Article
Immunology
Pauline Brochet, Barbara Ianni, Joao P. S. Nunes, Amanda F. Frade, Priscila C. Teixeira, Charles Mady, Ludmila R. P. Ferreira, Andreia Kuramoto, Cristina W. Pissetti, Bruno Saba, Darlan D. S. Candido, Fabricio Dias, Marcelo Sampaio, Jose A. Marin-Neto, Abilio Fragata, Ricardo C. F. Zaniratto, Sergio Siqueira, Giselle D. L. Peixoto, Vagner O. C. Rigaud, Paula Buck, Rafael R. Almeida, Hui Tzu Lin-Wang, Andre Schmidt, Martino Martinelli, Mario H. Hirata, Eduardo Donadi, Virmondes Rodrigues Junior, Alexandre C. Pereira, Jorge Kalil, Lionel Spinelli, Edecio Cunha-Neto, Christophe Chevillard
Summary: This study proposes two sets of DNA methylation biomarkers that can predict the occurrence and stage of Chagas disease cardiomyopathy. Using machine learning algorithms, predictions in a test cohort achieved an accuracy of over 95%. These biomarkers are also associated with immune response, nervous system, ion transport, and ATP synthesis pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Katherine R. McAleese, Janitzio J. Guzman, Lauren Thumm, Thomas B. Nutman, Adrienne Showler, Elise M. O'Connell
Summary: In a cohort of mostly Central American immigrants with neurocysticercosis (NCC), 3.1% were also diagnosed with Chagas disease (CD). The majority of patients were diagnosed with CD before the age of 50. The treatment of NCC provides an opportunity for early detection and potential treatment of CD in individuals from endemic areas.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Luis E. Echeverria, Sergio Alejandro Gomez-Ochoa, Lyda Z. Rojas, Karen Andrea Garcia-Rueda, Pedro Lopez-Aldana, Taulant Muka, Carlos A. Morillo
Summary: The study aimed to analyze the correlation of six biochemical markers with diastolic function echocardiographic markers and DD diagnosis in patients with Chronic Chagas Cardiomyopathy (CCM). Results showed that higher levels of NT-proBNP, Hs-cTnT, NGAL, and Cys-C were associated with an increased odds of having diastolic dysfunction in multivariate analyses. NT-proBNP had the highest AUC value for discriminating DD presence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Environmental Sciences
Sebastian Huhn, Beate Escher, Martin Krauss, Stefan Scholz, Jorg Hackermuller, Rolf Altenburger
Summary: Environmental factors and genetic predisposition contribute to the risk for adverse health outcomes; chemical exposures may substantially impact disease risk and adverse outcomes; exposomics explore the links between chemical exposure and health outcomes, capturing a comprehensive picture of the environmental chemical exposome and identifying associations for novel risk assessment and intervention.
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Article
Gastroenterology & Hepatology
Ashkan Rezazadeh Ardabili, Danny Goudkade, Dion Wintjens, Marielle Romberg-Camps, Bjorn Winkens, Marie Pierik, Heike Grabsch, Daisy Jonkers
Summary: The study found that certain histopathological features in colonic biopsies at the diagnosis of Crohn's disease may help predict the severity of the disease course, offering a novel approach to improving patient stratification and guiding clinical decision-making.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Biochemistry & Molecular Biology
Alex R. Medeiros, Leonardo L. G. Ferreira, Mariana L. de Souza, Celso de Oliveira Rezende Junior, Rocio Marisol Espinoza-Chavez, Luiz Carlos Dias, Adriano D. Andricopulo
Summary: The study explored the design of cruzain inhibitors based on imidazole scaffolds through molecular docking and quantitative structure-activity relationship analysis. Models were built and key structural properties determining cruzain inhibition were identified, revealing novel insights for the design of improved inhibitors.
Article
Medicine, General & Internal
Marcelo T. Holanda, Mauro F. F. Mediano, Alejandro M. Hasslocher-Moreno, Beatriz M. S. Gonzaga, Anna Cristina C. Carvalho, Roberto R. Ferreira, Luciana R. Garzoni, Fernanda S. Pereira-Silva, Luis O. Pimentel, Marcelo O. Mendes, Marcos J. Azevedo, Constanca Britto, Otacilio C. Moreira, Alice G. Fernandes, Carolina M. Santos, Jessica Constermani, Vitor B. Paravidino, Erica R. Maciel, Fernanda M. Carneiro, Sergio S. Xavier, Gilberto M. Sperandio da Silva, Priscila F. Santos, Henrique H. Veloso, Pedro E. A. A. Brasil, Andrea S. de Sousa, Maria G. Bonecini-de-Almeida, Paula S. da Silva, Luiz Henrique C. Sangenis, Roberto M. Saraiva, Tania C. Araujo-Jorge
Summary: The selenium treatment did not significantly improve cardiac function in chronic chagasic cardiomyopathy patients, although a potential beneficial influence of selenium was observed in the subgroup of patients at stage B2. Further studies exploring diverse selenium doses and associations in different stages of chronic chagasic cardiomyopathy are needed.
Review
Immunology
Eduardo G. Bruneto, Miguel M. Fernandes-Silva, Cristina Toledo-Cornell, Silvia Martins, Joao M. B. Ferreira, Valeria R. Correa, Joicely M. da Costa, Ana Yece das N. Pinto, Dilma do S. M. de Souza, Maria Carmelinda G. Pinto, Jose Albuquerque de F Neto, Alberto N. Ramos, James H. Maguire, Odilson M. Silvestre
Summary: Orally-transmitted acute Chagas disease is emerging as a significant public health problem, with considerable lethality in the first year after infection but a declining mortality rate over the years. Symptomatic cases have a similar lethality rate to those from other routes of infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Maria Gabriela Libisch, Natalia Rego, Carlos Robello
Summary: Chagas Disease is caused by the complex taxon T. cruzi, affecting nearly eight million people worldwide. T. cruzi has the ability to infect and interact with almost any nucleated cell, triggering molecular signaling cascades that depend on cell type, strain, and experimental variables. Host cell responses to infection, particularly in the respiratory chain and oxidative phosphorylation, vary depending on the T. cruzi strain and experimental model, while some responses remain consistent across strains, cell types, and conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucas A. M. Franco, Carlos H. V. Moreira, Lewis F. Buss, Lea C. Oliveira, Roberta C. R. Martins, Erika R. Manuli, Jose A. L. Lindoso, Michael P. Busch, Alexandre C. Pereira, Ester C. Sabino
Summary: Chagas disease is a major social and public health issue in Latin America, with adverse reactions to benznidazole (BZN) treatment potentially genetically determined. Genetic and transcriptomic analyses identified chromosome 16 gene region associations and enriched signaling pathways related to BZN adverse reactions. These findings suggest potential for patient risk stratification before initiating BZN treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lyda Z. Rojas, Sergio Alejandro Gomez-Ochao, Luis E. Echeverria, Paula Katherine Bautista-Nino, Lukas Hunziker, Michele F. Eisenga, Taulant Muka
Summary: This study aimed to analyze the association of circulating dehydroepiandrosterone sulfate (DHEA-S) levels with cardiovascular outcomes in patients with chronic Chagas cardiomyopathy (CCM). The results showed that higher DHEA-S levels were associated with lower mortality, heart transplantation, and LVAD implantation. Further larger studies are needed to confirm the results and assess causality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Parasitology
Flavio Campos Ferreira, Leilane Oliveira Goncalves, Jeronimo Conceicao Ruiz, Leonardo Barbosa Koerich, Fabiano Sviatopolk Mirsky Pais, Lileia Goncalves Diotaiuti, Carlota Josefovicz Belisario
Summary: This study identified and characterized microsatellite loci for future population genetic studies of P. megistus, showing high polymorphism and the potential for amplification across different geographic populations.
PARASITES & VECTORS
(2021)
Review
Immunology
Roberto Rodrigues Ferreira, Mariana Caldas Waghabi, Sabine Bailly, Jean-Jacques Feige, Alejandro M. Hasslocher-Moreno, Roberto M. Saraiva, Tania C. Araujo-Jorge
Summary: The anti-inflammatory cytokine TGF-beta plays a crucial role in Chagas disease, affecting the infection of Trypanosoma cruzi and the immune response and inflammation in the host. Inhibitors of the TGF-beta signaling pathway show promise as a potential therapeutic approach, and the level of TGF-beta in serum can serve as a biomarker of clinical relevance. Furthermore, TGF-beta polymorphisms are associated with susceptibility to Chagas disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eula G. A. Neves, Carolina C. Koh, Jose L. Padilha da Silva, Livia S. A. Passos, Fernanda N. A. Villani, Janete S. C. dos Santos, Cristiane A. S. Menezes, Vicente R. Silva, Julia P. A. S. Tormin, Guilherme F. B. Evangelista, Andrea Teixeira de Carvalho, Manoel Otavio da Costa Rocha, Bruno Nascimento, Kenneth John Gollob, Maria do Carmo P. Nunes, Walderez O. Dutra
Summary: Heart disease, including Chronic Chagas cardiomyopathy (CCC) and rheumatic heart disease (RHD), is a major cause of death worldwide. Despite distinct etiology, both diseases share common inflammatory pathways, as indicated by similar expression levels of various soluble factors. This study identified specific immunological distinctions between CCC and RHD, which may have implications for immune-based therapies in inflammatory cardiopathies.
Article
Immunology
Melissa S. Nolan, David Aguilar, Arunima Misra, Sarah M. Gunter, Tim Erickson, Rodion Gorchakov, Hilda Rivera, Susan P. Montgomery, Kristy O. Murray
Summary: This study identified a high prevalence of underdiagnosed Trypanosoma cruzi infection and discrepant results in clinical diagnostic assays among Latinx cardiac patients in the United States. It suggests that laboratory screening for T. cruzi infection would benefit this population.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Brian Custer, Eduard Grebe, Renata Buccheri, Sonia Bakkour, Mars Stone, Ligia Capuani, Cecilia Alencar, Luiz Amorim, Paula Loureiro, Anna Barbara Carneiro-Proietti, Alfredo Mendrone-Junior, Thelma Goncalez, Kui Gao, Kristin W. Livezey, Jeffrey M. Linnen, Don Brambilla, Chris McClure, Michael P. Busch, Ester C. Sabino
Summary: Testing blood donations for arboviruses in Brazil can contribute to public health, as the study found that transfusion recipients were likely exposed to Zika virus, chikungunya virus, and dengue virus viremic blood components during the study period.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Bruna Carvalho Silveira, Alexandre Pinto Ribeiro, Fabio Dumit Pizzinatto, Paloma Moraes Lobo, Hanna Rodrigues Miranda, Nathalia de Assis Pereira
Summary: This study found that the instillation of a commercial amniotic membrane extract did not accelerate corneal wound healing or suppress the early expression of MMP-9 in the tears of cats with experimentally induced superficial ulcerative keratitis.
VETERINARY OPHTHALMOLOGY
(2023)
Article
Engineering, Biomedical
Eran Zvuloni, Jesse Read, Antonio H. Ribeiro, Antonio Luiz P. Ribeiro, Joachim A. Behar
Summary: In recent research on 12-lead ECG analysis, deep learning has been extensively used. However, it is still unclear whether deep learning surpasses classical feature engineering based on domain knowledge. Furthermore, it is uncertain whether combining deep learning with feature engineering can improve performance over a single modality.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Mariana Yumi Miyadahira, Maria de Lourdes Brizot, Neal Alexander, Ester Cerdeira Sabino, Lea Campos de Oliveira da Silva, Mara Sandra Hoshida, Ana Maria da Silva Sousa Oliveira, Ana Claudia Silva Farche, Rossana Pulcineli Vieira Francisco, Philippe Mayaud
Summary: This study aims to determine the seroprevalence of SARS-CoV-2 among pregnant women at delivery in Sao Paulo, Brazil, and investigate the risk factors. The results showed that pregnant women can serve as a suitable population for SARS-CoV-2 serosurveillance. The study found a high seroprevalence among women at delivery in the early period of the pandemic, indicating their exposure to the virus.
Article
Dermatology
Valquiria Reis de Souza, Shannon Kelly, Ester Cerdeira Sabino, Franciane Mendes de Oliveira, Tassila Silva, Carolina Miranda Teixeira, Claudia Maximo, Paula Loureiro, Anna Barbara de Freitas Carneiro-Proietti, Isabel Gomes, Brian Custer, Cesar de Almeida-Neto
Summary: The prevalence of leg ulcers in this study was 21% among adult participants. Factors associated with leg ulcers included increasing age, male sex, chronic transfusion therapy, higher indirect bilirubin levels, and low hemoglobin levels. Participants who self-reported as Black, mixed, and other/unknown were more likely to have leg ulcers compared to those who self-reported as White.
ADVANCES IN SKIN & WOUND CARE
(2023)
Article
Infectious Diseases
Carolina dos Santos Lazari, Mariana Severo Ramundo, Felipe ten-Caten, Clarisse S. Bressan, Ana Maria Bispo de Filippis, Erika Regina Manuli, Isabella de Moraes, Geovana Maria Pereira, Marina Farrel Cortes, Darlan da Silva Candido, Alexandra L. Gerber, Ana Paula Guimaraes, Nuno Rodrigues Faria, Helder I. Nakaya, Ana Tereza R. Vasconcelos, Patricia Brasil, Glaucia Paranhos-Baccala, Ester Cerdeira Sabino
Summary: This study provides important insights into the prognostic evaluation of CHIKF, identifying sub-acute disease as a relevant predictor of evolution to chronic arthritis. Joint pain, edema, and multiple joint involvement were found to be risk factors for chronification.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Luis Antonio Rodriguez Carnero, Andreia Kuramoto, Lea Campos de Oliveira, Jhonatas Sirino Monteiro, Joao Carlos Setubal, Edecio Cunha-Neto, Ester Cerdeira Sabino, Ricardo Jose Giordano
Summary: This study used the gPhage platform to compare antigens and antibodies before and after treatment in 20 patients with chronic Chagas disease. The results showed a decrease in antibody levels and recognition of specific antigens after treatment. The gPhage data correlated with patient PCR-status and could predict patient response to treatment. In conclusion, the use of the gPhage platform contributes to the development of novel diagnostic tools for Chagas disease.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Hematology
Andre Rolim Belisario, Ana Cristina Simoes e Silva, Isabel Cristina Gomes Moura, Anna Barbara Carneiro-Proietti, Ester Cerdeira Sabino, Paula Loureiro, Claudia Maximo, Miriam V. Flor-Park, Daniela de Oliveira Werneck Rodrigues, Mina Cintho Ozahata, Rosimere Afonso Mota, Carla Luana Dinardo, Shannon Kelly, Brian Custer
Summary: Chronic kidney disease significantly affects the morbidity and mortality of sickle cell disease. This study aimed to evaluate the prevalence and risk factors for reduced estimated glomerular filtration rate (eGFR) among adults with sickle cell disease in Brazil. The results showed that one-quarter of the adults had eGFR below 90, and older age, male sex, higher diastolic blood pressure, lower hemoglobin, and lower reticulocyte levels were associated with decreased eGFR.
ANNALS OF HEMATOLOGY
(2023)
Article
Infectious Diseases
Renato A. Kfouri, Maria-Cristina C. Brandileone, Marco Aurelio P. Safadi, Rosana Richtmann, Alfredo E. Gilio, Flavia Rossi, Thais Guimaraes, Ana Luiza Bierrenbach, Jose C. Moraes, Sao Paulo Study Grp I. P. D. Sa Paulo Study Grp IPD
Summary: In Brazil, the National Immunization Program includes PCV10 for children < 2 years old and PPV23 for high-risk patients >= 2 years and institutionalized >= 60 years. PCV13 is only used in private clinics. A retrospective study on IPD patients in 5 hospitals in Brazil revealed that high-risk comorbidities were more common than at-risk conditions. This study suggests the need for expanded valence vaccines to provide broad prevention of IPD.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Bruno Oliveira Figueiredo Brito, Emilly Malveira Lima, Elsayed Z. Soliman, Eduardo Fernandes Silva, Maria Fernanda Lima-Costa, Antonio Luiz Pinho Ribeiro
Summary: This study investigates the development of electrocardiographic abnormalities in elderly Chagas disease patients and its impact on their survival. The study found that Chagas disease is associated with a higher risk of developing new ECG abnormalities, which in turn increases the risk of death. The newly developed cardiomyopathy in the elderly is as serious as in earlier stages.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Health Care Sciences & Services
Bruno Azevedo Chagas, Adriana Silvina Pagano, Raquel Oliveira Prates, Elisa Cordeiro Praes, Kicila Ferreguetti, Helena Vaz, Zilma Silveira Nogueira Reis, Leonardo Bonisson Ribeiro, Antonio Luiz Pinho Ribeiro, Thais Marques Pedroso, Alline Beleigoli, Clara Rodrigues Alves Oliveira, Milena Soriano Marcolino
Summary: This study evaluated the user experience quality of a COVID-19 chatbot in Brazil and found that overall, users had a positive experience with the chatbot. However, there are still areas for improvement.
JMIR HUMAN FACTORS
(2023)
Article
Infectious Diseases
Carl Jidling, Daniel Gedon, Thomas Schon, Claudia Di Lorenzo Oliveira, Clareci Silva C. Cardoso, Ariela Mota Ferreira, Luana Giatti, Sandhi Maria Barreto, Ester Sabino, Antonio L. P. Ribeiro, Antonio H. Ribeiro
Summary: The study developed an AI model for automatically detecting Chagas disease from electrocardiograms. The model shows promise in diagnosing chronic Chagas disease, but its performance in detecting non-chronic cases is limited.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Patricia Aparecida Tavares, Claudia Di Lorenzo Oliveira, Ariela Mota Ferreira, Nayara Ragi Baldoni, Nayara Dornela Quintino, Desiree Sant'Ana Haikal, Ana Luiza Bierrenbach, Antonio Luiz Pinho Ribeiro, Ester Cerdeira Sabino, Clareci Silva Cardoso
Summary: This study aimed to evaluate the psychometric properties of the World Health Organization Disability Assessment Schedule (WHODAS 2.0), specifically its 12-item shortened version (WHODAS-12) in patients with Chagas disease. The results showed that the WHODAS-12 is a valid and reliable measure for assessing disability in Brazilian patients with CD.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
Article
Hematology
Maria Auxiliadora Parreiras Martins, Joao Antonio de Queiroz Oliveira, Daniel Dias Ribeiro, Cibele Comini Cesar, Vandack Alencar Nobre, Daniel Moore Freitas Palhares, Manoel Otavio da Costa Rocha, Antonio Luiz Pinho Ribeiro
Summary: Anticoagulation clinics (ACs) have a greater impact on anticoagulation control than usual medical care (UMC). This study investigated the efficacy and safety of AC in patients treated at a Brazilian public hospital. The results showed that AC care helped increase the time in the therapeutic range (TTR) and had a favorable safety profile in a low-income setting.