Article
Surgery
Damien Bouriez, Yaniss Belaroussi, Mehdi Boubaddi, Paul Martre, Haythem Najah, Patrick Berger, Caroline Gronnier, Denis Collet
Summary: PEH repair significantly improves dyspnoea and FEV1 in patients, especially those with lower preoperative FEV1.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Maria E. Linnaus, Anna Garren, Jon C. Gould
Summary: The most common location and mechanism for hiatal hernia recurrence is anterior dilation of the hiatus. Further research should be conducted on outcomes following techniques designed to reinforce the anterior hiatus and prevent hiatal dilation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Colin P. Dunn, Jasmine Zhao, Jennifer C. Wang, Tanu A. Patel, Luke R. Putnam, Aleeson Eka, Caitlin C. Houghton, Nikolai A. Bildzukewicz, John C. Lipham
Summary: Magnetic sphincter augmentation in conjunction with large hiatal hernia repairs for patients with GERD achieves excellent long-term radiographic and clinical results, and a low overall need for reoperation, without the need for mesh.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Luca Giulini, Deepika Razia, Andres R. Latorre-Rodriguez, Mark Shacker, Mate Csucska, Sumeet K. Mittal
Summary: This study investigated the impact of hernia size on perioperative outcomes and the appropriateness of a watch-and-wait strategy for patients with asymptomatic large hernias. The results showed that large hernia repairs were associated with more postoperative complications and longer hospital stays compared to medium hernia repairs. Regardless of hernia size, good mid- and long-term quality of life outcomes can be achieved.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Naveen Perisetla, William N. Doyle Jr, Lauren Ladehoff, Nicole Natarelli, Valerie Nemov, Karthik Pittala, Joseph Sujka, Adham R. Saad, Chistopher DuCoin, Vic Velanovich
Summary: This study found that patients with spinal deformities had a higher risk of hiatal hernia recurrence after repair, with shorter time to recurrence and a greater likelihood of having complex and larger hiatal hernias.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Rocio E. Carrera Ceron, Robert B. Yates, Andrew S. Wright, H. Alejandro Rodriguez, Rebecca G. Lopez, Carlos A. Pellegrini, Brant K. Oelschlager
Summary: By reviewing surgical records, videos, and academic conference abstracts, we found no evidence of Type II hiatal hernias (HH). The current definition of Type II HH is problematic, as it can easily be mistaken for a paraesophageal hernia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Emergency Medicine
Marianne Apard, Celina Pognonec, Youri Yordanov, Pierre-Clement Thiebaud
Summary: The case study presented a 57-year-old woman with isolated shortness of breath who was diagnosed with symptomatic hiatal hernia causing cardiac compression. After upper gastrointestinal endoscopy and surgical repair, the patient was discharged in stable condition.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Veterinary Sciences
Sarah Tayler, Deirdre Mullowney, Alexandru Lataretu, Mark Plested, Jayson Tuan, Aarti Kathrani
Summary: This study reports a rare case of a geriatric cat with gastroesophageal intussusception, extreme esophageal dilatation, and laryngeal paralysis, all of which improved after treatment with unilateral arytenoid lateralization. It highlights the importance of thorough history taking and examination in cats with extreme esophageal dilatation to identify upper respiratory tract abnormalities that may be treated appropriately to resolve the esophageal dilatation.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Surgery
Kheman Rajkomar, Christophe R. Berney
Summary: This article systematically evaluates the repair of laparoscopic large hiatal hernia and proposes methods to improve surgical outcomes. Starting from defining and categorizing, it discusses preoperative evaluation, surgical techniques, issues in the repair phase, and postoperative investigations. The article is of great significance in improving the repair of large hiatal hernia.
Article
Surgery
Sharbel A. Elhage, Angela M. Kao, Michael Katzen, Jenny M. Shao, Tanushree Prasad, Vedra A. Augenstein, B. Todd Heniford, Paul D. Colavita
Summary: Elective repair versus watchful waiting in paraesophageal hernia (PEH) patients remains controversial. Generating predictive factors to determine patients at greatest risk for emergent repair may be helpful. Patients undergoing emergent repair are more likely to experience complications, require ICU care, have a higher mortality rate, and an increased likelihood of reoperation. An increase in intrathoracic hernia sac volume (HSV) predicts the need for emergent surgery. Patients with large PEH may benefit from early elective surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Walaa Abdelmoaty, Christy Dunst, Reid Fletcher, Huy Doan, Carmen Tugulan, Jarvis Walters, Daniel Davila-Bradley, Kevin Reavis, Lee Swanstrom, Steven DeMeester
Summary: This study used barium upper gastrointestinal series to evaluate the development and natural history of hiatal hernia. The results showed that both sliding and paraesophageal type hernias can develop over time and the majority of them increased in size. Additionally, 25% of sliding hernias became paraesophageal hernias. Recognizing changes in hiatal hernia size or type may be clinically relevant.
Article
Surgery
Robert Allman, James Speicher, Austin Rogers, Ethan Ledbetter, Aundrea Oliver, Mark Iannettoni, Carlos Anciano
Summary: The study aimed to show that adding a fundic gastropexy to laparoscopic hiatal hernia repair and magnetic sphincter augmentation in patients at high risk for hiatal hernia recurrence improved outcomes without altering perioperative course.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Valentine Cerbelle, Kevin Le Duc, Stephanie Lejeune, Sebastien Mur, Heloise Lerisson, Elodie Drumez, Rony Sfeir, Julien Bigot, Pauline Verpillat, Riadh Boukhris, Pascal Vaast, Clemence Mordacq, Caroline Thumerelle, Laurent Storme, Antoine Deschildre
Summary: Measurement of fetal lung volume can help identify infants with lower respiratory risk and provide better prediction and personalized follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Priscila R. Armijo, Crystal Krause, Tailong Xu, Valerie Shostrom, Dmitry Oleynikov
Summary: The study compared the efficiency of three types of mesh in hiatal hernia repair surgeries. While the surgical outcomes of the three mesh groups were similar, there was a significant difference in mesh costs. Surgeon and hospital preferences still play a role in choosing the type of mesh used, but knowledge of individual mesh costs can help in making more informed decisions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Benjamin Clapp, Ali M. Kara, Paul J. Nguyen-Lee, Hani M. Annabi, Luis Alvarado, John D. Marr, Omar M. Ghanem, Brian Davis
Summary: The use of bioabsorbable mesh in hiatal hernia repair is more effective in reducing hernia recurrence rate compared to simple suture cruroplasty, according to a meta-analysis of available literature.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Hematology
Gabrielle J. Pennings, Caroline J. Reddel, Mathew Traini, Magdalena Lam, Maaike Kockx, Vivien M. Chen, Leonard Kritharides
Summary: Platelets are capable of rapidly releasing IL-1 beta as an inflammatory mediator in response to specific agonists, independent of NLRP3 and caspase-1. This rapid release occurs in minutes following exposure to ADP and thrombin receptor agonists. Immature and mature IL-1 beta proteins were found in low abundance within human platelets and localized to various parts of the platelet structure.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Sonali R. Gnanenthiran, Austin C. C. Ng, Robert G. Cumming, David B. Brieger, David G. le Couteur, Louise M. Waite, Markus Seibel, David J. Handelsman, Vasi Naganathan, Leonard Kritharides, Fiona M. Blyth
Summary: Low hemoglobin levels were associated with increased risk of MACE, regardless of frailty status. A hemoglobin cutoff point of 140 g/L predicted long-term MACE, independent of other factors.每10g/L的血红蛋白下降与心血管事件的风险增加相关。
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Malcolm West, Adrienne Kirby, Ralph A. Stewart, Stefan Blankenberg, David Sullivan, Harvey D. White, David Hunt, Ian Marschner, Edward Janus, Leonard Kritharides, Gerald F. Watts, John Simes, Andrew M. Tonkin
Summary: This study found that elevated plasma cystatin C levels were associated with the development of chronic kidney disease, cardiovascular events, and all-cause mortality. Furthermore, this association was independent of estimated glomerular filtration rate (GFR).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Christopher C. Y. Wong, Ashkan Javadzadegan, Cuneyt Ada, Jerrett K. Lau, Ravinay Bhindi, William F. Fearon, Leonard Kritharides, Martin K. C. Ng, Andy S. C. Yong
Summary: This study aimed to evaluate the relationship between wall shear stress (WSS), functionally significant epicardial coronary stenoses, and microcirculatory dysfunction. The results showed that fractional flow reserve and instantaneous wave-free ratio independently predicted the total burden of low WSS and maximum lesion WSS in coronary arteries, while microcirculatory dysfunction was not associated with WSS.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Mingxi Hou, Karice Hyun, Derek P. Chew, Leonard Kritharides, David Amos, David Brieger
Summary: This study aimed to explore the patterns of P2Y12 inhibitor use and their association with outcomes in the Australian population. The results showed that in Australia, ticagrelor and prasugrel were mainly used in younger patients, while clopidogrel was mainly used in patients with higher baseline risks. The ticagrelor and prasugrel groups had reduced in-hospital deaths, major adverse cardiac events, and bleeding compared to the clopidogrel group, but these differences were no longer apparent after multivariable adjustment. There were no differences in outcomes between the treatment groups at 12 months, but the findings suggest room for improvement in guideline-driven usage of P2Y12 inhibitors.
HEART LUNG AND CIRCULATION
(2022)
Article
Medicine, General & Internal
Noor Alsadat, Karice Hyun, Farzaneh Boroumand, Craig Juergens, Leonard Kritharides, David B. Brieger
Summary: This study assessed lipid levels in ACS patients six or 12 months after discharge and found that almost half of the patients did not achieve target lipid levels. Factors associated with not reaching targets included age, use of lipid-lowering therapy, and cholesterol levels on admission. These patients are at increased risk of recurrent cardiovascular disease, highlighting the importance of optimizing therapy to improve outcomes.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Respiratory System
Samantha Herath, Farzad Bashirzadeh, Hema Mahajan, Alvin Ing, David Fielding
Summary: The study demonstrates that the combination of GenCut core biopsy with R-EBUS can effectively obtain samples of peripheral pulmonary lesions, potentially achieving a high diagnostic yield, with a high safety profile.
RESPIROLOGY CASE REPORTS
(2022)
Article
Hematology
Sonali R. Gnanenthiran, Gabrielle J. Pennings, Caroline J. Reddel, Heather Campbell, Maaike Kockx, Justin R. Hamilton, Vivien Chen, Leonard Kritharides
Summary: Aging is associated with increased basal platelet activation, ADP hyperreactivity, and thrombin resistance. In situ thrombin generation and systemic inflammation may be potential targets for preventing cardiovascular disease in the elderly.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Samantha Herath, Conroy Wong, Paul Dawkins, Andrew Veale, Elaine Yap, Jonathan Williamson, Irene Low, Hema Mahajan, Tania Prvan, Stuart Barnard, Stewart Hawkins, Dan Cookson, Tushar Singh, Alvin Ing
Summary: This study compared the differences between CT-TTB and Cryo-Radial biopsy in the diagnosis of lung nodules, and found that Cryo-Radial has comparable diagnostic yield and ability to perform EGFR testing with a significantly lower risk of pneumothorax compared to CT-TTB.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Respiratory System
Alvin J. Ing, Anand Jayapadman, Woo-Veen Kim, Chelsea Ly, Kevin Ho-Shon, Paul Lilburn, Alan Carew, Benjamin J. H. Ng, Tajalli Saghaie, Jonathan P. Williamson
Summary: This study investigates the efficacy of EPF in reversing CV in severe COPD patients, showing improvements in lung function and quality of life, with potential benefits in certain patients undergoing ELVR.
Editorial Material
Respiratory System
Alvin J. Ing, Tajalli Saghaie
Article
Cardiac & Cardiovascular Systems
Gabrielle J. Pennings, Caroline J. Reddel, Vivien M. Chen, Sonali R. Gnanenthiran, Leonard Kritharides
Summary: Colchicine has been proven to reduce cardiovascular death, myocardial infarction, ischemic stroke, and coronary revascularization in patients with coronary artery disease (CAD), even in those already on antiplatelet therapy. It not only has anti-inflammatory effects, but also exerts antiplatelet effects by primarily targeting collagen-induced platelet activation via glycoprotein (GP)VI, a critical receptor for arterial thrombosis formation. In vitro studies have shown that therapeutic concentrations of colchicine decrease collagen-induced platelet aggregation and modify GPVI signaling. Clinical studies have demonstrated a significant reduction in serum GPVI levels after 6 months of colchicine treatment in CAD patients, potentially reducing thrombotic risk. Future evaluation of colchicine's effects should include assessment of its impact on collagen-mediated platelet activation, in addition to its well-known anti-inflammatory effects.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Biyanka Jaltotage, Abdul Rahman Ihdayhid, Nick S. R. Lan, Faraz Pathan, Sanjay Patel, Clare Arnott, Gemma Figtree, Leonard Kritharides, Syed Mohammed Shamsul Islam, Clara K. Chow, James M. Rankin, Stephen J. Nicholls, Girish Dwivedi
Summary: This paper provides an Australian perspective on the current state and implementation challenges of artificial intelligence in cardiology. It highlights current AI applications and emphasizes the need to address issues such as data privacy, ethical considerations, and integration with existing infrastructures.
HEART LUNG AND CIRCULATION
(2023)
Article
Respiratory System
M. Hatch, P. Lilburn, C. Scott, A. Ing, D. Langton
Summary: In a cohort of severe asthmatics in the era of biological therapy, the safety and efficacy of bronchial thermoplasty (BT) was evaluated 5 years post-treatment. The results showed sustained improvement in symptoms control and reduced steroid requirement, but no change in spirometry. Mild localized radiological bronchiectasis was identified in some patients without clinical features.
Article
Peripheral Vascular Disease
Maaike Kockx, Lynne Roberts, Jeffrey Wang, Collin Tran, Mark A. Brown, Leonard Kritharides
Summary: After hypertensive pregnancy, ABCA1-mediated HDL cholesterol efflux capacity is impaired and continues to decrease postpartum. However, this decrease is unlikely to explain the long-term increased risk of cardiovascular disease in women with hypertensive pregnancies.
ATHEROSCLEROSIS PLUS
(2022)
