Article
Multidisciplinary Sciences
Ember (Yiwei) Lu, Hui-Han Chen, Hongqing Zhao, Sachiko Ozawa
Summary: This study investigated the impact of increasing pneumococcal conjugate vaccine (PCV) coverage on antimicrobial resistance (AMR) in China. Results showed that increasing vaccine coverage significantly reduced resistance against penicillin, amoxicillin, and third-generation cephalosporins, leading to a reduction in costs due to AMR.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ember (Yiwei) Lu, Hui-Han Chen, Hongqing Zhao, Sachiko Ozawa
Summary: This study examined the impact of increasing pneumococcal conjugate vaccine (PCV) coverage on antimicrobial resistance (AMR) in China. The findings suggest that higher PCV coverage can significantly reduce AMR against commonly used antibiotics and lead to substantial cost savings in terms of direct and indirect costs related to AMR. Understanding the benefits of vaccines in reducing AMR is crucial for driving appropriate investment in this area.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Gail L. Rodgers, Cynthia G. Whitney, Keith P. Klugman
Summary: Pneumococcal conjugate vaccine has successfully reduced the burden of disease and provided herd protection for those who cannot be vaccinated. While widely rolled out in poor countries, there are still many unvaccinated children in middle income countries. Solutions being considered include reducing doses and supporting more affordable vaccine sources.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ching-Fen Shen, Ju-Ling Chen, Chien-Chou Su, Wen-Liang Lin, Min-Ling Hsieh, Ching-Chun Liu, Ching-Lan Cheng
Summary: The implementation of PCV13 in Taiwan has significantly reduced hospitalizations for P-CAP, especially in children and adults, and has markedly decreased ICU rates and severe pneumonia cases.
Article
Respiratory System
Yan Li, Pingshu Zhang, Zhijie An, Chenyan Yue, Yamin Wang, Yunqiu Liu, Xiaodong Yuan, Ying Ma, Keli Li, Zundong Yin, Liye Wang, Huaqing Wang
Summary: This study aimed to evaluate the effectiveness of influenza and pneumococcal vaccines in patients with COPD. The results showed that both vaccines, when used separately or together, effectively reduced the risk of acute exacerbations, pneumonia, and hospitalizations in COPD patients, with the greatest effectiveness seen in preventing acute exacerbations.
Article
Immunology
Maria Gabriela Matta, Laura Pulido, Juan Jose Herrera-Paz, Jose M. Picco, Sebastian Wolff, Gary Tse, Sebastian Garcia -Zamora
Summary: The study aimed to describe the vaccination rates in volunteers from three regions of Argentina during the COVID-19 pandemic. A survey of 3853 adults in 2020 found that the influenza vaccination rate was 37.7%, pneumococcal vaccination rate was 24.7%, and both vaccines were received by 17.8% of the participants. The study showed suboptimal vaccination rates among high-risk patients in Argentina and highlighted the potential neglect of immunizations during the COVID-19 pandemic.
Article
Microbiology
Thomas Chandler, Stephen Furmanek, Ruth Carrico, Dawn Balcom, Forest Arnold, Julio Ramirez
Summary: This study analyzed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) for preventing hospitalization due to serotype-specific community-acquired pneumonia (CAP). The results showed that PPSV23 did not offer protection against CAP hospitalization caused by the vaccine-contained serotypes. This study highlights the importance of developing more effective vaccines for the prevention of hospitalization due to S. pneumoniae CAP.
Review
Microbiology
Nobuhiro Asai, Hiroshige Mikamo
Summary: Pneumococcal disease is a global burden with high mortality rates. The use of pneumococcal vaccines in children has been effective, but vaccination for at-risk individuals aged 19-64 requires careful consideration due to insufficient evidence.
Review
Pharmacology & Pharmacy
Matt Shirley
Summary: The introduction of multi-valent pneumococcal vaccines, such as PCV13, has significantly reduced the burden of Streptococcus pneumoniae infection globally. However, PCV13 does not cover all serotypes, and therefore, a new vaccine, PCV20, has been developed to expand the coverage. PCV20 has shown immunogenicity in adults and a similar safety profile to PCV13.
Article
Immunology
Julia L. Raboba, Vonintsoa L. Rahajamanana, Emilson P. R. Andriatahirintsoa, Ainamalala C. Razafindrakoto, Andry M. Andrianarivelo, Marcellin Nimpa Mengouo, Yolande Vuo Masembe, Goitom G. Weldegebriel, Linda de Gouveia, Jason M. Mwenda, Annick L. Robinson
Summary: The study assessed the impact of PCV10 on pneumococcal serotypes in children under 5 years in Madagascar. It found that the introduction of PCV10 led to a decrease in meningitis caused by S. pneumoniae and PCV10 vaccine serotypes. The research results show that PCV10 vaccine lowered the incidence of meningitis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pediatrics
I-Fan Chang, I-Fan Lin, Yun-Chung Liu, Chia-Ching Chou, Tu-Hsuan Chang, Ting-Yu Yen, Chun-Yi Lu, Luan-Yin Chang, Feipei Lai, Li-Min Huang
Summary: After the implementation of PCV13 vaccination, the incidence of invasive pneumococcal disease (IPD) and case-fatality rate in pediatric community-acquired pneumonia (CAP) significantly decreased in Taiwan. However, the rates of infections with other pathogens increased, which requires further surveillance for their clinical significance.
PEDIATRIC PULMONOLOGY
(2023)
Article
Immunology
S. Tay, A. C. Bowen, C. C. Blyth, P. Clifford, R. Clack, T. Ford, H. Herbert, J. Kuthubutheen, F. Mascaro, A. O'Mahoney, S. Rodrigues, T. Tran, A. J. Campbell
Summary: This study examined the pneumococcal immunization status and rate of invasive pneumococcal disease in children with cochlear implants. The majority of children were not up to date with additionally recommended pneumococcal vaccinations. Electronic reminders and a dedicated immunization clinic improved vaccination rates.
Article
Immunology
Jung Yeon Heo, Yu Bin Seo, Won Suk Choi, Eun Jin Kim, Hye Won Jeong, Jacob Lee, Jin Gu Yoon, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Joon Young Song
Summary: The effectiveness of pneumococcal vaccines against pneumococcal pneumonia is low in the elderly. However, sequential PCV13/PPSV23 vaccination shows the highest effectiveness in the younger subgroup.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Katherine Newell, Marc Fischer, Stephanie Massey, Laurie Orell, Jonathan Steinberg, Megan Tompkins, Louisa Castrodale, Joseph Mclaughlin
Summary: Streptococcus pneumoniae can co-infect with SARS-CoV-2, resulting in dual infection. A study conducted in Alaska found that IPD patients with SARS-CoV-2 had a higher mortality rate compared to those with IPD alone, and were more likely to be experiencing homelessness. This study highlights the importance of pneumococcal and COVID-19 vaccination among vulnerable populations.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Joseph A. Lewnard, Noga Givon-Lavi, Ron Dagan
Summary: The study analyzed the effectiveness of PCV in protecting children against pneumonia caused by different vaccine-targeted pneumococcal serotypes in southern Israel. The results showed that PCV could effectively reduce carriage of vaccine-serotype pneumococci and decrease the risk of disease progression.
CLINICAL INFECTIOUS DISEASES
(2021)