Article
Oncology
Audrey Moatti, Anais Debesset, Caroline Pilon, Asma Beldi-Ferchiou, Mathieu Leclerc, Rabah Redjoul, Frederic Charlotte, Nhu Hanh To, Adeline Bak, Yazid Belkacemi, Benoit Laurent Salomon, Fadi Issa, David Michonneau, Sebastien Maury, Jose Laurent Cohen, Allan Thiolat
Summary: This study reveals the potential of targeting TNFR2 to enhance anti-tumor responses and treat relapse of blood malignancies. The researchers also found that TNFR2 is over-expressed in Tregs from healthy donors and patients with leukemia relapse or GVHD. These findings provide new perspectives for the development of immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu
Summary: The study found that restoring autophagic flux of exhausted TILs through spermidine treatment can enhance the diversity of TCR repertoire, reduce the expression of inhibitory immunoreceptors (PD1, TIM3, or LAG3), improve proliferation and effector functions, leading to superior in vitro and in vivo antitumor activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Joseph R. Campbell, Bryan R. McDonald, Paul B. Mesko, Nathan O. Siemers, Priti B. Singh, Mark Selby, Tim W. Sproul, Alan J. Korman, Logan M. Vlach, Jeff Houser, Sharmila Sambanthamoorthy, Kai Lu, Sandra Hatcher, Jack Lohre, Renu Jain, Ruth Y. Lan
Summary: Research suggests that selectively depleting regulatory T cells using an anti-CCR8 antibody can enhance antitumor immune responses, whether used as a monotherapy or in combination with other immunotherapies.
Article
Oncology
Anders Handrup Kverneland, Christopher Aled Chamberlain, Troels Holz Borch, Morten Nielsen, Sofie Kirial Mork, Julie Westerlin Kjeldsen, Cathrine Lund Lorentzen, Lise Pyndt Jorgensen, Lene Buhl Riis, Christina Westmose Yde, Ozcan Met, Marco Donia, Inge Marie Svane
Summary: This study demonstrated high success rates of TIL expansion and tumor regressions in multiple solid cancer types when combining TIL ACT with CPIs. In vitro tumor reactivity was positively associated with treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Yue Ma, Xin Xu, Huaitao Wang, Yang Liu, Haiyan Piao
Summary: Cancer immunotherapy shows promising effects in fighting tumors, but regulatory T cells (Tregs) in the tumor microenvironment (TME) hinder immune responses and contribute to immunosuppression. Depleting or attenuating tumor-infiltrating Tregs can enhance anti-tumor immunity without disrupting normal immune function. Noncoding RNAs (ncRNAs) have the potential to regulate both cancer and immune cells, improving antitumor responses. This review focuses on the roles of immune checkpoints, inhibitory Tregs receptors, and ncRNAs in Treg plasticity and functionality.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Debottam Sinha, Sriganesh Srihari, Kirrliee Beckett, Laetitia Le Texier, Matthew Solomon, Archana Panikkar, George R. Ambalathingal, Lea Lekieffre, Pauline Crooks, Sweera Rehan, Michelle A. Neller, Corey Smith, Rajiv Khanna
Summary: Studies have shown that overcoming resistance to in vivo T-cell therapy can be achieved through the sequential infusion of two different allogeneic T-cell therapies restricted by different HLA alleles targeting EBV. Furthermore, the combination of inhibition of the programmed cell death protein-1/programmed death-ligand 1 axis with EBV-specific T-cell therapy significantly improves overall survival in tumor-bearing mice.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
HyeJin Yang, Seon-Young Park, Hyunjung Baek, Chanju Lee, Geehoon Chung, Xiao Liu, Ji Hwan Lee, Byungkyu Kim, Minjin Kwon, Hyojung Choi, Hyung Joon Kim, Jae Yoon Kim, Younsub Kim, Ye-Seul Lee, Gaheon Lee, Sun Kwang Kim, Jin Su Kim, Young -Tae Chang, Woo Sang Jung, Kyung Hwa Kim, Hyunsu Bae
Summary: AP antigen-specific regulatory T cells can suppress microglial proinflammatory activity and modulate microglial phenotype via bystander suppression. Single adoptive transfer of AP+ Tregs is sufficient to ameliorate cognitive impairments, AP accumulation, hyper-phosphorylation of tau, and neuroinflammation during AD pathology. AP-specific Tregs effectively inhibit inflammation in primary microglia induced by AP exposure, indicating bystander suppression where AP-specific Tregs promote immune tolerance by secreting cytokines to modulate immune responses during neurodegeneration.
Article
Oncology
Rosa A. van Amerongen, Renate S. Hagedoorn, Dennis F. G. Remst, Danique C. Assendelft, Dirk M. van der Steen, Anne K. Wouters, Marian van de Meent, Michel G. D. Kester, Arnoud H. de Ru, Marieke Griffioen, Peter A. van Veelen, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Summary: In this study, high-avidity WT1-specific T cells were identified from the allogeneic T-cell repertoire of healthy donors. These T cells showed potent and specific anti-WT1 activity against newly identified WT1 peptides derived from primary leukemia and ovarian carcinoma samples. Additionally, T-cell clones with T-cell receptor (TCR) gene transfer showed antitumor reactivity against WT1-expressing solid tumor cell lines, acute myeloid leukemia (AML) blasts, and ovarian carcinoma patient samples. These findings suggest that these TCRs and naturally expressed WT1 peptides have potential for TCR gene transfer strategies in patients with WT1-expressing tumors, including AML and ovarian carcinoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Sandhya Sharma, Mae Woods, Naren U. Mehta, Tim Sauer, Kathan S. Parikh, Michael Schmuck-Henneresse, Huimin Zhang, Birju Mehta, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney
Summary: This study found that depleting naive T cells before extracting antigen-specific T cells from patients can enhance their expansion, antigen specificity, and therapeutic potency. By using CD45RA-depleted PBMCs, EBV-specific T cells were successfully generated and applied in clinical trials for lymphoma and viral infections.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Juan Zhang, Xiaoqian Ma, Lu Cao, Xing He, Sang Li, Min Yang, Cejun Yang, Pengfei Rong, Shounan Yi, Kedar Ghimire, Xiangfeng Kong, Wei Wang
Summary: Hucb-Tregs treated with MSC-CM or MSC-derived exosomes were more suppressive and resistant to inflammatory stimulation. MSC-derived exosomes could activate autophagy and JAK3-Stat5 signaling pathway to promote Treg survival and regulate FOXP3 expression. MSC-derived exosomes could be an effective strategy to improve the Tregs-based cell therapy landscape.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Virology
Abdurrahman Simsek, Muhammed A. Kizmaz, Eren Cagan, Fatma Dombaz, Gulcin Tezcan, Ali Asan, H. Ibrahim Demir, S. Haldun Bal, Digdem Y. Ermis, Asli G. Dilektasli, Esra Kazak, E. Halis Akalin, H. Barbaros Oral, Ferah Budak
Summary: This study investigated the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and found that CD39(+) Tregs increased with disease severity in adult patients, while they decreased in an age-dependent manner in juvenile patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Microbiology
Alaa Elsaghir, Ehsan M. W. El-Sabaa, Abdulrahman K. Ahmed, Sayed F. Abdelwahab, Ibrahim M. Sayed, Mohamed A. El-Mokhtar
Summary: CD39 is a marker of immune cells that hydrolyzes ATP into adenosine, exerting an immunosuppressive effect. CD39 plays a regulatory role in various immunologic cells through purinergic signaling pathways. CD39+ T cells are implicated in viral infections and their expression is an indicator of lymphocyte exhaustion. CD39 levels in T lymphocytes can predict disease progression and immune response to antiviral drugs, while the percentage of CD39 and CD73 in B lymphocytes and monocytes affects the status of viral infections.
Article
Oncology
Jitendra Kumar, Ritesh Kumar, Amir Kumar Singh, Elviche L. Tsakem, Mahesh Kathania, Matthew J. Riese, Arianne L. Theiss, Marco L. Davila, K. Venuprasad
Summary: The study identified Cbl-b as a potential target for overcoming exhausted CAR T-cell function in solid tumors. Inhibition of Cbl-b restored effector function of exhausted T cells. Depletion of Cbl-b enhanced CAR T-cell efficacy in reducing tumor growth, decreasing exhausted T cells, and increasing effector cytokine expression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Kedar Kirtane, Hany Elmariah, Christine H. Chung, Daniel Abate-Daga
Summary: Immune checkpoint inhibitors have significantly changed the standard care for many solid tumor malignancies, but resistance remains common. Adoptive cellular therapy is a rapidly growing form of immunotherapy that shows promise in overcoming resistance mechanisms and has already revolutionized the treatment of hematologic malignancies. The use of ACT in solid tumor malignancies is still in its early stages, with promising therapies under active investigation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Xuebin Hu, Zhaojing Lu, Shanshan Yu, James Reilly, Fei Liu, Danna Jia, Yayun Qin, Shanshan Han, Xiliang Liu, Zhen Qu, Yuexia Lv, Jingzhen Li, Yuwen Huang, Tao Jiang, Haibo Jia, Qing Wang, Jingyu Liu, Xinhua Shu, Zhaohui Tang, Mugen Liu
Article
Hematology
Shanshan Yu, Tao Jiang, Danna Jia, Yundiao Han, Fei Liu, Yuwen Huang, Zhen Qu, Yuntong Zhao, Jiayi Tu, Yuexia Lv, Jingzhen Li, Xuebin Hu, Zhaojing Lu, Shanshan Han, Yayun Qin, Xiliang Liu, Shanglun Xie, Qing K. Wang, Zhaohui Tang, Daji Luo, Mugen Liu
Article
Genetics & Heredity
Meng Han, Miao Zhao, Chen Cheng, Yuan Huang, Shengna Han, Wenjuan Li, Xin Tu, Xuan Luo, Xiaoling Yu, Yinan Liu, Qiuyun Chen, Xiang Ren, Qing Kenneth Wang, Tie Ke
Article
Biochemistry & Molecular Biology
Hyosuk Cho, Gong-Qing Shen, Xiaofeng Wang, Fan Wang, Stephen Archacki, Yabo Li, Gang Yu, Susmita Chakrabarti, Qiuyun Chen, Qing Kenneth Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Genetics & Heredity
Hongbo Xiong, Qin Yang, Xiaoping Zhang, Pengxia Wang, Feifei Chen, Ying Liu, Pengyun Wang, Yuanyuan Zhao, Sisi Li, Yufeng Huang, Shanshan Chen, Xiaojing Wang, Hongfu Zhang, Dong Yu, Chencheng Tan, Cheng Fang, Yuan Huang, Gang Wu, Yanxia Wu, Xiang Cheng, Yuhua Liao, Rongfeng Zhang, Yanzong Yang, Tie Ke, Xiang Ren, Hui Li, Xin Tu, Yunlong Xia, Chengqi Xu, Qiuyun Chen, Qing K. Wang
ANNALS OF HUMAN GENETICS
(2019)
Article
Genetics & Heredity
Wei Li, Lingfang Tan, Xin Li, Xiaoyu Zhang, Xiaoyan Wu, Hongbo Chen, Lihua Hu, Xiaobei Wang, Xiaoping Luo, Fan Wang, Chengqi Xu, Qiuyun Chen, Runming Jin, Qing K. Wang
Article
Endocrinology & Metabolism
Yufeng Yao, Yong Li, Qixue Song, Changqin Hu, Wen Xie, Chengqi Xu, Qiuyun Chen, Qing K. Wang
Article
Biochemistry & Molecular Biology
Chen Cheng, Huixia Liu, Chengcheng Tan, Doudou Tong, Yongxuan Zhao, Xia Liu, Wenxia Si, Linlin Wang, Lina Liang, Jia Li, Chenghui Wang, Qiuyun Chen, Yimei Du, Qing K. Wang, Xiang Ren
Article
Biochemistry & Molecular Biology
Yong Li, Yufeng Yao, Jia Li, Qiuyun Chen, Lu Zhang, Qing K. Wang
Article
Cardiac & Cardiovascular Systems
Bo Tang, Yushuang Hu, Zhijie Wang, Chen Cheng, Pengyun Wang, Lina Liang, Hongbo Xiong, Chunyan Luo, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Qin Yang, Hongbo Xiong, Chengqi Xu, Yuan Huang, Xin Tu, Gang Wu, Fenfen Fug, Zhijie Wang, Longfei Wang, Yuanyuan Zhao, Sisi Li, Yufeng Huang, Chuchu Wang, Dan Wang, Yufeng Yao, Fan Wang, Yongbo Wang, Yu Xue, Pengyun Wang, Qiuyun Chen, Jielin Pu, Qing K. Wang
MOLECULAR GENETICS AND GENOMICS
(2019)
Article
Pharmacology & Pharmacy
Yufeng Yao, Hui Li, Xinwen Da, Zuhan He, Bo Tang, Yong Li, Changqing Hu, Chengqi Xu, Qiuyun Chen, Qing K. Wang
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Cardiac & Cardiovascular Systems
Yufeng Yao, Changqing Hu, Qixue Song, Yong Li, Xingwen Da, Yubin Yu, Hui Li, Ian M. Clark, Qiuyun Chen, Qing K. Wang
CARDIOVASCULAR RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Lina Liang, Xia Li, Sebastien Moutton, Samantha A. Schrier Vergano, Benjamin Cogne, de Anne Saint-Martin, Anna C. E. Hurst, Yushuang Hu, Olaf Bodamer, Julien Thevenon, Christina Y. Hung, Bertrand Isidor, Benedicte Gerard, Adelaide Rega, Sophie Nambot, Daphne Lehalle, Yannis Duffourd, Christel Thauvin-Robinet, Laurence Faivre, Stephane Bezieau, Leon S. Dure, Daniel C. Helbling, David Bick, Chengqi Xu, Qiuyun Chen, Grazia M. S. Mancini, Antonio Vitobello, Qing Kenneth Wang
HUMAN MOLECULAR GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Hyosuk Cho, Yabo Li, Stephen Archacki, Fan Wang, Gang Yu, Susmita Chakrabarti, Yang Guo, Qiuyun Chen, Qing Kenneth Wang