Article
Dentistry, Oral Surgery & Medicine
Nil Yakar, Nagihan Bostanci, Gueven Ozdemir, Harika Atmaca, Asena Turedi, Cagdas Sahin, Timur Kose, Gulnur Emingil
Summary: This study compared the levels of cytokines in saliva between postmenopausal and regularly menstruating women, and found that there was no significant difference after adjusting for other factors. Age may be a stronger confounding factor.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Nutrition & Dietetics
Chiara Mando, Silvio Abati, Gaia Maria Anelli, Chiara Favero, Anais Serati, Laura Dioni, Marta Zambon, Benedetta Albetti, Valentina Bollati, Irene Cetin
Summary: This study found that the epigenetic profile in the saliva of obese pregnant women is markedly different from that of normal-weight pregnant women, suggesting the presence of impaired mechanisms and damaged pathways. The characterization of this profile can serve as a promising tool for the identification of obesity-related altered mechanisms and the development of biomarkers for early diagnosis and treatment of pregnancy-adverse conditions.
Article
Dentistry, Oral Surgery & Medicine
Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
Summary: This study aimed to evaluate the levels of cytokines in saliva and gingival crevicular fluid (GCF) in patients with ulcerative colitis (UC), Crohn disease (CD), and non-IBD, and analyze their associations with periodontal conditions. The study found that UC and CD patients with periodontitis and gingivitis had higher levels of TNF-alpha and lower levels of IL-10 compared to non-IBD patients. Additionally, UC patients with periodontitis had higher scores of bleeding on probing and increased levels of IL-1 beta in saliva and GCF compared to CD patients. The study concluded that in the presence of periodontal diseases, UC and CD patients showed different expression levels of TNF-alpha, IL-1 beta, and IL-10 in oral secretions compared to non-IBD patients.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Health Care Sciences & Services
Ji-Youn Kim, Ki-Rim Kim, Han-Na Kim
Summary: The study identified IL-1α and IL-1β as significant biomarkers for periodontal disease by analyzing inflammatory cytokines in saliva, with IL-1β confirmed as a significant predictor for periodontitis with a sensitivity of 88.24% and specificity of 62.5%.
Article
Dentistry, Oral Surgery & Medicine
Ronaldo Lira-Junior, Susan M. Bissett, Philip M. Preshaw, John J. Taylor, Elisabeth A. Bostrom
Summary: This study evaluated the salivary levels of myeloid-related markers in relation to periodontal disease, observing significantly elevated levels in periodontitis and gingivitis patients compared to healthy individuals. Periodontal treatment partially modulated these markers, with S100A8/A9 potentially serving as an identifier for distinct groups of periodontitis patients.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Hend Alqaderi, Abeer Abdullah, Matthew Finkelman, Mohamed Abufarha, Sriraman Devarajan, Jehad Abubaker, Nikitha Ramesh, Mary Tavares, Fahd Al-Mulla, Saadoun Bin-Hasan
Summary: Poor sleep behavior can lead to inflammation and contribute to inflammatory diseases. This study found that adolescents who go to bed at or later than midnight have dysregulated levels of inflammatory biomarkers in their saliva and serum, indicating that disrupted circadian rhythm can trigger higher levels of systemic inflammation and potentially increase the risk of chronic inflammation and metabolic diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Neurosciences
Yi Yang, Jiaxi Lv, Huimin Bai, Liang Ren, Jing Yang, Yi Ding, Chengcheng Liu, Xueping Chen
Summary: Characterizing the periodontal status of patients with Alzheimer's disease (AD), investigating differences in salivary metabolism between patients with and without AD under the same periodontal conditions, and understanding how it is related to oral flora are critical. Dysregulation of specific bacterial flora in saliva plays a vital role in metabolic changes in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Kurushima, P. M. Wells, R. C. E. Bowyer, N. Zoheir, S. Doran, J. P. Richardson, D. D. Sprockett, D. A. Relman, C. J. Steves, L. Nibali
Summary: Limited evidence is available on how host genetic variants affect microbiota composition. This study examines the associations between candidate host genetic variants and microbial composition in saliva and gut. The findings suggest that certain genetic variants are associated with microbial diversity and composition, and periodontal status may drive variations in the microbiota.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Denise Biagini, Silvia Ghimenti, Alessio Lenzi, Andrea Bonini, Federico Vivaldi, Camille Oger, Jean-Marie Galano, Laurence Balas, Thierry Durand, Pietro Salvo, Fabio Di Francesco, Tommaso Lomonaco
Summary: Cardiovascular diseases (CVDs) are the leading cause of premature death and disability, and oxidative stress and inflammation play key roles. This study proposes a powerful MS-based platform for measuring salivary lipid mediators in CVD samples. Saliva, as a non-invasive alternative to blood, was collected from patients with heart failure, obesity, and hypertension. The results suggest that lipid mediators may serve as predictive markers for re-acutisation episodes in heart failure patients, providing opportunities for preventive intervention and reduced hospitalizations.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Microbiology
Suk Ji, Joong-Ki Kook, Soon-Nang Park, Yun Kyong Lim, Geum Hee Choi, Jae-Suk Jung
Summary: Periodontal disease is a common and costly condition that leads to tooth loss. This study analyzed the salivary microbiota to determine if specific bacterial species can distinguish the severity of periodontal disease. The findings suggest that P. gingivalis, T. forsythia, and F. alocis may serve as biomarkers for assessing the severity of periodontal disease in saliva.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Liza L. Ramenzoni, Marc P. Lehner, Manuela E. Kaufmann, Daniel Wiedemeier, Thomas Attin, Patrick R. Schmidlin
Summary: The study aimed to evaluate the effectiveness of diagnostic salivary tests to determine periodontal status. Concentrations of lactoferrin, hemoglobin, and leukocytes were found to be significantly higher in the stimulated and unstimulated saliva in periodontitis patients compared to healthy patients, whereas alkaline phosphatase levels were higher in unstimulated saliva of periodontitis patients. Periodontal biomarker analysis using test strips may provide a rapid and easy tool for distinguishing between periodontitis and healthy patients.
Article
Spectroscopy
Shuo Chen, Haotian Wu, Chen Chen, Daheng Wang, Yaru Yang, Zheng Zhou, Ruochen Zhu, Xiaoning He, Yaping Pan, Chen Li
Summary: This study explored a pre-treatment saliva SERS based prognostic protocol to predict the prognosis of periodontal non-surgery therapy in periodontitis patients. Significant differences in the levels of ascorbic acid, uric acid, and glutathione were observed between good prognosis group and poor prognosis group, which can serve as potential prognostic markers. The proposed prognostic model achieved high accuracy, sensitivity, and specificity. The excellent performance of this method demonstrated its potential for fast, accurate, and non-invasive prognostic prediction in periodontal non-surgery therapy, benefiting timely and rational guidance on clinical interventions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Multidisciplinary Sciences
Jose Jesus Blanco-Perez, Sara Blanco-Dorado, Javier Rodriguez-Garcia, M. Elena Gonzalez-Bello, Angel Salgado-Barreira, Adriana Carolina Caldera-Diaz, Abel Pallares-Sanmartin, Alberto Fernandez-Villar, Francisco Javier Gonzalez-Barcala
Summary: Silicosis is a lung disease caused by sustained inhalation of silica, leading to pulmonary fibrosis mediated by cytokines. This study aimed to determine the clinical significance of biomarkers in silicosis, assess their association with disease development and severity, and identify determinants of disease progression. The results indicated a potential role of IL-8 as a biomarker for silicosis presence and mortality prediction.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nimet Gul Gorgulu, Basak Dogan
Summary: The study found that levels of MMP-8 and MAF in saliva were significantly elevated in periodontitis patients, but decreased to healthy levels after NSPT. Salivary MMP-8 showed high diagnostic ability for identifying P-III-B and P-III-C cases.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Cell Biology
Jun-Ichi Nagao, Sari Kishikawa, Honami Tanaka, Kenji Toyonaga, Yuka Narita, Kanae Negoro-Yasumatsu, Sonoko Tasaki, Ken-Ichi Arita-Morioka, Jiro Nakayama, Yoshihiko Tanaka
Summary: This study demonstrates that gut translocation of the oral pathobiont Porphyromonas gingivalis exacerbates periodontitis and enhances Th17 cell differentiation. The Th17 cells responsive to the oral pathobiont are differentiated in Peyer's patches and translocated to peripheral immune tissues, and they can migrate to and accumulate in the mouth upon oral infection. The development of periodontitis is regulated by the intestinal microbiome, and altering the microbiome composition affects the development of periodontitis.
Article
Infectious Diseases
Eunhee Park, Julie Yip, Emily Harville, Marlene Nelson, Gloria Giarratano, Pierre Buekens, Jennifer Wagman
Summary: The study revealed various barriers to preventing congenital syphilis in Kern County, such as limited access to prenatal care, social, economic, and cultural barriers, substance use, and co-occurring intimate partner/domestic violence. Additionally, gaps in prenatal care providers included pregnant women's social economic vulnerabilities, stigma and shame around the vulnerabilities, distrust in the medical system, prenatal substance use, limited prenatal substance use disorder treatment facilities, and inadequate provider training on context-specific congenital syphilis management strategies. Pregnant/postpartum women and prenatal care providers also highlighted gaps in partner notification, screening, and treatment for syphilis.
BMC INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Emily W. Harville, Maeve E. Wallace, Hua He, Lydia A. Bazzano
Summary: Both cardiovascular and reproductive complications may have origins in utero or in early life. A study found that childhood cardiometabolic indicators may predict adverse birth outcomes, such as preterm birth and low birthweight.
Article
Environmental Sciences
Cataia Ives, Huaqin Pan, Stephen W. Edwards, Mark Nelms, Hannah Covert, Maureen Y. Lichtveld, Emily W. Harville, Jeffrey K. Wickliffe, Wilco Zijlmans, Carol M. Hamilton
Summary: The use of standardized measurement protocols and data standards improves the quality and consistency of data collection in environmental health studies, facilitating the combination of information from multiple studies. Our analysis of clinical measures and exposure assays from NIH resources revealed a wide collection of environmental assessment data and a lesser prevalence of biological assessment data. NIH resources can aid in identifying common data for meta-analysis and support data sharing.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Christopher K. Uejio, Elaina Gonsoroski, Samendra P. Sherchan, Leslie Beitsch, E. W. Harville, C. Blackmore, K. Pan, Maureen Y. Lichtveld
Summary: Harmful algal blooms can have negative impacts on water quality and human health, and monitoring these effects is challenging. This study suggests that 311 calls can be used to enhance the surveillance of harmful algal blooms, and highlights the potential for integrating water quality monitoring and the 311 dispatch systems to improve public health surveillance.
JOURNAL OF WATER AND HEALTH
(2022)
Correction
Public, Environmental & Occupational Health
Emily W. Harville, Ke Pan, Leslie Beitsch, Samendra P. Sherchan, Elaina Gonsoroski, Christopher Uejio, Maureen Y. Lichtveld
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Public, Environmental & Occupational Health
Emily W. Harville, Ke Pan, Leslie Beitsch, Samendra P. Sherchan, Elaina Gonsoroski, Christopher Uejio, Maureen Y. Lichtveld
Summary: This study examined the impact of Hurricane Michael on birth outcomes and found that low birth weight and small for gestational age were significantly higher in the year after the hurricane in the most-affected area. The effect was stronger when exposure occurred in the first trimester or in the 2 months after the hurricane.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Editorial Material
Public, Environmental & Occupational Health
Emily W. Harville
Summary: A recent study found that the COVID-19 vaccine has no impact on fertility in men or women, while COVID-19 infection may temporarily reduce male fertility. These findings are reassuring for those seeking pregnancy and highlight the need to incorporate reproductive health into clinical trials and advance fertility research on a global scale.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Genetics & Heredity
Hans Desale, Pierre Buekens, Jackeline Alger, Maria Luisa Cafferata, Emily Wheeler Harville, Claudia Herrera, Carine Truyens, Eric Dumonteil
Summary: The study assessed the epigenetic effects of in utero exposure to maternal Trypanosoma cruzi infection. By comparing the DNA methylation patterns of umbilical cord blood cells from uninfected babies with chagasic and uninfected mothers, a differential DNA methylation signature was identified. The genes affected are related to hematopoietic cell differentiation, immune response, and developmental disorders.
Article
Public, Environmental & Occupational Health
Emily W. Harville, Maeve E. Wallace, Katherine P. Theall
Summary: Access to housing is an important manifestation of structural racism and discrimination. This study examined the relationship between eviction and birth outcomes and found that living in areas with higher eviction rates was associated with a 12-13% increased odds of low birthweight. Non-Hispanic black women were more likely to live in areas with higher eviction rates, while Hispanic women had no significant association with low birthweight/preterm birth. Housing instability may be a key social determinant of poor birth outcomes.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Public, Environmental & Occupational Health
Clinton Hall, Ava Marie S. Conlin, Monica Burrell, Celeste J. Romano, Anna T. Bukowinski, Gia R. Gumbs, Emily W. Harville, Dana L. Thomas, Hristina Denic-Roberts, Jennifer A. Rusiecki
Summary: This study evaluated the potential adverse health outcomes among infants born to US Coast Guard responders to the Deepwater Horizon oil spill disaster. The health outcomes of infants born to male responders were similar to non-responders, while infants born to female responders had a higher frequency of poor live birth outcomes. However, the findings should be interpreted with caution due to the small sample size.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Josh Alarcon, Lauren Ward, Ke Pan, Elaina Gonsoroski, Christopher K. Uejio, Leslie Beitsch, Maureen Y. Lichtveld, Emily W. Harville, Samendra Sherchan
Summary: Increased occurrences of harmful algal blooms (HAB) in the Gulf of Mexico and worldwide have raised concerns about brevetoxin exposure leading to respiratory illness or death, highlighting the need for extensive scientific research and human health monitoring.
JOURNAL OF WATER AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Emily W. Harville, Moira E. Wood, Elizabeth F. Sutton
Summary: The effect of social distancing due to the COVID-19 pandemic on the mental health of pregnant women is of particular concern. The study found that greater social distancing was associated with more anxiety symptoms, but worse mental health, particularly anxiety, may also have contributed to greater social distancing behaviors.
Article
Public, Environmental & Occupational Health
E. W. Harville, K. Pan, L. Beitsch, C. K. Uejio, M. Lichtveld, S. Sherchan, C. Timuta
Summary: The study evaluated the changes in mental health and social risk factors in pregnant women affected by Hurricane Michael in October 2018. Data from the Universal Perinatal Risk Screen (UPRS) and vital statistics for the state of Florida were analyzed. The proportion of pregnant women screened decreased in the months after the hurricane, but there were no overall changes in scores. Referrals were lower in the immediate aftermath of Michael but increased in the year after. Individual risk factors on the screener did not change significantly, except for a decrease in the short term in illnesses requiring ongoing medical care and an increase in the longer term. Smoking during pregnancy was higher among women who experienced Michael during their pregnancies.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Ke Pan, Lydia A. Bazzano, Kalpana Betha, Brittany M. Charlton, Jorge E. Chavarro, Christina Cordero, Erica P. Gunderson, Catherine L. Haggerty, Jaime E. Hart, Anne Marie Jukic, Sylvia H. Ley, Gita D. Mishra, Sunni L. Mumford, Enrique F. Schisterman, Karen Schliep, Jeffrey G. Shaffer, Daniela Sotres-Alvarez, Joseph B. Stanford, Allen J. Wilcox, Lauren A. Wise, Edwina Yeung, Emily W. Harville
Summary: The PrePARED Consortium has created a valuable resource by merging data from multiple cohort studies to address preconception health. They have pooled individual-level data from 12 prospective studies and used a crosswalk-cataloging-harmonization procedure. The study provides opportunities to examine uncommon preconception risk factors and pregnancy-related events.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Health Care Sciences & Services
Pierre Buekens, Mabel Berrueta, Emily Harville, Agustina Mazzoni, Xu Xiong
LANCET REGIONAL HEALTH-AMERICAS
(2022)