ekelund, Berit Woetmann Pedersen, Ann Tabor, Line Rode
Summary: This study examined the relationship between mid-regional pro-atrial natriuretic peptide, a heart failure biomarker, and early-onset preeclampsia in the first trimester of pregnancy. The results showed that there was no significant difference in mid-regional pro-atrial natriuretic peptide levels between women with early-onset preeclampsia and the control group.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Acoustics
I. Riishede, L. Rode, L. Sperling, M. Overgaard, J. D. Ravn, P. Sandager, H. Skov, S. R. Wagner, P. Norgaard, T. D. Clausen, C. A. Juel Jensen, K. Pihl, F. S. Jorgensen, J. K. Munk, H. J. Zingenberg, N. G. Pedersen, M. R. Andersen, A. Wright, D. Wright, A. Tabor, C. K. Ekelund
Summary: This study investigates the predictive performance of the FMF first-trimester screening algorithm for pre-eclampsia in a Danish population and compares it with the current Danish strategy based on maternal risk factors. The results show that the FMF algorithm performs well in predicting pre-eclampsia and its performance in the Danish population is similar to other populations.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Pediatrics
Rasmus Kristensen, Camilla Omann, J. William Gaynor, Line Rode, Charlotte K. Ekelund, Vibeke E. Hjortdal
Summary: Increased nuchal translucency is associated with higher mortality in children with congenital heart defects (CHD), but the underlying cause is unknown.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cell Biology
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Geraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sebastien Jacques, Colin E. Murdoch, Francisco Miralles, Celine Mehats, Daniel Vaiman
Summary: In this study, we aimed to identify genetic variants affecting gene expression in the human placenta, specifically in normal and pathological situations. The analysis was constrained by the fact that placental tissue samples from diseased individuals are typically obtained at an earlier gestational age compared to control samples, leading to confounding factors in transcriptome regulation. To address this issue, we implemented a novel approach that accounted for gestational age and identified disease-specific cis-eQTLs. Through statistical correction and analysis, we identified a list of e-genes that significantly influenced expression levels, demonstrating the validity of our methodology for future research purposes.
Review
Public, Environmental & Occupational Health
Sara Jochumsen, Hanne Kristine Hegaard, Line Rode, Karsten Juhl Jorgensen, Nina Olsen Nathan
Summary: This study aimed to identify maternal factors associated with labor dystocia in low-risk nulliparous women. Seven cohort studies were included, and the results showed that advanced maternal age, higher BMI, shorter stature, fear of childbirth, and high caffeine intake were associated with an increased frequency of labor dystocia.
SEXUAL & REPRODUCTIVE HEALTHCARE
(2023)
Review
Obstetrics & Gynecology
Hiba J. Mustafa, Enaja Sambatur, Julie P. Barbera, Giorgio Pagani, Yuval Yaron, Caitlin D. Baptiste, Ronald J. Wapner, Asma Khalil
Summary: This study aimed to assess the diagnostic yield of prenatal exome sequencing after negative chromosomal microarray analysis in cases of prenatally diagnosed bilateral severe ventriculomegaly or hydrocephalus. The study identified relevant studies published until June 2022 and included studies in English reporting on the diagnostic yield of exome sequencing following negative chromosomal microarray analysis in cases of prenatally diagnosed bilateral severe ventriculomegaly. Meta-analysis was performed using a random-effects model to assess the incremental diagnostic yield of exome sequencing.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Medicine, General & Internal
Siang Ing Lee, Stephanie Hanley, Zoe Vowles, Rachel Plachcinski, Ngawai Moss, Megha Singh, Chris Gale, Adeniyi Francis Fagbamigbe, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O'Reilly, Gillian Santorelli, Helen Dolk, Holly Hope, Katherine M. Phillips, Kathryn Abel, Kelly-Ann Eastwood, Lisa Kent, Louise Locock, Maria Loane, Mohamed Mhereeg, Peter Brocklehurst, Sharon McCann, Sinead Brophy, Steven Wambua, Sudasing Pathirannehelage Buddhika Hemali Sudasinghe, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black, MuM PreDiCT Grp
Summary: This study developed a core outcome set for pregnant women with multimorbidity, aiming to address the heterogeneity in reported outcomes and improve the synthesis of research evidence. The core outcome set was developed through a systematic literature search, focus groups, Delphi surveys, and consensus meetings. It includes 11 outcomes, covering maternal and child outcomes.
Review
Medicine, General & Internal
Francesco D'Antonio, Nashwa Eltaweel, Smriti C. Prasad, Maria Elena C. Flacco, Lamberto C. Manzoli, Asma C. Khalil
Summary: This systematic review and meta-analysis aimed to evaluate the role of cervical cerclage in preventing preterm birth and adverse outcomes in twin pregnancies. The findings suggest that cervical cerclage in twin pregnancies with short cervical length or cervical dilatation is associated with a reduced risk of preterm birth and improved neonatal outcomes. However, confirmation of these findings in large and well-designed randomized controlled trials is needed for stronger evidence.
Article
Medicine, General & Internal
Nawa Schirwani-Hartl, Pilar Palmrich, Christina Haberl, Nicole Perkmann-Nagele, Herbert Kiss, Angelika Berger, Judith Rittenschober-Bohm, Gregor Kasprian, Patric Kienast, Asma Khalil, Julia Binder
Summary: This retrospective analysis investigated the efficacy of administering hyperimmune globulin (HIG) therapy every 2 weeks compared to every 4 weeks in pregnant women with primary cytomegalovirus (CMV) infection. The study found no significant difference in congenital CMV rates or fetal ultrasound and magnetic resonance imaging (MRI) anomalies between the two groups. Larger studies are needed to evaluate the impact of administering HIG every 2 weeks on maternal-fetal transmission rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Obstetrics & Gynecology
Anne Noll, Francesca Maria Russo, Johannes van der Merwe, Joanne Verweij, Monique Haak, Lotta Herling, Eleonor Tiblad, Liesbeth Lewi
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Eyal Krispin, Ali Javinani, Anthony O. Odibo, Jena L. Miller, Julien Stirnemann, Asma Khalil, Kurt Hecher, Ramen H. Chmait, Elena Carreras, Mounria Habli, Stephen Emery, Gerardo Sepulveda, Mark Kilby, Liesbeth Lewi, Lucas Otano, Michael V. Zaretsky, Nicolas Sananes, Yoav Yinon, Welsh Alec William, Ozhan M. Turan, Mar Bennasar, Ramesha Papanna, Femke Slaghekke, Tim Van Mieghem, Alireza Shamshirsaz
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Kobe Haenen, Simen Vergote, Yada Kunpalin, Luc De Catte, Roland Devlieger, Liesbeth Lewi, Hannes van der Merwe, Francesca Russo, Philippe De Vloo, Jan Deprest
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Sofia Mastrodima-Polychroniou, Serena Banh, Adalina Sacco, Emma Bredaki, Georgina Murray, Michael Aertsen, Frank Van Calenbergh, Philippe Devloo, Roland Devlieger, Liesbeth Lewi, Luc De Catte, Kelly Pegoretti Baruteau, Trevor Gaunt, George Attilakos, Ruwan Wimalasundera, Zubair Tahir, Dominic Thompson, Paolo De Coppi, Anna David, Jan Deprest
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)