Article
Peripheral Vascular Disease
Beata Korosi, Helga Gyongyosi, Dora Batta, Andrea Laszlo, Illes Kovacs, Andras Tisler, Orsolya Cseprekal, Zsofia Nemcsik-Bencze, Xenia Gonda, Zoltan Rihmer, Janos Nemcsik
Summary: White-coat and resistant hypertensive patients exhibit specific affective temperament patterns, and evaluating these patterns can provide insight into the psychopathological background of these conditions.
HYPERTENSION RESEARCH
(2021)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Medicine, General & Internal
Gyongyosi Helga, Korosi Beata Zita, Batta Dora, Laszlo Andrea, Nemcsik-Bencze Zsofia, Gonda Xenia, Rihmer Zoltan, Cseprekal Orsolya, Tisler Andras, Nemcsik Janos
Summary: This study aimed to investigate the relationship between affective temperaments and arterial stiffness index in chronic hypertensive patients. The results showed that depressive, cyclothymic, irritable, and anxious temperaments were associated with arterial stiffness index, independent of other factors. This suggests the importance of affective temperaments in cardiovascular prevention.
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Article
Clinical Neurology
Yidan Qiu, Shenglin She, Shufei Zhang, Fengchun Wu, Qunjun Liang, Yongjun Peng, Haishan Yuan, Yuping Ning, Huawang Wu, Ruiwang Huang
Summary: This study analyzed the association between affective temperaments and cortical myelin content (CMC) in the human brain. Results showed that hyperthymic temperament correlated negatively with CMC in certain brain regions, while cyclothymic temperament displayed a downward parabola-like correlation with CMC across different myelinated areas.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Article
Neurosciences
Shristi Khanal, Eugene Bok, Jaekwang Kim, Gyu Hwan Park, Dong-Young Choi
Summary: Parkinson's disease (PD) is a common neurodegenerative disease without known cure or therapy. Inosine, a purine nucleoside, can protect neuroblastoma cells and dopaminergic neurons through brain-derived neurotrophic factor (BDNF) upregulation and activation of its downstream signaling pathway. Adenosine receptors A1 and A2A play critical roles in mediating the neuroprotective effects of inosine. Inosine shows therapeutic potential in treating dopaminergic neurodegeneration in PD.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Milan Vecsey-Nagy, Balint Szilveszter, Marton Kolossvary, Melinda Boussoussou, Borbala Vattay, Xenia Gonda, Zoltan Rihmer, Bela Merkely, Pal Maurovich-Horvat, Janos Nemcsik
Summary: The study found that elevated hyperthymic affective temperament scores significantly decreased the odds of severe CAD, while dyslipidemia and cyclothymic affective temperament scores were positively associated with CAD. Ideal cutoff values for hyperthymic, cyclothymic, and irritable temperament scores were independently linked to severe CAD based on ROC analysis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Hayley Dingsdale, Samantha M. Garay, Hannah R. Tyson, Katrina A. Savory, Lorna A. Sumption, Jemima S. Kelleher, Kate Langley, Stephanie Van Goozen, Rosalind M. John
Summary: The study found a sex-specific association between cord serum BDNF levels at birth and attention development parameters in infants at one year old. This finding provides some support for the hypothesis that reduced serum BDNF levels at birth are linked to an increased risk for neurodevelopmental disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Tadahiro Numakawa, Haruki Odaka
Summary: BDNF plays a crucial role in various neural functions through the activation of its high-affinity receptor TrkB, and abnormalities in BDNF signaling have been implicated in neurodegenerative diseases such as Alzheimer's disease. Studies have shown the potential involvement of deregulated BDNF signaling in the pathophysiology of AD, and compounds like flavonoids may offer promise as BDNF-targeting therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Konstantinos N. Fountoulakis, Xenia Gonda
Summary: The study found age-related changes in higher and lower modules, with differences between genders in all levels of the model.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2022)
Review
Clinical Neurology
Xenia Gonda, Peter Dome, Joanna C. Neill, Frank Tarazi
Summary: The treatment of major depressive disorder (MDD) and treatment-resistant depression (TRD) is still a major unmet need. Current drugs have limited efficacy or undesirable side effects. Developing novel antidepressant drugs beyond the monoamine targets may be an effective strategy to improve the treatment of MDD and TRD.
Article
Medicine, General & Internal
Eorsi Daniel, Gacs Zsofia, Kun Eszter
Summary: The flu vaccination rate among the Hungarian adult population is unsatisfactory due to their inconsistent attitude towards vaccination. General practitioners play a crucial role in influencing people's decision-making, as shown by previous research. The study aimed to identify the factors driving and hindering flu vaccination among general practitioners and the general population. Results indicated that 93% of the adult population is aware of the influenza vaccine, with 30% of them preferring to follow their general practitioner's advice. General practitioners overestimated the vaccination coverage of their patients. The most common reasons for not getting vaccinated against flu were the perception of influenza not being dangerous, trust in one's own immune system, and fear of vaccine side effects.
Article
Cell Biology
Peter Mukli, Dee H. Wu, Tamas Csipo, Cameron D. Owens, Agnes Lipecz, Frigyes Samuel Racz, Fouad A. Zouein, Adam Tabak, Anna Csiszar, Zoltan Ungvari, Panayiotis D. Tsitouras, Andriy Yabluchanskiy
Summary: This study validated a panel of urinary oxidative stress biomarkers and found that they were positively or negatively correlated with age, suggesting their potential in assessing biological age and identifying individuals at accelerated risk for aging-related diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Psychiatry
Georgina Szabo, Michele Fornaro, Peter Dome, Szabolcs Varbiro, Xenia Gonda
Summary: This study conducted a systematic review and meta-analysis to investigate the association between affective temperament and treatment adherence. The results indicated that individuals with higher scores in cyclothymic, irritable, and depressive temperament were more likely to have poorer treatment adherence.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Gergely A. Visolyi, Beatrix A. Domjan, Mark M. Svebis, Anna Peterfi, Barbara D. Lovasz, Szilvia Meszaros, Viktor J. Horvath, Adam G. Tabak
Summary: This study aimed to compare the efficacy and safety of commercially available fixed-ratio combinations of GLP-1RAs and basal insulins in patients with type 2 diabetes. The results showed that both fixed-ratio combinations were more effective in reducing A1C levels compared to their individual components, with no significant difference between the combinations. GLP-1RAs and IDegLira were associated with lower weight gain and lower incidence of hypoglycemia compared to iGlarLixi and basal insulins.
CANADIAN JOURNAL OF DIABETES
(2023)
Letter
Cardiac & Cardiovascular Systems
Adam G. Tabak, Naveed Sattar, Mika Kivimaki
Article
Biochemistry & Molecular Biology
Zsolt Bagyura, Loretta Kiss, Arpad Lux, Csaba Csobay-Novak, Adam L. Jermendy, Livia Polgar, Adam G. Tabak, Pal Soos, Zsolt Szelid, Bela Merkely, Laszlo Kohidai, Eva Pallinger
Summary: Several inflammatory biomarkers are associated with an increased risk of cardiovascular disease. Neutrophil-to-lymphocyte ratio (NLR) and visceral adiposity index (VAI) are markers of subclinical inflammation and reflect the function and extent of adipose tissue. This study aimed to examine the association between NLR and coronary artery calcium score (CACS) in asymptomatic patients across different VAI tertiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Primary Health Care
Andras Mohos, Gergo Jozsef Szollosi, Laszlo Robert Kolozsvari, Jozsef Rinfel, Albert Varga, Maria Marko Kucsera, Csenge Hargittay, Peter Torzsa
Summary: The shortage of family physicians in Hungary is a significant challenge, especially in rural and deprived areas. This study investigated medical students' attitudes towards rural family medicine and found that only 5% of participants plan to become family doctors and work in rural areas. Medical students with a rural origin and an interest in family medicine are more likely to plan to work in rural areas.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Primary Health Care
Sara Ares-Blanco, Marina Guisado-Clavero, Lourdes Ramos Del Rio, Ileana Gefaell Larrondo, Louise Fitzgerald, Limor Adler, Radost Assenova, Maria Bakola, Sabine Bayen, Elena Brutskaya-Stempkovskaya, Iliana-Carmen Busneag, Philippe-Richard Domeyer, Dragan Gjorgjievski, Kathryn Hoffmann, Oksana Ilkov, Vasilis Trifon Karathanos, Aleksandar Kirkovski, Snezana Knezevic, Buesra Cimen Korkmaz, Bruno Heleno, Katarzyna Nessler, Liubove Murauskiene, Ana Luisa Neves, Naldy Parodi Lopez, Abel Perjes, Davorina Petek, Ferdinando Petrazzuoli, Goranka Petricek, Bohumil Seifert, Alicia Serafini, Theresa Sentker, Paula Tiili, Peter Torzsa, Bert Vaes, Gijs van Pottebergh, Shlomo Vinker, Maria Pilar Astier-Pena, Raquel Gomez-Bravo, Heidrun Lingner
Summary: This study demonstrated the involvement of primary health care centers in Europe in diagnosing, treating, and monitoring COVID-19 patients. The similarities and differences in patient's clinical pathways among European countries were highlighted.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Gergely A. Visolyi, Attila Kun, Orsolya Szalai, Mark M. Svebis, Beatrix A. Domjan, Laszlo Zsirai, Adam G. Tabak
Summary: Untreated 'mild' gestational diabetes mellitus (GDM) in pregnant women had worse pregnancy outcomes compared to normal glucose tolerant women, but these differences were explained by pre-pregnancy BMI after adjustment.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Urology & Nephrology
Akos Geza Petho, Peter Kevei, Mark Juha, Agnes Koczy, Nora Ledo, Andras Tisler, Istvan Takacs, Adam G. Tabak
Summary: This study assessed the mortality of hospitalized COVID-19 patients before the vaccination era and found that previously hemodialysis patients had significantly better survival. In contrast, patients with chronic kidney disease who did not receive hemodialysis treatment had increased mortality.
Review
Health Care Sciences & Services
Xenia Gonda, Gianluca Serafini, Peter Dome
Summary: The fight against suicide is challenging, as it is a complex and threatening psychiatric phenomenon. Despite advances in neurobiology research, identifying and predicting suicide remains a major challenge. Utilizing specific biological and genetic markers as intervention targets, such as the involvement of neuroinflammation, could provide a novel approach in the treatment of suicidal behavior.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Geriatrics & Gerontology
Viktor J. Horvath, Magdolna Bekeffy, Zsuzsanna Nemeth, Emese Szelke, Vince Fazekas-Pongor, Noemi Hajdu, Mark M. Svebis, Jozsef Pinter, Beatrix A. Domjan, Szilvia Meszaros, Anna E. Korei, Arpad Kezdi, Ibolya Kocsis, Katalin Kristof, Peter Kempler, Ferenc Rozgonyi, Istvan Takacs, Adam G. Tabak
Summary: Vaccination, especially booster vaccination, reduces the mortality rate among hospitalized COVID-19 patients. This study suggests that primary and booster vaccinations can improve the survival of patients during the delta wave of the pandemic. The findings of this study may enhance the quality of patient-provider discussions at the time of admission.
Article
Public, Environmental & Occupational Health
Ana Isabel Ribeiro, Silvia Fraga, Milton Severo, Michelle Kelly-Irving, Cyrille Delpierre, Silvia Stringhini, Mika Kivimaki, Stephane Joost, Idris Guessous, Gianluca Severi, Graham Giles, Carlotta Sacerdote, Paolo Vineis, Henrique Barros
Summary: This study suggests that the adverse health effects of living in disadvantaged neighborhoods are more pronounced among individuals with lower levels of education, exacerbating social inequalities in health. This finding highlights the importance of addressing health disparities at both individual and community levels in policies aimed at reducing health inequalities.
LANCET PUBLIC HEALTH
(2022)
